SitesBLAST
Comparing RR42_RS13630 FitnessBrowser__Cup4G11:RR42_RS13630 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
O33819 4-hydroxybenzoyl-CoA reductase subunit alpha; 4-HBCR subunit alpha; EC 1.1.7.1 from Thauera aromatica (see paper)
37% identity, 99% coverage: 5:757/764 of query aligns to 10:766/769 of O33819
1rm6A Structure of 4-hydroxybenzoyl-coa reductase from thauera aromatica (see paper)
37% identity, 99% coverage: 5:757/764 of query aligns to 2:758/761 of 1rm6A
- active site: Q206 (= Q206), T241 (≠ I241), Y318 (≠ V318), L322 (≠ R322), R350 (= R350), E718 (= E717), G719 (≠ T718)
- binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): G235 (= G235), G236 (= G236), F237 (= F237), G238 (= G238), R350 (= R350), I473 (≠ M474), G474 (= G475), Q475 (= Q476), G476 (= G477), Y513 (≠ L514), S514 (≠ A515), S515 (= S516), V517 (= V518), T518 (= T519), L646 (≠ I645), N647 (= N646), V651 (= V650), Q654 (= Q653), K714 (= K713), E715 (≠ G714), A716 (= A715), S717 (= S716), E718 (= E717)
1t3qB Crystal structure of quinoline 2-oxidoreductase from pseudomonas putida 86 (see paper)
31% identity, 97% coverage: 19:756/764 of query aligns to 27:785/786 of 1t3qB
- active site: Q224 (= Q206), A259 (≠ I241), E336 (vs. gap), V343 (≠ R322), R371 (= R350), E743 (= E717), S744 (≠ T718)
- binding pterin cytosine dinucleotide: G254 (= G236), F255 (= F237), R371 (= R350), S506 (≠ M474), G507 (= G475), Q508 (= Q476), H510 (≠ A478), T513 (≠ M481), Y545 (≠ L514), S547 (= S516), G549 (≠ V518), A550 (≠ T519), C666 (= C641), I670 (= I645), I674 (≠ A649), V675 (= V650), Q678 (= Q653), K739 (= K713), G740 (= G714), M741 (≠ A715), G742 (≠ S716)
7dqxD Crystal structure of xanthine dehydrogenase family protein
31% identity, 96% coverage: 16:751/764 of query aligns to 16:764/770 of 7dqxD
- binding pterin cytosine dinucleotide: G247 (= G235), S248 (≠ G236), F249 (= F237), R363 (= R350), V491 (≠ M474), G492 (= G475), Q493 (= Q476), G494 (= G477), V498 (≠ M481), S530 (= S513), W531 (≠ L514), S532 (≠ A515), S533 (= S516), R534 (= R517), S535 (≠ V518), T536 (= T519), T658 (≠ A649), T659 (≠ V650), Q662 (= Q653), G725 (= G714), L726 (≠ A715), G727 (≠ S716), E728 (= E717)
P19913 Carbon monoxide dehydrogenase large chain; CO dehydrogenase subunit L; CO-DH L; EC 1.2.5.3 from Hydrogenophaga pseudoflava (Pseudomonas carboxydoflava) (see paper)
29% identity, 98% coverage: 11:757/764 of query aligns to 20:800/803 of P19913
- R384 (= R350) modified: 4-hydroxyarginine
1ffvB Carbon monoxide dehydrogenase from hydrogenophaga pseudoflava (see paper)
29% identity, 97% coverage: 19:757/764 of query aligns to 25:794/797 of 1ffvB
- active site: Q231 (= Q206), V266 (≠ I241), P343 (vs. gap), I349 (≠ V318), R378 (= R350), C379 (vs. gap), E751 (= E717), S752 (≠ T718)
- binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): G260 (= G235), G261 (= G236), F262 (= F237), G263 (= G238), A376 (= A348), R378 (= R350), C379 (vs. gap), Q516 (≠ M474), G517 (= G475), Q518 (= Q476), H520 (≠ A478), T523 (≠ M481), Y556 (≠ L514), G557 (≠ A515), S558 (= S516), S560 (≠ V518), T561 (= T519), C674 (= C641), I678 (= I645), I683 (≠ V650), Q686 (= Q653), K747 (= K713), G748 (= G714), V749 (≠ A715), A750 (≠ S716), E751 (= E717)
1ffuB Carbon monoxide dehydrogenase from hydrogenophaga pseudoflava which lacks the mo-pyranopterin moiety of the molybdenum cofactor (see paper)
29% identity, 97% coverage: 19:757/764 of query aligns to 25:794/797 of 1ffuB
- active site: Q231 (= Q206), V266 (≠ I241), P343 (vs. gap), I349 (≠ V318), R378 (= R350), C379 (vs. gap), E751 (= E717), S752 (≠ T718)
- binding cytidine-5'-diphosphate: Q518 (= Q476), H520 (≠ A478), T523 (≠ M481), S558 (= S516), S560 (≠ V518), T561 (= T519), C674 (= C641), T676 (≠ K643), I678 (= I645), I683 (≠ V650), K747 (= K713), G748 (= G714), V749 (≠ A715), A750 (≠ S716)
1n62B Crystal structure of the mo,cu-co dehydrogenase (codh), n- butylisocyanide-bound state (see paper)
29% identity, 93% coverage: 21:734/764 of query aligns to 31:775/804 of 1n62B
- active site: Q235 (= Q206), V270 (≠ I241), P347 (vs. gap), I353 (≠ V318), R382 (= R350), C383 (vs. gap), E758 (= E717), S759 (≠ T718)
- binding cu(i)-s-mo(iv)(=o)o-nbic cluster: G267 (= G238), V379 (vs. gap), A380 (= A348), R382 (= R350), C383 (vs. gap), F385 (= F352), Y563 (≠ L514), G564 (≠ A515), E758 (= E717)
- binding pterin cytosine dinucleotide: G265 (= G236), F266 (= F237), R382 (= R350), Q523 (≠ M474), G524 (= G475), Q525 (= Q476), H527 (≠ A478), T530 (≠ M481), T562 (≠ S513), Y563 (≠ L514), G564 (≠ A515), S565 (= S516), S567 (≠ V518), T568 (= T519), C681 (= C641), I685 (= I645), I689 (≠ A649), I690 (≠ V650), Q693 (= Q653), K754 (= K713), G755 (= G714), V756 (≠ A715), G757 (≠ S716), E758 (= E717)
1n5wB Crystal structure of the cu,mo-co dehydrogenase (codh); oxidized form (see paper)
29% identity, 93% coverage: 21:734/764 of query aligns to 31:775/804 of 1n5wB
- active site: Q235 (= Q206), V270 (≠ I241), P347 (vs. gap), I353 (≠ V318), R382 (= R350), C383 (vs. gap), E758 (= E717), S759 (≠ T718)
- binding cu(i)-s-mo(vi)(=o)oh cluster: G267 (= G238), A380 (= A348), R382 (= R350), C383 (vs. gap), Y563 (≠ L514), G564 (≠ A515), E758 (= E717)
- binding pterin cytosine dinucleotide: G265 (= G236), F266 (= F237), R382 (= R350), Q523 (≠ M474), G524 (= G475), Q525 (= Q476), H527 (≠ A478), T530 (≠ M481), T562 (≠ S513), Y563 (≠ L514), S565 (= S516), S567 (≠ V518), T568 (= T519), C681 (= C641), I685 (= I645), I689 (≠ A649), I690 (≠ V650), Q693 (= Q653), K754 (= K713), G755 (= G714), V756 (≠ A715), E758 (= E717)
P19919 Carbon monoxide dehydrogenase large chain; CO dehydrogenase subunit L; CO-DH L; EC 1.2.5.3 from Afipia carboxidovorans (strain ATCC 49405 / DSM 1227 / KCTC 32145 / OM5) (Oligotropha carboxidovorans) (see 2 papers)
29% identity, 93% coverage: 21:734/764 of query aligns to 36:780/809 of P19919
- C388 (vs. gap) binding
- E763 (= E717) binding
1n63B Crystal structure of the cu,mo-co dehydrogenase (codh); carbon monoxide reduced state (see paper)
29% identity, 93% coverage: 21:734/764 of query aligns to 32:776/805 of 1n63B
- active site: Q236 (= Q206), V271 (≠ I241), P348 (vs. gap), I354 (≠ V318), R383 (= R350), C384 (vs. gap), E759 (= E717), S760 (≠ T718)
- binding cu(i)-s-mo(iv)(=o)oh cluster: G268 (= G238), A381 (= A348), R383 (= R350), C384 (vs. gap), Y564 (≠ L514), G565 (≠ A515), E759 (= E717)
- binding pterin cytosine dinucleotide: G266 (= G236), F267 (= F237), R383 (= R350), Q524 (≠ M474), G525 (= G475), Q526 (= Q476), H528 (≠ A478), T531 (≠ M481), T563 (≠ S513), Y564 (≠ L514), S566 (= S516), S568 (≠ V518), T569 (= T519), C682 (= C641), I686 (= I645), I690 (≠ A649), I691 (≠ V650), Q694 (= Q653), K755 (= K713), G756 (= G714), V757 (≠ A715), E759 (= E717)
1zxiB Reconstituted co dehydrogenase from oligotropha carboxidovorans (see paper)
29% identity, 93% coverage: 21:734/764 of query aligns to 31:775/804 of 1zxiB
- active site: Q235 (= Q206), V270 (≠ I241), P347 (vs. gap), I353 (≠ V318), R382 (= R350), C383 (vs. gap), E758 (= E717), S759 (≠ T718)
- binding copper (ii) ion: C383 (vs. gap), S384 (≠ G351), E758 (= E717)
- binding cu(i)-s-mo(vi)(=o)oh cluster: F266 (= F237), G267 (= G238), A380 (= A348), Y381 (≠ F349), R382 (= R350), C383 (vs. gap), Y563 (≠ L514), G564 (≠ A515), E758 (= E717)
- binding pterin cytosine dinucleotide: G265 (= G236), F266 (= F237), R382 (= R350), Q523 (≠ M474), G524 (= G475), Q525 (= Q476), H527 (≠ A478), T530 (≠ M481), T562 (≠ S513), Y563 (≠ L514), S565 (= S516), S567 (≠ V518), T568 (= T519), C681 (= C641), I685 (= I645), I689 (≠ A649), I690 (≠ V650), Q693 (= Q653), K754 (= K713), G755 (= G714), V756 (≠ A715), E758 (= E717)
1n60B Crystal structure of the cu,mo-co dehydrogenase (codh); cyanide- inactivated form (see paper)
29% identity, 93% coverage: 21:734/764 of query aligns to 30:774/803 of 1n60B
- active site: Q234 (= Q206), V269 (≠ I241), P346 (vs. gap), I352 (≠ V318), R381 (= R350), C382 (vs. gap), E757 (= E717), S758 (≠ T718)
- binding pterin cytosine dinucleotide: G264 (= G236), F265 (= F237), R381 (= R350), Q522 (≠ M474), G523 (= G475), Q524 (= Q476), H526 (≠ A478), T529 (≠ M481), T561 (≠ S513), Y562 (≠ L514), G563 (≠ A515), S564 (= S516), S566 (≠ V518), T567 (= T519), C680 (= C641), I684 (= I645), I688 (≠ A649), I689 (≠ V650), Q692 (= Q653), K753 (= K713), G754 (= G714), V755 (≠ A715), E757 (= E717)
- binding mo(vi)(=o)(oh)2 cluster: F265 (= F237), G266 (= G238), Y562 (≠ L514), G563 (≠ A515), E757 (= E717)
3hrdE Crystal structure of nicotinate dehydrogenase (see paper)
38% identity, 53% coverage: 6:411/764 of query aligns to 7:412/420 of 3hrdE
- active site: Q207 (= Q206), L242 (≠ I241), R318 (≠ V318), H322 (≠ R322), R350 (= R350)
- binding calcium ion: T206 (= T205), N208 (≠ S207), D212 (≠ A211), K241 (= K240), L242 (≠ I241), D243 (≠ E243)
- binding pterin cytosine dinucleotide: G237 (= G236), F238 (= F237), R350 (= R350)
- binding selenium atom: F238 (= F237), A348 (= A348), F349 (= F349), R350 (= R350)
3hrdA Crystal structure of nicotinate dehydrogenase (see paper)
38% identity, 53% coverage: 6:411/764 of query aligns to 7:412/420 of 3hrdA
- active site: Q207 (= Q206), L242 (≠ I241), R318 (≠ V318), H322 (≠ R322), R350 (= R350)
- binding pterin cytosine dinucleotide: G236 (= G235), G237 (= G236), F238 (= F237), R350 (= R350)
- binding magnesium ion: T206 (= T205), N208 (≠ S207), D212 (≠ A211), K241 (= K240), L242 (≠ I241), D243 (≠ E243), T305 (≠ C305), Y308 (= Y308), A309 (= A309), S346 (≠ R346)
- binding nicotinic acid: A314 (≠ D314), R318 (≠ V318), F352 (= F352)
- binding selenium atom: F238 (= F237), G239 (= G238), A348 (= A348), F349 (= F349), R350 (= R350)
Q0QLF2 Nicotinate dehydrogenase large molybdopterin subunit; NDH; Nicotinic acid hydroxylase large molybdopterin subunit; NAH; EC 1.17.1.5 from Eubacterium barkeri (Clostridium barkeri) (see 2 papers)
38% identity, 53% coverage: 6:411/764 of query aligns to 8:413/425 of Q0QLF2
Sites not aligning to the query:
- 1 modified: Initiator methionine, Removed
- 2:425 modified: mature protein, Nicotinate dehydrogenase large molybdopterin subunit
4zohA Crystal structure of glyceraldehyde oxidoreductase (see paper)
27% identity, 98% coverage: 6:750/764 of query aligns to 3:701/701 of 4zohA
- active site: Q186 (= Q206), I219 (= I241), V298 (≠ M316), S300 (≠ V318), M304 (≠ R322), R332 (= R350), E668 (= E717), A669 (≠ T718)
- binding pterin cytosine dinucleotide: G213 (= G235), A214 (≠ G236), F215 (= F237), R332 (= R350), H442 (≠ M474), G443 (= G475), Q444 (= Q476), D446 (≠ A478), W482 (≠ L514), S484 (= S516), T486 (≠ V518), V487 (≠ T519), I594 (= I645), N595 (= N646), L598 (≠ A649), Q602 (= Q653), K664 (= K713), G665 (= G714), I666 (≠ A715), G667 (≠ S716), E668 (= E717)
2e1qA Crystal structure of human xanthine oxidoreductase mutant, glu803val (see paper)
28% identity, 98% coverage: 6:756/764 of query aligns to 548:1287/1307 of 2e1qA
- active site: Q742 (= Q206), V777 (≠ I241), R855 (≠ V318), H859 (≠ R322), R887 (= R350), G1235 (≠ S716), E1236 (= E717)
- binding bicarbonate ion: R814 (= R275), H815 (≠ S276), I852 (≠ V315), F886 (= F349), F889 (= F352), G890 (= G353), Q893 (= Q356)
- binding calcium ion: E715 (≠ Y180), H716 (≠ P181), Y718 (= Y183), T741 (= T205), T747 (≠ A211), S780 (≠ E244), T781 (≠ S245), S784 (= S247), T811 (vs. gap), G812 (= G273)
- binding fe2/s2 (inorganic) cluster: L719 (= L184)
- binding hydroxy(dioxo)molybdenum: F773 (= F237), G774 (= G238), R887 (= R350), A1053 (≠ L514), A1054 (= A515), E1236 (= E717)
Sites not aligning to the query:
- binding flavin-adenine dinucleotide: 43, 44, 230, 231, 232, 233, 234, 235, 236, 237, 238, 311, 312, 316, 320, 321, 324, 325, 327, 328, 333, 334, 377, 378
- binding fe2/s2 (inorganic) cluster: 40, 41, 42, 44, 46, 47, 49, 71, 110, 111, 112, 114, 146, 148
3sr6C Crystal structure of reduced bovine xanthine oxidase in complex with arsenite (see paper)
28% identity, 98% coverage: 5:756/764 of query aligns to 2:742/745 of 3sr6C
- active site: Q197 (= Q206), E232 (= E243), R310 (≠ V318), H314 (≠ R322), R342 (= R350), G690 (≠ S716), E691 (= E717)
- binding [arsenothionito(2-)-kappa~2~O,S](oxo)molybdenum: G229 (= G238), F344 (= F352), A508 (≠ L514), A509 (= A515), E691 (= E717)
3b9jC Structure of xanthine oxidase with 2-hydroxy-6-methylpurine (see paper)
28% identity, 98% coverage: 5:756/764 of query aligns to 2:742/758 of 3b9jC
- active site: Q197 (= Q206), E232 (= E243), R310 (≠ V318), H314 (≠ R322), R342 (= R350), G690 (≠ S716), E691 (= E717)
- binding 6-methyl-3,9-dihydro-2H-purin-2-one: E232 (= E243), R310 (≠ V318), F344 (= F352), F439 (≠ G443), T440 (≠ N444), A509 (= A515), E691 (= E717)
- binding calcium ion: R269 (= R275), H270 (≠ S276)
Query Sequence
>RR42_RS13630 FitnessBrowser__Cup4G11:RR42_RS13630
MSTSTVGSATPQVTAREKVMGRAVYAGDIKQAGMLHAKVLRSPYPHARIVRIDTAAARAL
RGVKLVLTGEDTPSRLWGTHRKEQRILAAGVVRHVGEEVAAVVAVDEETARDALDLIRVE
YEELPAIFSPDAALADGAAELHPGTRNIAHEMHIERGDVEAGFARAAVVYEATYDMHSQY
PGYLEPMATVAAQDGNGRLTVWASTQSVFLARARLAEALDRPVSTIRVIQAVTGGGFGAK
IVEESNSLIAALLATRLDRPVRLVNNRLEDFLGARSSVPARVWLKMGLDAQGMIVAKDVN
IVAECGAYAGLAGDVMHVTAMRSDNMHRVENVRSNAVLAYTNNPPRGAFRGFGGQQMQFP
LNSHLTMLAEMLGMDPIEVHKRNAIRSGDTSVHGWKIGSSGLVECLEQTREAIQWDARRA
DASRRTGTRRRGLGIAAAMHVSGNRTLGNWDGSTIVLKVNEDGRVMLLTSECDMGQGANT
MLSQICAQELGIALSHVTVSAPDTDVAPFCLGSLASRVTIISGNAVMRAAREAKQKLLAV
AAGKLGVPQDELDLIDGVIRARHDDTTRATLAEIARLHIFRHGGEGLMVRATYDAPTVMH
DANYYGNIAPAYSFAAQAVEVEVDTVTGQITLIDSFVSDDCGKAINPLAVHGQTHGATVQ
AIGWTLYEHVQVEDGRILNGNFADYTMPTADAVPALRTDVVESVEPNGPYGAKGASETAI
LPGAAAIANAVYDAIGVRIASLPITPEKVLAALRERKENEARHA
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory