Comparing RR42_RS16500 FitnessBrowser__Cup4G11:RR42_RS16500 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
3mmtA Crystal structure of fructose bisphosphate aldolase from bartonella henselae, bound to fructose bisphosphate (see paper)
59% identity, 94% coverage: 14:331/340 of query aligns to 14:336/341 of 3mmtA
Q9SJQ9 Fructose-bisphosphate aldolase 6, cytosolic; AtFBA6; Cytosolic aldolase 2; cAld2; EC 4.1.2.13 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
54% identity, 96% coverage: 6:332/340 of query aligns to 11:338/358 of Q9SJQ9
6rngB Dipeptide gly-pro binds to a glycolytic enzyme fructose bisphosphate aldolase
54% identity, 96% coverage: 6:332/340 of query aligns to 6:333/334 of 6rngB
P07764 Fructose-bisphosphate aldolase; EC 4.1.2.13 from Drosophila melanogaster (Fruit fly) (see 2 papers)
53% identity, 96% coverage: 4:331/340 of query aligns to 13:342/361 of P07764
Sites not aligning to the query:
5tklA Crystal structure of fbp aldolase from toxoplasma gondii, condensation intermediate (see paper)
53% identity, 96% coverage: 6:331/340 of query aligns to 15:343/350 of 5tklA
Sites not aligning to the query:
4tr9A Ternary co-crystal structure of fructose-bisphosphate aldolase from plasmodium falciparum in complex with trap and a small molecule inhibitor (see paper)
49% identity, 97% coverage: 2:332/340 of query aligns to 12:345/347 of 4tr9A
2ephD Crystal structure of fructose-bisphosphate aldolase from plasmodium falciparum in complex with trap-tail determined at 2.7 angstrom resolution (see paper)
49% identity, 97% coverage: 2:332/340 of query aligns to 14:347/351 of 2ephD
P04075 Fructose-bisphosphate aldolase A; Lung cancer antigen NY-LU-1; Muscle-type aldolase; EC 4.1.2.13 from Homo sapiens (Human) (see 11 papers)
51% identity, 97% coverage: 2:331/340 of query aligns to 11:343/364 of P04075
Sites not aligning to the query:
4aldA Human muscle fructose 1,6-bisphosphate aldolase complexed with fructose 1,6-bisphosphate (see paper)
51% identity, 97% coverage: 2:331/340 of query aligns to 10:342/363 of 4aldA
Sites not aligning to the query:
2ot0A Fructose-1,6-bisphosphate aldolase from rabbit muscle in complex with a c-terminal peptide of wiskott-aldrich syndrome protein (see paper)
50% identity, 99% coverage: 2:337/340 of query aligns to 10:348/356 of 2ot0A
Sites not aligning to the query:
5tlzA Fructose-1,6-bisphosphate aldolase from rabbit muscle in complex with the inhibitor naphthalene 2,6-bisphosphate (see paper)
51% identity, 97% coverage: 2:331/340 of query aligns to 7:339/346 of 5tlzA
Sites not aligning to the query:
1zalA Fructose-1,6-bisphosphate aldolase from rabbit muscle in complex with partially disordered tagatose-1,6-bisphosphate, a weak competitive inhibitor (see paper)
51% identity, 97% coverage: 2:331/340 of query aligns to 10:342/363 of 1zalA
Sites not aligning to the query:
1zajA Fructose-1,6-bisphosphate aldolase from rabbit muscle in complex with mannitol-1,6-bisphosphate, a competitive inhibitor (see paper)
51% identity, 97% coverage: 2:331/340 of query aligns to 10:342/363 of 1zajA
Sites not aligning to the query:
Q944G9 Fructose-bisphosphate aldolase 2, chloroplastic; AtFBA2; EC 4.1.2.13 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
50% identity, 96% coverage: 6:331/340 of query aligns to 54:378/398 of Q944G9
Sites not aligning to the query:
P00883 Fructose-bisphosphate aldolase A; Muscle-type aldolase; EC 4.1.2.13 from Oryctolagus cuniculus (Rabbit) (see 5 papers)
51% identity, 97% coverage: 2:331/340 of query aligns to 11:343/364 of P00883
Sites not aligning to the query:
5tlwA Fructose-1,6-bisphosphate aldolase from rabbit muscle in complex with the inhibitor 1-phosphate-benzene 4-bisphosphonate (see paper)
51% identity, 97% coverage: 2:331/340 of query aligns to 10:342/349 of 5tlwA
Sites not aligning to the query:
5tleA Fructose-1,6-bisphosphate aldolase from rabbit muscle in complex with the inhibitor 2-phosphate-naphthalene 6-bisphosphonate (see paper)
51% identity, 97% coverage: 2:331/340 of query aligns to 10:342/349 of 5tleA
Sites not aligning to the query:
3tu9A Crystal structure of rabbit muscle aldolase bound with 5-o-methyl mannitol 1,6-phosphate (see paper)
51% identity, 97% coverage: 2:331/340 of query aligns to 10:342/349 of 3tu9A
Sites not aligning to the query:
2ot1A Fructose-1,6-bisphosphate aldolase from rabbit muscle in complex with naphthol as-e phosphate, a competitive inhibitor (see paper)
51% identity, 97% coverage: 2:331/340 of query aligns to 10:342/349 of 2ot1A
Sites not aligning to the query:
5tlhA Fructose-1,6-bisphosphate aldolase from rabbit muscle in complex with the inhibitor 2-naphthol 6-bisphosphonate (see paper)
51% identity, 97% coverage: 2:331/340 of query aligns to 10:342/350 of 5tlhA
Sites not aligning to the query:
>RR42_RS16500 FitnessBrowser__Cup4G11:RR42_RS16500
MDTRSELQATVDALVQAGKGLLAADESGATIAKRFERIGVASSEESRRAWRNLLLSTPGL
GECISGVILYEETLGQCADDGTPLPALAARHGIVPGIKVDKGKLALAHAPGDEITEGLDG
LAKRLAAYRQQGARFAKWRAVYNVSGELPSRLAIQANAQALARYAAICQEMGVVPIVEPE
VLMDGAHAMARCAEVTEAVLHDVFHALHRHAVVLEHMLLKPSMVLPGKDAGHAAPAEVAM
QTVQVLKRTVPAAVPGIFFLSGGQTPIEATANLDAMNRLAPLPWRLSFSYGRALQEPPLL
AWRGEAANAAQAQRALLQRSRLNGLASLGQYEAALETAAG
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory