SitesBLAST
Comparing RR42_RS17315 FitnessBrowser__Cup4G11:RR42_RS17315 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
7bkbB Formate dehydrogenase - heterodisulfide reductase - formylmethanofuran dehydrogenase complex from methanospirillum hungatei (hexameric, composite structure) (see paper)
21% identity, 57% coverage: 179:416/421 of query aligns to 9:268/296 of 7bkbB
- binding Non-cubane [4Fe-4S]-cluster: G9 (= G179), C10 (= C180), C42 (= C212), C43 (= C213), C79 (≠ A252), C82 (= C255), G156 (≠ P323), C157 (= C324), C197 (= C356), C198 (= C357), C235 (≠ N394), F237 (≠ G396), F237 (≠ G396), C238 (= C397)
Q007T0 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur subunit of complex II; Ip; EC 1.3.5.1 from Sus scrofa (Pig) (see paper)
28% identity, 21% coverage: 16:102/421 of query aligns to 175:270/280 of Q007T0
- C186 (= C25) binding
- C189 (= C28) binding
- C192 (= C31) binding
- C196 (= C35) binding
- W201 (≠ L40) binding
- C243 (= C75) binding
- C249 (= C81) binding
- C253 (= C85) binding
Sites not aligning to the query:
- 93 binding
- 98 binding
- 101 binding
- 113 binding
Q9YHT2 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur subunit of complex II; Ip; EC 1.3.5.1 from Gallus gallus (Chicken) (see 2 papers)
25% identity, 23% coverage: 7:102/421 of query aligns to 179:280/290 of Q9YHT2
- C196 (= C25) binding
- C199 (= C28) binding
- C202 (= C31) binding
- C206 (= C35) binding
- W211 (≠ L40) binding
- C253 (= C75) binding
- C259 (= C81) binding
- C263 (= C85) binding
Sites not aligning to the query:
- 103 binding
- 108 binding
- 111 binding
- 123 binding
3sfeB Crystal structure of porcine mitochondrial respiratory complex ii bound with oxaloacetate and thiabendazole (see paper)
28% identity, 21% coverage: 16:102/421 of query aligns to 140:235/240 of 3sfeB
- binding fe3-s4 cluster: C161 (= C35), Y171 (≠ L45), P174 (= P48), C208 (= C75), T210 (= T77), I211 (≠ C78), M212 (≠ R79), N213 (= N80), C214 (= C81)
- binding iron/sulfur cluster: C151 (= C25), I152 (≠ V26), L153 (≠ H27), C154 (= C28), A155 (≠ G29), C157 (= C31), A175 (≠ R49), C218 (= C85), P219 (= P86), K220 (≠ S87), L222 (≠ V89)
- binding 2-(1,3-thiazol-4-yl)-1h-benzimidazole: H209 (≠ L76), I211 (≠ C78)
Sites not aligning to the query:
8gs8B Cryo-em structure of the human respiratory complex ii (see paper)
28% identity, 21% coverage: 16:102/421 of query aligns to 141:236/239 of 8gs8B
- binding fe3-s4 cluster: C162 (= C35), Y172 (≠ L45), P175 (= P48), C209 (= C75), H210 (≠ L76), T211 (= T77), I212 (≠ C78), M213 (≠ R79), N214 (= N80), C215 (= C81)
- binding iron/sulfur cluster: C152 (= C25), C155 (= C28), C158 (= C31), A176 (≠ R49), C219 (= C85)
- binding ubiquinone-1: P163 (= P36), W167 (≠ L40), I212 (≠ C78)
Sites not aligning to the query:
3sfdB Crystal structure of porcine mitochondrial respiratory complex ii bound with oxaloacetate and pentachlorophenol (see paper)
28% identity, 21% coverage: 16:102/421 of query aligns to 139:234/239 of 3sfdB
- binding fe3-s4 cluster: C160 (= C35), Y170 (≠ L45), P173 (= P48), C207 (= C75), T209 (= T77), I210 (≠ C78), M211 (≠ R79), N212 (= N80), C213 (= C81)
- binding pentachlorophenol: P161 (= P36), W165 (≠ L40), I210 (≠ C78)
- binding iron/sulfur cluster: C150 (= C25), I151 (≠ V26), L152 (≠ H27), C153 (= C28), A154 (≠ G29), C156 (= C31), A174 (≠ R49), C217 (= C85), P218 (= P86), K219 (≠ S87)
Sites not aligning to the query:
3aegB Crystal structure of porcine heart mitochondrial complex ii bound with n-biphenyl-3-yl-2-iodo-benzamide
28% identity, 21% coverage: 16:102/421 of query aligns to 139:234/239 of 3aegB
- binding N-biphenyl-3-yl-2-iodobenzamide: S162 (≠ T37), W164 (≠ Q39), W165 (≠ L40), H208 (≠ L76)
- binding fe3-s4 cluster: C160 (= C35), Y170 (≠ L45), P173 (= P48), C207 (= C75), I210 (≠ C78), M211 (≠ R79), C213 (= C81), I227 (≠ V95)
- binding iron/sulfur cluster: C150 (= C25), I151 (≠ V26), L152 (≠ H27), C153 (= C28), A154 (≠ G29), C156 (= C31), A174 (≠ R49), C217 (= C85)
Sites not aligning to the query:
3aeeB Crystal structure of porcine heart mitochondrial complex ii bound with atpenin a5
28% identity, 21% coverage: 16:102/421 of query aligns to 139:234/239 of 3aeeB
- binding 3-[(2s,4s,5r)-5,6-dichloro-2,4-dimethyl-1-oxohexyl]-4-hydroxy-5,6-dimethoxy-2(1h)-pyridinone: W165 (≠ L40), H208 (≠ L76), I210 (≠ C78)
- binding fe3-s4 cluster: C160 (= C35), Y170 (≠ L45), P173 (= P48), C207 (= C75), T209 (= T77), I210 (≠ C78), M211 (≠ R79), N212 (= N80), C213 (= C81)
- binding iron/sulfur cluster: C150 (= C25), L152 (≠ H27), C153 (= C28), C156 (= C31), A174 (≠ R49), C217 (= C85), P218 (= P86), L221 (≠ V89)
Sites not aligning to the query:
3aedB Crystal structure of porcine heart mitochondrial complex ii bound with 2-iodo-n-phenyl-benzamide
28% identity, 21% coverage: 16:102/421 of query aligns to 139:234/239 of 3aedB
- binding 2-iodo-N-phenylbenzamide: P161 (= P36), W165 (≠ L40), H208 (≠ L76), I210 (≠ C78)
- binding fe3-s4 cluster: C160 (= C35), Y170 (≠ L45), P173 (= P48), C207 (= C75), I210 (≠ C78), M211 (≠ R79), N212 (= N80), C213 (= C81)
- binding iron/sulfur cluster: C150 (= C25), I151 (≠ V26), L152 (≠ H27), C153 (= C28), A154 (≠ G29), C156 (= C31), C217 (= C85), L221 (≠ V89)
Sites not aligning to the query:
3aecB Crystal structure of porcine heart mitochondrial complex ii bound with 2-iodo-n-(1-methylethyl)-benzamid
28% identity, 21% coverage: 16:102/421 of query aligns to 139:234/239 of 3aecB
- binding 2-iodo-N-(1-methylethyl)benzamide: P161 (= P36), W165 (≠ L40), H208 (≠ L76)
- binding fe3-s4 cluster: C160 (= C35), Y170 (≠ L45), P173 (= P48), C207 (= C75), I210 (≠ C78), M211 (≠ R79), N212 (= N80), C213 (= C81)
- binding iron/sulfur cluster: C150 (= C25), I151 (≠ V26), L152 (≠ H27), C153 (= C28), C156 (= C31), A174 (≠ R49), C217 (= C85), P218 (= P86), L221 (≠ V89)
Sites not aligning to the query:
3aebB Crystal structure of porcine heart mitochondrial complex ii bound with n-(3-phenoxy-phenyl)-2-trifluoromethyl-benzamide
28% identity, 21% coverage: 16:102/421 of query aligns to 139:234/239 of 3aebB
- binding fe3-s4 cluster: C160 (= C35), Y170 (≠ L45), P173 (= P48), C207 (= C75), T209 (= T77), I210 (≠ C78), M211 (≠ R79), N212 (= N80), C213 (= C81)
- binding N-(3-phenoxyphenyl)-2-(trifluoromethyl)benzamide: W165 (≠ L40), H208 (≠ L76)
- binding iron/sulfur cluster: C150 (= C25), I151 (≠ V26), L152 (≠ H27), C153 (= C28), A154 (≠ G29), C156 (= C31), A174 (≠ R49), C217 (= C85), L221 (≠ V89)
Sites not aligning to the query:
3aeaB Crystal structure of porcine heart mitochondrial complex ii bound with n-(3-dimethylaminomethyl-phenyl)-2-trifluoromethyl-benzamide (see paper)
28% identity, 21% coverage: 16:102/421 of query aligns to 139:234/239 of 3aeaB
- binding fe3-s4 cluster: C160 (= C35), Y170 (≠ L45), P173 (= P48), C207 (= C75), T209 (= T77), I210 (≠ C78), M211 (≠ R79), N212 (= N80), C213 (= C81)
- binding N-{3-[(dimethylamino)methyl]phenyl}-2-(trifluoromethyl)benzamide: P161 (= P36), W165 (≠ L40), H208 (≠ L76), I210 (≠ C78)
- binding iron/sulfur cluster: C150 (= C25), I151 (≠ V26), L152 (≠ H27), C153 (= C28), C156 (= C31), A174 (≠ R49), C217 (= C85), P218 (= P86), L221 (≠ V89)
Sites not aligning to the query:
3ae9B Crystal structure of porcine heart mitochondrial complex ii bound with n-(3-pentafluorophenyloxy-phenyl)-2-trifluoromethyl-benzamide (see paper)
28% identity, 21% coverage: 16:102/421 of query aligns to 139:234/239 of 3ae9B
- binding fe3-s4 cluster: C160 (= C35), Y170 (≠ L45), P173 (= P48), C207 (= C75), H208 (≠ L76), T209 (= T77), I210 (≠ C78), M211 (≠ R79), N212 (= N80), C213 (= C81)
- binding N-[3-(pentafluorophenoxy)phenyl]-2-(trifluoromethyl)benzamide: P161 (= P36), W165 (≠ L40), H208 (≠ L76)
- binding iron/sulfur cluster: C150 (= C25), I151 (≠ V26), L152 (≠ H27), C153 (= C28), A154 (≠ G29), C156 (= C31), A174 (≠ R49), C217 (= C85), L221 (≠ V89)
Sites not aligning to the query:
3ae8B Crystal structure of porcine heart mitochondrial complex ii bound with n-(3-isopropoxy-phenyl)-2-trifluoromethylbenzamide
28% identity, 21% coverage: 16:102/421 of query aligns to 139:234/239 of 3ae8B
- binding fe3-s4 cluster: C160 (= C35), P173 (= P48), C207 (= C75), T209 (= T77), I210 (≠ C78), M211 (≠ R79), C213 (= C81)
- binding N-[3-(1-methylethoxy)phenyl]-2-(trifluoromethyl)benzamide: S162 (≠ T37), W165 (≠ L40), H208 (≠ L76)
- binding iron/sulfur cluster: C150 (= C25), I151 (≠ V26), L152 (≠ H27), C153 (= C28), C156 (= C31), A174 (≠ R49), C217 (= C85), P218 (= P86), L221 (≠ V89)
Sites not aligning to the query:
3ae7B Crystal structure of porcine heart mitochondrial complex ii bound with 2-iodo-n-(3-isopropoxy-phenyl)-benzamide (see paper)
28% identity, 21% coverage: 16:102/421 of query aligns to 139:234/239 of 3ae7B
- binding 2-iodo-N-[3-(1-methylethoxy)phenyl]benzamide: P161 (= P36), W165 (≠ L40), H208 (≠ L76), I210 (≠ C78)
- binding fe3-s4 cluster: C160 (= C35), Y170 (≠ L45), P173 (= P48), C207 (= C75), T209 (= T77), I210 (≠ C78), M211 (≠ R79), C213 (= C81)
- binding iron/sulfur cluster: C150 (= C25), I151 (≠ V26), L152 (≠ H27), C153 (= C28), C156 (= C31), A174 (≠ R49), C217 (= C85), P218 (= P86)
Sites not aligning to the query:
3ae6B Crystal structure of porcine heart mitochondrial complex ii bound with n-(3-isopropoxy-phenyl)-phthalamicacid
28% identity, 21% coverage: 16:102/421 of query aligns to 139:234/239 of 3ae6B
- binding fe3-s4 cluster: C160 (= C35), Y170 (≠ L45), P173 (= P48), C207 (= C75), I210 (≠ C78), M211 (≠ R79), N212 (= N80), C213 (= C81)
- binding 2-{[3-(1-methylethoxy)phenyl]carbamoyl}benzoic acid: S162 (≠ T37), W165 (≠ L40)
- binding iron/sulfur cluster: C150 (= C25), I151 (≠ V26), L152 (≠ H27), C153 (= C28), A154 (≠ G29), C156 (= C31), A174 (≠ R49), C217 (= C85), P218 (= P86), L221 (≠ V89)
Sites not aligning to the query:
3ae4B Crystal structure of porcine heart mitochondrial complex ii bound with 2-iodo-n-methyl-benzamide
28% identity, 21% coverage: 16:102/421 of query aligns to 139:234/239 of 3ae4B
- binding fe3-s4 cluster: C160 (= C35), S162 (≠ T37), P173 (= P48), C207 (= C75), M211 (≠ R79), N212 (= N80), C213 (= C81)
- binding 2-iodo-N-methylbenzamide: W165 (≠ L40), H208 (≠ L76), I210 (≠ C78)
- binding iron/sulfur cluster: C150 (= C25), I151 (≠ V26), C153 (= C28), A154 (≠ G29), C156 (= C31), A174 (≠ R49), C217 (= C85), P218 (= P86)
Sites not aligning to the query:
3ae3B Crystal structure of porcine heart mitochondrial complex ii bound with 2-nitro-n-phenyl-benzamide
28% identity, 21% coverage: 16:102/421 of query aligns to 139:234/239 of 3ae3B
- binding fe3-s4 cluster: C160 (= C35), Y170 (≠ L45), P173 (= P48), C207 (= C75), T209 (= T77), I210 (≠ C78), M211 (≠ R79), N212 (= N80), C213 (= C81)
- binding 2-nitro-N-phenylbenzamide: P161 (= P36), S162 (≠ T37), W165 (≠ L40), H208 (≠ L76)
- binding iron/sulfur cluster: C150 (= C25), I151 (≠ V26), L152 (≠ H27), C153 (= C28), A154 (≠ G29), C156 (= C31), C217 (= C85), P218 (= P86), L221 (≠ V89)
Sites not aligning to the query:
3ae1B Crystal structure of porcine heart mitochondrial complex ii bound with n-phenyl-2-(trifluoromethyl)-benzamide
28% identity, 21% coverage: 16:102/421 of query aligns to 139:234/239 of 3ae1B
- binding fe3-s4 cluster: C160 (= C35), Y170 (≠ L45), P173 (= P48), C207 (= C75), T209 (= T77), I210 (≠ C78), M211 (≠ R79), N212 (= N80), C213 (= C81)
- binding iron/sulfur cluster: C150 (= C25), I151 (≠ V26), L152 (≠ H27), C153 (= C28), A154 (≠ G29), C156 (= C31), A174 (≠ R49), C217 (= C85), K219 (≠ S87), L221 (≠ V89)
- binding N-phenyl-2-(trifluoromethyl)benzamide: H208 (≠ L76), I210 (≠ C78)
Sites not aligning to the query:
3abvB Crystal structure of porcine heart mitochondrial complex ii bound with n-biphenyl-3-yl-2-trifluoromethyl-benzamide (see paper)
28% identity, 21% coverage: 16:102/421 of query aligns to 139:234/239 of 3abvB
- binding fe3-s4 cluster: C160 (= C35), P173 (= P48), C207 (= C75), T209 (= T77), I210 (≠ C78), M211 (≠ R79), C213 (= C81)
- binding N-biphenyl-3-yl-2-(trifluoromethyl)benzamide: W165 (≠ L40), H208 (≠ L76)
- binding iron/sulfur cluster: C150 (= C25), I151 (≠ V26), L152 (≠ H27), C153 (= C28), A154 (≠ G29), C156 (= C31), A174 (≠ R49), C217 (= C85), P218 (= P86), L221 (≠ V89)
Sites not aligning to the query:
Query Sequence
>RR42_RS17315 FitnessBrowser__Cup4G11:RR42_RS17315
MQTTLAEFLRDTPDGEEAKSIVGKCVHCGFCTATCPTYQLLGDELDGPRGRIYLMKQVLE
GQPVTQSTRLHLDRCLTCRNCESTCPSGVKYGRLVDIGRKVVDDRLEAQGIQRPARERFA
RWALRETMTRPALFGTAMRMGQRVRPLLPQALRNKVPQAVDAGAWPRTTHARKMLLLDGC
VQPSMSPNINAATARVFDRLGVQLVMAREAGCCGAVRYHTGDHDGGLDNMRRNIDAWWPA
VQAGAEAIVMTASGCGVMVKEYGHLLRNDAHYADRARQISALTKDLSELLPNFADALQDA
AAEAGSSKGTNGTDGQRVAYHPPCTLQHGQQIRGKVEALLTGLGVDVKLCADSHLCCGSA
GTYSVLQPALSYRLRDEKLANLQALKPEAIVSANIGCITHLQSGTGTPVMHWIELVDRML
G
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory