Comparing RR42_RS18810 FitnessBrowser__Cup4G11:RR42_RS18810 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
4qq7A Crystal structure of putative stringent starvation protein a from burkholderia cenocepacia with bound glutathione
97% identity, 100% coverage: 1:203/203 of query aligns to 2:204/204 of 4qq7A
4hojA Crystal structure of glutathione transferase homolog from neisseria gonorrhoeae, target efi-501841, with bound glutathione
70% identity, 100% coverage: 2:203/203 of query aligns to 1:197/197 of 4hojA
3qagA Human glutathione transferase o2 with glutathione -new crystal form (see paper)
34% identity, 88% coverage: 1:179/203 of query aligns to 22:200/238 of 3qagA
6mhdA Glutathione s-transferase omega 1 bound to covalent inhibitor 44 (see paper)
33% identity, 97% coverage: 4:199/203 of query aligns to 29:223/244 of 6mhdA
Sites not aligning to the query:
6mhcA Glutathione s-transferase omega 1 bound to covalent inhibitor 37 (see paper)
33% identity, 97% coverage: 4:199/203 of query aligns to 29:223/244 of 6mhcA
Sites not aligning to the query:
P78417 Glutathione S-transferase omega-1; GSTO-1; Glutathione S-transferase omega 1-1; GSTO 1-1; Glutathione-dependent dehydroascorbate reductase; Monomethylarsonic acid reductase; MMA(V) reductase; S-(Phenacyl)glutathione reductase; SPG-R; EC 2.5.1.18; EC 1.8.5.1; EC 1.20.4.2 from Homo sapiens (Human) (see 5 papers)
33% identity, 97% coverage: 4:199/203 of query aligns to 26:220/241 of P78417
Sites not aligning to the query:
4yqvA Glutathione s-transferase omega 1 bound to covalent inhibitor c4-10 (see paper)
33% identity, 97% coverage: 4:199/203 of query aligns to 22:216/237 of 4yqvA
Sites not aligning to the query:
4yqmA Glutathione s-transferase omega 1 bound to covalent inhibitor c1-27 (see paper)
33% identity, 97% coverage: 4:199/203 of query aligns to 22:216/237 of 4yqmA
1eemA Glutathione transferase from homo sapiens (see paper)
33% identity, 97% coverage: 4:199/203 of query aligns to 22:216/237 of 1eemA
6pnoA Human gsto1-1 complexed with 2-chloro-n-(4-chloro-3-(n- isopropylsulfamoyl)phenyl)acetamide (see paper)
33% identity, 97% coverage: 4:199/203 of query aligns to 24:218/239 of 6pnoA
Sites not aligning to the query:
6pnmA Human gsto1-1 complexed with 2-chloro-n-(4-chloro-3- (morpholinosulfonyl)phenyl)acetamide (see paper)
33% identity, 97% coverage: 4:199/203 of query aligns to 24:218/239 of 6pnmA
Sites not aligning to the query:
5v3qA Human gsto1-1 complexed with ml175 (see paper)
33% identity, 97% coverage: 4:199/203 of query aligns to 24:218/239 of 5v3qA
Sites not aligning to the query:
5uehA Structure of gsto1 covalently conjugated to quinolinic acid fluorosulfate (see paper)
33% identity, 97% coverage: 4:199/203 of query aligns to 24:218/239 of 5uehA
Sites not aligning to the query:
6pnnA Human gsto1-1 complexed with 2-chloro-n-(4-chloro-3-(n-(2- methoxyethyl)-n-methylsulfamoyl)phenyl)acetamide (see paper)
33% identity, 97% coverage: 4:199/203 of query aligns to 23:217/238 of 6pnnA
Sites not aligning to the query:
6mhbA Glutathione s-transferase omega 1 bound to covalent inhibitor 18 (see paper)
32% identity, 97% coverage: 4:199/203 of query aligns to 21:212/233 of 6mhbA
Sites not aligning to the query:
4yquA Glutathione s-transferase omega 1 bound to covalent inhibitor c1-31 (see paper)
32% identity, 97% coverage: 4:199/203 of query aligns to 23:214/235 of 4yquA
Sites not aligning to the query:
Q9H4Y5 Glutathione S-transferase omega-2; GSTO-2; Glutathione S-transferase omega 2-2; GSTO 2-2; Glutathione-dependent dehydroascorbate reductase; Monomethylarsonic acid reductase; MMA(V) reductase; EC 2.5.1.18; EC 1.8.5.1; EC 1.20.4.2 from Homo sapiens (Human) (see 2 papers)
34% identity, 88% coverage: 1:179/203 of query aligns to 23:201/243 of Q9H4Y5
4is0A Structural insights into omega-class glutathione transferases: a snapshot of enzyme reduction and identification of the non-catalytic ligandin site. (see paper)
32% identity, 97% coverage: 4:199/203 of query aligns to 23:217/238 of 4is0A
Sites not aligning to the query:
3vlnA Human glutathione transferase o1-1 c32s mutant in complex with ascorbic acid (see paper)
32% identity, 97% coverage: 4:199/203 of query aligns to 24:218/239 of 3vlnA
6srbB Crystal structure of glutathione transferase omega 3c from trametes versicolor (see paper)
28% identity, 97% coverage: 2:198/203 of query aligns to 19:217/233 of 6srbB
Sites not aligning to the query:
>RR42_RS18810 FitnessBrowser__Cup4G11:RR42_RS18810
MMVLYSGTTCPFSQRCRLVLFEKGMDFEIRDVDLFNKPEDISVMNPYGQVPILVERDLIL
YESNIINEYIDERFPHPQLMPADPVQRARARLFLFNFEKELFTHVYALENEKGKAAEKNH
ERARSAIRDRLTQLAPIFVKNKYMLGEEFSMLDVAIAPLLWRLDHYGIELSKNAAPLLKY
AERIFSRPAYIEALTPSEKVMRR
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory