SitesBLAST – Find functional sites

 

SitesBLAST

Comparing RR42_RS19700 FitnessBrowser__Cup4G11:RR42_RS19700 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 13 hits to proteins with known functional sites (download)

2xtsD Crystal structure of the sulfane dehydrogenase soxcd from paracoccus pantotrophus (see paper)
37% identity, 55% coverage: 23:209/337 of query aligns to 1:173/204 of 2xtsD

query
sites
2xtsD
R
 
K
A
 
L
A
 
G
L
 
L
G
 
G
R
 
R
T
 
E
A
 
A
T
 
L
P
 
P
A
 
E
E
 
E
V
 
I
K
 
S
A
 
A
W
 
W
D
 
D
I
 
T
D
 
A
V
 
V
R
 
L
P
 
P
D
 
D
F
 
G
Q
 
Q
G
 
G
L
 
L
P
 
R
K
 
P
G
 
G
S
 
S
G
 
G
T
 
D
V
 
V
S
 
A
Q
 
T
G
 
G
Q
 
D
K
 
A
I
 
L
W
 
F
D
 
A
G
 
D
K
x
N
C
|
C
A
 
A
S
 
S
C
|
C
H
|
H
G
 
G
D
 
D
F
 
F
G
 
A
E
 
E
S
 
G
N
 
L
E
 
D
V
 
S
F
x
W
S
x
P
P
 
V
I
x
L
V
 
A
G
 
G
G
 
G
T
 
D
S
 
-
A
 
-
E
 
-
D
 
-
I
 
-
R
 
-
R
 
-
G
 
-
R
 
-
V
 
-
A
 
G
S
 
S
L
 
L
T
 
T
G
 
D
N
 
P
Q
 
R
P
 
P
Y
 
V
R
 
K
T
 
T
T
 
I
L
 
G
M
 
S
K
 
Y
V
x
W
S
 
P
T
 
Y
V
 
L
S
 
S
T
 
T
L
 
V
W
 
Y
D
 
D
Y
|
Y
I
x
V
H
 
H
R
 
R
A
 
S
M
|
M
P
|
P
W
x
F
N
 
G
A
 
S
P
 
A
R
 
Q
S
 
T
L
 
L
S
 
S
A
 
V
D
 
D
D
 
D
V
 
T
Y
 
Y
A
 
A
V
 
I
T
 
T
A
 
A
Y
 
F
L
 
L
L
 
L
N
 
Y
L
 
S
G
 
N
D
 
G
I
 
L
V
 
V
P
 
E
A
 
D
E
 
D
F
 
F
T
 
V
L
 
L
S
 
T
D
 
H
G
 
E
N
 
N
I
 
F
A
 
T
E
 
Q
V
 
V
Q
 
-
Q
 
-
K
 
V
M
 
L
P
 
P
N
 
N
R
 
-
N
 
-
G
 
-
M
 
-
T
 
-
L
 
-
Q
 
A
H
 
E
G
 
G
L
 
F
W
 
Y
P
 
P
G
 
-
R
 
D
G
 
D
R
 
R
A
 
D
D
 
Q
T
 
T
R
 
E
-
 
Y
-
 
P
-
 
L
-
 
F
-
 
S
N
 
K
A
 
E
A
 
P
C
 
C
M
 
M
K
 
T
D
 
D
C
 
C
T
 
A
P
 
V
T
 
G
V
 
V
R
 
E
I
 
I

2d0sA Crystal structure of the cytochrome c552 from moderate thermophilic bacterium, hydrogenophilus thermoluteolus (see paper)
48% identity, 23% coverage: 261:337/337 of query aligns to 4:79/79 of 2d0sA

query
sites
2d0sA
L
 
L
A
 
A
S
 
K
Q
 
A
Y
 
K
Q
 
G
C
|
C
M
 
M
A
 
A
C
|
C
H
|
H
A
 
A
T
 
I
D
 
D
R
 
K
K
 
K
L
 
L
V
 
V
G
 
G
P
|
P
S
 
S
F
 
Y
A
 
K
E
 
D
V
 
V
A
 
A
R
 
K
K
 
K
Y
|
Y
Q
 
T
G
 
E
Q
 
A
D
 
D
A
 
V
Q
 
P
D
 
K
A
 
-
L
 
L
A
 
V
H
 
E
K
|
K
I
x
V
R
 
K
A
 
K
G
 
G
G
 
G
Q
x
A
G
|
G
A
x
V
W
|
W
G
|
G
S
 
P
M
x
V
P
 
P
M
|
M
P
|
P
P
 
P
Q
x
H
A
 
P
Q
 
Q
I
 
V
P
 
A
D
 
E
S
 
A
D
 
D
L
 
I
R
 
E
T
 
K
V
 
I
V
 
V
G
 
R
W
 
W
I
 
V
L
 
L
E
 
T
A
 
L
K
 
K

5xecA Heterodimer constructed from pa cyt c551-ht cyt c552 and ht cyt c552- pa cyt c551 chimeric proteins (see paper)
54% identity, 21% coverage: 267:337/337 of query aligns to 12:82/82 of 5xecA

query
sites
5xecA
C
|
C
M
 
V
A
 
A
C
|
C
H
|
H
A
 
A
T
 
I
D
 
D
R
 
T
K
 
K
L
 
K
V
 
V
G
|
G
P
|
P
S
 
A
F
x
Y
A
 
A
E
 
D
V
 
V
A
 
A
R
 
K
K
 
K
Y
|
Y
Q
 
A
G
 
G
-
 
R
Q
 
K
D
 
D
A
 
A
Q
 
V
D
 
D
A
x
Y
L
 
L
A
 
A
H
 
G
K
 
K
I
|
I
R
 
K
A
 
K
G
 
G
G
 
G
Q
x
S
G
|
G
A
x
V
W
|
W
G
|
G
S
 
S
M
x
V
P
 
P
M
|
M
P
 
P
P
 
P
Q
|
Q
A
 
-
Q
 
N
I
 
V
P
 
T
D
 
D
S
 
A
D
 
E
L
 
A
R
 
K
T
 
Q
V
 
L
V
 
A
G
 
Q
W
 
W
I
|
I
L
 
L
E
 
S
A
 
I
K
 
K

5aurA Hydrogenobacter thermophilus cytochrome c552 dimer formed by domain swapping at n-terminal region (see paper)
51% identity, 23% coverage: 260:337/337 of query aligns to 3:83/83 of 5aurA

query
sites
5aurA
K
 
Q
L
 
L
A
 
A
S
 
K
Q
 
Q
Y
 
K
Q
 
G
C
|
C
M
 
M
A
 
A
C
|
C
H
|
H
-
 
D
-
 
L
-
 
K
A
 
A
T
 
G
D
 
G
R
 
G
K
 
K
L
 
K
V
 
V
G
 
G
P
|
P
S
 
A
F
x
Y
A
 
A
E
 
D
V
 
V
A
 
A
R
 
K
K
 
K
Y
|
Y
Q
 
A
G
 
G
-
 
R
Q
 
K
D
 
D
A
 
A
Q
 
V
D
 
D
A
x
Y
L
 
L
A
 
A
H
 
G
K
 
K
I
|
I
R
 
K
A
 
K
G
 
G
G
 
G
Q
x
S
G
|
G
A
x
V
W
|
W
G
|
G
S
 
S
M
x
V
P
|
P
M
|
M
P
 
P
P
 
P
Q
|
Q
A
 
-
Q
 
N
I
 
V
P
 
T
D
 
D
S
 
A
D
 
E
L
 
A
R
 
K
T
 
Q
V
 
L
V
 
A
G
 
Q
W
 
W
I
 
I
L
 
L
E
 
S
A
 
I
K
 
K

1a56A Primary sequence and solution conformation of ferricytochromE C-552 from nitrosomonas europaea, nmr, mean structure refined with explicit hydrogen bond constraints (see paper)
43% identity, 23% coverage: 259:337/337 of query aligns to 2:81/81 of 1a56A

query
sites
1a56A
A
 
A
K
 
D
L
 
L
A
 
A
S
 
K
Q
 
K
Y
 
N
Q
x
N
C
|
C
M
 
I
A
 
A
C
|
C
H
|
H
A
 
Q
T
 
V
D
 
E
R
 
T
K
 
K
L
 
V
V
|
V
G
|
G
P
|
P
S
 
A
F
 
L
A
 
K
E
 
D
V
 
I
A
 
A
R
 
A
K
 
K
Y
 
Y
Q
 
A
G
 
D
Q
 
K
D
 
D
-
 
D
A
 
A
Q
 
A
D
 
T
A
 
Y
L
 
L
A
 
A
H
 
G
K
|
K
I
|
I
R
 
K
A
 
G
G
 
G
G
x
S
Q
 
S
G
 
G
A
 
V
W
|
W
G
 
G
S
x
Q
M
x
I
P
 
P
M
|
M
P
 
P
P
 
P
Q
x
N
A
x
V
Q
x
N
I
 
V
P
 
S
D
 
D
S
 
A
D
 
D
L
 
A
R
 
K
T
 
A
V
 
L
V
 
A
G
 
D
W
 
W
I
 
I
L
 
L
E
 
T
A
 
L
K
 
K

1corA Investigation of the solution conformation of cytochromE C-551 from pseudomonas stutzeri (see paper)
48% identity, 24% coverage: 258:337/337 of query aligns to 3:82/82 of 1corA

query
sites
1corA
G
 
G
A
 
E
K
 
A
L
 
L
A
 
F
S
 
K
Q
 
S
Y
x
K
Q
 
P
C
|
C
M
 
A
A
 
A
C
|
C
H
|
H
A
 
S
T
 
I
D
 
D
R
 
A
K
 
K
L
 
L
V
|
V
G
|
G
P
|
P
S
 
A
F
 
F
A
 
K
E
 
E
V
 
V
A
 
A
R
 
A
K
 
K
Y
 
Y
Q
 
A
G
 
G
Q
 
Q
D
 
D
-
 
G
A
 
A
Q
 
A
D
 
D
A
 
L
L
|
L
A
 
A
H
 
G
K
x
H
I
|
I
R
 
K
A
 
N
G
 
G
G
x
S
Q
|
Q
G
|
G
A
x
V
W
|
W
G
|
G
S
 
P
M
x
I
P
 
P
M
|
M
P
 
P
P
 
P
Q
x
N
A
 
P
Q
 
-
I
 
V
P
 
T
D
 
E
S
 
E
D
 
E
L
 
A
R
 
K
T
 
I
V
 
L
V
 
A
G
 
E
W
 
W
I
 
I
L
 
L
E
 
S
A
 
Q
K
 
K

2exvA Crystal structure of the f7a mutant of the cytochrome c551 from pseudomonas aeruginosa (see paper)
46% identity, 23% coverage: 261:337/337 of query aligns to 6:82/82 of 2exvA

query
sites
2exvA
L
 
L
A
 
A
S
 
K
Q
 
N
Y
 
K
Q
 
G
C
|
C
M
 
V
A
 
A
C
|
C
H
|
H
A
 
A
T
 
I
D
 
D
R
 
T
K
 
K
L
 
M
V
 
V
G
|
G
P
|
P
S
 
A
F
 
Y
A
 
K
E
 
D
V
 
V
A
 
A
R
 
A
K
 
K
Y
 
F
Q
 
A
G
 
G
Q
 
Q
D
 
A
A
 
G
Q
 
A
D
 
E
A
 
A
-
 
E
L
 
L
A
 
A
H
 
Q
K
x
R
I
|
I
R
 
K
A
 
N
G
 
G
G
x
S
Q
|
Q
G
|
G
A
x
V
W
|
W
G
|
G
S
 
P
M
x
I
P
|
P
M
|
M
P
 
P
P
 
P
Q
x
N
A
 
A
Q
 
-
I
 
V
P
 
S
D
 
D
S
 
D
D
 
E
L
 
A
R
 
Q
T
 
T
V
 
L
V
 
A
G
 
K
W
 
W
I
 
V
L
 
L
E
 
S
A
 
Q
K
 
K

5xecC Heterodimer constructed from pa cyt c551-ht cyt c552 and ht cyt c552- pa cyt c551 chimeric proteins (see paper)
46% identity, 23% coverage: 260:337/337 of query aligns to 3:80/80 of 5xecC

query
sites
5xecC
K
 
Q
L
 
L
A
 
A
S
 
K
Q
 
Q
Y
 
K
Q
 
G
C
|
C
M
 
M
A
 
A
C
|
C
H
|
H
A
 
D
T
 
L
D
 
K
R
 
A
K
 
K
L
 
M
V
 
V
G
 
G
P
|
P
S
 
A
F
x
Y
A
 
K
E
 
D
V
 
V
A
 
A
R
 
A
K
 
K
Y
 
F
Q
 
A
G
 
G
Q
 
Q
D
 
A
A
 
G
Q
 
A
D
 
E
A
 
A
-
 
E
L
|
L
A
 
A
H
 
Q
K
x
R
I
 
I
R
 
K
A
 
N
G
 
G
G
 
S
Q
|
Q
G
 
G
A
x
V
W
|
W
G
|
G
S
 
P
M
x
I
P
 
P
M
|
M
P
 
P
P
 
P
Q
x
N
A
 
A
Q
 
-
I
 
V
P
 
S
D
 
D
S
 
D
D
 
E
L
 
A
R
 
Q
T
 
T
V
 
L
V
 
A
G
 
K
W
 
W
I
 
V
L
 
L
E
 
S
A
 
Q
K
 
K

P00099 Cytochrome c-551; Cytochrome C8; Cytochrome c551 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 4 papers)
47% identity, 21% coverage: 267:337/337 of query aligns to 34:104/104 of P00099

query
sites
P00099
C
|
C
M
x
V
A
|
A
C
|
C
H
|
H
A
|
A
T
x
I
D
|
D
R
x
T
K
|
K
L
x
M
V
|
V
G
|
G
P
|
P
S
x
A
F
x
Y
A
x
K
E
x
D
V
|
V
A
|
A
R
x
A
K
|
K
Y
x
F
Q
x
A
G
|
G
Q
|
Q
D
x
A
A
x
G
Q
x
A
D
x
E
A
|
A
-
x
E
L
|
L
A
|
A
H
x
Q
K
x
R
I
|
I
R
x
K
A
x
N
G
|
G
G
x
S
Q
|
Q
G
|
G
A
x
V
W
|
W
G
|
G
S
x
P
M
x
I
P
|
P
M
|
M
P
|
P
P
|
P
Q
x
N
A
|
A
Q
 
-
I
x
V
P
x
S
D
|
D
S
x
D
D
x
E
L
x
A
R
x
Q
T
|
T
V
x
L
V
x
A
G
x
K
W
|
W
I
x
V
L
|
L
E
x
S
A
x
Q
K
|
K

Sites not aligning to the query:

351cA Structure of cytochrome c551 from p. Aeruginosa refined at 1.6 angstroms resolution and comparison of the two redox forms (see paper)
47% identity, 21% coverage: 267:337/337 of query aligns to 12:82/82 of 351cA

query
sites
351cA
C
|
C
M
 
V
A
 
A
C
|
C
H
|
H
A
 
A
T
 
I
D
 
D
R
 
T
K
 
K
L
 
M
V
 
V
G
|
G
P
|
P
S
 
A
F
x
Y
A
 
K
E
 
D
V
 
V
A
 
A
R
 
A
K
 
K
Y
 
F
Q
 
A
G
 
G
Q
 
Q
D
 
A
A
 
G
Q
 
A
D
 
E
A
 
A
-
 
E
L
|
L
A
 
A
H
 
Q
K
x
R
I
|
I
R
 
K
A
 
N
G
 
G
G
 
S
Q
|
Q
G
|
G
A
x
V
W
|
W
G
|
G
S
 
P
M
x
I
P
|
P
M
|
M
P
 
P
P
 
P
Q
 
N
A
 
A
Q
 
-
I
 
V
P
 
S
D
 
D
S
 
D
D
 
E
L
 
A
R
 
Q
T
 
T
V
 
L
V
 
A
G
 
K
W
 
W
I
 
V
L
 
L
E
 
S
A
 
Q
K
 
K

6kq1A Crystal structure of cytochrome c551 from pseudomonas sp. Strain mt-1.
44% identity, 24% coverage: 258:337/337 of query aligns to 3:82/82 of 6kq1A

query
sites
6kq1A
G
 
G
A
x
E
K
 
A
L
 
L
A
 
F
S
 
K
Q
 
S
Y
x
K
Q
 
P
C
|
C
M
 
A
A
 
A
C
|
C
H
|
H
A
 
S
T
 
I
D
 
D
R
 
A
K
 
K
L
 
M
V
 
V
G
|
G
P
|
P
S
 
A
F
 
L
A
 
K
E
 
E
V
|
V
A
 
A
R
 
A
K
 
K
Y
|
Y
Q
 
A
G
 
G
Q
 
Q
D
 
E
-
 
G
A
 
A
Q
 
A
D
 
D
A
 
L
L
|
L
A
 
A
H
 
G
K
x
H
I
|
I
R
 
K
A
 
N
G
 
G
G
 
T
Q
|
Q
G
|
G
A
x
N
W
|
W
G
|
G
S
 
P
M
x
I
P
 
P
M
|
M
P
 
P
P
 
P
Q
x
N
A
 
P
Q
 
-
I
 
V
P
 
T
D
 
E
S
 
E
D
x
E
L
 
A
R
 
K
T
 
T
V
 
L
V
 
A
G
 
E
W
 
W
I
 
V
L
 
L
E
 
S
A
 
L
K
 
K

Sites not aligning to the query:

1cchA The solution conformation of cytochromE C-551 from p.Stutzeri zobell determined by nmr+ (see paper)
41% identity, 24% coverage: 258:337/337 of query aligns to 3:82/82 of 1cchA

query
sites
1cchA
G
 
G
A
 
E
K
 
A
L
 
L
A
 
F
S
 
K
Q
 
S
Y
 
K
Q
 
P
C
|
C
M
 
A
A
 
A
C
|
C
H
|
H
A
 
S
T
 
V
D
 
D
R
 
T
K
 
K
L
 
M
V
 
V
G
 
G
P
 
P
S
 
A
F
 
L
A
 
K
E
 
E
V
 
V
A
 
A
R
 
A
K
 
K
Y
 
N
Q
 
A
G
 
G
-
 
V
Q
 
E
D
 
G
A
 
A
Q
 
A
D
 
D
A
 
T
L
|
L
A
 
A
H
 
L
K
x
H
I
|
I
R
 
K
A
 
N
G
 
G
G
x
S
Q
|
Q
G
 
G
A
x
V
W
|
W
G
|
G
S
 
P
M
x
I
P
 
P
M
|
M
P
|
P
P
 
P
Q
x
N
A
 
P
Q
 
-
I
 
V
P
 
T
D
 
E
S
 
E
D
 
E
L
 
A
R
 
K
T
 
I
V
 
L
V
 
A
G
 
E
W
 
W
I
 
V
L
 
L
E
 
S
A
 
L
K
 
K

4xxlA Crystal structure of class 1 cytochrome mtod from sideroxydans lithotrophicus es-1 (see paper)
31% identity, 23% coverage: 257:334/337 of query aligns to 6:88/92 of 4xxlA

query
sites
4xxlA
A
 
A
G
 
A
A
 
K
K
 
S
L
 
L
A
 
A
S
 
R
Q
 
E
Y
 
N
Q
 
N
C
|
C
M
 
F
A
 
K
C
|
C
H
|
H
A
 
G
T
 
V
D
 
D
R
 
K
K
 
E
L
 
K
V
 
D
G
|
G
P
|
P
S
 
S
F
x
Y
A
 
K
E
 
K
V
 
V
A
 
A
R
 
E
K
|
K
Y
|
Y
Q
 
R
G
 
G
Q
 
K
-
 
A
D
 
D
A
 
A
Q
 
E
D
 
A
A
 
K
L
 
L
A
 
I
H
 
H
K
x
H
I
 
V
R
 
T
A
 
S
G
 
G
G
 
E
Q
 
K
G
x
A
A
x
K
W
 
F
G
 
P
S
 
D
M
 
G
P
 
H
M
 
E
P
 
E
P
 
E
Q
x
H
A
 
K
Q
 
N
I
 
I
-
 
N
-
 
G
-
 
K
-
 
A
-
 
S
P
 
P
D
 
E
S
 
A
D
 
-
L
 
I
R
 
K
T
 
N
V
 
L
V
 
V
G
 
D
W
 
W
I
 
I
L
 
L

Query Sequence

>RR42_RS19700 FitnessBrowser__Cup4G11:RR42_RS19700
MLACAAALCVQVAMAAAPADSARAALGRTATPAEVKAWDIDVRPDFQGLPKGSGTVSQGQ
KIWDGKCASCHGDFGESNEVFSPIVGGTSAEDIRRGRVASLTGNQPYRTTLMKVSTVSTL
WDYIHRAMPWNAPRSLSADDVYAVTAYLLNLGDIVPAEFTLSDGNIAEVQQKMPNRNGMT
LQHGLWPGRGRADTRNAACMKDCTPTVRIVSTMPAYARDAHGDLAAQQRTVGPTRGWAGG
GASAPAAATPATLGETAGAKLASQYQCMACHATDRKLVGPSFAEVARKYQGQDAQDALAH
KIRAGGQGAWGSMPMPPQAQIPDSDLRTVVGWILEAK

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory