SitesBLAST
Comparing RR42_RS19850 FitnessBrowser__Cup4G11:RR42_RS19850 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
8i01A Crystal structure of escherichia coli glyoxylate carboligase
80% identity, 98% coverage: 1:578/591 of query aligns to 2:579/594 of 8i01A
- binding flavin-adenine dinucleotide: R155 (= R154), G212 (= G211), G213 (= G212), G214 (= G213), N217 (= N216), T238 (= T237), L239 (= L238), M240 (= M239), V256 (= V255), G257 (= G256), Q259 (= Q258), T260 (= T259), G279 (= G278), N280 (= N279), R281 (= R280), A283 (= A282), R285 (= R284), H286 (= H285), D303 (= D302), I304 (= I303), Q308 (= Q307), D322 (= D321), A323 (= A322), G417 (= G416)
- binding magnesium ion: D447 (= D446), F452 (= F451), E455 (= E454), N474 (= N473), Y476 (= Y475)
- binding thiamine diphosphate: G395 (= G394), L396 (= L395), S397 (= S396), L422 (= L421), G446 (= G445), D447 (= D446), F448 (≠ Y447), D449 (= D448), N474 (= N473), Y476 (= Y475), L477 (= L476), G478 (= G477), L479 (= L478), I480 (= I479)
- binding 2,3-dimethoxy-5-methyl-1,4-benzoquinone: Q354 (= Q353), C492 (= C491), Q494 (= Q493)
Sites not aligning to the query:
8beoB Crystal structure of e. Coli glyoxylate carboligase mutant i393a with map
80% identity, 97% coverage: 3:578/591 of query aligns to 2:577/592 of 8beoB
- binding methyl hydrogen (s)-acetylphosphonate: C490 (= C491), Q492 (= Q493)
- binding flavin-adenine dinucleotide: R153 (= R154), P154 (= P155), G210 (= G211), G211 (= G212), G212 (= G213), N215 (= N216), T236 (= T237), L237 (= L238), M238 (= M239), V254 (= V255), G255 (= G256), Q257 (= Q258), T258 (= T259), G277 (= G278), N278 (= N279), R279 (= R280), A281 (= A282), R283 (= R284), H284 (= H285), D301 (= D302), I302 (= I303), Q306 (= Q307), D320 (= D321), A321 (= A322), G415 (= G416)
- binding magnesium ion: D445 (= D446), F450 (= F451), L451 (≠ M452), E453 (= E454), N472 (= N473), Y474 (= Y475)
- binding 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-{(1s)-1-hydroxy-1-[(r)-hydroxy(methoxy)phosphoryl]ethyl}-5-(2-{[(s)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium: R283 (= R284), G393 (= G394), L394 (= L395), S395 (= S396), L420 (= L421), G444 (= G445), D445 (= D446), F446 (≠ Y447), D447 (= D448), N472 (= N473), Y474 (= Y475), L475 (= L476), G476 (= G477), L477 (= L478), I478 (= I479)
- binding 2,3-dimethoxy-5-methyl-1,4-benzoquinone: Q352 (= Q353), R356 (= R357)
Sites not aligning to the query:
8beoA Crystal structure of e. Coli glyoxylate carboligase mutant i393a with map
80% identity, 97% coverage: 3:578/591 of query aligns to 2:577/592 of 8beoA
- binding flavin-adenine dinucleotide: R153 (= R154), P154 (= P155), G210 (= G211), G211 (= G212), G212 (= G213), N215 (= N216), T236 (= T237), L237 (= L238), M238 (= M239), V254 (= V255), G255 (= G256), Q257 (= Q258), T258 (= T259), G277 (= G278), N278 (= N279), R279 (= R280), A281 (= A282), R283 (= R284), H284 (= H285), D301 (= D302), I302 (= I303), Q306 (= Q307), D320 (= D321), A321 (= A322), I397 (= I398), G415 (= G416)
- binding magnesium ion: R384 (= R385), V405 (= V406), F406 (≠ N407), H410 (= H411), D445 (= D446), F450 (= F451), L451 (≠ M452), E453 (= E454), N472 (= N473), Y474 (= Y475)
- binding 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-{(1s)-1-hydroxy-1-[(r)-hydroxy(methoxy)phosphoryl]ethyl}-5-(2-{[(s)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium: R283 (= R284), G393 (= G394), L394 (= L395), S395 (= S396), L420 (= L421), G444 (= G445), D445 (= D446), F446 (≠ Y447), D447 (= D448), N472 (= N473), Y474 (= Y475), L475 (= L476), G476 (= G477), L477 (= L478), I478 (= I479)
- binding 2,3-dimethoxy-5-methyl-1,4-benzoquinone: E248 (≠ P249), Q352 (= Q353)
Sites not aligning to the query:
8i07D Crystal structure of escherichia coli glyoxylate carboligase double mutant in complex with glycolaldehyde
79% identity, 98% coverage: 1:578/591 of query aligns to 2:579/594 of 8i07D
- binding 2-oxidanylethanal: R285 (= R284), I480 (= I479)
- binding flavin-adenine dinucleotide: R155 (= R154), P156 (= P155), G212 (= G211), G213 (= G212), G214 (= G213), N217 (= N216), T238 (= T237), L239 (= L238), M240 (= M239), V256 (= V255), G257 (= G256), Q259 (= Q258), T260 (= T259), G279 (= G278), N280 (= N279), R281 (= R280), R285 (= R284), H286 (= H285), D303 (= D302), I304 (= I303), Q308 (= Q307), D322 (= D321), A323 (= A322), I399 (= I398), G417 (= G416)
- binding magnesium ion: D447 (= D446), F452 (= F451), L453 (≠ M452), E455 (= E454), N474 (= N473), Y476 (= Y475)
- binding thiamine diphosphate: V52 (= V51), T76 (= T75), G395 (= G394), L396 (= L395), S397 (= S396), L422 (= L421), G446 (= G445), D447 (= D446), F448 (≠ Y447), D449 (= D448), N474 (= N473), Y476 (= Y475), L477 (= L476), G478 (= G477), L479 (= L478), I480 (= I479)
- binding ubiquinone-1: Q354 (= Q353), R358 (= R357), C492 (= C491), Q494 (= Q493)
Sites not aligning to the query:
8i07A Crystal structure of escherichia coli glyoxylate carboligase double mutant in complex with glycolaldehyde
79% identity, 98% coverage: 1:578/591 of query aligns to 2:579/594 of 8i07A
- binding flavin-adenine dinucleotide: R155 (= R154), P156 (= P155), G212 (= G211), G213 (= G212), G214 (= G213), N217 (= N216), T238 (= T237), L239 (= L238), M240 (= M239), V256 (= V255), G257 (= G256), Q259 (= Q258), T260 (= T259), G279 (= G278), N280 (= N279), R281 (= R280), R285 (= R284), H286 (= H285), D303 (= D302), I304 (= I303), Q308 (= Q307), D322 (= D321), A323 (= A322), I394 (= I393), I399 (= I398), G417 (= G416)
- binding magnesium ion: D447 (= D446), F452 (= F451), L453 (≠ M452), E455 (= E454), N474 (= N473), Y476 (= Y475)
- binding thiamine diphosphate: I394 (= I393), G395 (= G394), L396 (= L395), S397 (= S396), L422 (= L421), G446 (= G445), D447 (= D446), F448 (≠ Y447), D449 (= D448), N474 (= N473), Y476 (= Y475), L477 (= L476), G478 (= G477), L479 (= L478), I480 (= I479)
- binding ubiquinone-1: Q354 (= Q353), C492 (= C491), Q494 (= Q493)
Sites not aligning to the query:
6lpiB Crystal structure of ahas holo-enzyme (see paper)
35% identity, 80% coverage: 14:486/591 of query aligns to 16:468/539 of 6lpiB
- active site: I27 (≠ V25), G29 (= G27), G30 (≠ A28), S31 (≠ A29), I32 (= I30), E53 (≠ V51), C76 (≠ T75), F115 (= F114), Q116 (= Q115), E117 (≠ A116), K165 (≠ F164), M256 (≠ L257), A283 (≠ H285), V375 (≠ I393), G401 (= G419), M403 (≠ L421), D428 (= D446), N455 (= N473), A457 (≠ Y475), L458 (= L476), L460 (= L478), V461 (≠ I479), Q464 (≠ A482)
- binding flavin-adenine dinucleotide: R155 (= R154), G212 (= G211), G213 (= G212), G214 (= G213), T236 (= T237), L237 (= L238), M238 (= M239), L254 (≠ V255), M256 (≠ L257), H257 (≠ Q258), G276 (= G278), A277 (≠ N279), R278 (= R280), D280 (≠ A282), R282 (= R284), A283 (≠ H285), D300 (= D302), I301 (= I303), D319 (= D321), V320 (≠ A322), M380 (≠ I398), G398 (= G416)
- binding magnesium ion: D428 (= D446), N455 (= N473)
- binding thiamine diphosphate: E53 (≠ V51), C76 (≠ T75), P79 (= P78), G376 (= G394), Q377 (≠ L395), H378 (≠ S396), G401 (= G419), M403 (≠ L421), G427 (= G445), D428 (= D446), G429 (≠ Y447), S430 (≠ D448), M433 (≠ F451), N455 (= N473), A457 (≠ Y475), L458 (= L476), G459 (= G477), L460 (= L478), V461 (≠ I479)
P09342 Acetolactate synthase 1, chloroplastic; ALS I; Acetohydroxy-acid synthase I; Acetolactate synthase I; EC 2.2.1.6 from Nicotiana tabacum (Common tobacco) (see 2 papers)
31% identity, 93% coverage: 5:551/591 of query aligns to 95:638/667 of P09342
- C161 (= C72) modified: Disulfide link with 307
- P194 (= P105) mutation to Q: In C3; highly resistant to sulfonylurea herbicides.
- C307 (≠ V214) modified: Disulfide link with 161
P09114 Acetolactate synthase 2, chloroplastic; ALS II; Acetohydroxy-acid synthase II; Acetolactate synthase II; EC 2.2.1.6 from Nicotiana tabacum (Common tobacco) (see paper)
32% identity, 93% coverage: 5:551/591 of query aligns to 92:635/664 of P09114
- P191 (= P105) mutation to A: In S4-Hra; highly resistant to sulfonylurea herbicides; when associated with L-568.
- W568 (≠ A482) mutation to L: In S4-Hra; highly resistant to sulfonylurea herbicides; when associated with A-191.
6u9dB Saccharomyces cerevisiae acetohydroxyacid synthase (see paper)
30% identity, 97% coverage: 13:587/591 of query aligns to 21:601/607 of 6u9dB
- active site: Y33 (≠ V25), G35 (= G27), G36 (≠ A28), A37 (= A29), I38 (= I30), E59 (≠ V51), T82 (= T75), F121 (= F114), Q122 (= Q115), E123 (≠ A116), K171 (≠ F164), M274 (≠ L257), V301 (≠ H285), V417 (≠ I393), G443 (= G419), M445 (≠ L421), D470 (= D446), N497 (= N473), E499 (≠ Y475), Q500 (≠ L476), M502 (≠ L478), V503 (≠ I479), W506 (≠ A482)
- binding methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate: G36 (≠ A28), V111 (≠ A104), P112 (= P105), F121 (= F114), K171 (≠ F164), D299 (≠ N283), R300 (= R284), M502 (≠ L478), W506 (≠ A482)
- binding flavin-adenine dinucleotide: R161 (= R154), A228 (≠ G212), G229 (= G213), N232 (= N216), T254 (= T237), L255 (= L238), Q256 (≠ M239), L272 (≠ V255), M274 (≠ L257), G294 (= G278), R296 (= R280), D298 (≠ A282), R300 (= R284), V301 (≠ H285), E327 (≠ D302), V328 (≠ I303), N332 (≠ Q307), D346 (= D321), A347 (= A322), M422 (≠ I398), G440 (= G416), G441 (≠ Q417)
- binding magnesium ion: D470 (= D446), N497 (= N473)
- binding thiamine diphosphate: E59 (≠ V51), P85 (= P78), V417 (≠ I393), G418 (= G394), Q419 (≠ L395), H420 (≠ S396), G443 (= G419), M445 (≠ L421), A471 (≠ Y447), S472 (≠ D448), N497 (= N473), E499 (≠ Y475), Q500 (≠ L476), G501 (= G477), M502 (≠ L478), V503 (≠ I479)
1n0hA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorimuron ethyl (see paper)
31% identity, 97% coverage: 13:587/591 of query aligns to 19:593/599 of 1n0hA
- active site: Y31 (≠ V25), G33 (= G27), G34 (≠ A28), A35 (= A29), I36 (= I30), E57 (≠ V51), T80 (= T75), F119 (= F114), Q120 (= Q115), E121 (≠ A116), K169 (≠ F164), R230 (≠ E221), M266 (≠ L257), V293 (≠ H285), V409 (≠ I393), L434 (≠ A418), G435 (= G419), M437 (≠ L421), D462 (= D446), N489 (= N473), E491 (≠ Y475), Q492 (≠ L476), M494 (≠ L478), V495 (≠ I479), W498 (≠ A482), L520 (≠ V514), G525 (= G519), L526 (≠ C520), K559 (≠ R557)
- binding 4-{[(4'-amino-2'-methylpyrimidin-5'-yl)methyl]amino}pent-3-enyl diphosphate: V409 (≠ I393), G410 (= G394), Q411 (≠ L395), H412 (≠ S396), G435 (= G419), M437 (≠ L421), G461 (= G445), D462 (= D446), A463 (≠ Y447), S464 (≠ D448), M467 (≠ F451), N489 (= N473), E491 (≠ Y475), Q492 (≠ L476), G493 (= G477), V495 (≠ I479)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: G34 (≠ A28), A35 (= A29), V109 (≠ A104), P110 (= P105), F119 (= F114), K169 (≠ F164), M266 (≠ L257), D291 (≠ N283), R292 (= R284), V495 (≠ I479), W498 (≠ A482)
- binding flavin-adenine dinucleotide: R159 (= R154), G219 (= G211), A220 (≠ G212), G221 (= G213), N224 (= N216), T246 (= T237), L247 (= L238), Q248 (≠ M239), L264 (≠ V255), G265 (= G256), M266 (≠ L257), H267 (≠ Q258), G286 (= G278), A287 (≠ N279), R288 (= R280), D290 (≠ A282), R292 (= R284), V293 (≠ H285), E319 (≠ D302), V320 (≠ I303), N324 (≠ Q307), G337 (≠ S320), D338 (= D321), A339 (= A322), M414 (≠ I398), G432 (= G416), G433 (≠ Q417)
- binding magnesium ion: D462 (= D446), N489 (= N473), E491 (≠ Y475)
- binding thiamine diphosphate: Y31 (≠ V25), E57 (≠ V51), P83 (= P78)
P07342 Acetolactate synthase catalytic subunit, mitochondrial; Acetohydroxy-acid synthase catalytic subunit; AHAS; ALS; EC 2.2.1.6 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
30% identity, 97% coverage: 13:587/591 of query aligns to 101:681/687 of P07342
- R241 (= R154) binding
- 355:376 (vs. 258:280, 17% identical) binding
- 407:426 (vs. 302:321, 20% identical) binding
1t9bB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
30% identity, 97% coverage: 13:587/591 of query aligns to 17:589/595 of 1t9bB
- active site: Y29 (≠ V25), G31 (= G27), G32 (≠ A28), A33 (= A29), I34 (= I30), E55 (≠ V51), T78 (= T75), F117 (= F114), Q118 (= Q115), E119 (≠ A116), K167 (≠ F164), R226 (≠ E221), M262 (≠ L257), V289 (≠ H285), V405 (≠ I393), L430 (≠ A418), G431 (= G419), M433 (≠ L421), D458 (= D446), N485 (= N473), E487 (≠ Y475), Q488 (≠ L476), M490 (≠ L478), V491 (≠ I479), W494 (≠ A482), L516 (≠ V514), G521 (= G519), L522 (≠ C520), K555 (≠ R557)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: V107 (≠ A104), P108 (= P105), D287 (≠ N283), R288 (= R284), M490 (≠ L478), W494 (≠ A482)
- binding flavin-adenine dinucleotide: R157 (= R154), G215 (= G211), A216 (≠ G212), G217 (= G213), N220 (= N216), T242 (= T237), L243 (= L238), Q244 (≠ M239), M259 (= M254), L260 (≠ V255), M262 (≠ L257), H263 (≠ Q258), G282 (= G278), A283 (≠ N279), R284 (= R280), D286 (≠ A282), R288 (= R284), V289 (≠ H285), E315 (≠ D302), V316 (≠ I303), N320 (≠ Q307), G333 (≠ S320), D334 (= D321), A335 (= A322), Q409 (= Q397), M410 (≠ I398), G428 (= G416), G429 (≠ Q417)
- binding magnesium ion: D458 (= D446), N485 (= N473), E487 (≠ Y475)
P17597 Acetolactate synthase, chloroplastic; AtALS; Acetohydroxy-acid synthase; Protein CHLORSULFURON RESISTANT 1; EC 2.2.1.6 from Arabidopsis thaliana (Mouse-ear cress) (see 8 papers)
33% identity, 82% coverage: 5:486/591 of query aligns to 98:578/670 of P17597
- A122 (= A29) mutation to V: Reduced catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
- M124 (≠ N31) mutation to E: Reduced catalytic activity. Resistant to imidazolinone herbicides and reduced sensitivity to sulfonylurea herbicides.; mutation to I: No effect on catalytic activity. Increased resistance to imidazolinone herbicides.
- E144 (≠ V51) binding
- S186 (= S94) binding
- P197 (= P105) mutation to S: In csr1-1/GH50; resistant to sulfonylurea but not to imidazolinone herbicides.
- R199 (≠ A107) mutation R->A,E: No effect on catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
- Q207 (= Q115) binding
- K220 (= K128) binding
- R246 (= R154) binding ; binding
- K256 (≠ F164) binding
- G308 (= G212) binding
- TL 331:332 (= TL 237:238) binding
- C340 (≠ D246) modified: Cysteine sulfinic acid (-SO2H)
- LGMH 349:352 (≠ VGLQ 255:258) binding
- GVRFD 371:375 (≠ GNRWA 278:282) binding
- DR 376:377 (≠ NR 283:284) binding
- DI 395:396 (= DI 302:303) binding
- DV 414:415 (≠ DA 321:322) binding
- QH 487:488 (≠ LS 395:396) binding
- GG 508:509 (≠ GQ 416:417) binding
- GAM 511:513 (≠ GPL 419:421) binding
- D538 (= D446) binding
- DGS 538:540 (≠ DYD 446:448) binding
- N565 (= N473) binding
- NQHLGM 565:570 (≠ NSYLGL 473:478) binding
- H567 (≠ Y475) binding
- W574 (≠ A482) binding ; mutation to L: Increased catalytic activity. Resistant to imidazolinone and sulfonylurea herbicides.; mutation to S: Slightly decreased catalytic activity. Resistant to imidazolinone and sulfonylurea herbicides.
Sites not aligning to the query:
- 653 binding ; S→A: No effect on catalytic activity or sensitivity to herbicides.; S→F: No effect on catalytic activity. Resistant to imidazolinone herbicides and also slightly sulfonylurea-resistant.; S→N: In csr1-2/GH90; no effect on catalytic activity. Resistant to imidazolinone but not to sulfonylurea herbicides.; S→T: No effect on catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
5k2oA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, pyrithiobac (see paper)
33% identity, 82% coverage: 5:486/591 of query aligns to 13:493/585 of 5k2oA
- active site: Y33 (≠ V25), G35 (= G27), G36 (≠ A28), A37 (= A29), S38 (≠ I30), E59 (≠ V51), T82 (= T75), F121 (= F114), Q122 (= Q115), E123 (≠ A116), K171 (≠ F164), M266 (≠ L257), V293 (≠ H285), V400 (≠ I393), G426 (= G419), M428 (≠ L421), D453 (= D446), N480 (= N473), H482 (≠ Y475), L483 (= L476), M485 (≠ L478), V486 (≠ I479), W489 (≠ A482)
- binding 2-chloranyl-6-(4,6-dimethoxypyrimidin-2-yl)sulfanyl-benzoic acid: M266 (≠ L257), R292 (= R284), W489 (≠ A482)
- binding flavin-adenine dinucleotide: R161 (= R154), G222 (= G211), G223 (= G212), G224 (= G213), T246 (= T237), L247 (= L238), M248 (= M239), L264 (≠ V255), G286 (= G278), R288 (= R280), D290 (≠ A282), V293 (≠ H285), D310 (= D302), I311 (= I303), D329 (= D321), V330 (≠ A322), Q404 (= Q397), M405 (≠ I398), G423 (= G416)
- binding magnesium ion: D453 (= D446), N480 (= N473), H482 (≠ Y475)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (≠ I393), G401 (= G394), Q402 (≠ L395), H403 (≠ S396), M428 (≠ L421), D453 (= D446), G454 (≠ Y447), S455 (≠ D448), N480 (= N473), H482 (≠ Y475), L483 (= L476), G484 (= G477), M485 (≠ L478), V486 (≠ I479)
Sites not aligning to the query:
8et4A Crystal structure of wild-type arabidopsis thaliana acetohydroxyacid synthase in complex with amidosulfuron (see paper)
33% identity, 82% coverage: 5:486/591 of query aligns to 13:493/582 of 8et4A
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V400 (≠ I393), G401 (= G394), Q402 (≠ L395), H403 (≠ S396), G426 (= G419), M428 (≠ L421), G452 (= G445), D453 (= D446), G454 (≠ Y447), S455 (≠ D448), M458 (≠ F451), N480 (= N473), H482 (≠ Y475), L483 (= L476), G484 (= G477), M485 (≠ L478), V486 (≠ I479)
- binding flavin-adenine dinucleotide: R161 (= R154), G222 (= G211), G223 (= G212), G224 (= G213), T246 (= T237), L247 (= L238), M248 (= M239), L264 (≠ V255), M266 (≠ L257), H267 (≠ Q258), G286 (= G278), V287 (≠ N279), R288 (= R280), D290 (≠ A282), R292 (= R284), V293 (≠ H285), D310 (= D302), I311 (= I303), D329 (= D321), V330 (≠ A322), M405 (≠ I398), G423 (= G416)
- binding magnesium ion: F370 (≠ R361), D453 (= D446), M458 (≠ F451), Q461 (≠ E454), N480 (= N473), H482 (≠ Y475)
- binding N-{[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]sulfamoyl}-N-methylmethanesulfonamide: M266 (≠ L257), R292 (= R284), M485 (≠ L478), W489 (≠ A482)
Sites not aligning to the query:
5wj1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a triazolopyrimidine herbicide, penoxsulam (see paper)
33% identity, 82% coverage: 5:486/591 of query aligns to 13:493/582 of 5wj1A
- active site: Y33 (≠ V25), G35 (= G27), G36 (≠ A28), A37 (= A29), S38 (≠ I30), E59 (≠ V51), T82 (= T75), F121 (= F114), Q122 (= Q115), E123 (≠ A116), K171 (≠ F164), M266 (≠ L257), V293 (≠ H285), V400 (≠ I393), G426 (= G419), M428 (≠ L421), D453 (= D446), N480 (= N473), H482 (≠ Y475), L483 (= L476), M485 (≠ L478), V486 (≠ I479), W489 (≠ A482)
- binding flavin-adenine dinucleotide: R161 (= R154), G222 (= G211), G223 (= G212), G224 (= G213), T246 (= T237), L247 (= L238), M248 (= M239), M263 (= M254), L264 (≠ V255), G286 (= G278), R288 (= R280), V293 (≠ H285), D310 (= D302), I311 (= I303), D329 (= D321), V330 (≠ A322), M405 (≠ I398), G423 (= G416), G424 (≠ Q417)
- binding magnesium ion: D453 (= D446), N480 (= N473), H482 (≠ Y475)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: M266 (≠ L257), D291 (≠ N283), R292 (= R284), M485 (≠ L478), W489 (≠ A482)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (≠ I393), G401 (= G394), Q402 (≠ L395), H403 (≠ S396), M428 (≠ L421), D453 (= D446), G454 (≠ Y447), S455 (≠ D448), M458 (≠ F451), N480 (= N473), H482 (≠ Y475), L483 (= L476), G484 (= G477), M485 (≠ L478), V486 (≠ I479)
Sites not aligning to the query:
5k6tA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, propoxycarbazone-sodium (see paper)
33% identity, 82% coverage: 5:486/591 of query aligns to 13:493/582 of 5k6tA
- active site: Y33 (≠ V25), G35 (= G27), G36 (≠ A28), A37 (= A29), S38 (≠ I30), E59 (≠ V51), T82 (= T75), F121 (= F114), Q122 (= Q115), E123 (≠ A116), K171 (≠ F164), M266 (≠ L257), V293 (≠ H285), V400 (≠ I393), G426 (= G419), M428 (≠ L421), D453 (= D446), N480 (= N473), H482 (≠ Y475), L483 (= L476), M485 (≠ L478), V486 (≠ I479), W489 (≠ A482)
- binding methyl 2-[(4-methyl-5-oxidanylidene-3-propoxy-1,2,4-triazol-1-yl)carbonylsulfamoyl]benzoate: H267 (≠ Q258), R292 (= R284), M485 (≠ L478), W489 (≠ A482)
- binding flavin-adenine dinucleotide: R161 (= R154), G222 (= G211), G223 (= G212), G224 (= G213), T246 (= T237), L247 (= L238), M248 (= M239), L264 (≠ V255), G286 (= G278), R288 (= R280), D290 (≠ A282), R292 (= R284), V293 (≠ H285), D310 (= D302), I311 (= I303), D329 (= D321), V330 (≠ A322), Q404 (= Q397), M405 (≠ I398), G423 (= G416)
- binding magnesium ion: D453 (= D446), N480 (= N473), H482 (≠ Y475)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V400 (≠ I393), G401 (= G394), Q402 (≠ L395), H403 (≠ S396), G426 (= G419), M428 (≠ L421), G452 (= G445), G454 (≠ Y447), S455 (≠ D448), N480 (= N473), H482 (≠ Y475), L483 (= L476), G484 (= G477)
Sites not aligning to the query:
5k6rA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, thiencarbazone-methyl (see paper)
33% identity, 82% coverage: 5:486/591 of query aligns to 13:493/582 of 5k6rA
- active site: Y33 (≠ V25), G35 (= G27), G36 (≠ A28), A37 (= A29), S38 (≠ I30), E59 (≠ V51), T82 (= T75), F121 (= F114), Q122 (= Q115), E123 (≠ A116), K171 (≠ F164), M266 (≠ L257), V293 (≠ H285), V400 (≠ I393), G426 (= G419), M428 (≠ L421), D453 (= D446), N480 (= N473), H482 (≠ Y475), L483 (= L476), M485 (≠ L478), V486 (≠ I479), W489 (≠ A482)
- binding methyl 4-[(3-methoxy-4-methyl-5-oxidanylidene-1,2,4-triazol-1-yl)carbonylsulfamoyl]-5-methyl-thiophene-3-carboxylate: R292 (= R284), W489 (≠ A482)
- binding flavin-adenine dinucleotide: R161 (= R154), G222 (= G211), G223 (= G212), G224 (= G213), T246 (= T237), L247 (= L238), M248 (= M239), L264 (≠ V255), M266 (≠ L257), G286 (= G278), R288 (= R280), R292 (= R284), V293 (≠ H285), D310 (= D302), I311 (= I303), G328 (≠ S320), D329 (= D321), V330 (≠ A322), M405 (≠ I398), G423 (= G416)
- binding magnesium ion: D453 (= D446), N480 (= N473), H482 (≠ Y475)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V400 (≠ I393), G401 (= G394), Q402 (≠ L395), H403 (≠ S396), G426 (= G419), M428 (≠ L421), D453 (= D446), G454 (≠ Y447), S455 (≠ D448), M458 (≠ F451), N480 (= N473), H482 (≠ Y475), L483 (= L476), G484 (= G477), M485 (≠ L478), V486 (≠ I479)
Sites not aligning to the query:
1z8nA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with an imidazolinone herbicide, imazaquin (see paper)
33% identity, 82% coverage: 5:486/591 of query aligns to 13:493/582 of 1z8nA
- active site: Y33 (≠ V25), G35 (= G27), G36 (≠ A28), A37 (= A29), S38 (≠ I30), E59 (≠ V51), T82 (= T75), F121 (= F114), Q122 (= Q115), E123 (≠ A116), K171 (≠ F164), M266 (≠ L257), V293 (≠ H285), V400 (≠ I393), G426 (= G419), M428 (≠ L421), D453 (= D446), N480 (= N473), H482 (≠ Y475), L483 (= L476), M485 (≠ L478), V486 (≠ I479), W489 (≠ A482)
- binding 2-(4-isopropyl-4-methyl-5-oxo-4,5-dihydro-1h-imidazol-2-yl)quinoline-3-carboxylic acid: K135 (= K128), R161 (= R154), Y191 (= Y178), R194 (≠ L181), D291 (≠ N283), R292 (= R284), D312 (≠ E304), W489 (≠ A482)
- binding flavin-adenine dinucleotide: R161 (= R154), G222 (= G211), G224 (= G213), T246 (= T237), L247 (= L238), M248 (= M239), L264 (≠ V255), G265 (= G256), M266 (≠ L257), H267 (≠ Q258), G286 (= G278), V287 (≠ N279), R288 (= R280), D290 (≠ A282), R292 (= R284), V293 (≠ H285), D310 (= D302), I311 (= I303), D329 (= D321), V330 (≠ A322), M405 (≠ I398), G423 (= G416), G424 (≠ Q417)
- binding magnesium ion: D453 (= D446), N480 (= N473)
- binding thiamine diphosphate: V400 (≠ I393), G401 (= G394), Q402 (≠ L395), H403 (≠ S396), G426 (= G419), M428 (≠ L421), G452 (= G445), G454 (≠ Y447), S455 (≠ D448), N480 (= N473), H482 (≠ Y475), L483 (= L476), G484 (= G477), M485 (≠ L478), V486 (≠ I479)
Sites not aligning to the query:
1yi1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl (see paper)
33% identity, 82% coverage: 5:486/591 of query aligns to 13:493/582 of 1yi1A
- active site: Y33 (≠ V25), G35 (= G27), G36 (≠ A28), A37 (= A29), S38 (≠ I30), E59 (≠ V51), T82 (= T75), F121 (= F114), Q122 (= Q115), E123 (≠ A116), K171 (≠ F164), M266 (≠ L257), V293 (≠ H285), V400 (≠ I393), G426 (= G419), M428 (≠ L421), D453 (= D446), N480 (= N473), H482 (≠ Y475), L483 (= L476), M485 (≠ L478), V486 (≠ I479), W489 (≠ A482)
- binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: D291 (≠ N283), R292 (= R284), W489 (≠ A482)
- binding flavin-adenine dinucleotide: R161 (= R154), G223 (= G212), G224 (= G213), T246 (= T237), L247 (= L238), M248 (= M239), M263 (= M254), L264 (≠ V255), G265 (= G256), M266 (≠ L257), H267 (≠ Q258), G286 (= G278), V287 (≠ N279), R288 (= R280), D290 (≠ A282), V293 (≠ H285), D310 (= D302), I311 (= I303), D329 (= D321), V330 (≠ A322), M405 (≠ I398), G423 (= G416), G424 (≠ Q417)
- binding magnesium ion: D453 (= D446), N480 (= N473), H482 (≠ Y475)
Sites not aligning to the query:
Query Sequence
>RR42_RS19850 FitnessBrowser__Cup4G11:RR42_RS19850
MPKMRAVDAAIAVLEKEGITTAFGVPGAAINPFYSAMRRAGTIDHFLARHVEGASHMAEG
YTRAEAGNIGVCIGTSGPAGTDMITGLYSAWADSIPILCITGQAPRARLYKEDFQAVDIE
SIAKPVTKWAVTVREPALVPQVFQQAFHLMRSGRPGPVLIDLPFDVQVAEIEFDPETYQP
LAPYKPVASRAQIEKAIAMLNAAERPLIVCGGGVINADAAELLVEFAELVNVPVVPTLMG
WGVLADDHPLQAGMVGLQTSHRYGNATMLASDFVLGIGNRWANRHTGSVEVYTKGRKFVH
VDIEPTQIGRVFGPDLGIVSDAKAALEQFVEVAREMKMAGRLPCRKSWVADVQKRRRTMQ
RKSDFDNVPVKPQRVYREMNQYFPRDVRYVSTIGLSQIAAAQFLSVNEPRHWINCGQAGP
LGWTIPAAIGVKVASPESDVVAISGDYDFQFMIEELAVAAQFKVPYIHLVVNNSYLGLIR
QAQRNFEMDYCVQLAFDNVNSPELNGYGVDHVKVVEGLGCKAIRVFKPEDIAPAFAEARD
LMAEFSVPVVVEVILERVTNIAMGTEIDNINEFEPIEDIEEAILKEEVETA
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory