Comparing RR42_RS20325 FitnessBrowser__Cup4G11:RR42_RS20325 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
Q3L181 Perakine reductase; EC 1.1.1.317 from Rauvolfia serpentina (Serpentine wood) (Ophioxylon serpentinum) (see paper)
47% identity, 95% coverage: 6:321/334 of query aligns to 5:316/337 of Q3L181
3v0sA Crystal structure of perakine reductase, founder member of a novel akr subfamily with unique conformational changes during NADPH binding (see paper)
45% identity, 93% coverage: 6:315/334 of query aligns to 5:278/287 of 3v0sA
P46336 Aldo-keto reductase IolS; AKR11A; Vegetative protein 147; VEG147; EC 1.1.1.- from Bacillus subtilis (strain 168) (see paper)
35% identity, 93% coverage: 6:314/334 of query aligns to 5:309/310 of P46336
O14295 Pyridoxal reductase; PL reductase; PL-red; EC 1.1.1.65 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
34% identity, 97% coverage: 11:333/334 of query aligns to 6:332/333 of O14295
1pz0A Structure of NADPH-dependent family 11 aldo-keto reductase akr11a(holo) (see paper)
35% identity, 93% coverage: 6:314/334 of query aligns to 4:308/311 of 1pz0A
8hnqA The structure of a alcohol dehydrogenase akr13b2 with NADP
35% identity, 88% coverage: 17:311/334 of query aligns to 28:286/286 of 8hnqA
P80874 Aldo-keto reductase YhdN; AKR11B; General stress protein 69; GSP69; EC 1.1.1.- from Bacillus subtilis (strain 168) (see paper)
33% identity, 89% coverage: 17:314/334 of query aligns to 16:310/331 of P80874
1pz1A Structure of NADPH-dependent family 11 aldo-keto reductase akr11b(holo) (see paper)
33% identity, 89% coverage: 17:314/334 of query aligns to 16:310/333 of 1pz1A
5danA Crystal structure of a novel aldo keto reductase tm1743 from thermotoga maritima in complex with NADP+
31% identity, 93% coverage: 5:313/334 of query aligns to 4:273/274 of 5danA
6kiyA Crystal structure of a thermostable aldo-keto reductase tm1743 in complex with inhibitor epalrestat (see paper)
31% identity, 93% coverage: 5:313/334 of query aligns to 5:274/275 of 6kiyA
6kikA Crystal structure of a thermostable aldo-keto reductase tm1743 in complex with inhibitor tolrestat (see paper)
31% identity, 93% coverage: 5:313/334 of query aligns to 5:274/275 of 6kikA
6ow0A Crystal structure of mithramycin 3-side chain keto-reductase mtmw in complex with NAD+ and peg (see paper)
33% identity, 93% coverage: 4:314/334 of query aligns to 3:316/323 of 6ow0A
4aubB The complex structure of the bacterial aldo-keto reductase akr14a1 with NADP and citrate (see paper)
31% identity, 92% coverage: 5:311/334 of query aligns to 14:318/335 of 4aubB
Sites not aligning to the query:
6ow0B Crystal structure of mithramycin 3-side chain keto-reductase mtmw in complex with NAD+ and peg (see paper)
32% identity, 93% coverage: 4:314/334 of query aligns to 3:292/301 of 6ow0B
Q9P7U2 Putative aryl-alcohol dehydrogenase C977.14c; EC 1.1.1.- from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
31% identity, 94% coverage: 7:321/334 of query aligns to 12:349/351 of Q9P7U2
6hg6A Clostridium beijerinckii aldo-keto reductase cbei_3974 with NADPH (see paper)
28% identity, 92% coverage: 6:313/334 of query aligns to 13:310/313 of 6hg6A
P77256 NADH-specific methylglyoxal reductase; AKR11B2; EC 1.1.1.- from Escherichia coli (strain K12) (see paper)
32% identity, 90% coverage: 7:306/334 of query aligns to 13:313/326 of P77256
3n6qD Crystal structure of yghz from e. Coli (see paper)
30% identity, 92% coverage: 5:311/334 of query aligns to 15:305/315 of 3n6qD
8hw0A The structure of akr6d1
31% identity, 88% coverage: 5:298/334 of query aligns to 4:301/329 of 8hw0A
5t79A X-ray crystal structure of a novel aldo-keto reductases for the biocatalytic conversion of 3-hydroxybutanal to 1,3-butanediol (see paper)
31% identity, 93% coverage: 5:314/334 of query aligns to 16:313/315 of 5t79A
>RR42_RS20325 FitnessBrowser__Cup4G11:RR42_RS20325
MTALRKLGRHGPQVFPLGLGCMGMSEFYGAHDDAESIRTINHAIDNGVNFIDTADIYGPY
TNESLVGRAIAARRDSVVLATKFGIVRDAANLVARGVDGRPEYVRASCDASLKRLGVEHI
DLYYQHRVDPQVPIEETVGAMAELVKAGKVRWLGLSEAGAQTIERAHAVHPITALQSEYS
LWTRDVEAGGDQSILATCQRLGIAFVPYSPLGRGFLTGTIRSPEDFAQDDYRRTSPRFMG
ENFARNLALVDKVNALARDKGCSPAQLALAWVLARGEMLAPIPGTRRVANLDDNLGALDV
VLDAADMAAIDAVFPADAVAGTRYPGQVMSLLAR
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory