Comparing RR42_RS21235 FitnessBrowser__Cup4G11:RR42_RS21235 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 17 hits to proteins with known functional sites (download)
4ga6A Crystal structure of amp phosphorylasE C-terminal deletion mutant in complex with substrates (see paper)
38% identity, 64% coverage: 241:676/679 of query aligns to 58:492/493 of 4ga6A
Q5JCX3 AMP phosphorylase; AMPpase; Nucleoside monophosphate phosphorylase; NMP phosphorylase; EC 2.4.2.57 from Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1)) (see paper)
38% identity, 64% coverage: 241:676/679 of query aligns to 58:492/503 of Q5JCX3
4ga4A Crystal structure of amp phosphorylase n-terminal deletion mutant (see paper)
39% identity, 60% coverage: 268:676/679 of query aligns to 1:408/418 of 4ga4A
2wk6A Structural features of native human thymidine phosphorylase and in complex with 5-iodouracil (see paper)
31% identity, 56% coverage: 272:650/679 of query aligns to 4:407/446 of 2wk6A
P19971 Thymidine phosphorylase; TP; Gliostatin; Platelet-derived endothelial cell growth factor; PD-ECGF; TdRPase; EC 2.4.2.4 from Homo sapiens (Human) (see 3 papers)
31% identity, 56% coverage: 272:650/679 of query aligns to 38:441/482 of P19971
Sites not aligning to the query:
2j0fA Structural basis for non-competitive product inhibition in human thymidine phosphorylase: implication for drug design (see paper)
31% identity, 56% coverage: 272:650/679 of query aligns to 5:408/446 of 2j0fA
1brwB The crystal structure of pyrimidine nucleoside phosphorylase in a closed conformation (see paper)
29% identity, 59% coverage: 272:674/679 of query aligns to 5:422/433 of 1brwB
1brwA The crystal structure of pyrimidine nucleoside phosphorylase in a closed conformation (see paper)
29% identity, 59% coverage: 272:674/679 of query aligns to 5:422/433 of 1brwA
1uouA Crystal structure of human thymidine phosphorylase in complex with a small molecule inhibitor (see paper)
31% identity, 56% coverage: 272:650/679 of query aligns to 6:399/438 of 1uouA
5olnB X-ray structure of the complex pyrimidine-nucleoside phosphorylase from bacillus subtilis at 1.88 a (see paper)
28% identity, 56% coverage: 272:652/679 of query aligns to 6:401/434 of 5olnB
7m7kB Crystal structure of uridine bound to geobacillus thermoglucosidasius pyrimidine nucleoside phosphorylase pynp
27% identity, 59% coverage: 272:674/679 of query aligns to 4:421/432 of 7m7kB
P77836 Pyrimidine-nucleoside phosphorylase; PYNP; Py-NPase; EC 2.4.2.2 from Geobacillus stearothermophilus (Bacillus stearothermophilus) (see paper)
26% identity, 59% coverage: 272:675/679 of query aligns to 5:423/433 of P77836
4lhmA Thymidine phosphorylase from e.Coli with 3'-azido-3'-deoxythymidine (see paper)
28% identity, 57% coverage: 269:658/679 of query aligns to 3:411/440 of 4lhmA
Sites not aligning to the query:
4eadA Thymidine phosphorylase from e.Coli with 3'-azido-2'-fluoro- dideoxyuridine
28% identity, 57% coverage: 269:658/679 of query aligns to 3:411/440 of 4eadA
4yyyB X-ray structure of the thymidine phosphorylase from salmonella typhimurium in complex with uridine (see paper)
27% identity, 57% coverage: 269:652/679 of query aligns to 3:405/440 of 4yyyB
4yekA X-ray structure of the thymidine phosphorylase from salmonella typhimurium in complex with thymidine (see paper)
27% identity, 57% coverage: 269:652/679 of query aligns to 3:405/440 of 4yekA
5ey3A X-ray structure of the thymidine phosphorylase from salmonella typhimurium in complex with cytidine and sulphate
27% identity, 57% coverage: 269:652/679 of query aligns to 5:407/442 of 5ey3A
>RR42_RS21235 FitnessBrowser__Cup4G11:RR42_RS21235
MQAAGTLFLVVGPSGAGKDSLMDGARAALLADPRYVFARRVITRPTGSPGEDHEGVTQVE
FSAREAANAFLITWAAHGLRYGLPASLLDELERGRHVIANGSRGIVAALAGQLRNFVVIH
VTAPLQVLAQRIAARGRESGDAVLRRLERMPDPIPAGVASVCVSNDAAMDVGIARFLEAL
RTAPAPLKARRMPIATGDAHIAYVSPAFSAGQTRMAVRSGTVEIPAALHVVESPALLQDE
EIGLSDALFDRLGAAPGSTVRLRRIPGPVSRDVLRKKLRGDALSEAEYEAVLRDAVEGRY
TEIELTAFLVAASQHLTDAEVVSVARARTRFAPRIGWDEPIVVDKHSMGGVPGSRITLIV
VPIVAAFGLAMPKTSSRAITSAAGTAEAMETVARVDLDIDDVRRCVEQARACIAWNGRLN
HSAIDDVMNAITRPLGLDTNRWSVASILSKKYTAGSTHVIVDLPFGPQAKLKSQAEAQAL
GVLFEAVGAGLGMQVRAFATHGSKPIGRGVGPALEVRDVLQVLNGSPDAPADLREKALFF
AGQILAFDPAVGSPAEGRRMAGELLACGAASAAFDRIVAAQGARAAPDAPGQHVHTVPAS
TAGVVADINGFAIAGIARGAGAPRRPGAGVDLLCTVGDRLVAGQPLFRIHAQTASDLEAG
VRAHASAELAGPPIRILAD
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory