SitesBLAST
Comparing RR42_RS21485 FitnessBrowser__Cup4G11:RR42_RS21485 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
7uyyA The crystal structure of the pseudomonas aeruginosa aldehyde dehydrogenase encoded by the pa4189 gene in complex with nadh (see paper)
78% identity, 98% coverage: 1:446/454 of query aligns to 49:494/496 of 7uyyA
- binding 1,4-dihydronicotinamide adenine dinucleotide: V165 (= V117), L166 (= L118), P167 (= P119), W168 (= W120), K192 (= K144), G225 (= G177), G229 (= G181), F243 (= F195), G245 (= G197), S246 (= S198), T249 (= T201), L252 (= L204), F253 (= F205), Y256 (= Y208), C269 (= C221), G270 (= G222), C303 (= C255), H350 (= H302), K353 (= K305), F400 (= F352)
5iuwA Crystal structure of indole-3-acetaldehyde dehydrogenase in complexed with NAD+ and iaa (see paper)
48% identity, 98% coverage: 1:447/454 of query aligns to 46:495/495 of 5iuwA
- active site: N166 (= N121), K189 (= K144), E265 (= E220), C300 (= C255), E399 (= E350), D476 (= D428)
- binding 1h-indol-3-ylacetic acid: F167 (= F122), M170 (≠ L125), C300 (= C255), D457 (≠ G408), F465 (= F416)
- binding nicotinamide-adenine-dinucleotide: I162 (≠ V117), V163 (≠ L118), P164 (= P119), W165 (= W120), N166 (= N121), K189 (= K144), G222 (= G177), G226 (= G181), K227 (≠ E182), F240 (= F195), T241 (= T196), G242 (= G197), S243 (= S198), I246 (≠ T201), Y253 (= Y208), E265 (= E220), A266 (≠ C221), C300 (= C255), E399 (= E350), F401 (= F352)
5iuvA Crystal structure of indole-3-acetaldehyde dehydrogenase in complexed with NAD+ (see paper)
48% identity, 98% coverage: 1:447/454 of query aligns to 46:495/495 of 5iuvA
- active site: N166 (= N121), K189 (= K144), E265 (= E220), C300 (= C255), E399 (= E350), D476 (= D428)
- binding nicotinamide-adenine-dinucleotide: I162 (≠ V117), V163 (≠ L118), P164 (= P119), W165 (= W120), N166 (= N121), K189 (= K144), S191 (≠ A146), G222 (= G177), G226 (= G181), K227 (≠ E182), F240 (= F195), T241 (= T196), G242 (= G197), S243 (= S198), I246 (≠ T201), Y253 (= Y208), E265 (= E220), A266 (≠ C221), C300 (= C255), E399 (= E350), F401 (= F352)
7jsoA P. Syringae alda indole-3-acetaldehyde dehydrogenase c302a mutant in complex with NAD+ and iaa (see paper)
48% identity, 98% coverage: 1:447/454 of query aligns to 46:495/495 of 7jsoA
- active site: N166 (= N121), E265 (= E220), A300 (≠ C255), D476 (= D428)
- binding 1h-indol-3-ylacetic acid: F167 (= F122), W174 (= W129), V299 (≠ N254), A300 (≠ C255), T301 (≠ S256), D457 (≠ G408), F465 (= F416)
- binding 1,4-dihydronicotinamide adenine dinucleotide: I162 (≠ V117), V163 (≠ L118), P164 (= P119), W165 (= W120), K189 (= K144), E192 (≠ K147), G222 (= G177), G226 (= G181), K227 (≠ E182), F240 (= F195), G242 (= G197), S243 (= S198), I246 (≠ T201), A266 (≠ C221), G267 (= G222), A300 (≠ C255), E399 (= E350), F401 (= F352)
4pz2B Structure of zm aldh2-6 (rf2f) in complex with NAD (see paper)
44% identity, 98% coverage: 1:443/454 of query aligns to 39:484/494 of 4pz2B
- active site: N159 (= N121), K182 (= K144), E258 (= E220), C292 (= C255), E392 (= E350), D469 (= D428)
- binding nicotinamide-adenine-dinucleotide: I155 (≠ V117), I156 (≠ L118), P157 (= P119), W158 (= W120), N159 (= N121), M164 (= M126), K182 (= K144), A184 (= A146), E185 (≠ K147), G215 (= G177), G219 (= G181), F233 (= F195), T234 (= T196), G235 (= G197), S236 (= S198), V239 (≠ T201), E258 (= E220), L259 (≠ C221), C292 (= C255), E392 (= E350), F394 (= F352)
4pxlA Structure of zm aldh2-3 (rf2c) in complex with NAD (see paper)
40% identity, 98% coverage: 1:443/454 of query aligns to 34:476/486 of 4pxlA
- active site: N154 (= N121), K177 (= K144), E253 (= E220), C287 (= C255), E384 (= E350), D461 (= D428)
- binding nicotinamide-adenine-dinucleotide: I150 (≠ V117), V151 (≠ L118), P152 (= P119), W153 (= W120), K177 (= K144), E180 (≠ K147), G210 (= G177), G214 (= G181), A215 (≠ E182), F228 (= F195), G230 (= G197), S231 (= S198), V234 (≠ T201), E253 (= E220), G255 (= G222), C287 (= C255), Q334 (≠ H302), K337 (= K305), E384 (= E350), F386 (= F352)
Q56YU0 Aldehyde dehydrogenase family 2 member C4; ALDH1a; Protein REDUCED EPIDERMAL FLUORESCENCE 1; EC 1.2.1.3 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
40% identity, 97% coverage: 4:443/454 of query aligns to 51:491/501 of Q56YU0
- G152 (≠ S104) mutation to E: In ref1-7; reduced activity on sinapaldehyde.
- G416 (≠ A367) mutation to R: In ref1-6; reduced activity on sinapaldehyde.
5gtlA NADPH complex structure of aldehyde dehydrogenase from bacillus cereus
40% identity, 97% coverage: 7:447/454 of query aligns to 49:490/491 of 5gtlA
- active site: N165 (= N121), K188 (= K144), E263 (= E220), C297 (= C255), E394 (= E350), E471 (≠ D428)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: I161 (≠ V117), P163 (= P119), K188 (= K144), A190 (= A146), E191 (≠ K147), Q192 (≠ E148), G221 (= G177), G225 (= G181), G241 (= G197), S242 (= S198), T245 (= T201), L264 (≠ C221), C297 (= C255), E394 (= E350), F396 (= F352)
5gtkA NAD+ complex structure of aldehyde dehydrogenase from bacillus cereus
40% identity, 97% coverage: 7:447/454 of query aligns to 49:490/491 of 5gtkA
- active site: N165 (= N121), K188 (= K144), E263 (= E220), C297 (= C255), E394 (= E350), E471 (≠ D428)
- binding nicotinamide-adenine-dinucleotide: I161 (≠ V117), I162 (≠ L118), P163 (= P119), W164 (= W120), K188 (= K144), E191 (≠ K147), G221 (= G177), G225 (= G181), A226 (≠ E182), F239 (= F195), G241 (= G197), S242 (= S198), T245 (= T201), Y248 (≠ L204), L264 (≠ C221), C297 (= C255), Q344 (≠ H302), R347 (≠ K305), E394 (= E350), F396 (= F352)
4fr8A Crystal structure of human aldehyde dehydrogenase-2 in complex with nitroglycerin (see paper)
40% identity, 99% coverage: 3:450/454 of query aligns to 43:491/493 of 4fr8A
- active site: N162 (= N121), K185 (= K144), Q261 (≠ E220), C295 (= C255), E392 (= E350), E469 (≠ D428)
- binding nicotinamide-adenine-dinucleotide: I158 (≠ V117), I159 (≠ L118), W161 (= W120), K185 (= K144), G218 (= G177), G222 (= G181), A223 (≠ E182), F236 (= F195), G238 (= G197), S239 (= S198), I242 (≠ T201), Q342 (≠ H302), K345 (= K305), E392 (= E350), F394 (= F352)
- binding propane-1,2,3-triyl trinitrate: F163 (= F122), L166 (= L125), W170 (= W129), F289 (≠ W249), S294 (≠ N254), C295 (= C255), D450 (≠ G408), F452 (≠ G410)
4fr8C Crystal structure of human aldehyde dehydrogenase-2 in complex with nitroglycerin (see paper)
40% identity, 99% coverage: 3:450/454 of query aligns to 46:494/496 of 4fr8C
- active site: N165 (= N121), K188 (= K144), Q264 (≠ E220), C298 (= C255), E395 (= E350), E472 (≠ D428)
- binding nicotinamide-adenine-dinucleotide: I161 (≠ V117), I162 (≠ L118), W164 (= W120), K188 (= K144), G221 (= G177), G225 (= G181), A226 (≠ E182), F239 (= F195), G241 (= G197), S242 (= S198), I245 (≠ T201), Q345 (≠ H302), E395 (= E350), F397 (= F352)
O14293 Putative aldehyde dehydrogenase-like protein C9E9.09c; EC 1.2.1.- from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
42% identity, 98% coverage: 3:447/454 of query aligns to 53:497/503 of O14293
- S248 (= S198) modified: Phosphoserine
Sites not aligning to the query:
- 501 modified: Phosphoserine
5l13A Structure of aldh2 in complex with 2p3 (see paper)
40% identity, 99% coverage: 3:450/454 of query aligns to 44:492/494 of 5l13A
- active site: N163 (= N121), K186 (= K144), E262 (= E220), C296 (= C255), E393 (= E350), E470 (≠ D428)
- binding 2,3,5-trimethyl-6-propyl-7H-furo[3,2-g][1]benzopyran-7-one: F164 (= F122), M168 (= M126), W171 (= W129), F290 (≠ W249), C295 (≠ N254), C296 (= C255), C297 (≠ S256), D451 (≠ G408), F453 (≠ G410)
4kwgA Crystal structure analysis of aldh2+aldib13 (see paper)
40% identity, 99% coverage: 3:450/454 of query aligns to 44:492/494 of 4kwgA
- active site: N163 (= N121), K186 (= K144), E262 (= E220), C296 (= C255), E393 (= E350), E470 (≠ D428)
- binding 7-bromo-5-methyl-1H-indole-2,3-dione: F164 (= F122), M168 (= M126), C295 (≠ N254), C296 (= C255), C297 (≠ S256), D451 (≠ G408), F453 (≠ G410)
4kwfA Crystal structure analysis of aldh2+aldib33 (see paper)
40% identity, 99% coverage: 3:450/454 of query aligns to 44:492/494 of 4kwfA
- active site: N163 (= N121), K186 (= K144), E262 (= E220), C296 (= C255), E393 (= E350), E470 (≠ D428)
- binding 1-benzyl-1H-indole-2,3-dione: F164 (= F122), M168 (= M126), W171 (= W129), E262 (= E220), C295 (≠ N254), C296 (= C255), C297 (≠ S256), D451 (≠ G408), F453 (≠ G410), F459 (= F416)
3sz9A Crystal structure of human aldh2 modified with the beta-elimination product of aldi-3; 1-(4-ethylbenzene)prop-2-en-1-one (see paper)
40% identity, 99% coverage: 3:450/454 of query aligns to 44:492/494 of 3sz9A
- active site: N163 (= N121), K186 (= K144), E262 (= E220), C296 (= C255), E393 (= E350), E470 (≠ D428)
- binding 1-(4-ethylphenyl)propan-1-one: F164 (= F122), C295 (≠ N254), C296 (= C255), D451 (≠ G408), F453 (≠ G410), F459 (= F416)
3injA Human mitochondrial aldehyde dehydrogenase complexed with agonist alda-1 (see paper)
40% identity, 99% coverage: 3:450/454 of query aligns to 44:492/494 of 3injA
- active site: N163 (= N121), K186 (= K144), E262 (= E220), C296 (= C255), E393 (= E350), E470 (≠ D428)
- binding N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide: M118 (≠ E76), F164 (= F122), L167 (= L125), F286 (≠ N245), F290 (≠ W249), D451 (≠ G408), F453 (≠ G410)
2vleA The structure of daidzin, a naturally occurring anti alcohol- addiction agent, in complex with human mitochondrial aldehyde dehydrogenase (see paper)
40% identity, 99% coverage: 3:450/454 of query aligns to 44:492/494 of 2vleA
- active site: N163 (= N121), K186 (= K144), E262 (= E220), C296 (= C255), E393 (= E350), E470 (≠ D428)
- binding daidzin: M118 (≠ E76), F164 (= F122), M168 (= M126), W171 (= W129), F286 (≠ N245), F290 (≠ W249), C295 (≠ N254), C296 (= C255), D451 (≠ G408), V452 (≠ E409), F453 (≠ G410)
1o01B Human mitochondrial aldehyde dehydrogenase complexed with crotonaldehyde, NAD(h) and mg2+ (see paper)
40% identity, 99% coverage: 3:450/454 of query aligns to 44:492/494 of 1o01B
- active site: N163 (= N121), K186 (= K144), E262 (= E220), C296 (= C255), E393 (= E350), E470 (≠ D428)
- binding (2e)-but-2-enal: C296 (= C255), C297 (≠ S256), F453 (≠ G410)
- binding nicotinamide-adenine-dinucleotide: I159 (≠ V117), I160 (≠ L118), P161 (= P119), W162 (= W120), K186 (= K144), E189 (≠ K147), G219 (= G177), G223 (= G181), A224 (≠ E182), F237 (= F195), G239 (= G197), S240 (= S198), I243 (≠ T201), L263 (≠ C221), G264 (= G222), C296 (= C255), Q343 (≠ H302), E393 (= E350), F395 (= F352)
1cw3A Human mitochondrial aldehyde dehydrogenase complexed with NAD+ and mn2+ (see paper)
40% identity, 99% coverage: 3:450/454 of query aligns to 44:492/494 of 1cw3A
- active site: N163 (= N121), K186 (= K144), E262 (= E220), C296 (= C255), E393 (= E350), E470 (≠ D428)
- binding magnesium ion: D103 (= D61), Q190 (≠ E148)
- binding nicotinamide-adenine-dinucleotide: I159 (≠ V117), I160 (≠ L118), P161 (= P119), W162 (= W120), K186 (= K144), G219 (= G177), G223 (= G181), A224 (≠ E182), F237 (= F195), G239 (= G197), S240 (= S198), I243 (≠ T201), L263 (≠ C221), G264 (= G222), C296 (= C255), Q343 (≠ H302), K346 (= K305), E393 (= E350), F395 (= F352)
Sites not aligning to the query:
Query Sequence
>RR42_RS21485 FitnessBrowser__Cup4G11:RR42_RS21485
LPEITACDALDVDIAVAKAKAAFEDGRWHRRSPAQCKATLLRFADLLEQHAHELAVMESL
DSGKPIRECQATDVPETIHTIRWHAELIDKIYDSTAPVGSNALSLVVREPIGVVGLVLPW
NFPLLMLAWKIGPSLAAGCSIIVKPAKETTLTALRVAELAHEAGVPAGVFNVLPGGGKDV
GEPLGKHMDVSMVSFTGSTDTGRLFLRYAADSNLKRIVLECGGKNPAVVMNDVEDIDVVA
QHVVNGAFWNMGENCSASSRLIVHAEVKDNLLAHIGVHLREWKMGDPLDPEHRIGSLVSE
SHFRKGQSYIELANAENLRVAFGGGTEGETFVEPTVVDGVGQHSRLFKEEIFGPILSVTT
FTSTEEAIALANDSVYGLAASVYTSNLNNAIRLSREIRAGVVTVNCFGEGDVTTPFGGYK
ESGFGGRDKSIWAHDQYTEIKTIWIDVPDRAAVK
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory