SitesBLAST
Comparing RR42_RS21615 FitnessBrowser__Cup4G11:RR42_RS21615 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 8 hits to proteins with known functional sites (download)
8gy3A Cryo-em structure of membrane-bound aldehyde dehydrogenase from gluconobacter oxydans
45% identity, 42% coverage: 568:988/1000 of query aligns to 5:429/440 of 8gy3A
- binding heme c: Y52 (≠ D615), C53 (= C616), C56 (= C619), H57 (= H620), S84 (≠ T644), I86 (= I646), W97 (= W657), F102 (= F662), L117 (= L677), F121 (= F681), F126 (= F686), R163 (= R723), C203 (= C762), C206 (= C765), H207 (= H766), A232 (= A792), P233 (= P793), L235 (= L795), W245 (= W805), Y253 (= Y813), L254 (= L814), G263 (= G823), S264 (≠ A824), M269 (= M829), Y292 (≠ F854), C337 (= C894), C340 (= C897), H341 (= H898), P353 (= P911), L355 (= L913), N358 (= N916), N359 (≠ T917), V372 (= V930), I377 (= I935), G382 (≠ T940), Q383 (≠ S941), I386 (≠ G944), M388 (= M946), F391 (= F949)
- binding ubiquinone-10: E55 (≠ V618), T76 (= T636), F78 (= F638), Y118 (= Y678), P119 (= P679), I160 (≠ Y720), G166 (≠ M726), Q167 (≠ A727), F169 (vs. gap), W170 (= W729), H202 (= H761), R210 (= R769), L213 (= L772)
7w2jC Cryo-em structure of membrane-bound fructose dehydrogenase from gluconobacter japonicus
39% identity, 37% coverage: 604:969/1000 of query aligns to 1:370/418 of 7w2jC
- binding heme c: C13 (= C616), C16 (= C619), H17 (= H620), T42 (= T644), I44 (= I646), Y55 (≠ W657), L75 (= L677), Y76 (= Y678), A78 (= A680), M79 (≠ F681), R122 (= R723), H161 (= H761), C162 (= C762), C165 (= C765), H166 (= H766), A191 (= A792), P192 (= P793), R223 (≠ A824), P227 (= P828), M228 (= M829), V289 (≠ A893), C290 (= C894), C293 (= C897), H294 (= H898), Y305 (≠ I909), Y306 (≠ K910), P307 (= P911), L309 (= L913), N312 (= N916), T313 (= T917), T314 (≠ N918), D322 (≠ N926), I327 (≠ L931), V331 (≠ I935), R333 (≠ T937), I340 (≠ G944), M342 (= M946), P343 (= P947), F345 (= F949)
8jejC Cryo-em structure of na-dithionite reduced membrane-bound fructose dehydrogenase from gluconobacter japonicus
38% identity, 37% coverage: 604:969/1000 of query aligns to 1:384/413 of 8jejC
- binding heme c: C13 (= C616), C16 (= C619), H17 (= H620), T42 (= T644), I44 (= I646), F60 (= F662), L64 (≠ M666), L75 (= L677), Y76 (= Y678), M79 (≠ F681), P80 (= P682), Y84 (≠ F686), R122 (= R723), C162 (= C762), C165 (= C765), H166 (= H766), I186 (≠ A787), W189 (= W790), A191 (= A792), P192 (= P793), I194 (≠ L795), W205 (= W805), Y213 (= Y813), R223 (≠ A824), M228 (= M829), V303 (≠ A893), C304 (= C894), C307 (= C897), H308 (= H898), Y320 (≠ K910), P321 (= P911), L323 (= L913), T327 (= T917), T328 (≠ N918), D336 (≠ N926), I341 (≠ L931), V345 (≠ I935), R347 (≠ T937), I354 (≠ G944), M356 (= M946), F359 (= F949), I376 (≠ L961)
- binding ubiquinone-10: M36 (≠ F638), P77 (= P679), S124 (≠ L725), W128 (= W729), C165 (= C765), L173 (≠ G773)
Sites not aligning to the query:
Q47945 Alcohol dehydrogenase (quinone), cytochrome c subunit; ADH; Alcohol dehydrogenase (quinone), subunit II; Cytochrome c-553; Cytochrome c553; Ethanol:Q2 reductase; G3-ADH subunit II; Quinohemoprotein-cytochrome c complex; Ubiquinol oxidase; EC 1.1.5.5 from Gluconobacter oxydans (strain 621H) (Gluconobacter suboxydans) (see paper)
34% identity, 39% coverage: 602:991/1000 of query aligns to 42:438/478 of Q47945
Sites not aligning to the query:
- 1:36 signal peptide
- 37 modified: Pyrrolidone carboxylic acid
8gy2B Cryo-em structure of membrane-bound alcohol dehydrogenase from gluconobacter oxydans
35% identity, 39% coverage: 602:991/1000 of query aligns to 4:400/433 of 8gy2B
- binding heme c: C18 (= C616), C21 (= C619), H22 (= H620), T46 (= T644), I48 (= I646), Y59 (≠ W657), L68 (≠ M666), R73 (≠ H671), V79 (≠ L677), Y80 (= Y678), M83 (≠ F681), F88 (= F686), R126 (= R723), H165 (= H761), C166 (= C762), C169 (= C765), H170 (= H766), I201 (≠ E791), A202 (= A792), P203 (= P793), L205 (= L795), W216 (= W805), F224 (≠ Y813), A234 (= A824), V235 (≠ A825), F236 (≠ A826), F236 (≠ A826), M239 (= M829), N301 (≠ A893), C302 (= C894), C305 (= C897), H306 (= H898), M316 (≠ I909), F317 (≠ K910), P318 (= P911), L320 (= L913), P324 (≠ T917), G342 (= G934), S352 (≠ D942), V354 (≠ G944), M356 (= M946), F359 (= F949), M375 (≠ L965)
- binding ubiquinone-10: C21 (= C619), L34 (= L632), P39 (= P637), P81 (= P679), L129 (≠ M726), W132 (= W729), E168 (≠ A764), R173 (= R769), I197 (≠ A787), D241 (≠ P831)
Sites not aligning to the query:
8hddB Complex structure of catalytic, small, and a partial electron transfer subunits from burkholderia cepacia fad glucose dehydrogenase
37% identity, 10% coverage: 887:987/1000 of query aligns to 23:121/121 of 8hddB
- binding protoporphyrin ix containing fe: C30 (= C894), C33 (= C897), H34 (= H898), Y46 (≠ K910), P47 (= P911), T54 (≠ N918), V66 (= V930), I67 (≠ L931), R73 (≠ T937), I80 (≠ L943), M82 (= M946), P83 (= P947)
8gy3C Cryo-em structure of membrane-bound aldehyde dehydrogenase from gluconobacter oxydans
24% identity, 51% coverage: 34:546/1000 of query aligns to 203:727/732 of 8gy3C
- binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): G374 (≠ H184), F375 (≠ D185), L379 (= L189), L499 (≠ P311), R500 (= R312), V624 (≠ E439), D625 (≠ Q440), Q632 (≠ L448), T687 (≠ A504), G688 (≠ T505), L689 (= L506), G690 (= G507), E691 (≠ T508)
Sites not aligning to the query:
- binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 38, 39, 40, 41, 42, 45, 79, 80, 81, 83, 84
5y6qC Crystal structure of an aldehyde oxidase from methylobacillus sp. Ky4400 (see paper)
26% identity, 35% coverage: 56:406/1000 of query aligns to 99:436/748 of 5y6qC
Sites not aligning to the query:
- active site: 715, 716
- binding pterin cytosine dinucleotide: 461, 462, 463, 464, 468, 500, 502, 503, 504, 505, 638, 640, 641, 648, 711, 713, 714, 715
Query Sequence
>RR42_RS21615 FitnessBrowser__Cup4G11:RR42_RS21615
MAPASPGAWQPPPEREWLAGHVIRPPVLAWQTGTLLSARLIGCDETAARALPGVATVLRR
GDFLGIAADTAPQALQAAHALRARWQAPPKAAASGLPLARRIVAEHGDAAQAMADAAGRS
AQDYPWPLAGLQAAGCSAMAEWRDGALRVWLPSRRPGALRAELAALLGIGEDRITLICWQ
APGHDEDPLYAHHAAADAALLAHSAGRVVRVRVEAHELGATQAVVNTHIESAWTRDGEIA
AYAVNTAVDARGSAAVMHAPPLALWLTRTTAPVTEIEPQASAGGDTRDDAILPPYRFDSL
SVTQADLPGQPRVESTPAQAARAHVFAHESHLDEVAAASAQDPVALRLRHLDDTRGAGLV
RRVAAQANWQPRGERPQAQQNVRRGRGFAYASTIEAGLADGGQPVHSWSAWVAEVEVDAT
TGEVSVTGVTLGHDSDAGEQGGVDAVALQQEAARAAQQLTVDGSRSDSWPAANLPAVHDA
SLPALATAQLPEVRVGGALRPASATLGTSAAVTLPAAPAVANAIFDATGVRLREPPFSGE
RIRLALAAQANPESTPKRGAARKRNWLLAGATAAAGLFVTAMPWRAPIAPVAPPGAGFYS
AATIERGRLVAAAGDCAVCHTAPNGARNAGGLALDTPFGTIYSTNITPDVETGIGNWSYA
AFERAMRQGIHRDGRHLYPAFPYTAFAKTSDGDLQALYAYLMAAEPVRAKAPETALAFPY
NLRPLMAGWNLLFHSPKPFEADPARSAQWNRGAYLAEGLGHCSACHSPRNALGAEQGGRR
YLGGGEAEGWEAPALGKLSHAPVPWTEQALFSYLRTGYAPHHGAAAGPMAPVIEELALLP
EEDVRAIAHYVASFGDAQPDAALASAQARQLEQRSADAARTLGGPAARLYQNACAVCHQS
DQGIRQFGIKPSLALNTNLHGDKPDNLIRVLLDGIPTPGTSDLGYMPAFGESLDDRQLTQ
LVHYLRKRFAPDKPAWDNVDDTLARLRAAPAHRPNHQPNH
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory