Comparing RR42_RS24180 FitnessBrowser__Cup4G11:RR42_RS24180 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 5 hits to proteins with known functional sites (download)
O14289 3-isopropylmalate dehydratase; Alpha-IPM isomerase; IPMI; Isopropylmalate isomerase; EC 4.2.1.33 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
50% identity, 96% coverage: 3:210/216 of query aligns to 539:734/758 of O14289
Sites not aligning to the query:
P9WK95 3-isopropylmalate dehydratase small subunit; Alpha-IPM isomerase; IPMI; Isopropylmalate isomerase; EC 4.2.1.33 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
41% identity, 99% coverage: 1:213/216 of query aligns to 1:193/198 of P9WK95
2pkpA Crystal structure of 3-isopropylmalate dehydratase (leud)from methhanocaldococcus jannaschii dsm2661 (mj1271) (see paper)
31% identity, 68% coverage: 18:163/216 of query aligns to 13:129/167 of 2pkpA
Q58667 Methanogen homoaconitase small subunit; HACN; Homoaconitate hydratase; EC 4.2.1.114 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
31% identity, 68% coverage: 18:163/216 of query aligns to 13:129/170 of Q58667
P20004 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Bos taurus (Bovine) (see 2 papers)
41% identity, 25% coverage: 79:132/216 of query aligns to 658:711/780 of P20004
Sites not aligning to the query:
>RR42_RS24180 FitnessBrowser__Cup4G11:RR42_RS24180
MEKFTIHRGLVAPLDRGNVDTDAIIPKQFLKSIKRTGFGPNLFDEWRYKDVGEPGMDNSK
RPLNPDFVLNQPRYQGASILLARRNFGCGSSREHAPWALTQYGFHAVIAPSFADIFFNNC
YKNGLLPVVLTEQQVDHLFNETNAFKGYQLTIDLDKQAVITASGQGYEFDIAPFRKYCML
NGFDDIRLTLRHADKIKVFEAERVAKMPWLKPRLAG
Or try a new SitesBLAST search
SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory