Comparing RR42_RS24325 FitnessBrowser__Cup4G11:RR42_RS24325 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
5ugrA Malyl-coa lyase from methylobacterium extorquens (see paper)
43% identity, 100% coverage: 1:306/307 of query aligns to 5:322/323 of 5ugrA
4l9yC Crystal structure of rhodobacter sphaeroides malyl-coa lyase in complex with magnesium, glyoxylate, and propionyl-coa (see paper)
41% identity, 98% coverage: 3:304/307 of query aligns to 5:314/316 of 4l9yC
Q3J5L6 L-malyl-CoA/beta-methylmalyl-CoA lyase; (3S)-malyl-CoA/beta-methylmalyl-CoA lyase; (S)-citramalyl-CoA lyase; EC 4.1.3.24; EC 4.1.3.25 from Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.) (Rhodobacter sphaeroides) (see paper)
41% identity, 98% coverage: 3:304/307 of query aligns to 6:315/318 of Q3J5L6
4l9zA Crystal structure of rhodobacter sphaeroides malyl-coa lyase in complex with magnesium, oxalate, and coa (see paper)
41% identity, 98% coverage: 3:304/307 of query aligns to 4:313/313 of 4l9zA
4l9yA Crystal structure of rhodobacter sphaeroides malyl-coa lyase in complex with magnesium, glyoxylate, and propionyl-coa (see paper)
41% identity, 98% coverage: 3:304/307 of query aligns to 5:314/314 of 4l9yA
4l80C Crystal structure of chloroflexus aurantiacus malyl-coa lyase in complex with magnesium, oxalate, and propionyl-coa (see paper)
31% identity, 98% coverage: 8:307/307 of query aligns to 23:347/347 of 4l80C
S5N020 Malyl-CoA/beta-methylmalyl-CoA/citramalyl-CoA lyase; (3S)-3-carboxy-3-hydroxypropanoyl-CoA glyoxylate-lyase; (3S)-citramalyl-CoA pyruvate-lyase; (S)-citramalyl-CoA lyase; Erythro-beta-methylmalyl-CoA; L-malyl-CoA lyase; EC 4.1.3.24; EC 4.1.3.25 from Chloroflexus aurantiacus (see paper)
31% identity, 98% coverage: 8:307/307 of query aligns to 24:348/348 of S5N020
Q8N0X4 Citramalyl-CoA lyase, mitochondrial; (3S)-malyl-CoA thioesterase; Beta-methylmalate synthase; Citrate lyase subunit beta-like protein; Citrate lyase beta-like; Malate synthase; EC 4.1.3.25; EC 3.1.2.30; EC 2.3.3.-; EC 2.3.3.9 from Homo sapiens (Human) (see 5 papers)
32% identity, 93% coverage: 12:298/307 of query aligns to 45:331/340 of Q8N0X4
Sites not aligning to the query:
5vxoA Crystal structure analysis of human clybl in complex with propionyl- coa (see paper)
32% identity, 93% coverage: 12:298/307 of query aligns to 6:292/298 of 5vxoA
5vxcA Crystal structure analysis of human clybl in complex with free coash (see paper)
32% identity, 93% coverage: 12:298/307 of query aligns to 6:292/301 of 5vxcA
Q9RUZ0 Citrate lyase subunit beta-like protein; EC 4.1.-.- from Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / CCUG 27074 / LMG 4051 / NBRC 15346 / NCIMB 9279 / VKM B-1422 / R1)
29% identity, 91% coverage: 8:287/307 of query aligns to 4:269/284 of Q9RUZ0
1sgjB Crystal structure of citrate lyase beta subunit
28% identity, 79% coverage: 8:251/307 of query aligns to 1:230/231 of 1sgjB
1sgjA Crystal structure of citrate lyase beta subunit
28% identity, 79% coverage: 8:251/307 of query aligns to 1:230/231 of 1sgjA
3r4iA Crystal structure of a citrate lyase (bxe_b2899) from burkholderia xenovorans lb400 at 2.24 a resolution
25% identity, 93% coverage: 22:306/307 of query aligns to 23:310/321 of 3r4iA
6aq4C Crystal structure of protein cite from mycobacterium tuberculosis in complex with magnesium, pyruvate and citramalyl-coa (see paper)
30% identity, 82% coverage: 35:287/307 of query aligns to 29:253/267 of 6aq4C
6aq4B Crystal structure of protein cite from mycobacterium tuberculosis in complex with magnesium, pyruvate and citramalyl-coa (see paper)
30% identity, 82% coverage: 35:287/307 of query aligns to 29:253/268 of 6aq4B
Sites not aligning to the query:
6as5A Crystal structure of protein cite from mycobacterium tuberculosis in complex with magnesium, acetoacetate and coenzyme a (see paper)
30% identity, 82% coverage: 35:287/307 of query aligns to 27:251/267 of 6as5A
Sites not aligning to the query:
6arbA Crystal structure of protein cite from mycobacterium tuberculosis in complex with magnesium, pyruvate and coenzyme a (see paper)
30% identity, 82% coverage: 35:287/307 of query aligns to 28:252/268 of 6arbA
Sites not aligning to the query:
D4GTL2 Malate synthase; MSH; EC 2.3.3.9 from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii) (see paper)
26% identity, 86% coverage: 22:284/307 of query aligns to 27:296/433 of D4GTL2
Sites not aligning to the query:
5taoA Haloferax volcanii malate synthase lead(ii) complex
26% identity, 79% coverage: 17:259/307 of query aligns to 16:271/356 of 5taoA
>RR42_RS24325 FitnessBrowser__Cup4G11:RR42_RS24325
MHQTSPRPTRRRRVQLATPGSSEKMMEKAASSNADHVFLDLEDAVAPNQKVAARKKIIDA
LNHLDWQGKVRCVRINDLSTEYAYEDIIEIVEGAGHNLDTIMMTKVNGPADVLFADRLLS
MMEKKLRLPRRIGLEALIEEVPGLQNVEAIAQSTERLECLIFGMGDFSAAMGVNLESIGN
TGGYPGDIWHYARFRLIMACRAADIDPVDGPWAEFRDSEGYRNECRRAGTLGCVGKWAIH
PSQIEIALAEFSPDPAKVAQARKLESAYVQAEAEGLGAINVDGVMVDVATMRLLRNTVLK
KAQMYGL
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory