Comparing RR42_RS24410 FitnessBrowser__Cup4G11:RR42_RS24410 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
8skyB Crystal structure of yisk from bacillus subtilis in complex with oxalate (see paper)
46% identity, 77% coverage: 64:285/289 of query aligns to 78:303/303 of 8skyB
8sutA Crystal structure of yisk from bacillus subtilis in complex with reaction product 4-hydroxy-2-oxoglutaric acid (see paper)
46% identity, 76% coverage: 64:282/289 of query aligns to 79:301/303 of 8sutA
6iymA Fumarylacetoacetate hydrolase (eafah) from psychrophilic exiguobacterium antarcticum (see paper)
42% identity, 82% coverage: 47:283/289 of query aligns to 31:275/277 of 6iymA
6j5xB Crystal structure of fumarylpyruvate hydrolase from corynebacterium glutamicum in complex with mn2+ and pyruvate (see paper)
42% identity, 76% coverage: 62:280/289 of query aligns to 53:274/280 of 6j5xB
6j5xA Crystal structure of fumarylpyruvate hydrolase from corynebacterium glutamicum in complex with mn2+ and pyruvate (see paper)
42% identity, 76% coverage: 62:280/289 of query aligns to 53:274/280 of 6j5xA
8gstC Crystal structure of l-2,4-diketo-3-deoxyrhamnonate hydrolase from sphingomonas sp. (Pyruvate bound-form) (see paper)
38% identity, 92% coverage: 11:276/289 of query aligns to 15:272/290 of 8gstC
8gsrA Crystal structure of l-2,4-diketo-3-deoxyrhamnonate hydrolase from sphingomonas sp. (Apo-form) (see paper)
38% identity, 92% coverage: 11:276/289 of query aligns to 15:272/290 of 8gsrA
6v77B Crystal structure of a putative hpce protein from mycobacterium smegmatis
37% identity, 90% coverage: 17:276/289 of query aligns to 12:269/279 of 6v77B
6jvwB Crystal structure of maleylpyruvate hydrolase from sphingobium sp. Syk-6 in complex with manganese (ii) ion and pyruvate (see paper)
37% identity, 96% coverage: 1:278/289 of query aligns to 1:256/264 of 6jvwB
4dbhA Crystal structure of cg1458 with inhibitor (see paper)
42% identity, 76% coverage: 64:282/289 of query aligns to 50:266/269 of 4dbhA
3r6oA Crystal structure of a probable 2-hydroxyhepta-2,4-diene-1, 7- dioateisomerase from mycobacterium abscessus (see paper)
34% identity, 94% coverage: 14:285/289 of query aligns to 11:263/265 of 3r6oA
3qdfA Crystal structure of 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase from mycobacterium marinum (see paper)
41% identity, 79% coverage: 60:287/289 of query aligns to 51:252/252 of 3qdfA
1gttA Crystal structure of hpce (see paper)
42% identity, 63% coverage: 73:253/289 of query aligns to 218:392/421 of 1gttA
Q6P587 Acylpyruvase FAHD1, mitochondrial; Fumarylacetoacetate hydrolase domain-containing protein 1; FAH domain-containing protein 1; Oxaloacetate decarboxylase; OAA decarboxylase; YisK-like protein; EC 3.7.1.5; EC 4.1.1.112 from Homo sapiens (Human) (see 3 papers)
36% identity, 68% coverage: 79:275/289 of query aligns to 20:212/224 of Q6P587
6fogA X-ray structure of homo sapiens fumarylacetoacetate hydrolase domain containing protein 1 (fahd1) in complex with inhibitor oxalate at 1.94a resolution. (see paper)
36% identity, 68% coverage: 79:275/289 of query aligns to 15:207/218 of 6fogA
Sites not aligning to the query:
6sbiA X-ray structure of murine fumarylacetoacetate hydrolase domain containing protein 1 (fahd1) in complex with inhibitor oxalate (see paper)
34% identity, 71% coverage: 79:283/289 of query aligns to 14:214/216 of 6sbiA
6j5yA Crystal structure of fumarylpyruvate hydrolase from pseudomonas aeruginosa in complex with mn2+ and pyruvate (see paper)
31% identity, 72% coverage: 78:285/289 of query aligns to 25:233/233 of 6j5yA
3v77A Crystal structure of a putative fumarylacetoacetate isomerase/hydrolase from oleispira antarctica (see paper)
30% identity, 70% coverage: 72:272/289 of query aligns to 10:209/224 of 3v77A
1nkqA Crystal structure of yeast ynq8, a fumarylacetoacetate hydrolase family protein
28% identity, 67% coverage: 78:272/289 of query aligns to 10:222/247 of 1nkqA
P16930 Fumarylacetoacetase; FAA; Beta-diketonase; Fumarylacetoacetate hydrolase; EC 3.7.1.2 from Homo sapiens (Human) (see 14 papers)
29% identity, 51% coverage: 127:274/289 of query aligns to 196:387/419 of P16930
Sites not aligning to the query:
>RR42_RS24410 FitnessBrowser__Cup4G11:RR42_RS24410
MRLATFETTPGRPRPGLVVDDGIIDVSLHIPGVPADTVNLIENWCQWQDALARLVTRVRA
DVRLDGVTLLAPVPRPGKILGIGLNYADHVAESKMEPPTDQLWFAKMPTAVTGPFSAIEI
PMVSDALDYEAELAFIIGRRCRHVSKSDAHKFIFGYCAANDVSVRDWQFRTTQFLLGKSF
DTHAPFGPWIVTADDINDPHELPIRCFVNGELRQKSNTRNLIFNCYAQIEHLSKVMTLEP
GDVIFTGTPGGVGWGHKPPRPLRSGDRVRVEIDGIGAIENLVRTETKSH
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory