SitesBLAST
Comparing RR42_RS25005 FitnessBrowser__Cup4G11:RR42_RS25005 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
5gtlA NADPH complex structure of aldehyde dehydrogenase from bacillus cereus
45% identity, 98% coverage: 9:494/495 of query aligns to 8:490/491 of 5gtlA
- active site: N165 (= N166), K188 (= K189), E263 (= E264), C297 (= C298), E394 (= E398), E471 (≠ K475)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: I161 (= I162), P163 (= P164), K188 (= K189), A190 (= A191), E191 (= E192), Q192 (≠ D193), G221 (= G222), G225 (= G226), G241 (= G242), S242 (= S243), T245 (= T246), L264 (= L265), C297 (= C298), E394 (= E398), F396 (= F400)
5gtkA NAD+ complex structure of aldehyde dehydrogenase from bacillus cereus
45% identity, 98% coverage: 9:494/495 of query aligns to 8:490/491 of 5gtkA
- active site: N165 (= N166), K188 (= K189), E263 (= E264), C297 (= C298), E394 (= E398), E471 (≠ K475)
- binding nicotinamide-adenine-dinucleotide: I161 (= I162), I162 (= I163), P163 (= P164), W164 (= W165), K188 (= K189), E191 (= E192), G221 (= G222), G225 (= G226), A226 (≠ S227), F239 (= F240), G241 (= G242), S242 (= S243), T245 (= T246), Y248 (≠ R249), L264 (= L265), C297 (= C298), Q344 (= Q345), R347 (= R348), E394 (= E398), F396 (= F400)
4pxlA Structure of zm aldh2-3 (rf2c) in complex with NAD (see paper)
46% identity, 96% coverage: 19:494/495 of query aligns to 7:480/486 of 4pxlA
- active site: N154 (= N166), K177 (= K189), E253 (= E264), C287 (= C298), E384 (= E398), D461 (≠ K475)
- binding nicotinamide-adenine-dinucleotide: I150 (= I162), V151 (≠ I163), P152 (= P164), W153 (= W165), K177 (= K189), E180 (= E192), G210 (= G222), G214 (= G226), A215 (≠ S227), F228 (= F240), G230 (= G242), S231 (= S243), V234 (≠ T246), E253 (= E264), G255 (= G266), C287 (= C298), Q334 (= Q345), K337 (≠ R348), E384 (= E398), F386 (= F400)
4o6rA Crystal structure of a putative aldehyde dehydrogenase from burkholderia cenocepacia
45% identity, 96% coverage: 19:495/495 of query aligns to 5:480/489 of 4o6rA
- active site: N150 (= N166), K173 (= K189), E248 (= E264), C282 (= C298), E383 (= E398), E460 (≠ K475)
- binding adenosine monophosphate: I146 (= I162), V147 (≠ I163), K173 (= K189), G206 (= G222), G210 (= G226), Q211 (≠ S227), F224 (= F240), G226 (= G242), S227 (= S243), T230 (= T246), R233 (= R249)
5l13A Structure of aldh2 in complex with 2p3 (see paper)
45% identity, 97% coverage: 17:494/495 of query aligns to 13:489/494 of 5l13A
- active site: N163 (= N166), K186 (= K189), E262 (= E264), C296 (= C298), E393 (= E398), E470 (≠ K475)
- binding 2,3,5-trimethyl-6-propyl-7H-furo[3,2-g][1]benzopyran-7-one: F164 (≠ G167), M168 (≠ S171), W171 (= W174), F290 (≠ T292), C295 (≠ I297), C296 (= C298), C297 (≠ A299), D451 (≠ G456), F453 (≠ L458)
4kwgA Crystal structure analysis of aldh2+aldib13 (see paper)
45% identity, 97% coverage: 17:494/495 of query aligns to 13:489/494 of 4kwgA
- active site: N163 (= N166), K186 (= K189), E262 (= E264), C296 (= C298), E393 (= E398), E470 (≠ K475)
- binding 7-bromo-5-methyl-1H-indole-2,3-dione: F164 (≠ G167), M168 (≠ S171), C295 (≠ I297), C296 (= C298), C297 (≠ A299), D451 (≠ G456), F453 (≠ L458)
4kwfA Crystal structure analysis of aldh2+aldib33 (see paper)
45% identity, 97% coverage: 17:494/495 of query aligns to 13:489/494 of 4kwfA
- active site: N163 (= N166), K186 (= K189), E262 (= E264), C296 (= C298), E393 (= E398), E470 (≠ K475)
- binding 1-benzyl-1H-indole-2,3-dione: F164 (≠ G167), M168 (≠ S171), W171 (= W174), E262 (= E264), C295 (≠ I297), C296 (= C298), C297 (≠ A299), D451 (≠ G456), F453 (≠ L458), F459 (= F464)
3sz9A Crystal structure of human aldh2 modified with the beta-elimination product of aldi-3; 1-(4-ethylbenzene)prop-2-en-1-one (see paper)
45% identity, 97% coverage: 17:494/495 of query aligns to 13:489/494 of 3sz9A
- active site: N163 (= N166), K186 (= K189), E262 (= E264), C296 (= C298), E393 (= E398), E470 (≠ K475)
- binding 1-(4-ethylphenyl)propan-1-one: F164 (≠ G167), C295 (≠ I297), C296 (= C298), D451 (≠ G456), F453 (≠ L458), F459 (= F464)
3injA Human mitochondrial aldehyde dehydrogenase complexed with agonist alda-1 (see paper)
45% identity, 97% coverage: 17:494/495 of query aligns to 13:489/494 of 3injA
- active site: N163 (= N166), K186 (= K189), E262 (= E264), C296 (= C298), E393 (= E398), E470 (≠ K475)
- binding N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide: M118 (≠ F119), F164 (≠ G167), L167 (= L170), F286 (≠ M288), F290 (≠ T292), D451 (≠ G456), F453 (≠ L458)
2vleA The structure of daidzin, a naturally occurring anti alcohol- addiction agent, in complex with human mitochondrial aldehyde dehydrogenase (see paper)
45% identity, 97% coverage: 17:494/495 of query aligns to 13:489/494 of 2vleA
- active site: N163 (= N166), K186 (= K189), E262 (= E264), C296 (= C298), E393 (= E398), E470 (≠ K475)
- binding daidzin: M118 (≠ F119), F164 (≠ G167), M168 (≠ S171), W171 (= W174), F286 (≠ M288), F290 (≠ T292), C295 (≠ I297), C296 (= C298), D451 (≠ G456), V452 (= V457), F453 (≠ L458)
1o01B Human mitochondrial aldehyde dehydrogenase complexed with crotonaldehyde, NAD(h) and mg2+ (see paper)
45% identity, 97% coverage: 17:494/495 of query aligns to 13:489/494 of 1o01B
- active site: N163 (= N166), K186 (= K189), E262 (= E264), C296 (= C298), E393 (= E398), E470 (≠ K475)
- binding (2e)-but-2-enal: C296 (= C298), C297 (≠ A299), F453 (≠ L458)
- binding nicotinamide-adenine-dinucleotide: I159 (= I162), I160 (= I163), P161 (= P164), W162 (= W165), K186 (= K189), E189 (= E192), G219 (= G222), G223 (= G226), A224 (≠ S227), F237 (= F240), G239 (= G242), S240 (= S243), I243 (≠ T246), L263 (= L265), G264 (= G266), C296 (= C298), Q343 (= Q345), E393 (= E398), F395 (= F400)
1cw3A Human mitochondrial aldehyde dehydrogenase complexed with NAD+ and mn2+ (see paper)
45% identity, 97% coverage: 17:494/495 of query aligns to 13:489/494 of 1cw3A
- active site: N163 (= N166), K186 (= K189), E262 (= E264), C296 (= C298), E393 (= E398), E470 (≠ K475)
- binding magnesium ion: V34 (= V38), D103 (= D105), Q190 (≠ D193)
- binding nicotinamide-adenine-dinucleotide: I159 (= I162), I160 (= I163), P161 (= P164), W162 (= W165), K186 (= K189), G219 (= G222), G223 (= G226), A224 (≠ S227), F237 (= F240), G239 (= G242), S240 (= S243), I243 (≠ T246), L263 (= L265), G264 (= G266), C296 (= C298), Q343 (= Q345), K346 (≠ R348), E393 (= E398), F395 (= F400)
2onmA Human mitochondrial aldehyde dehydrogenase asian variant, aldh2 2, Complexed with NAD+ (see paper)
47% identity, 92% coverage: 17:473/495 of query aligns to 13:468/494 of 2onmA
- active site: N163 (= N166), K186 (= K189), E262 (= E264), C296 (= C298), E393 (= E398)
- binding adenosine-5'-diphosphate: E189 (= E192), G219 (= G222), G223 (= G226), A224 (≠ S227), F237 (= F240), G239 (= G242), S240 (= S243), I243 (≠ T246)
Sites not aligning to the query:
4fr8A Crystal structure of human aldehyde dehydrogenase-2 in complex with nitroglycerin (see paper)
45% identity, 97% coverage: 17:494/495 of query aligns to 12:488/493 of 4fr8A
- active site: N162 (= N166), K185 (= K189), Q261 (≠ E264), C295 (= C298), E392 (= E398), E469 (≠ K475)
- binding nicotinamide-adenine-dinucleotide: I158 (= I162), I159 (= I163), W161 (= W165), K185 (= K189), G218 (= G222), G222 (= G226), A223 (≠ S227), F236 (= F240), G238 (= G242), S239 (= S243), I242 (≠ T246), Q342 (= Q345), K345 (≠ R348), E392 (= E398), F394 (= F400)
- binding propane-1,2,3-triyl trinitrate: F163 (≠ G167), L166 (= L170), W170 (= W174), F289 (≠ T292), S294 (≠ I297), C295 (= C298), D450 (≠ G456), F452 (≠ L458)
4fr8C Crystal structure of human aldehyde dehydrogenase-2 in complex with nitroglycerin (see paper)
46% identity, 92% coverage: 17:473/495 of query aligns to 15:470/496 of 4fr8C
- active site: N165 (= N166), K188 (= K189), Q264 (≠ E264), C298 (= C298), E395 (= E398)
- binding nicotinamide-adenine-dinucleotide: I161 (= I162), I162 (= I163), W164 (= W165), K188 (= K189), G221 (= G222), G225 (= G226), A226 (≠ S227), F239 (= F240), G241 (= G242), S242 (= S243), I245 (≠ T246), Q345 (= Q345), E395 (= E398), F397 (= F400)
Sites not aligning to the query:
1nzwA Cys302ser mutant of human mitochondrial aldehyde dehydrogenase complexed with nadh and mg2+ (see paper)
45% identity, 97% coverage: 17:494/495 of query aligns to 13:489/494 of 1nzwA
- active site: N163 (= N166), K186 (= K189), E262 (= E264), S296 (≠ C298), E393 (= E398), E470 (≠ K475)
- binding 1,4-dihydronicotinamide adenine dinucleotide: I159 (= I162), I160 (= I163), P161 (= P164), K186 (= K189), E189 (= E192), G219 (= G222), P220 (≠ G223), G223 (= G226), A224 (≠ S227), F237 (= F240), G239 (= G242), S240 (= S243), I243 (≠ T246), E262 (= E264), G264 (= G266), S296 (≠ C298), Q343 (= Q345), E393 (= E398), F395 (= F400)
P20000 Aldehyde dehydrogenase, mitochondrial; ALDH class 2; ALDH-E2; ALDHI; EC 1.2.1.3 from Bos taurus (Bovine) (see 2 papers)
46% identity, 92% coverage: 18:473/495 of query aligns to 40:494/520 of P20000
Sites not aligning to the query:
- 1:21 modified: transit peptide, Mitochondrion
7radA Crystal structure analysis of aldh1b1
44% identity, 96% coverage: 19:494/495 of query aligns to 14:488/493 of 7radA
- binding nicotinamide-adenine-dinucleotide: I158 (= I162), I159 (= I163), P160 (= P164), W161 (= W165), N162 (= N166), M167 (≠ S171), K185 (= K189), E188 (= E192), G218 (= G222), G222 (= G226), A223 (≠ S227), T237 (= T241), G238 (= G242), S239 (= S243), V242 (≠ T246), E261 (= E264), L262 (= L265), C295 (= C298), E392 (= E398), F394 (= F400)
- binding 3-(2-methoxyphenyl)-1-(4-phenylphenyl)-6,7,8,9-tetrahydro-5~{H}-imidazo[1,2-a][1,3]diazepine: L113 (= L116), E117 (≠ F119), F163 (≠ G167), E285 (≠ M288), F289 (≠ T292), N450 (≠ G456), V452 (≠ L458)
7mjdA Crystal structure analysis of aldh1b1
44% identity, 96% coverage: 19:494/495 of query aligns to 14:488/493 of 7mjdA
- binding nicotinamide-adenine-dinucleotide: I158 (= I162), I159 (= I163), P160 (= P164), W161 (= W165), N162 (= N166), M167 (≠ S171), K185 (= K189), E188 (= E192), G218 (= G222), G222 (= G226), F236 (= F240), T237 (= T241), G238 (= G242), S239 (= S243), V242 (≠ T246), E261 (= E264), L262 (= L265), C295 (= C298), E392 (= E398), F394 (= F400)
- binding 8-(2-methoxyphenyl)-10-(4-phenylphenyl)-1$l^{4},8-diazabicyclo[5.3.0]deca-1(7),9-diene: E117 (≠ F119), E285 (≠ M288), F289 (≠ T292), N450 (≠ G456), V452 (≠ L458)
7mjcA Crystal structure analysis of aldh1b1
44% identity, 96% coverage: 19:494/495 of query aligns to 14:488/493 of 7mjcA
- binding nicotinamide-adenine-dinucleotide: I158 (= I162), I159 (= I163), P160 (= P164), W161 (= W165), N162 (= N166), K185 (= K189), E188 (= E192), G218 (= G222), G222 (= G226), T237 (= T241), G238 (= G242), S239 (= S243), V242 (≠ T246), E261 (= E264), L262 (= L265), C295 (= C298), E392 (= E398), F394 (= F400)
Query Sequence
>RR42_RS25005 FitnessBrowser__Cup4G11:RR42_RS25005
MSSTTYGVQTPAFVGGTKRLFIGGAWVPAASGKAFDTVNPATGEVIARLAQADQTDIDRA
VTAARQAFEGPWNQWTHSDRQRLLIRIHDVVEKHFDELALIETLDMGAPLVRTRGLKSFL
LQLILFYASQTAAGGVQTPLNALPGKFATLKIKAPVGVVAGIIPWNGPLLSQWWILGATL
ATGCTAVLKPAEDASLSALRMAELLQEAGVPAGVINVVTGYGGEAGSALAEHPGVDRIAF
TGSPETGRRIVRASAGNFKRVSVELGGKSPDIVFDDANLDKAVPGVAMGVFTNTGQICAA
GTRVLVQRRIYDEFIERLKAFSTSLKIGNGLDPQVQLGPIVSQRQLDRVMHYVDVGGQEG
AELACGGRRLGGELAAGYFVEPTVFTGVHNDMTIAREEIFGPVASVMPFDTPEQALRIAN
DTSFGLAGGVWTQNLSTAHRFAQGIQAGTIWVNCYGVLDPQVGFGGYKLSGYGWKGAAEQ
VDSYLYQKAVYMNLD
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory