SitesBLAST
Comparing RR42_RS26255 FitnessBrowser__Cup4G11:RR42_RS26255 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
5iuwA Crystal structure of indole-3-acetaldehyde dehydrogenase in complexed with NAD+ and iaa (see paper)
57% identity, 98% coverage: 8:498/499 of query aligns to 5:495/495 of 5iuwA
- active site: N166 (= N169), K189 (= K192), E265 (= E268), C300 (= C303), E399 (= E402), D476 (= D479)
- binding 1h-indol-3-ylacetic acid: F167 (≠ Y170), M170 (≠ L173), C300 (= C303), D457 (≠ M460), F465 (= F468)
- binding nicotinamide-adenine-dinucleotide: I162 (≠ V165), V163 (= V166), P164 (= P167), W165 (= W168), N166 (= N169), K189 (= K192), G222 (= G225), G226 (= G229), K227 (≠ Q230), F240 (= F243), T241 (= T244), G242 (= G245), S243 (= S246), I246 (≠ T249), Y253 (= Y256), E265 (= E268), A266 (≠ C269), C300 (= C303), E399 (= E402), F401 (= F404)
5iuvA Crystal structure of indole-3-acetaldehyde dehydrogenase in complexed with NAD+ (see paper)
57% identity, 98% coverage: 8:498/499 of query aligns to 5:495/495 of 5iuvA
- active site: N166 (= N169), K189 (= K192), E265 (= E268), C300 (= C303), E399 (= E402), D476 (= D479)
- binding nicotinamide-adenine-dinucleotide: I162 (≠ V165), V163 (= V166), P164 (= P167), W165 (= W168), N166 (= N169), K189 (= K192), S191 (≠ A194), G222 (= G225), G226 (= G229), K227 (≠ Q230), F240 (= F243), T241 (= T244), G242 (= G245), S243 (= S246), I246 (≠ T249), Y253 (= Y256), E265 (= E268), A266 (≠ C269), C300 (= C303), E399 (= E402), F401 (= F404)
7jsoA P. Syringae alda indole-3-acetaldehyde dehydrogenase c302a mutant in complex with NAD+ and iaa (see paper)
56% identity, 98% coverage: 8:498/499 of query aligns to 5:495/495 of 7jsoA
- active site: N166 (= N169), E265 (= E268), A300 (≠ C303), D476 (= D479)
- binding 1h-indol-3-ylacetic acid: F167 (≠ Y170), W174 (= W177), V299 (≠ I302), A300 (≠ C303), T301 (≠ I304), D457 (≠ M460), F465 (= F468)
- binding 1,4-dihydronicotinamide adenine dinucleotide: I162 (≠ V165), V163 (= V166), P164 (= P167), W165 (= W168), K189 (= K192), E192 (= E195), G222 (= G225), G226 (= G229), K227 (≠ Q230), F240 (= F243), G242 (= G245), S243 (= S246), I246 (≠ T249), A266 (≠ C269), G267 (= G270), A300 (≠ C303), E399 (= E402), F401 (= F404)
7uyyA The crystal structure of the pseudomonas aeruginosa aldehyde dehydrogenase encoded by the pa4189 gene in complex with nadh (see paper)
51% identity, 99% coverage: 1:496/499 of query aligns to 1:493/496 of 7uyyA
- binding 1,4-dihydronicotinamide adenine dinucleotide: V165 (= V165), L166 (≠ V166), P167 (= P167), W168 (= W168), K192 (= K192), G225 (= G225), G229 (= G229), F243 (= F243), G245 (= G245), S246 (= S246), T249 (= T249), L252 (≠ R252), F253 (= F253), Y256 (= Y256), C269 (= C269), G270 (= G270), C303 (= C303), H350 (≠ Q350), K353 (≠ R353), F400 (= F404)
4o6rA Crystal structure of a putative aldehyde dehydrogenase from burkholderia cenocepacia
47% identity, 96% coverage: 19:498/499 of query aligns to 2:479/489 of 4o6rA
- active site: N150 (= N169), K173 (= K192), E248 (= E268), C282 (= C303), E383 (= E402), E460 (≠ D479)
- binding adenosine monophosphate: I146 (≠ V165), V147 (= V166), K173 (= K192), G206 (= G225), G210 (= G229), Q211 (= Q230), F224 (= F243), G226 (= G245), S227 (= S246), T230 (= T249), R233 (= R252)
4pxlA Structure of zm aldh2-3 (rf2c) in complex with NAD (see paper)
47% identity, 97% coverage: 17:498/499 of query aligns to 1:480/486 of 4pxlA
- active site: N154 (= N169), K177 (= K192), E253 (= E268), C287 (= C303), E384 (= E402), D461 (= D479)
- binding nicotinamide-adenine-dinucleotide: I150 (≠ V165), V151 (= V166), P152 (= P167), W153 (= W168), K177 (= K192), E180 (= E195), G210 (= G225), G214 (= G229), A215 (≠ Q230), F228 (= F243), G230 (= G245), S231 (= S246), V234 (≠ T249), E253 (= E268), G255 (= G270), C287 (= C303), Q334 (= Q350), K337 (≠ R353), E384 (= E402), F386 (= F404)
4pz2B Structure of zm aldh2-6 (rf2f) in complex with NAD (see paper)
48% identity, 96% coverage: 21:498/499 of query aligns to 11:488/494 of 4pz2B
- active site: N159 (= N169), K182 (= K192), E258 (= E268), C292 (= C303), E392 (= E402), D469 (= D479)
- binding nicotinamide-adenine-dinucleotide: I155 (≠ V165), I156 (≠ V166), P157 (= P167), W158 (= W168), N159 (= N169), M164 (= M174), K182 (= K192), A184 (= A194), E185 (= E195), G215 (= G225), G219 (= G229), F233 (= F243), T234 (= T244), G235 (= G245), S236 (= S246), V239 (≠ T249), E258 (= E268), L259 (≠ C269), C292 (= C303), E392 (= E402), F394 (= F404)
4go4A Crystal structure of pnpe in complex with nicotinamide adenine dinucleotide
46% identity, 96% coverage: 19:498/499 of query aligns to 1:477/487 of 4go4A
- active site: N149 (= N169), K172 (= K192), E247 (= E268), C281 (= C303), E381 (= E402), E458 (≠ D479)
- binding nicotinamide-adenine-dinucleotide: I145 (≠ V165), V146 (= V166), W148 (= W168), N149 (= N169), F154 (≠ M174), K172 (= K192), G205 (= G225), G209 (= G229), Q210 (= Q230), F223 (= F243), T224 (= T244), G225 (= G245), S226 (= S246), T229 (= T249), E247 (= E268), G249 (= G270), C281 (= C303), E381 (= E402), F383 (= F404)
5gtlA NADPH complex structure of aldehyde dehydrogenase from bacillus cereus
45% identity, 98% coverage: 12:498/499 of query aligns to 8:490/491 of 5gtlA
- active site: N165 (= N169), K188 (= K192), E263 (= E268), C297 (= C303), E394 (= E402), E471 (≠ D479)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: I161 (≠ V165), P163 (= P167), K188 (= K192), A190 (= A194), E191 (= E195), Q192 (= Q196), G221 (= G225), G225 (= G229), G241 (= G245), S242 (= S246), T245 (= T249), L264 (≠ C269), C297 (= C303), E394 (= E402), F396 (= F404)
5gtkA NAD+ complex structure of aldehyde dehydrogenase from bacillus cereus
45% identity, 98% coverage: 12:498/499 of query aligns to 8:490/491 of 5gtkA
- active site: N165 (= N169), K188 (= K192), E263 (= E268), C297 (= C303), E394 (= E402), E471 (≠ D479)
- binding nicotinamide-adenine-dinucleotide: I161 (≠ V165), I162 (≠ V166), P163 (= P167), W164 (= W168), K188 (= K192), E191 (= E195), G221 (= G225), G225 (= G229), A226 (≠ Q230), F239 (= F243), G241 (= G245), S242 (= S246), T245 (= T249), Y248 (≠ R252), L264 (≠ C269), C297 (= C303), Q344 (= Q350), R347 (= R353), E394 (= E402), F396 (= F404)
P20000 Aldehyde dehydrogenase, mitochondrial; ALDH class 2; ALDH-E2; ALDHI; EC 1.2.1.3 from Bos taurus (Bovine) (see 2 papers)
46% identity, 96% coverage: 19:498/499 of query aligns to 38:515/520 of P20000
Sites not aligning to the query:
- 1:21 modified: transit peptide, Mitochondrion
5l13A Structure of aldh2 in complex with 2p3 (see paper)
45% identity, 96% coverage: 21:498/499 of query aligns to 14:489/494 of 5l13A
- active site: N163 (= N169), K186 (= K192), E262 (= E268), C296 (= C303), E393 (= E402), E470 (≠ D479)
- binding 2,3,5-trimethyl-6-propyl-7H-furo[3,2-g][1]benzopyran-7-one: F164 (≠ Y170), M168 (= M174), W171 (= W177), F290 (≠ S297), C295 (≠ I302), C296 (= C303), C297 (≠ I304), D451 (≠ M460), F453 (≠ S462)
4kwgA Crystal structure analysis of aldh2+aldib13 (see paper)
45% identity, 96% coverage: 21:498/499 of query aligns to 14:489/494 of 4kwgA
- active site: N163 (= N169), K186 (= K192), E262 (= E268), C296 (= C303), E393 (= E402), E470 (≠ D479)
- binding 7-bromo-5-methyl-1H-indole-2,3-dione: F164 (≠ Y170), M168 (= M174), C295 (≠ I302), C296 (= C303), C297 (≠ I304), D451 (≠ M460), F453 (≠ S462)
4kwfA Crystal structure analysis of aldh2+aldib33 (see paper)
45% identity, 96% coverage: 21:498/499 of query aligns to 14:489/494 of 4kwfA
- active site: N163 (= N169), K186 (= K192), E262 (= E268), C296 (= C303), E393 (= E402), E470 (≠ D479)
- binding 1-benzyl-1H-indole-2,3-dione: F164 (≠ Y170), M168 (= M174), W171 (= W177), E262 (= E268), C295 (≠ I302), C296 (= C303), C297 (≠ I304), D451 (≠ M460), F453 (≠ S462), F459 (= F468)
3sz9A Crystal structure of human aldh2 modified with the beta-elimination product of aldi-3; 1-(4-ethylbenzene)prop-2-en-1-one (see paper)
45% identity, 96% coverage: 21:498/499 of query aligns to 14:489/494 of 3sz9A
- active site: N163 (= N169), K186 (= K192), E262 (= E268), C296 (= C303), E393 (= E402), E470 (≠ D479)
- binding 1-(4-ethylphenyl)propan-1-one: F164 (≠ Y170), C295 (≠ I302), C296 (= C303), D451 (≠ M460), F453 (≠ S462), F459 (= F468)
3injA Human mitochondrial aldehyde dehydrogenase complexed with agonist alda-1 (see paper)
45% identity, 96% coverage: 21:498/499 of query aligns to 14:489/494 of 3injA
- active site: N163 (= N169), K186 (= K192), E262 (= E268), C296 (= C303), E393 (= E402), E470 (≠ D479)
- binding N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide: M118 (≠ E124), F164 (≠ Y170), L167 (= L173), F286 (≠ I293), F290 (≠ S297), D451 (≠ M460), F453 (≠ S462)
2vleA The structure of daidzin, a naturally occurring anti alcohol- addiction agent, in complex with human mitochondrial aldehyde dehydrogenase (see paper)
45% identity, 96% coverage: 21:498/499 of query aligns to 14:489/494 of 2vleA
- active site: N163 (= N169), K186 (= K192), E262 (= E268), C296 (= C303), E393 (= E402), E470 (≠ D479)
- binding daidzin: M118 (≠ E124), F164 (≠ Y170), M168 (= M174), W171 (= W177), F286 (≠ I293), F290 (≠ S297), C295 (≠ I302), C296 (= C303), D451 (≠ M460), V452 (≠ D461), F453 (≠ S462)
1o01B Human mitochondrial aldehyde dehydrogenase complexed with crotonaldehyde, NAD(h) and mg2+ (see paper)
45% identity, 96% coverage: 21:498/499 of query aligns to 14:489/494 of 1o01B
- active site: N163 (= N169), K186 (= K192), E262 (= E268), C296 (= C303), E393 (= E402), E470 (≠ D479)
- binding (2e)-but-2-enal: C296 (= C303), C297 (≠ I304), F453 (≠ S462)
- binding nicotinamide-adenine-dinucleotide: I159 (≠ V165), I160 (≠ V166), P161 (= P167), W162 (= W168), K186 (= K192), E189 (= E195), G219 (= G225), G223 (= G229), A224 (≠ Q230), F237 (= F243), G239 (= G245), S240 (= S246), I243 (≠ T249), L263 (≠ C269), G264 (= G270), C296 (= C303), Q343 (= Q350), E393 (= E402), F395 (= F404)
1cw3A Human mitochondrial aldehyde dehydrogenase complexed with NAD+ and mn2+ (see paper)
45% identity, 96% coverage: 21:498/499 of query aligns to 14:489/494 of 1cw3A
- active site: N163 (= N169), K186 (= K192), E262 (= E268), C296 (= C303), E393 (= E402), E470 (≠ D479)
- binding magnesium ion: V34 (≠ I41), D103 (= D109), Q190 (= Q196)
- binding nicotinamide-adenine-dinucleotide: I159 (≠ V165), I160 (≠ V166), P161 (= P167), W162 (= W168), K186 (= K192), G219 (= G225), G223 (= G229), A224 (≠ Q230), F237 (= F243), G239 (= G245), S240 (= S246), I243 (≠ T249), L263 (≠ C269), G264 (= G270), C296 (= C303), Q343 (= Q350), K346 (≠ R353), E393 (= E402), F395 (= F404)
Q56YU0 Aldehyde dehydrogenase family 2 member C4; ALDH1a; Protein REDUCED EPIDERMAL FLUORESCENCE 1; EC 1.2.1.3 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
43% identity, 96% coverage: 21:498/499 of query aligns to 20:495/501 of Q56YU0
- G152 (≠ A152) mutation to E: In ref1-7; reduced activity on sinapaldehyde.
- G416 (≠ A419) mutation to R: In ref1-6; reduced activity on sinapaldehyde.
Query Sequence
>RR42_RS26255 FitnessBrowser__Cup4G11:RR42_RS26255
MSDLRDLAYWRKQAATVSIRSQAYIDGRWADAADGATFETINPATGKALARVAACGAQDV
DRAVAAARKAFQSGVWSDTPRSARKATLLRLSHLIETHREELALLETLDMGKPIAETLQY
DIPEAGRTYAWYAEAIDKIYDEIAPTGPGVLATITREPLGVVAAVVPWNYPLLMASWKVA
PALAAGNSVVLKPAEQSPLTALRLAELAEEAGIPAGVFNVVPGLGAAAGQALGRHPDVDC
IAFTGSTATGKRFMEYSGQSNLKRVWLECGGKSPHIVFDDCPDLDRAAQAAAIGIFSNQG
EICIAGSRLYVQSGIYDAFMEKLEAHAARMQPGDPLDPATAMGAIVDGAQLQRVMSYVKS
GEDEGARLRAGGKRAHTDSGGFYMQPTIFECPTQSLTIVREEIFGPVLAVTRFESEEEAI
RMANDSPYGLGSGLWTSNLSRAHRVSRKLQAGLVWVNCYMDSDVTVPFGGVKQSGSGRDK
SLHALDKYTDLKTTWISLA
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory