SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing RR42_RS27380 FitnessBrowser__Cup4G11:RR42_RS27380 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

5g4jA Phospholyase a1rdf1 from arthrobacter in complex with phosphoethanolamine (see paper)
45% identity, 96% coverage: 13:429/435 of query aligns to 2:421/423 of 5g4jA

query
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active site: S14 (≠ Y25), Y130 (= Y141), D201 (= D209), D234 (= D242), Q237 (= Q245), K264 (= K272), T294 (= T302), K395 (= K403)
binding {5-hydroxy-6-methyl-4-[(E)-{[2-(phosphonooxy)ethyl]imino}methyl]pyridin-3-yl}methyl dihydrogen phosphate: Y44 (= Y55), R73 (= R84), G103 (= G114), S104 (= S115), Y130 (= Y141), H131 (= H142), D234 (= D242), V236 (= V244), Q237 (= Q245), K264 (= K272), T294 (= T302), R397 (= R405)

5g4iA Plp-dependent phospholyase a1rdf1 from arthrobacter aurescens tc1 (see paper)
45% identity, 96% coverage: 13:429/435 of query aligns to 2:421/423 of 5g4iA

query
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5g4iA

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active site: S14 (≠ Y25), Y130 (= Y141), D201 (= D209), D234 (= D242), Q237 (= Q245), K264 (= K272), T294 (= T302), K395 (= K403)
binding pyridoxal-5'-phosphate: G103 (= G114), S104 (= S115), H131 (= H142), D234 (= D242), V236 (= V244), Q237 (= Q245), K264 (= K272)
binding phosphate ion: Y44 (= Y55), R397 (= R405)

6torB Human o-phosphoethanolamine phospho-lyase (see paper)
46% identity, 91% coverage: 33:430/435 of query aligns to 1:398/404 of 6torB

query
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6torB

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active site: Y109 (= Y141), D212 (= D242), K244 (= K272)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: S81 (≠ T113), G82 (= G114), S83 (= S115), Y109 (= Y141), H110 (= H142), H112 (≠ V144), D212 (= D242), Q215 (= Q245)

1zobA Crystal structure of dialkylglycine decarboxylases bound with calcium ion
34% identity, 89% coverage: 31:417/435 of query aligns to 23:418/431 of 1zobA

query
sites
1zobA

E

E

P

P

L

M

H

I

I

I

V

E

R

R

G

A

D

K

G

G

V

S

W

F

L

V

Y

Y

D

D

A

A

N

D

G

G

E

R

R

A

Y

I

L

L

D

D

A

F

Y

T

N

S

N

G

V

Q

A

M

S

S

-

A

-

V

V

L

G

G

H

H

C

C

H

H

P

P

Q

E

V

I

V

V

Q

S

A

V

I

I

A

G

R

E

Q

Y

A

A

A

G

Q

K

L

L

N

D

-

H

T
x
L

H

F

T
x
S

R

E

Y

M

L

L

H

S

E

R

G

P

I

V

L

V

D

D

Y

L

A

A

Q

T

R

R

L

L

L

A

A

N

T

I

M

T

P

P

D

P

A

G

L

L

G

D

H

R

A

A

M

L

L

L

T

L

C

S

T
|
T

G

G

S
x
A

E

E

A

S

N
|
N

D

E

L

A

A

A

M

I

R

R

I

M

A

A

R

K

A

L

H

V

T

T

G

G

A

K

Q

Y

G

E

L

I

I

V

I

G

T

F

R

A

F

Q

A

S

Y
x
W

H
|
H

G

G

V

M

T

T

A

G

S

A

I

A

A

A

E

S

A

A

S

T

P

Y

S

S

L

A

G

G

R

R

Y

K

-

G

-

V

-

G

-

P

V

A

K

A

L

V

G

G

D

S

N

F

V

-

R

-

T

A

V

I

P

P

A

A

P

P

D

F

S

T

Y

Y

R

R

V

P

V

R

P

F

A

E

Q

R

L

N

G

G

A

A

V

Y

-

D

F

Y

A

L

E

A

G

E

V

L

R

D

H

Y

A

A

I

F

E

D

-

L

-

I

D

D

L

R

R

Q

A

S

H

S

G

G

I

-

R

N

P

L

A

A

L

F

L

I

V

A

D
x
E

T

P

V

I

F

L

S

S

D

G

G

G

I

I

F

I

T

E

D

L

P

P

P

D

G

G

F

Y

L

M

K

A

D

A

A

L

V

K

A

R

A

K

I

C

R

E

A

A

A

R

G

G

G

M

V

L

F

L

I

I

A

L

D
|
D

E

E

V
x
A

Q
|
Q

P

T

G

G

L

V

G

G

R

R

T

T

G

G

E

T

A

M

F

F

W

-

G

A

F

C

Q

Q

R

R

H

D

G

G

V

V

V

T

P

P

D

D

I

I

V

L

T

T

M

L

G

S

K
|
K

P

T

M

L

G

G

N

A

G

G

H

L

P

P

L

L

A

A

G

A

L

I

A

-

V

V

R

T

P

S

E

A

V

A

L

I

E

E

A

E

F

R

G

A

R

H

E

E

C

L

R

G

Y

Y

-

L

-

F

F

Y

N

T

T
|
T

F

H

G
x
V

G
x
S

N
x
D

P

P

V

L

S

P

V

A

A

A

A

V

G

G

M

L

A

R

V

V

L

L

D

D

V

V

I

V

E

Q

Q

R

T

D

Q

G

L

L

M

V

A

A

Q

R

V

A

R

N

R

V

V

M

G

G

K

D

Y

R

L

L

R

R

E

R

R

G

L

L

A

L

G

D

V

L

A

M

A

E

R

R

R

F

P

D

L

C

I

I

G

G

D

D

I

V

R

R

G

G

A

R

G

G

L

L

F

L

V

L

A

G

V

V

E

E

F

I

V

V

E

K

D

D

G

R

D

R

A

T

A

K

R

E

P

P

A

A

T

D

A

G

R

L

T

G

A

A

R

K

I

I

V

T

N

R

-

E

-

C

-

M

-

N

-

L

G

G

L

L

R

S

R

M

R

N

H

I

V

V

L

Q

V

L

G

P

A

G

T

M

G

G

E

-

A

-

N

G

I

V

L

F

K
x
R

I

I

R

A

P

P

M

L

V

T

F

V

T

S

E

E

A

D

H

E

A

I

D

D

L

L

active site: W136 (≠ Y141), E208 (≠ D209), D241 (= D242), Q244 (= Q245), K270 (= K272), T301 (= T302), R404 (≠ K403)
binding calcium ion: L76 (≠ T81), S78 (≠ T83), V303 (≠ G304), S304 (≠ G305), D305 (≠ N306)
binding pyridoxal-5'-phosphate: T108 (= T113), A110 (≠ S115), N113 (= N118), W136 (≠ Y141), H137 (= H142), E208 (≠ D209), D241 (= D242), A243 (≠ V244), Q244 (= Q245), K270 (= K272)

Sites not aligning to the query:

active site: 19

1zc9A The crystal structure of dialkylglycine decarboxylase complex with pyridoxamine 5-phosphate (see paper)
34% identity, 89% coverage: 31:417/435 of query aligns to 23:418/431 of 1zc9A

query
sites
1zc9A

E

E

P

P

L

M

H

I

I

I

V

E

R

R

G

A

D

K

G

G

V

S

W

F

L

V

Y

Y

D

D

A

A

N

D

G

G

E

R

R

A

Y

I

L

L

D

D

A

F

Y

T

N

S

N

G

V

Q

A

M

S

S

-

A

-

V

V

L

G

G

H

H

C

C

H

H

P

P

Q

E

V

I

V

V

Q

S

A

V

I

I

A

G

R

E

Q

Y

A

A

A

G

Q

K

L

L

N

D

-

H

T

L

H

F

T

S

R

E

Y

M

L

L

H

S

E

R

G

P

I

V

L

V

D

D

Y

L

A

A

Q

T

R

R

L

L

L

A

A

N

T

I

M

T

P

P

D

P

A

G

L

L

G

D

H

R

A

A

M

L

L

L

T

L

C

S

T

T

G
|
G

S
x
A

E

E

A

S

N

N

D

E

L

A

A

A

M

I

R

R

I

M

A

A

R

K

A

L

H

V

T

T

G

G

A

K

Q

Y

G

E

L

I

I

V

I

G

T

F

R

A

F

Q

A

S

Y
x
W

H
|
H

G

G

V

M

T

T

A

G

S

A

I

A

A

A

E

S

A

A

S

T

P

Y

S

S

L

A

G

G

R

R

Y

K

-

G

-

V

-

G

-

P

V

A

K

A

L

V

G

G

D

S

N

F

V

-

R

-

T

A

V

I

P

P

A

A

P

P

D

F

S

T

Y

Y

R

R

V

P

V

R

P

F

A

E

Q

R

L

N

G

G

A

A

V

Y

-

D

F

Y

A

L

E

A

G

E

V

L

R

D

H

Y

A

A

I

F

E

D

-

L

-

I

D

D

L

R

R

Q

A

S

H

S

G

G

I

-

R

N

P

L

A

A

L

F

L

I

V

A

D
x
E

T

P

V

I

F

L

S

S

D

G

G

G

I

I

F

I

T

E

D

L

P

P

P

D

G

G

F

Y

L

M

K

A

D

A

A

L

V

K

A

R

A

K

I

C

R

E

A

A

A

R

G

G

G

M

V

L

F

L

I

I

A

L

D
|
D

E

E

V
x
A

Q
|
Q

P

T

G

G

L

V

G

G

R

R

T

T

G

G

E

T

A

M

F

F

W

-

G

A

F

C

Q

Q

R

R

H

D

G

G

V

V

V

T

P

P

D

D

I

I

V

L

T

T

M

L

G

S

K
|
K

P

T

M

L

G

G

N

A

G

G

H

L

P

P

L

L

A

A

G

A

L

I

A

-

V

V

R

T

P

S

E

A

V

A

L

I

E

E

A

E

F

R

G

A

R

H

E

E

C

L

R

G

Y

Y

-

L

-

F

F

Y

N

T

T
|
T

F

H

G

V

G

S

N

D

P

P

V

L

S

P

V

A

A

A

A

V

G

G

M

L

A

R

V

V

L

L

D

D

V

V

I

V

E

Q

Q

R

T

D

Q

G

L

L

M

V

A

A

Q

R

V

A

R

N

R

V

V

M

G

G

K

D

Y

R

L

L

R

R

E

R

R

G

L

L

A

L

G

D

V

L

A

M

A

E

R

R

R

F

P

D

L

C

I

I

G

G

D

D

I

V

R

R

G

G

A

R

G

G

L

L

F

L

V

L

A

G

V

V

E

E

F

I

V

V

E

K

D

D

G

R

D

R

A

T

A

K

R

E

P

P

A

A

T

D

A

G

R

L

T

G

A

A

R

K

I

I

V

T

N

R

-

E

-

C

-

M

-

N

-

L

G

G

L

L

R

S

R

M

R

N

H

I

V

V

L

Q

V

L

G

P

A

G

T

M

G

G

E

-

A

-

N

G

I

V

L

F

K
x
R

I

I

R

A

P

P

M

L

V

T

F

V

T

S

E

E

A

D

H

E

A

I

D

D

L

L

active site: W136 (≠ Y141), E208 (≠ D209), D241 (= D242), Q244 (= Q245), K270 (= K272), T301 (= T302), R404 (≠ K403)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G109 (= G114), A110 (≠ S115), W136 (≠ Y141), H137 (= H142), E208 (≠ D209), D241 (= D242), A243 (≠ V244), Q244 (= Q245), K270 (= K272)

Sites not aligning to the query:

active site: 19

1m0qA Structure of dialkylglycine decarboxylase complexed with s-1- aminoethanephosphonate (see paper)
34% identity, 89% coverage: 31:417/435 of query aligns to 23:418/431 of 1m0qA

query
sites
1m0qA

E

E

P

P

L

M

H

I

I

I

V

E

R

R

G

A

D

K

G

G

V

S

W

F

L

V

Y

Y

D

D

A

A

N

D

G

G

E

R

R

A

Y

I

L

L

D

D

A

F

Y

T

N

S

N

G

V
x
Q

A

M

S

S

-

A

-

V

V

L

G

G

H

H

C

C

H

H

P

P

Q

E

V

I

V

V

Q

S

A

V

I

I

A

G

R

E

Q

Y

A

A

A

G

Q

K

L

L

N

D

-

H

T

L

H

F

T

S

R

E

Y

M

L

L

H

S

E

R

G

P

I

V

L

V

D

D

Y

L

A

A

Q

T

R

R

L

L

L

A

A

N

T

I

M

T

P

P

D

P

A

G

L

L

G

D

H

R

A

A

M

L

L

L

T

L

C

S

T
|
T

G

G

S
x
A

E

E

A

S

N

N

D

E

L

A

A

A

M

I

R

R

I

M

A

A

R

K

A

L

H

V

T

T

G

G

A

K

Q

Y

G

E

L

I

I

V

I

G

T

F

R

A

F

Q

A

S

Y
x
W

H
|
H

G

G

V

M

T

T

A

G

S

A

I

A

A

A

E

S

A

A

S

T

P

Y

S

S

L

A

G

G

R

R

Y

K

-

G

-

V

-

G

-

P

V

A

K

A

L

V

G

G

D

S

N

F

V

-

R

-

T

A

V

I

P

P

A

A

P

P

D

F

S

T

Y

Y

R

R

V

P

V

R

P

F

A

E

Q

R

L

N

G

G

A

A

V

Y

-

D

F

Y

A

L

E

A

G

E

V

L

R

D

H

Y

A

A

I

F

E

D

-

L

-

I

D

D

L

R

R

Q

A

S

H

S

G

G

I

-

R

N

P

L

A

A

L

F

L

I

V

A

D
x
E

T

P

V

I

F

L

S

S

S
|
S

D

G

G

G

I

I

F

I

T

E

D

L

P

P

P

D

G

G

F

Y

L

M

K

A

D

A

A

L

V

K

A

R

A

K

I

C

R

E

A

A

A

R

G

G

G

M

V

L

F

L

I

I

A

L

D
|
D

E

E

V
x
A

Q
|
Q

P

T

G

G

L

V

G

G

R

R

T

T

G

G

E

T

A

M

F

F

W

-

G

A

F

C

Q

Q

R

R

H

D

G

G

V

V

V

T

P

P

D

D

I

I

V

L

T

T

M

L

G

S

K
|
K

P

T

M

L

G

G

N

A

G

G

H

L

P

P

L

L

A

A

G

A

L

I

A

-

V

V

R

T

P

S

E

A

V

A

L

I

E

E

A

E

F

R

G

A

R

H

E

E

C

L

R

G

Y

Y

-

L

-

F

F

Y

N

T

T
|
T

F

H

G

V

G

S

N

D

P

P

V

L

S

P

V

A

A

A

A

V

G

G

M

L

A

R

V

V

L

L

D

D

V

V

I

V

E

Q

Q

R

T

D

Q

G

L

L

M

V

A

A

Q

R

V

A

R

N

R

V

V

M

G

G

K

D

Y

R

L

L

R

R

E

R

R

G

L

L

A

L

G

D

V

L

A

M

A

E

R

R

R

F

P

D

L

C

I

I

G

G

D

D

I

V

R

R

G

G

A

R

G

G

L

L

F

L

V

L

A

G

V

V

E

E

F

I

V

V

E

K

D

D

G

R

D

R

A

T

A

K

R

E

P

P

A

A

T

D

A

G

R

L

T

G

A

A

R

K

I

I

V

T

N

R

-

E

-

C

-

M

-

N

-

L

G

G

L

L

R

S

R

M

R

N

H

I

V

V

L

Q

V

L

G

P

A

G

T

M

G

G

E

-

A

-

N

G

I

V

L

F

K
x
R

I

I

R

A

P

P

M

L

V

T

F

V

T

S

E

E

A

D

H

E

A

I

D

D

L

L

active site: W136 (≠ Y141), E208 (≠ D209), D241 (= D242), Q244 (= Q245), K270 (= K272), T301 (= T302), R404 (≠ K403)
binding (1s)-1-[((1e)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylene)amino]ethylphosphonic acid: Q50 (≠ V58), T108 (= T113), A110 (≠ S115), W136 (≠ Y141), H137 (= H142), E208 (≠ D209), S213 (= S214), D241 (= D242), A243 (≠ V244), Q244 (= Q245), K270 (= K272), R404 (≠ K403)

Sites not aligning to the query:

active site: 19

1m0pA Structure of dialkylglycine decarboxylase complexed with 1-amino-1- phenylethanephosphonate (see paper)
34% identity, 89% coverage: 31:417/435 of query aligns to 23:418/431 of 1m0pA

query
sites
1m0pA

E

E

P

P

L

M

H

I

I

I

V

E

R

R

G

A

D

K

G

G

V

S

W

F

L

V

Y

Y

D

D

A

A

N

D

G

G

E

R

R

A

Y

I

L

L

D

D

A

F

Y

T

N

S

N

G

V
x
Q

A

M

S

S

-

A

-

V

V

L

G

G

H

H

C

C

H

H

P

P

Q

E

V

I

V

V

Q

S

A

V

I

I

A

G

R

E

Q

Y

A

A

A

G

Q

K

L

L

N

D

-

H

T

L

H

F

T

S

R

E

Y

M

L

L

H

S

E

R

G

P

I

V

L

V

D

D

Y

L

A

A

Q

T

R

R

L

L

L

A

A

N

T

I

M

T

P

P

D

P

A

G

L

L

G

D

H

R

A

A

M

L

L

L

T

L

C

S

T
|
T

G

G

S
x
A

E

E

A

S

N

N

D

E

L

A

A

A

M

I

R

R

I

M

A

A

R

K

A

L

H

V

T

T

G

G

A

K

Q

Y

G

E

L

I

I

V

I

G

T

F

R

A

F

Q

A

S

Y
x
W

H
|
H

G

G

V

M

T

T

A

G

S

A

I

A

A

A

E

S

A

A

S

T

P

Y

S

S

L

A

G

G

R

R

Y

K

-

G

-

V

-

G

-

P

V

A

K

A

L

V

G

G

D

S

N

F

V

-

R

-

T

A

V

I

P

P

A

A

P

P

D

F

S

T

Y

Y

R

R

V

P

V

R

P

F

A

E

Q

R

L

N

G

G

A

A

V

Y

-

D

F

Y

A

L

E

A

G

E

V

L

R

D

H

Y

A

A

I

F

E

D

-

L

-

I

D

D

L

R

R

Q

A

S

H

S

G

G

I

-

R

N

P

L

A

A

L

F

L

I

V

A

D
x
E

T

P

V

I

F

L

S

S

S
|
S

D

G

G

G

I

I

F

I

T

E

D

L

P

P

P

D

G

G

F

Y

L

M

K

A

D

A

A

L

V

K

A

R

A

K

I

C

R

E

A

A

A

R

G

G

G

M

V

L

F

L

I

I

A

L

D
|
D

E

E

V
x
A

Q
|
Q

P

T

G

G

L

V

G

G

R

R

T

T

G

G

E

T

A

M

F

F

W

-

G

A

F

C

Q

Q

R

R

H

D

G

G

V

V

V

T

P

P

D

D

I

I

V

L

T

T

M

L

G

S

K
|
K

P

T

M

L

G

G

N

A

G

G

H

L

P

P

L

L

A

A

G

A

L

I

A

-

V

V

R

T

P

S

E

A

V

A

L

I

E

E

A

E

F

R

G

A

R

H

E

E

C

L

R

G

Y

Y

-

L

-

F

F

Y

N

T

T
|
T

F

H

G

V

G

S

N

D

P

P

V

L

S

P

V

A

A

A

A

V

G

G

M

L

A

R

V

V

L

L

D

D

V

V

I

V

E

Q

Q

R

T

D

Q

G

L

L

M

V

A

A

Q

R

V

A

R

N

R

V

V

M

G

G

K

D

Y

R

L

L

R

R

E

R

R

G

L

L

A

L

G

D

V

L

A

M

A

E

R

R

R

F

P

D

L

C

I

I

G

G

D

D

I

V

R

R

G

G

A

R

G

G

L

L

F

L

V

L

A

G

V

V

E

E

F

I

V

V

E

K

D

D

G

R

D

R

A

T

A

K

R

E

P

P

A

A

T

D

A

G

R

L

T

G

A

A

R

K

I

I

V

T

N

R

-

E

-

C

-

M

-

N

-

L

G

G

L

L

R

S

R

M

R

N

H

I

V

V

L

Q

V

L

G

P

A

G

T

M

G

G

E

-

A

-

N

G

I

V

L

F

K
x
R

I

I

R

A

P

P

M

L

V

T

F

V

T

S

E

E

A

D

H

E

A

I

D

D

L

L

active site: W136 (≠ Y141), E208 (≠ D209), D241 (= D242), Q244 (= Q245), K270 (= K272), T301 (= T302), R404 (≠ K403)
binding (1r)-1-[((1e)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylene)amino]-1-phenylethylphosphonic acid: Q50 (≠ V58), T108 (= T113), A110 (≠ S115), W136 (≠ Y141), H137 (= H142), E208 (≠ D209), S213 (= S214), D241 (= D242), A243 (≠ V244), Q244 (= Q245), K270 (= K272), R404 (≠ K403)

Sites not aligning to the query:

active site: 19

1m0oA Structure of dialkylglycine decarboxylase complexed with 1-amino-1- methylpropanephosphonate (see paper)
34% identity, 89% coverage: 31:417/435 of query aligns to 23:418/431 of 1m0oA

query
sites
1m0oA

E

E

P

P

L

M

H

I

I

I

V

E

R

R

G

A

D

K

G

G

V

S

W

F

L

V

Y

Y

D

D

A

A

N

D

G

G

E

R

R

A

Y

I

L

L

D

D

A

F

Y

T

N

S

N

G

V
x
Q

A

M

S

S

-

A

-

V

V

L

G

G

H

H

C

C

H

H

P

P

Q

E

V

I

V

V

Q

S

A

V

I

I

A

G

R

E

Q

Y

A

A

A

G

Q

K

L

L

N

D

-

H

T

L

H

F

T

S

R

E

Y

M

L

L

H

S

E

R

G

P

I

V

L

V

D

D

Y

L

A

A

Q

T

R

R

L

L

L

A

A

N

T

I

M

T

P

P

D

P

A

G

L

L

G

D

H

R

A

A

M

L

L

L

T

L

C

S

T

T

G
|
G

S
x
A

E

E

A

S

N

N

D

E

L

A

A

A

M

I

R

R

I

M

A

A

R

K

A

L

H

V

T

T

G

G

A

K

Q

Y

G

E

L

I

I

V

I

G

T

F

R

A

F

Q

A

S

Y
x
W

H
|
H

G

G

V

M

T

T

A

G

S

A

I

A

A

A

E

S

A

A

S

T

P

Y

S

S

L

A

G

G

R

R

Y

K

-

G

-

V

-

G

-

P

V

A

K

A

L

V

G

G

D

S

N

F

V

-

R

-

T

A

V

I

P

P

A

A

P

P

D

F

S

T

Y

Y

R

R

V

P

V

R

P

F

A

E

Q

R

L

N

G

G

A

A

V

Y

-

D

F

Y

A

L

E

A

G

E

V

L

R

D

H

Y

A

A

I

F

E

D

-

L

-

I

D

D

L

R

R

Q

A

S

H

S

G

G

I

-

R

N

P

L

A

A

L

F

L

I

V

A

D
x
E

T

P

V

I

F

L

S

S

D

G

G

G

I

I

F

I

T

E

D

L

P

P

P

D

G

G

F

Y

L

M

K

A

D

A

A

L

V

K

A

R

A

K

I

C

R

E

A

A

A

R

G

G

G

M

V

L

F

L

I

I

A

L

D
|
D

E

E

V

A

Q
|
Q

P

T

G

G

L

V

G

G

R

R

T

T

G

G

E

T

A

M

F

F

W

-

G

A

F

C

Q

Q

R

R

H

D

G

G

V

V

V

T

P

P

D

D

I

I

V

L

T

T

M

L

G

S

K
|
K

P

T

M

L

G

G

N

A

G

G

H

L

P

P

L

L

A

A

G

A

L

I

A

-

V

V

R

T

P

S

E

A

V

A

L

I

E

E

A

E

F

R

G

A

R

H

E

E

C

L

R

G

Y

Y

-

L

-

F

F

Y

N

T

T
|
T

F

H

G

V

G

S

N

D

P

P

V

L

S

P

V

A

A

A

A

V

G

G

M

L

A

R

V

V

L

L

D

D

V

V

I

V

E

Q

Q

R

T

D

Q

G

L

L

M

V

A

A

Q

R

V

A

R

N

R

V

V

M

G

G

K

D

Y

R

L

L

R

R

E

R

R

G

L

L

A

L

G

D

V

L

A

M

A

E

R

R

R

F

P

D

L

C

I

I

G

G

D

D

I

V

R

R

G

G

A

R

G

G

L

L

F

L

V

L

A

G

V

V

E

E

F

I

V

V

E

K

D

D

G

R

D

R

A

T

A

K

R

E

P

P

A

A

T

D

A

G

R

L

T

G

A

A

R

K

I

I

V

T

N

R

-

E

-

C

-

M

-

N

-

L

G

G

L

L

R

S

R

M

R

N

H

I

V

V

L

Q

V

L

G

P

A

G

T

M

G

G

E

-

A

-

N

G

I

V

L

F

K
x
R

I

I

R

A

P

P

M

L

V

T

F

V

T

S

E

E

A

D

H

E

A

I

D

D

L

L

active site: W136 (≠ Y141), E208 (≠ D209), D241 (= D242), Q244 (= Q245), K270 (= K272), T301 (= T302), R404 (≠ K403)
binding (1r)-1-[((1e)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylene)amino]-1-methylpropylphosphonic acid: Q50 (≠ V58), G109 (= G114), A110 (≠ S115), W136 (≠ Y141), H137 (= H142), E208 (≠ D209), D241 (= D242), Q244 (= Q245), K270 (= K272), R404 (≠ K403)

Sites not aligning to the query:

active site: 19

1m0nA Structure of dialkylglycine decarboxylase complexed with 1- aminocyclopentanephosphonate (see paper)
34% identity, 89% coverage: 31:417/435 of query aligns to 23:418/431 of 1m0nA

query
sites
1m0nA

E

E

P

P

L

M

H

I

I

I

V

E

R

R

G

A

D

K

G

G

V

S

W

F

L

V

Y

Y

D

D

A

A

N

D

G

G

E

R

R

A

Y

I

L

L

D

D

A

F

Y

T

N

S

N

G

V
x
Q

A
x
M

S

S

-

A

-

V

V

L

G

G

H

H

C

C

H

H

P

P

Q

E

V

I

V

V

Q

S

A

V

I

I

A

G

R

E

Q

Y

A

A

A

G

Q

K

L

L

N

D

-

H

T

L

H

F

T

S

R

E

Y

M

L

L

H

S

E

R

G

P

I

V

L

V

D

D

Y

L

A

A

Q

T

R

R

L

L

L

A

A

N

T

I

M

T

P

P

D

P

A

G

L

L

G

D

H

R

A

A

M

L

L

L

T

L

C

S

T

T

G

G

S
x
A

E

E

A

S

N
|
N

D

E

L

A

A

A

M

I

R

R

I

M

A

A

R

K

A

L

H

V

T

T

G

G

A

K

Q

Y

G

E

L

I

I

V

I

G

T

F

R

A

F

Q

A

S

Y
x
W

H
|
H

G

G

V

M

T

T

A

G

S

A

I

A

A

A

E

S

A

A

S

T

P

Y

S

S

L

A

G

G

R

R

Y

K

-

G

-

V

-

G

-

P

V

A

K

A

L

V

G

G

D

S

N

F

V

-

R

-

T

A

V

I

P

P

A

A

P

P

D

F

S

T

Y

Y

R

R

V

P

V

R

P

F

A

E

Q

R

L

N

G

G

A

A

V

Y

-

D

F

Y

A

L

E

A

G

E

V

L

R

D

H

Y

A

A

I

F

E

D

-

L

-

I

D

D

L

R

R

Q

A

S

H

S

G

G

I

-

R

N

P

L

A

A

L

F

L

I

V

A

D
x
E

T

P

V

I

F

L

S

S

S
|
S

D

G

G

G

I

I

F

I

T

E

D

L

P

P

P

D

G

G

F

Y

L

M

K

A

D

A

A

L

V

K

A

R

A

K

I

C

R

E

A

A

A

R

G

G

G

M

V

L

F

L

I

I

A

L

D
|
D

E

E

V
x
A

Q
|
Q

P

T

G

G

L

V

G

G

R

R

T

T

G

G

E

T

A

M

F

F

W

-

G

A

F

C

Q

Q

R

R

H

D

G

G

V

V

V

T

P

P

D

D

I

I

V

L

T

T

M

L

G

S

K
|
K

P

T

M

L

G

G

N

A

G

G

H

L

P

P

L

L

A

A

G

A

L

I

A

-

V

V

R

T

P

S

E

A

V

A

L

I

E

E

A

E

F

R

G

A

R

H

E

E

C

L

R

G

Y

Y

-

L

-

F

F

Y

N

T

T
|
T

F

H

G

V

G

S

N

D

P

P

V

L

S

P

V

A

A

A

A

V

G

G

M

L

A

R

V

V

L

L

D

D

V

V

I

V

E

Q

Q

R

T

D

Q

G

L

L

M

V

A

A

Q

R

V

A

R

N

R

V

V

M

G

G

K

D

Y

R

L

L

R

R

E

R

R

G

L

L

A

L

G

D

V

L

A

M

A

E

R

R

R

F

P

D

L

C

I

I

G

G

D

D

I

V

R

R

G

G

A

R

G

G

L

L

F

L

V

L

A

G

V

V

E

E

F

I

V

V

E

K

D

D

G

R

D

R

A

T

A

K

R

E

P

P

A

A

T

D

A

G

R

L

T

G

A

A

R

K

I

I

V

T

N

R

-

E

-

C

-

M

-

N

-

L

G

G

L

L

R

S

R

M

R

N

H

I

V

V

L

Q

V

L

G

P

A

G

T

M

G

G

E

-

A

-

N

G

I

V

L

F

K
x
R

I

I

R

A

P

P

M

L

V

T

F

V

T

S

E

E

A

D

H

E

A

I

D

D

L

L

active site: W136 (≠ Y141), E208 (≠ D209), D241 (= D242), Q244 (= Q245), K270 (= K272), T301 (= T302), R404 (≠ K403)
binding 1-[((1e)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylene)amino]cyclopentylphosphonic acid: Q50 (≠ V58), M51 (≠ A59), A110 (≠ S115), N113 (= N118), W136 (≠ Y141), H137 (= H142), E208 (≠ D209), S213 (= S214), D241 (= D242), A243 (≠ V244), Q244 (= Q245), K270 (= K272), R404 (≠ K403)

Sites not aligning to the query:

active site: 19

1dgdA An alkali metal ion size-dependent switch in the active site structure of dialkylglycine decarboxylase (see paper)
34% identity, 89% coverage: 31:417/435 of query aligns to 23:418/431 of 1dgdA

query
sites
1dgdA

E

E

P

P

L

M

H

I

I

I

V

E

R

R

G

A

D

K

G

G

V

S

W

F

L

V

Y

Y

D

D

A

A

N

D

G

G

E

R

R

A

Y

I

L

L

D

D

A

F

Y

T

N

S

N

G

V

Q

A

M

S

S

-

A

-

V

V

L

G

G

H

H

C

C

H

H

P

P

Q

E

V

I

V

V

Q

S

A

V

I

I

A

G

R

E

Q

Y

A

A

A

G

Q

K

L

L

N

D

-

H

T

L

H

F

T

S

R

G

Y

M

L

L

H

S

E

R

G

P

I

V

L

V

D

D

Y

L

A

A

Q

T

R

R

L

L

L

A

A

N

T

I

M

T

P

P

D

P

A

G

L

L

G

D

H

R

A

A

M

L

L

L

T

L

C

S

T
|
T

G
|
G

S
x
A

E

E

A

S

N

N

D

E

L

A

A

A

M

I

R

R

I

M

A

A

R

K

A

L

H

V

T

T

G

G

A

K

Q

Y

G

E

L

I

I

V

I

G

T

F

R

A

F

Q

A

S

Y
x
W

H
|
H

G

G

V

M

T

T

A

G

S

A

I

A

A

A

E

S

A

A

S

T

P

Y

S

S

L

A

G

G

R

R

Y

K

-

G

-

V

-

G

-

P

V

A

K

A

L

V

G

G

D

S

N

F

V

-

R

-

T

A

V

I

P

P

A

A

P

P

D

F

S

T

Y

Y

R

R

V

P

V

R

P

F

A

E

Q

R

L

N

G

G

A

A

V

Y

-

D

F

Y

A

L

E

A

G

E

V

L

R

D

H

Y

A

A

I

F

E

D

-

L

-

I

D

D

L

R

R

Q

A

S

H

S

G

G

I

-

R

N

P

L

A

A

L

F

L

I

V

A

D
x
E

T

P

V

I

F

L

S

S

D

G

G

G

I

I

F

I

T

E

D

L

P

P

P

D

G

G

F

Y

L

M

K

A

D

A

A

L

V

K

A

R

A

K

I

C

R

E

A

A

A

R

G

G

G

M

V

L

F

L

I

I

A

L

D
|
D

E

E

V
x
A

Q
|
Q

P

T

G

G

L

V

G

G

R

R

T

T

G

G

E

T

A

M

F

F

W

-

G

A

F

C

Q

Q

R

R

H

D

G

G

V

V

V

T

P

P

D

D

I

I

V

L

T

T

M

L

G

S

K
|
K

P

T

M

L

G

G

N

A

G

G

H

L

P

P

L

L

A

A

G

A

L

I

A

-

V

V

R

T

P

S

E

A

V

A

L

I

E

E

A

E

F

R

G

A

R

H

E

E

C

L

R

G

Y

Y

-

L

-

F

F

Y

N

T

T
|
T

F

H

G

V

G

S

N

D

P

P

V

L

S

P

V

A

A

A

A

V

G

G

M

L

A

R

V

V

L

L

D

D

V

V

I

V

E

Q

Q

R

T

D

Q

G

L

L

M

V

A

A

Q

R

V

A

R

N

R

V

V

M

G

G

K

D

Y

R

L

L

R

R

E

R

R

G

L

L

A

L

G

D

V

L

A

M

A

E

R

R

R

F

P

D

L

C

I

I

G

G

D

D

I

V

R

R

G

G

A

R

G

G

L

L

F

L

V

L

A

G

V

V

E

E

F

I

V

V

E

K

D

D

G

R

D

R

A

T

A

K

R

E

P

P

A

A

T

D

A

G

R

L

T

G

A

A

R

K

I

I

V

T

N

R

-

E

-

C

-

M

-

N

-

L

G

G

L

L

R

S

R

M

R

N

H

I

V

V

L

Q

V

L

G

P

A

G

T

M

G

G

E

-

A

-

N

G

I

V

L

F

K
x
R

I

I

R

A

P

P

M

L

V

T

F

V

T

S

E

E

A

D

H

E

A

I

D

D

L

L

active site: W136 (≠ Y141), E208 (≠ D209), D241 (= D242), Q244 (= Q245), K270 (= K272), T301 (= T302), R404 (≠ K403)
binding pyridoxal-5'-phosphate: T108 (= T113), G109 (= G114), A110 (≠ S115), W136 (≠ Y141), H137 (= H142), E208 (≠ D209), D241 (= D242), A243 (≠ V244), Q244 (= Q245), K270 (= K272)

Sites not aligning to the query:

active site: 19

1d7vA Crystal structure of the complex of 2,2-dialkylglycine decarboxylase with nma (see paper)
34% identity, 89% coverage: 31:417/435 of query aligns to 23:418/431 of 1d7vA

query
sites
1d7vA

E

E

P

P

L

M

H

I

I

I

V

E

R

R

G

A

D

K

G

G

V

S

W

F

L

V

Y

Y

D

D

A

A

N

D

G

G

E

R

R

A

Y

I

L

L

D

D

A

F

Y

T

N

S

N

G

V

Q

A

M

S

S

-

A

-

V

V

L

G

G

H

H

C

C

H

H

P

P

Q

E

V

I

V

V

Q

S

A

V

I

I

A

G

R

E

Q

Y

A

A

A

G

Q

K

L

L

N

D

-
x
H

T
x
L

H
x
F

T
x
S

R

G

Y

M

L

L

H

S

E

R

G

P

I

V

L

V

D

D

Y

L

A

A

Q

T

R

R

L

L

L

A

A

N

T

I

M

T

P

P

D

P

A

G

L

L

G

D

H

R

A

A

M

L

L

L

T

L

C

S

T

T

G

G

S
x
A

E

E

A

S

N

N

D

E

L

A

A

A

M

I

R

R

I

M

A

A

R

K

A

L

H

V

T

T

G

G

A

K

Q

Y

G

E

L

I

I

V

I

G

T

F

R

A

F

Q

A

S

Y
x
W

H
|
H

G

G

V

M

T

T

A

G

S

A

I

A

A

A

E

S

A

A

S

T

P

Y

S

S

L

A

G

G

R

R

Y

K

-

G

-

V

-

G

-

P

V

A

K

A

L

V

G

G

D

S

N

F

V

-

R

-

T

A

V

I

P

P

A

A

P

P

D

F

S

T

Y

Y

R

R

V

P

V

R

P

F

A

E

Q

R

L

N

G

G

A

A

V

Y

-

D

F

Y

A

L

E

A

G

E

V

L

R

D

H

Y

A

A

I

F

E

D

-

L

-

I

D

D

L

R

R

Q

A

S

H

S

G

G

I

-

R

N

P

L

A

A

L

F

L

I

V

A

D
x
E

T

P

V

I

F

L

S

S

S
|
S

D

G

G

G

I

I

F

I

T

E

D

L

P

P

P

D

G

G

F

Y

L

M

K

A

D

A

A

L

V

K

A

R

A

K

I

C

R

E

A

A

A

R

G

G

G

M

V

L

F

L

I

I

A

L

D
|
D

E

E

V
x
A

Q
|
Q

P

T

G

G

L

V

G

G

R

R

T

T

G

G

E

T

A

M

F

F

W

-

G

A

F

C

Q

Q

R

R

H

D

G

G

V

V

V

T

P

P

D

D

I

I

V

L

T

T

M

L

G

S

K
|
K

P

T

M

L

G

G

N

A

G

G

H

L

P

P

L

L

A

A

G

A

L

I

A

-

V

V

R

T

P

S

E

A

V

A

L

I

E

E

A

E

F

R

G

A

R

H

E

E

C

L

R

G

Y

Y

-

L

-

F

F

Y

N

T

T
|
T

F
x
H

G
x
V

G
x
S

N
x
D

P

P

V

L

S

P

V

A

A

A

A

V

G

G

M

L

A

R

V

V

L

L

D

D

V

V

I

V

E

Q

Q

R

T

D

Q

G

L

L

M

V

A

A

Q

R

V

A

R

N

R

V

V

M

G

G

K

D

Y

R

L

L

R

R

E

R

R

G

L

L

A

L

G

D

V

L

A

M

A

E

R

R

R

F

P

D

L

C

I

I

G

G

D

D

I

V

R

R

G

G

A

R

G

G

L

L

F

L

V

L

A

G

V

V

E

E