Comparing RR42_RS27740 FitnessBrowser__Cup4G11:RR42_RS27740 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 8 hits to proteins with known functional sites (download)
E9AE57 Fumarate hydratase 2; Fumarase 2; LmFH-2; EC 4.2.1.2 from Leishmania major (see paper)
33% identity, 96% coverage: 16:492/497 of query aligns to 82:563/568 of E9AE57
6unzA Crystal structure of cytosolic fumarate hydratase from leishmania major (see paper)
33% identity, 96% coverage: 16:492/497 of query aligns to 62:534/539 of 6unzA
6msnA Crystal structure of cytosolic fumarate hydratase from leishmania major in a complex with inhibitor thiomalate (see paper)
33% identity, 96% coverage: 16:492/497 of query aligns to 55:527/532 of 6msnA
6uqnB Crystal structure of r173a variant of cytosolic fumarate hydratase from leishmania major in a complex with fumarate and s-malate (see paper)
33% identity, 96% coverage: 16:492/497 of query aligns to 55:527/532 of 6uqnB
6uoiA Crystal structure of cytosolic fumarate hydratase from leishmania major in a complex with malonate (see paper)
33% identity, 96% coverage: 16:492/497 of query aligns to 57:530/535 of 6uoiA
P14407 Fumarate hydratase class I, anaerobic; D-tartrate dehydratase; Fumarase B; EC 4.2.1.2; EC 4.2.1.81 from Escherichia coli (strain K12) (see paper)
31% identity, 90% coverage: 50:495/497 of query aligns to 89:538/548 of P14407
6msoA Crystal structure of mitochondrial fumarate hydratase from leishmania major in a complex with inhibitor thiomalate (see paper)
31% identity, 93% coverage: 29:491/497 of query aligns to 67:536/540 of 6msoA
Q4QAU9 Fumarate hydratase 1, mitochondrial; Fumarase 1; LmFH-1; EC 4.2.1.2 from Leishmania major (see paper)
31% identity, 93% coverage: 29:491/497 of query aligns to 76:545/549 of Q4QAU9
>RR42_RS27740 FitnessBrowser__Cup4G11:RR42_RS27740
MIVIFQEDVVDSIADALQYVSYYHPVDFVQALKRAFAAEPAGAARDAIEQLLVNSRMSAE
AHRPICQDTGVAQVFMTVGMDVRFAARDGAALLSVQQMVDAAVRRGYTHSANPLRATMVG
SALGERRNTGDNTPGFLQLELVPGNTIKMTVVAKGGGGDVKAKFATLNPSDSLVDWILAA
IPQMGAGWCPPGVLGVGVGGTPEQAMLAAKRALFSPIDIHALRDKGPANDTERLRLALFE
RINALGIGAQGLGGLATVLDVKVAALPCHAATLPVALIPNCAATRFVTVELDGSGPARLE
PPPADTWDGIPGALTAKPGRVVDLDNLDAAQVAQWQVGETLRLRGRLLTARDAAHKRLVA
MLDAGEPLPVPLRNRAIYYVGPVDAVGDEAVGPAGPTTATRMDKFVPQLLEQTGLLLMIG
KAERGPVAIEAIRRHGAAYLIAVGGAAYLISRAIRKARVLAFAELGMEAIYEFEVEDMPA
TVAVDATGRSIHRIVAG
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory