SitesBLAST

N127 (= N26) to K: in D2HGA1; uncertain significance; complete loss of catalytic activity; dbSNP:rs762857195
G131 (= G30) to V: in D2HGA1; uncertain significance; complete loss of catalytic activity
I147 (vs. gap) to S: in D2HGA1; uncertain significance; severe phenotype; almost complete loss of catalytic activity; dbSNP:rs121434361
M153 (≠ L50) to T: in D2HGA1; uncertain significance; significant loss of catalytic activity; to V: in D2HGA1; uncertain significance; significant loss of catalytic activity; dbSNP:rs1432270139
C172 (≠ T69) to Y: in D2HGA1; uncertain significance; moderate reduction in catalytic activity; dbSNP:rs773735172
P189 (≠ A86) to L: in D2HGA1; uncertain significance; almost complete loss of catalytic activity; dbSNP:rs587783517
A205 (= A103) to V: in D2HGA1; uncertain significance; almost complete loss of catalytic activity; dbSNP:rs750889931
A231 (≠ G129) to V: in D2HGA1; uncertain significance; significant loss of catalytic activity
G233 (= G131) to S: in D2HGA1; uncertain significance; no effect on catalytic activity; dbSNP:rs374535734

Sites not aligning to the query:

15 R → G: in dbSNP:rs4675887
109 S → W: in D2HGA1; uncertain significance; significant loss of catalytic activity; dbSNP:rs142050154
169:521 natural variant: Missing (in D2HGA1; uncertain significance)
375 D → Y: in D2HGA1; uncertain significance; moderate reduction in catalytic activity; dbSNP:rs267606759
386 binding ; binding ; binding ; R→A: Loss of catalytic activity.
390 binding ; binding ; T→A: Significantly reduced catalytic activity.
399 V → M: in D2HGA1; uncertain significance; moderate reduction in catalytic activity; dbSNP:rs746519212
400:521 natural variant: Missing (in D2HGA1; uncertain significance; complete loss of catalytic activity)
401 binding ; binding ; K→A: Loss of catalytic activity.
419 R → H: in D2HGA1; uncertain significance; moderate reduction in catalytic activity; dbSNP:rs199908032
426 A → T: in D2HGA1; uncertain significance; no effect on catalytic activity; dbSNP:rs146578303
434 binding ; H→A: Loss of catalytic activity.
436 G → V: slight reduction in catalytic activity
439 N → D: in D2HGA1; uncertain significance; mild phenotype; moderate reduction in catalytic activity; dbSNP:rs121434362
441 binding ; H→A: Loss of catalytic activity.
443 binding ; N→A: Significantly reduced catalytic activity.
444 V → A: in D2HGA1; uncertain significance; severe phenotype; significant reduction in catalytic activity; dbSNP:rs121434360
446 A → V: in D2HGA1; uncertain significance; moderate reduction in catalytic activity; dbSNP:rs746956176
475 binding ; E→A: Loss of catalytic activity.
476 binding ; binding ; binding ; H→A: Loss of catalytic activity.
477 G → R: in D2HGA1; uncertain significance; almost complete loss of catalytic activity; dbSNP:rs1453924640

O00116 Alkyldihydroxyacetonephosphate synthase, peroxisomal; Alkyl-DHAP synthase; Aging-associated gene 5 protein; Alkylglycerone-phosphate synthase; EC 2.5.1.26 from Homo sapiens (Human) (see 2 papers)
29% identity, 47% coverage: 5:173/357 of query aligns to 212:384/658 of O00116

query
sites
O00116

P

P

T

T

E

C

V

H

S

D

H

D

L

V

I

V

E

K

T

I

V

V

L

N

H

L

A

A

R

C

K

K

T

Y

K

N

T

L

S

C

L

I

N

I

I

P

V

I

G

G

T

T

K

S

C

V

F

S

Y

Y

G

G

-

L

-

M

-

C

-

P

-

A

-

D

E

E

E

T

P

R

S

T

G

I

E

I

P

S

C

L

D

D

V

T

R

S

R

Q

L

M

S

N

G

R

I

I

C

L

S

W

Y

V

E

D

P

E

S

N

E

N

L

L

V

T

V

A

T

H

A

V

R

E

A

A

G

G

T

I

P

T

L

G

E

Q

E

E

L

L

E

E

A

R

V

Q

L

L

A

K

E

E

H

S

N

G

Q

Y

Y

C

L

T

A

G

F

H

E

E

P

P

P

D

R

S

F

L

A

-

K

E

G

F

S

S

T

T

V

V

G

G

A

W

V

V

A

S

A

T

G

R

L

A

S

S

G

G

P

M

A

K

R

K

V

N

G

I

V

Y

G

G

S

N

I

I

R

E

D

D

F

L

V

V

L

V

G

H

A

I

T

K

M

M

I

V

N

T

G

P

K

R

G

G

E

-

L

I

T

E

F

K

G

S

G

C

Q

Q

V

G

M

P

K

R

N

M

V

S

A

T

G

G

Y

P

D

D

V

I

S

H

R

H

L

F

L

I

A

M

G

G

S

S

M

E

G

G

I

T

L

L

G

G

V

V

I

I

C

T

E

E

V

A

S

T

L

I

K

K

V

I

L

R

P

P

I

V

Sites not aligning to the query:

182 R → Q: in RCDP3; severely reduced protein levels
419 Important for enzyme activity; R → H: in RCDP3; loss of enzyme activity; dbSNP:rs121434411
471 E → K: in RCDP3; severely reduced protein levels
568 T → M: in RCDP3; does not affect protein levels; dbSNP:rs387907214

6lpnB Crystal structure of human d-2-hydroxyglutarate dehydrogenase in apo form (see paper)
30% identity, 46% coverage: 7:172/357 of query aligns to 59:222/467 of 6lpnB

query
sites
6lpnB

E

E

V

V

S

S

H

H

L

I

I

L

E

R

T

-

V

-

L

-

H

H

A

C

R

H

K

E

T

R

K

N

T

L

S

A

L

V

N

N

I
x
P

V

Q

G
|
G

G
x
N

T
|
T

K
x
G

C
x
M

F

V

Y

G

G
|
G

E
x
S

E

V

P

P

S

V

G

F

E

D

P

E

C

I

-

I

-

L

D

S

V

T

R

A

R

R

L

M

S

N

G

R

I

V

C

L

S

S

Y

F

E

H

P

S

S

V

E

S

L

G

V

I

V

L

T

V

A

C

R

Q

A

A

G

G

T

C

P

V

L

L

E

E

L

L

E

S

A

R

V

Y

L

V

A

E

E

E

H

R

N

D

Q

F

Y

I

L

M

A

P

F

L

E

D

P

-

R
x
L

F

G

A
|
A

K

K

G

G

S

S

T
x
C

-
x
H

V

I

G

G

G
|
G

A
x
N

V

V

A
|
A

A
x
T

G

N

L

A

S

G

G

G

P

L

A

R

R

F

V

L

G

R

V

Y

G

G

S

S

I

L

R

H

D

G

F

T

V

V

L

L

G

G

A

L

T

E

M

V

I

V

N

L

G

A

K

D

G

G

E

T

L

V

L

L

T

D

F

C

G

L

G

T

Q

S

V

L

M

R

K

K

N

D

V

N

A

T

G

G

Y

Y

D

D

V

L

S

K

R

Q

L

L

L

F

A

I

G

G

S

S

M

E

G
|
G

I

T

L

L

G

G

V
x
I

I
|
I

C

T

E

T

V

V

S

S

L

I

K

L

V

C

L

P

P

P

binding flavin-adenine dinucleotide: P76 (≠ I27), G78 (= G29), G79 (= G30), N80 (≠ G31), T81 (= T32), G82 (≠ K33), M83 (≠ C34), G86 (= G37), S87 (≠ E38), L140 (≠ R91), A142 (= A93), C146 (≠ T97), H147 (vs. gap), G150 (= G100), N151 (≠ A101), A153 (= A103), T154 (≠ A104), G208 (= G158), I212 (≠ V162), I213 (= I163)

Sites not aligning to the query:

binding flavin-adenine dinucleotide: 40, 423, 460

6lpxA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with 2-oxoglutarate (2-og) (see paper)
30% identity, 46% coverage: 7:172/357 of query aligns to 58:221/466 of 6lpxA

query
sites
6lpxA

E

E

V

V

S

S

H

H

L

I

I

L

E

R

T

-

V

-

L

-

H

H

A

C

R

H

K

E

T

R

K

N

T

L

S

A

L

V

N

N

I
x
P

V
x
Q

G
|
G

G
x
N

T
|
T

K
x
G

C
x
M

F

V

Y

G

G
|
G

E
x
S

E

V

P

P

S

V

G

F

E

D

P

E

C

I

-

I

-

L

D

S

V

T

R

A

R

R

L

M

S

N

G

R

I

V

C

L

S

S

Y

F

E

H

P

S

S

V

E

S

L

G

V

I

V

L

T

V

A

C

R

Q

A

A

G

G

T

C

P

V

L

L

E

E

L

L

E

S

A

R

V

Y

L

V

A

E

E

E

H

R

N

D

Q

F

Y

I

L

M

A

P

F

L

E

D

P

-

R
x
L

F
x
G

A
|
A

K

K

G

G

S

S

T
x
C

-

H

V

I

G

G

G
|
G

A
x
N

V

V

A
|
A

A
x
T

G

N

L

A

S

G

G
|
G

P

L

A

R

R

F

V

L

G

R

V

Y

G

G

S

S

I

L

R

H

D

G

F

T

V

V

L

L

G

G

A

L

T

E

M

V

I

V

N

L

G

A

K

D

G

G

E

T

L

V

L

L

T

D

F

C

G

L

G

T

Q

S

V

L

M

R

K

K

N

D

V

N

A

T

G

G

Y

Y

D

D

V

L

S

K

R

Q

L

L

L

F

A

I

G

G

S

S

M

E

G
|
G

I

T

L

L

G

G

V

I

I
|
I

C

T

E

T

V

V

S

S

L

I

K

L

V

C

L

P

P

P

binding flavin-adenine dinucleotide: P75 (≠ I27), Q76 (≠ V28), G77 (= G29), G78 (= G30), N79 (≠ G31), T80 (= T32), G81 (≠ K33), M82 (≠ C34), G85 (= G37), S86 (≠ E38), L139 (≠ R91), G140 (≠ F92), A141 (= A93), C145 (≠ T97), G149 (= G100), N150 (≠ A101), A152 (= A103), T153 (≠ A104), G157 (= G108), G207 (= G158), I212 (= I163)

Sites not aligning to the query:

binding 2-oxoglutaric acid: 333, 337, 348, 379, 381, 388, 423
binding flavin-adenine dinucleotide: 39, 422, 459
binding zinc ion: 381, 388, 422

6lpuA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with l-2-hydroxyglutarate (l-2-hg) (see paper)
30% identity, 46% coverage: 7:172/357 of query aligns to 58:221/466 of 6lpuA

query
sites
6lpuA

E

E

V

V

S

S

H

H

L

I

I

L

E

R

T

-

V

-

L

-

H

H

A

C

R

H

K

E

T

R

K

N

T

L

S

A

L

V

N

N

I
x
P

V

Q

G
|
G

G
x
N

T
|
T

K
x
G

C

M

F

V

Y

G

G
|
G

E
x
S

E

V

P

P

S

V

G

F

E

D

P

E

C

I

-

I

-

L

D

S

V

T

R

A

R

R

L

M

S

N

G

R

I

V

C

L

S

S

Y

F

E

H

P

S

S

V

E

S

L

G

V

I

V

L

T

V

A

C

R

Q

A

A

G

G

T

C

P

V

L

L

E

E

L

L

E

S

A

R

V

Y

L

V

A

E

E

E

H

R

N

D

Q

F

Y

I

L

M

A

P

F

L

E

D

P

-

R
x
L

F
x
G

A
|
A

K

K

G

G

S

S

T
x
C

-
x
H

V

I

G
|
G

A
x
N

V

V

A
|
A

A
x
T

G

N

L
x
A

S

G

G

G

P

L

A

R

R

F

V

L

G

R

V

Y

G

G

S

S

I

L

R

H

D

G

F

T

V

V

L

L

G

G

A

L

T

E

M

V

I

V

N

L

G

A

K

D

G

G

E

T

L

V

L

L

T

D

F

C

G

L

G

T

Q

S

V

L

M

R

K

K

N

D

V

N

A

T

G

G

Y

Y

D

D

V

L

S

K

R

Q

L

L

L

F

A

I

G

G

S

S

M
x
E

G
|
G

I

T

L

L

G

G

V
x
I

I
|
I

C

T

E

T

V

V

S

S

L

I

K

L

V

C

L

P

P

P

binding flavin-adenine dinucleotide: P75 (≠ I27), G77 (= G29), G78 (= G30), N79 (≠ G31), T80 (= T32), G81 (≠ K33), G85 (= G37), S86 (≠ E38), L139 (≠ R91), G140 (≠ F92), A141 (= A93), C145 (≠ T97), H146 (vs. gap), G148 (= G99), G149 (= G100), N150 (≠ A101), A152 (= A103), T153 (≠ A104), A155 (≠ L106), E206 (≠ M157), G207 (= G158), I211 (≠ V162), I212 (= I163)

Sites not aligning to the query:

binding flavin-adenine dinucleotide: 39, 422, 459
binding (2s)-2-hydroxypentanedioic acid: 333, 337, 348, 379, 381, 388, 423
binding zinc ion: 381, 388, 422

6lpqA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with d-malate (d-mal) (see paper)
30% identity, 46% coverage: 7:172/357 of query aligns to 58:221/466 of 6lpqA

query
sites
6lpqA

E

E

V

V

S

S

H

H

L

I

I

L

E

R

T

-

V

-

L

-

H

H

A

C

R

H

K

E

T

R

K

N

T

L

S

A

L

V

N

N

I
x
P

V

Q

G
|
G

G
x
N

T
|
T

K
x
G

C
x
M

F

V

Y

G

G
|
G

E
x
S

E

V

P

P

S

V

G

F

E

D

P

E

C

I

-

I

-

L

D

S

V

T

R

A

R

R

L

M

S

N

G

R

I

V

C

L

S

S

Y

F

E

H

P

S

S

V

E

S

L

G

V

I

V

L

T

V

A

C

R

Q

A

A

G

G

T

C

P

V

L

L

E

E

L

L

E

S

A

R

V

Y

L

V

A

E

E

E

H

R

N

D

Q

F

Y

I

L

M

A

P

F

L

E

D

P

-

R
x
L

F
x
G

A
|
A

K

K

G

G

S

S

T
x
C

-
x
H

V

I

G

G

G
|
G

A
x
N

V

V

A
|
A

A
x
T

G

N

L
x
A

S

G

G
|
G

P

L

A

R

R

F

V

L

G

R

V

Y

G

G

S

S

I

L

R

H

D

G

F

T

V

V

L

L

G

G

A

L

T

E

M

V

I

V

N

L

G

A

K

D

G

G

E

T

L

V

L

L

T

D

F

C

G

L

G

T

Q

S

V

L

M

R

K

K

N

D

V

N

A

T

G

G

Y

Y

D

D

V

L

S

K

R

Q

L

L

L

F

A

I

G

G

S

S

M
x
E

G
|
G

I

T

L

L

G

G

V
x
I

I
|
I

C

T

E

T

V

V

S

S

L

I

K

L

V

C

L

P

P

P

binding flavin-adenine dinucleotide: P75 (≠ I27), G77 (= G29), G78 (= G30), N79 (≠ G31), T80 (= T32), G81 (≠ K33), G85 (= G37), S86 (≠ E38), L139 (≠ R91), G140 (≠ F92), A141 (= A93), C145 (≠ T97), H146 (vs. gap), G149 (= G100), N150 (≠ A101), A152 (= A103), T153 (≠ A104), A155 (≠ L106), G157 (= G108), E206 (≠ M157), G207 (= G158), I211 (≠ V162), I212 (= I163)
binding d-malate: M82 (≠ C34)

Sites not aligning to the query:

binding flavin-adenine dinucleotide: 39, 422, 459
binding d-malate: 333, 337, 348, 379, 381, 388, 422, 423
binding zinc ion: 381, 388, 422

6lppA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with d-2-hydroxyglutarate (d-2-hg) (see paper)
30% identity, 46% coverage: 7:172/357 of query aligns to 58:221/466 of 6lppA

query
sites
6lppA

E

E

V

V

S

S

H

H

L

I

I

L

E

R

T

-

V

-

L

-

H

H

A

C

R

H

K

E

T

R

K

N

T

L

S

A

L

V

N

N

I
x
P

V

Q

G
|
G

G
x
N

T
|
T

K
x
G

C
x
M

F

V

Y

G

G
|
G

E
x
S

E

V

P

P

S

V

G

F

E

D

P

E

C

I

-

I

-

L

D

S

V

T

R

A

R

R

L

M

S

N

G

R

I

V

C

L

S

S

Y

F

E

H

P

S

S

V

E

S

L

G

V

I

V

L

T

V

A

C

R

Q

A

A

G

G

T

C

P

V

L

L

E

E

L

L

E

S

A

R

V

Y

L

V

A

E

E

E

H

R

N

D

Q

F

Y

I

L

M

A

P

F

L

E

D

P

-

R
x
L

F
x
G

A
|
A

K

K

G

G

S

S

T
x
C

-

H

V

I

G

G

G
|
G

A
x
N

V

V

A
|
A

A
x
T

G

N

L
x
A

S

G

G
|
G

P

L

A

R

R

F

V

L

G

R

V

Y

G

G

S

S

I

L

R

H

D

G

F

T

V

V

L

L

G

G

A

L

T

E

M

V

I

V

N

L

G

A

K

D

G

G

E

T

L

V

L

L

T

D

F

C

G

L

G

T

Q

S

V

L

M

R

K

K

N

D

V

N

A

T

G

G

Y

Y

D

D

V

L

S

K

R

Q

L

L

L

F

A

I

G

G

S

S

M

E

G
|
G

I

T

L

L

G

G

V

I

I
|
I

C

T

E

T

V

V

S

S

L

I

K

L

V

C

L

P

P

P

binding flavin-adenine dinucleotide: P75 (≠ I27), G77 (= G29), G78 (= G30), N79 (≠ G31), T80 (= T32), G81 (≠ K33), M82 (≠ C34), G85 (= G37), S86 (≠ E38), L139 (≠ R91), G140 (≠ F92), A141 (= A93), C145 (≠ T97), G149 (= G100), N150 (≠ A101), A152 (= A103), T153 (≠ A104), A155 (≠ L106), G157 (= G108), G207 (= G158), I212 (= I163)

Sites not aligning to the query:

binding (2R)-2-hydroxypentanedioic acid: 333, 337, 348, 379, 381, 388, 390, 423
binding flavin-adenine dinucleotide: 39, 422, 423
binding zinc ion: 381, 388, 422

5ae3A Ether lipid-generating enzyme agps in complex with antimycin a (see paper)
28% identity, 47% coverage: 5:172/357 of query aligns to 118:289/539 of 5ae3A

query
sites
5ae3A

P

P

T

T

E

C

V

H

S

D

H

D

L

V

I

V

E

K

T

I

V

V

L

N

H

L

A

A

R

C

K

K

T

Y

K

N

T

L

S

C

L

I

N

I

I
x
P

V
x
I

G
|
G

T
|
T

K
x
S

C
x
V

F

S

Y

Y

G

G

-
x
L

-

M

-

C

-

P

-

A

-

D

E

E

E

T

P

R

S

T

G

I

E

I

P

S

C

L

D

D

V

T

R

S

R

Q

L

M

S

N

G

R

I

I

C

L

S

W

Y

V

E

D

P

E

S

N

E

N

L

L

V

T

V

A

T

H

A

V

R

E

A

A

G

G

T

I

P

T

L

G

E

Q

E

E

L

L

E

E

A

R

V

Q

L

L

A

K

E

E

H

S

N

G

Q

Y

Y

C

L

T

A

G

F

H

E

E

P
|
P

P
x
D

R
x
S

F

L

A

-

K

E

G

F

S
|
S

T
|
T

V

V

G

G

G
|
G

A
x
W

V

I

A
x
S

A
x
T

G

R

L
x
A

S
|
S

G

G

P

M

A

K

R

K

V

N

G

I

V

Y

G

G

S

N

I

I

R

E

D

D

F

L

V

V

L

V

G

H

A

M

T

K

M

V

I

V

N

T

G

P

K

R

G

G

E

-

L

V

L

I

T

E

F

K

G

S

G

C

Q

Q

V

G

M

P

K

R

N

M

V

S

A

T

G

G

Y

P

D

D

V

I

S

H

R

H

L

F

L

I

A

M

G

G

S

S

M
x
E

G

G

I

T

L

L

G

G

V
|
V

I
|
I

C

T

E

E

V

A

S

T

L

I

K

K

V

I

L

R

P

P

binding flavin-adenine dinucleotide: P140 (≠ I27), I141 (≠ V28), G142 (= G29), G143 (= G30), G144 (= G31), T145 (= T32), S146 (≠ K33), V147 (≠ C34), L151 (vs. gap), P208 (= P89), D209 (≠ P90), S210 (≠ R91), S214 (= S96), T215 (= T97), G218 (= G100), W219 (≠ A101), S221 (≠ A103), T222 (≠ A104), A224 (≠ L106), S225 (= S107), E274 (≠ M157), V279 (= V162), I280 (= I163)

Sites not aligning to the query:

6gouA Development of alkyl glycerone phosphate synthase inhibitors: complex with inhibitor 2i (see paper)
28% identity, 47% coverage: 5:172/357 of query aligns to 132:303/554 of 6gouA

query
sites
6gouA

P

P

T

T

E

C

V

H

S

D

H

D

L

V

I

V

E

K

T

I

V

V

L

N

H

L

A

A

R

C

K

K

T

Y

K

N

T

L

S

C

L

I

N

I

I
x
P

V
x
I

G
|
G

T
|
T

K
x
S

C
x
V

F

S

Y

Y

G
|
G

-

L

-

M

-

C

-

P

-

A

-

D

E

E

E

T

P

R

S

T

G

I

E

I

P

S

C

L

D

D

V

T

R

S

R

Q

L

M

S

N

G

R

I

I

C

L

S

W

Y

V

E

D

P

E

S

N

E

N

L

L

V

T

V

A

T

H

A

V

R

E

A

A

G

G

T

I

P

T

L

G

E

Q

E

E

L

L

E

E

A

R

V

Q

L

L

A

K

E

E

H

S

N

G

Q

Y

Y

C

L

T

A

G

F

H

E

E

P
|
P

P
x
D

R
x
S

F

L

A

-

K

E

G

F

S
|
S

T
|
T

V

V

G

G

G
|
G

A
x
W

V

I

A
x
S

A
x
T

G

R

L
x
A

S
|
S

G

G

P

M

A

K

R

K

V

N

G

I

V

Y

G

G

S

N

I

I

R

E

D

D

F

L

V

V

L

V

G

H

A

M

T

K

M

V

I

V

N

T

G

P

K

R

G

G

E

-

L

V

L

I

T

E

F

K

G

S

G

C

Q

Q

V

G

M

P

K

R

N

M

V

S

A

T

G

G

Y

P

D

D

V

I

S

H

R

H

L

F

L

I

A

M

G

G

S

S

M
x
E

G

G

I

T

L

L

G

G

V
|
V

I
|
I

C

T

E

E

V

A

S

T

L

I

K

K

V

I

L

R

P

P

binding (3~{S})-3-[2,6-bis(fluoranyl)phenyl]-~{N}-[(2-oxidanylidene-1,3-dihydrobenzimidazol-5-yl)methyl]butanamide: D223 (≠ P90)
binding flavin-adenine dinucleotide: P154 (≠ I27), I155 (≠ V28), G156 (= G29), G157 (= G30), G158 (= G31), T159 (= T32), S160 (≠ K33), V161 (≠ C34), G164 (= G37), P222 (= P89), D223 (≠ P90), S224 (≠ R91), S228 (= S96), T229 (= T97), G232 (= G100), W233 (≠ A101), S235 (≠ A103), T236 (≠ A104), A238 (≠ L106), S239 (= S107), E288 (≠ M157), V293 (= V162), I294 (= I163)

Sites not aligning to the query:

5ae2A Ether lipid-generating enzyme agps in complex with inhibitor 1e (see paper)
28% identity, 47% coverage: 5:172/357 of query aligns to 123:294/561 of 5ae2A

query
sites
5ae2A

P

P

T

T

E

C

V

H

S

D

H

D

L

V

I

V

E

K

T

I

V

V

L

N

H

L

A

A

R

C

K

K

T

Y

K

N

T

L

S

C

L

I

N

I

I
x
P

V
x
I

G
|
G

T
|
T

K
x
S

C

V

F

S

Y

Y

G
|
G

-
x
L

-

M

-

C

-

P

-

A

-

D

E

E

E

T

P

R

S

T

G

I

E

I

P

S

C

L

D

D

V

T

R

S

R

Q

L

M

S

N

G

R

I

I

C

L

S

W

Y

V

E

D

P

E

S

N

E

N

L

L

V

T

V

A

T

H

A

V

R

E

A

A

G

G

T

I

P

T

L

G

E

Q

E

E

L

L

E

E

A

R

V

Q

L

L

A

K

E

E

H

S

N

G

Q

Y

Y

C

L

T

A

G

F

H

E

E

P
|
P

P
x
D

R
x
S

F

L

A

-

K

E

G

F

S
|
S

T
|
T

V

V

G

G

G
|
G

A
x
W

V

I

A
x
S

A
x
T

G

R

L
x
A

S
|
S

G

G

P

M

A

K

R

K

V

N

G

I

V

Y

G

G

S

N

I

I

R

E

D

D

F

L

V

V

L

V

G

H

A

M

T

K

M

V

I

V

N

T

G

P

K

R

G

G

E

-

L

V

L

I

T

E

F

K

G

S

G

C

Q

Q

V

G

M

P

K

R

N

M

V

S

A

T

G

G

Y

P

D

D

V

I

S

H

R

H

L

F

L

I

A

M

G

G

S

S

M
x
E

G

G

I

T

L

L

G

G

V
|
V

I
|
I

C

T

E

E

V

A

S

T

L

I

K

K

V

I

L

R

P

P

binding flavin-adenine dinucleotide: P145 (≠ I27), I146 (≠ V28), G147 (= G29), G148 (= G30), G149 (= G31), T150 (= T32), S151 (≠ K33), G155 (= G37), L156 (vs. gap), P213 (= P89), D214 (≠ P90), S215 (≠ R91), S219 (= S96), T220 (= T97), G223 (= G100), W224 (≠ A101), S226 (≠ A103), T227 (≠ A104), A229 (≠ L106), S230 (= S107), E279 (≠ M157), V284 (= V162), I285 (= I163)

Sites not aligning to the query:

5adzC Ether lipid-generating enzyme agps in complex with inhibitor 1a (see paper)
28% identity, 47% coverage: 5:172/357 of query aligns to 132:303/557 of 5adzC

query
sites
5adzC

P

P

T

T

E

C

V

H

S

D

H

D

L

V

I

V

E

K

T

I

V

V

L

N

H

L

A

A

R

C

K

K

T

Y

K

N

T

L

S

C

L

I

N

I

I
x
P

V
x
I

G
|
G

T
|
T

K
x
S

C

V

F

S

Y

Y

G

G

-

L

-

M

-

C

-

P

-

A

-

D

E

E

E

T

P

R

S

T

G

I

E

I

P

S

C

L

D

D

V

T

R

S

R

Q

L

M

S

N

G

R

I

I

C

L

S

W

Y

V

E

D

P

E

S

N

E

N

L

L

V

T

V

A

T

H

A

V

R

E

A

A

G

G

T

I

P

T

L

G

E

Q

E

E

L

L

E

E

A

R

V

Q

L

L

A

K

E

E

H

S

N

G

Q

Y

Y

C

L

T

A

G

F

H

E

E

P
|
P

P
x
D

R
x
S

F

L

A

-

K

E

G

F

S
|
S

T
|
T

V

V

G

G

G
|
G

A
x
W

V

I

A
x
S

A
x
T

G

R

L
x
A

S
|
S

G

G

P

M

A

K

R

K

V

N

G

I

V

Y

G

G

S

N

I

I

R

E

D

D

F

L

V

V

L

V

G

H

A

M

T

K

M

V

I

V

N

T

G

P

K

R

G

G

E

-

L

V

L

I

T

E

F

K

G

S

G

C

Q

Q

V

G

M

P

K

R

N

M

V

S

A

T

G

G

Y

P

D

D

V

I

S

H

R

H

L

F

L

I

A

M

G

G

S

S

M
x
E

G
|
G

I

T

L

L

G

G

V

V

I
|
I

C

T

E

E

V

A

S

T

L

I

K

K

V

I

L

R

P

P

binding flavin-adenine dinucleotide: P154 (≠ I27), I155 (≠ V28), G156 (= G29), G157 (= G30), G158 (= G31), T159 (= T32), S160 (≠ K33), P222 (= P89), D223 (≠ P90), S224 (≠ R91), S228 (= S96), T229 (= T97), G232 (= G100), W233 (≠ A101), S235 (≠ A103), T236 (≠ A104), A238 (≠ L106), S239 (= S107), E288 (≠ M157), G289 (= G158), I294 (= I163)
binding (3S)-3-(2-fluorophenyl)-N-((2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)methyl)butanamide): D223 (≠ P90)

Sites not aligning to the query:

P97275 Alkyldihydroxyacetonephosphate synthase, peroxisomal; Alkyl-DHAP synthase; Alkylglycerone-phosphate synthase; EC 2.5.1.26 from Cavia porcellus (Guinea pig) (see 4 papers)
28% identity, 47% coverage: 5:172/357 of query aligns to 212:383/658 of P97275

query
sites
P97275

P

P

T

T

E

C

V

H

S

D

H

D

L

V

I

V

E

K

T

I

V

V

L

N

H

L

A

A

R

C

K

K

T

Y

K

N

T

L

S

C

L

I

N

I

I
x
P

V
x
I

G
|
G

T
|
T

K
x
S

C

V

F

S

Y

Y

G

G

-

L

-

M

-

C

-

P

-

A

-

D

E

E

E

T

P

R

S

T

G

I

E

I

P

S

C

L

D

D

V

T

R

S

R

Q

L

M

S

N

G

R

I

I

C

L

S

W

Y

V

E

D

P

E

S

N

E

N

L

L

V

T

V

A

T

H

A

V

R

E

A

A

G

G

T

I

P

T

L

G

E

Q

E

E

L

L

E

E

A

R

V

Q

L

L

A

K

E

E

H

S

N

G

Q

Y

Y

C

L

T

A

G

F
x
H

E

E

P

P

P
x
D

R
x
S

F
x
L

A

-

K
x
E

G
x
F

S
|
S

T
|
T

V

V

G

G

A

W

V

I

A

S

A
x
T

G
x
R

L
x
A

S
|
S

G

G

P

M

A

K

R

K

V

N

G

I

V

Y

G

G

S

N

I

I

R

E

D

D

F

L

V

V

L

V

G

H

A

M

T

K

M

V

I

V

N

T

G

P

K

R

G

G

E

-

L

V

L

I

T

E

F

K

G

S

G

C

Q

Q

V

G

M

P

K

R

N

M

V

S

A

T

G

G

Y

P

D

D

V

I

S

H

R

H

L

F

L

I

A

M

G

G

S
|
S

M
x
E

G
|
G

I
x
T

L
|
L

G
|
G

V
|
V

I
|
I

C

T

E

E

V

A

S

T

L

I

K

K

V

I

L

R

P

P

234:240 (vs. 27:33, 57% identical) binding
H300 (≠ F87) mutation to A: Loss of activity.
303:309 (vs. 90:97, 25% identical) binding
T309 (= T97) mutation to I: Impaired FAD binding and protein stability. Loss of activity.
TRAS 316:319 (≠ AGLS 104:107) binding
S367 (= S156) mutation to A: Strongly reduced activity.
368:374 (vs. 157:163, 71% identical) binding

Sites not aligning to the query:

1:58 modified: transit peptide, Peroxisome
419 Important for enzyme activity; R→H: Loss of activity.; R→K: Strongly reduced activity.
469 L→P: Impaired FAD binding and protein stability. Loss of activity.
515 binding ; R→L: Impaired FAD binding and protein stability. Loss of activity.
576 C→A: No effect on activity.
578 active site, Proton donor/acceptor; Y→F: Loss of activity.
615 H→A: Loss of activity.
615:617 Important for enzyme activity
616 H→A: Loss of activity.
617 H→A: Loss of activity.
654:658 Important for enzyme activity

4bc9A Mammalian alkyldihydroxyacetonephosphate synthase: wild-type, adduct with cyanoethyl (see paper)
28% identity, 47% coverage: 5:172/357 of query aligns to 123:294/555 of 4bc9A

query
sites
4bc9A

P

P

T

T

E

C

V

H

S

D

H

D

L

V

I

V

E

K

T

I

V

V

L

N

H

L

A

A

R

C

K

K

T

Y

K

N

T

L

S

C

L

I

N

I

I
x
P

V
x
I

G
|
G

T
|
T

K
x
S

C
x
V

F

S

Y

Y

G
|
G

-
x
L

-

M

-

C

-

P

-

A

-

D

E

E

E

T

P

R

S

T

G

I

E

I

P

S

C

L

D

D

V

T

R

S

R

Q

L

M

S

N

G

R

I

I

C

L

S

W

Y

V

E

D

P

E

S

N

E

N

L

L

V

T

V

A

T

H

A

V

R

E

A

A

G

G

T

I

P

T

L

G

E

Q

E

E

L

L

E

E

A

R

V

Q

L

L

A

K

E

E

H

S

N

G

Q

Y

Y

C

L

T

A

G

F

H

E

E

P
|
P

P
x
D

R
x
S

F

L

A

-

K

E

G

F

S
|
S

T
|
T

V

V

G

G

G
|
G

A
x
W

V

I

A
x
S

A
x
T

G

R

L
x
A

S
|
S

G

G

P

M

A

K

R

K

V

N

G

I

V

Y

G

G

S

N

I

I

R

E

D

D

F

L

V

V

L

V

G

H

A

M

T

K

M

V

I

V

N

T

G

P

K

R

G

G

E

-

L

V

L

I

T

E

F

K

G

S

G

C

Q

Q

V

G

M

P

K

R

N

M

V

S

A

T

G

G

Y

P

D

D

V

I

S

H

R

H

L

F

L

I

A

M

G

G

S

S

M
x
E

G

G

I

T

L

L

G

G

V
|
V

I
|
I

C

T

E

E

V

A

S

T

L

I

K

K

V

I

L

R

P

P

binding propanenitrile: D214 (≠ P90)
binding flavin-adenine dinucleotide: P145 (≠ I27), I146 (≠ V28), G147 (= G29), G148 (= G30), G149 (= G31), T150 (= T32), S151 (≠ K33), V152 (≠ C34), G155 (= G37), L156 (vs. gap), P213 (= P89), D214 (≠ P90), S215 (≠ R91), S219 (= S96), T220 (= T97), G223 (= G100), W224 (≠ A101), S226 (≠ A103), T227 (≠ A104), A229 (≠ L106), S230 (= S107), E279 (≠ M157), V284 (= V162), I285 (= I163)

Sites not aligning to the query:

5ae1B Ether lipid-generating enzyme agps in complex with inhibitor zinc69435460 (see paper)
28% identity, 47% coverage: 5:172/357 of query aligns to 118:289/539 of 5ae1B

query
sites
5ae1B

P

P

T

T

E

C

V

H

S

D

H

D

L

V

I

V

E

K

T

I

V

V

L

N

H

L

A

A

R

C

K

K

T

Y

K

N

T

L

S

C

L

I

N

I

I
x
P

V
x
I

G
|
G

T
|
T

K
x
S

C

V

F

S

Y

Y

G
|
G

-
x
L

-

M

-

C

-

P

-

A

-

D

E

E

E

T

P

R

S

T

G

I

E

I

P

S

C

L

D

D

V

T

R

S

R

Q

L

M

S

N

G

R

I

I

C

L

S

W

Y

V

E

D

P

E

S

N

E

N

L

L

V

T

V

A

T

H

A

V

R

E

A

A

G

G

T

I

P

T

L

G

E

Q

E

E

L

L

E

E

A

R

V

Q

L

L

A

K

E

E

H

S

N

G

Q

Y

Y

C

L

T

A

G

F

H

E

E

P
|
P

P
x
D

R
x
S

F

L

A

-

K

E

G

F

S
|
S

T
|
T

V

V

G

G

G
|
G

A
x
W

V

I

A
x
S

A
x
T

G

R

L
x
A

S
|
S

G

G

P

M

A

K

R

K

V

N

G

I

V

Y

G

G

S

N

I

I

R

E

D

D

F

L

V

V

L

V

G

H

A

M

T

K

M

V

I

V

N

T

G

P

K

R

G

G

E

-

L

V

L

I

T

E

F

K

G

S

G

C

Q

Q

V

G

M

P

K

R

N

M

V

S

A

T

G

G

Y

P

D

D

V

I

S

H

R

H

L

F

L

I

A

M

G

G

S

S

M
x
E

G

G

I

T

L

L

G

G

V
|
V

I
|
I

C

T

E

E

V

A

S

T

L

I

K

K

V

I

L

R

P

P

binding flavin-adenine dinucleotide: P140 (≠ I27), I141 (≠ V28), G142 (= G29), G143 (= G30), G144 (= G31), T145 (= T32), S146 (≠ K33), G150 (= G37), L151 (vs. gap), P208 (= P89), D209 (≠ P90), S210 (≠ R91), S214 (= S96), T215 (= T97), G218 (= G100), W219 (≠ A101), S221 (≠ A103), T222 (≠ A104), A224 (≠ L106), S225 (= S107), E274 (≠ M157), V279 (= V162), I280 (= I163)

Sites not aligning to the query:

4bc9B Mammalian alkyldihydroxyacetonephosphate synthase: wild-type, adduct with cyanoethyl (see paper)
28% identity, 47% coverage: 5:172/357 of query aligns to 118:289/542 of 4bc9B

query
sites
4bc9B

P

P

T

T

E

C

V

H

S

D

H

D

L

V

I

V

E

K

T

I

V

V

L

N

H

L

A

A

R

C

K

K

T

Y

K

N

T

L

S

C

L

I

N

I

I
x
P

V

I

G
|
G

T
|
T

K
x
S

C
x
V

F

S

Y

Y

G
|
G

-
x
L

-

M

-

C

-

P

-

A

-

D

E

E

E

T

P

R

S

T

G

I

E

I

P

S

C

L

D

D

V

T

R

S

R

Q

L

M

S

N

G

R

I

I

C

L

S

W

Y

V

E

D

P

E

S

N

E

N

L

L

V

T

V

A

T

H

A

V

R

E

A

A

G

G

T

I

P

T

L

G

E

Q

E

E

L

L

E

E

A

R

V

Q

L

L

A

K

E

E

H

S

N

G

Q

Y

Y

C

L

T

A

G

F

H

E

E

P
|
P

P
x
D

R
x
S

F

L

A

-

K

E

G

F

S
|
S

T
|
T

V

V

G

G

G
|
G

A
x
W

V

I

A
x
S

A
x
T

G

R

L
x
A

S
|
S

G

G

P

M

A

K

R

K

V

N

G

I

V

Y

G

G

S

N

I

I

R

E

D

D

F

L

V

V

L

V

G

H

A

M

T

K

M

V

I

V

N

T

G

P

K

R

G

G

E

-

L

V

L

I

T

E

F

K

G

S

G

C

Q

Q

V

G

M

P

K

R

N

M

V

S

A

T

G

G

Y

P

D

D

V

I

S

H

R

H

L

F

L

I

A

M

G

G

S

S

M
x
E

G
|
G

I

T

L

L

G

G

V

V

I
|
I

C

T

E

E

V

A

S

T

L

I

K

K

V

I

L

R

P

P

binding propanenitrile: D209 (≠ P90)
binding flavin-adenine dinucleotide: P140 (≠ I27), G142 (= G29), G143 (= G30), G144 (= G31), T145 (= T32), S146 (≠ K33), V147 (≠ C34), G150 (= G37), L151 (vs. gap), P208 (= P89), D209 (≠ P90), S210 (≠ R91), S214 (= S96), T215 (= T97), G218 (= G100), W219 (≠ A101), S221 (≠ A103), T222 (≠ A104), A224 (≠ L106), S225 (= S107), E274 (≠ M157), G275 (= G158), I280 (= I163)

Sites not aligning to the query:

4bc7B Mammalian alkyldihydroxyacetonephosphate synthase: arg419his mutant (see paper)
28% identity, 47% coverage: 5:172/357 of query aligns to 118:289/543 of 4bc7B

query
sites
4bc7B

P

P

T

T

E

C

V

H

S

D

H

D

L

V

I

V

E

K

T

I

V

V

L

N

H

L

A

A

R

C

K

K

T

Y

K

N

T

L

S

C

L

I

N

I

I
x
P

V

I

G
|
G

T
|
T

K
x
S

C
x
V

F

S

Y

Y

G
|
G

-
x
L

-

M

-

C

-

P

-

A

-

D

E

E

E

T

P

R

S

T

G

I

E

I

P

S

C

L

D

D

V

T

R

S

R

Q

L

M

S

N

G

R

I

I

C

L

S

W

Y

V

E

D

P

E

S

N

E

N

L

L

V

T

V

A

T

H

A

V

R

E

A

A

G

G

T

I

P

T

L

G

E

Q

E

E

L

L

E

E

A

R

V

Q

L

L

A

K

E

E

H

S

N

G

Q

Y

Y

C

L

T

A

G

F

H

E

E

P
|
P

P
x
D

R
x
S

F

L

A

-

K

E

G

F

S
|
S

T
|
T

V

V

G

G

G
|
G

A

W

V

I

A
x
S

A
x
T

G

R

L
x
A

S
|
S

G

G

P

M

A

K

R

K

V

N

G

I

V

Y

G

G

S

N

I

I

R

E

D

D

F

L

V

V

L

V

G

H

A

M

T

K

M

V

I

V

N

T

G

P

K

R

G

G

E

-

L

V

L

I

T

E

F

K

G

S

G

C

Q

Q

V

G

M

P

K

R

N

M

V

S

A

T

G

G

Y

P

D

D

V

I

S

H

R

H

L

F

L

I

A

M

G

G

S

S

M
x
E

G
|
G

I

T

L

L

G

G

V

V

I
|
I

C

T

E

E

V

A

S

T

L

I

K

K

V

I

L

R

P

P

binding flavin-adenine dinucleotide: P140 (≠ I27), G142 (= G29), G143 (= G30), G144 (= G31), T145 (= T32), S146 (≠ K33), V147 (≠ C34), G150 (= G37), L151 (vs. gap), P208 (= P89), D209 (≠ P90), S210 (≠ R91), S214 (= S96), T215 (= T97), G218 (= G100), S221 (≠ A103), T222 (≠ A104), A224 (≠ L106), S225 (= S107), E274 (≠ M157), G275 (= G158), I280 (= I163)

Sites not aligning to the query:

5ae2B Ether lipid-generating enzyme agps in complex with inhibitor 1e (see paper)
28% identity, 47% coverage: 5:172/357 of query aligns to 118:289/542 of 5ae2B

query
sites
5ae2B

P

P

T

T

E

C

V

H

S

D

H

D

L

V

I

V

E

K

T

I

V

V

L

N

H

L

A

A

R

C

K

K

T

Y

K

N

T

L

S

C

L

I

N

I

I
x
P

V

I

G
|
G

T
|
T

K
x
S

C

V

F

S

Y

Y

G
|
G

-
x
L

-

M

-

C

-

P

-

A

-

D

E

E

E

T

P

R

S

T

G

I

E

I

P

S

C

L

D

D

V

T

R

S

R

Q

L

M

S

N

G

R

I

I

C

L

S

W

Y

V

E

D

P

E

S

N

E

N

L

L

V

T

V

A

T

H

A

V

R

E

A

A

G

G

T

I

P

T

L

G

E

Q

E

E

L

L

E

E

A

R

V

Q

L

L

A

K

E

E

H

S

N

G

Q

Y

Y

C

L

T

A

G

F

H

E

E

P
|
P

P
x
D

R
x
S

F

L

A

-

K

E

G

F

S
|
S

T
|
T

V

V

G

G

G
|
G

A
x
W

V

I

A
x
S

A
x
T

G

R

L
x
A

S
|
S

G

G

P

M

A

K

R

K

V

N

G

I

V

Y

G

G

S

N

I

I

R

E

D

D

F

L

V

V

L

V

G

H

A

M

T

K

M

V

I

V

N

T

G

P

K

R

G

G

E

-

L

V

L

I

T

E

F

K

G

S

G

C

Q

Q

V

G

M

P

K

R

N

M

V

S

A

T

G

G

Y

P

D

D

V

I

S

H

R

H

L

F

L

I

A

M

G

G

S

S

M
x
E

G
|
G

I

T

L

L

G

G

V
|
V

I
|
I

C

T

E

E

V

A

S

T

L

I

K

K

V

I

L

R

P

P

binding flavin-adenine dinucleotide: P140 (≠ I27), G142 (= G29), G143 (= G30), G144 (= G31), T145 (= T32), S146 (≠ K33), G150 (= G37), L151 (vs. gap), P208 (= P89), D209 (≠ P90), S210 (≠ R91), S214 (= S96), T215 (= T97), G218 (= G100), W219 (≠ A101), S221 (≠ A103), T222 (≠ A104), A224 (≠ L106), S225 (= S107), E274 (≠ M157), G275 (= G158), V279 (= V162), I280 (= I163)

Sites not aligning to the query:

5adzA Ether lipid-generating enzyme agps in complex with inhibitor 1a (see paper)
28% identity, 47% coverage: 5:172/357 of query aligns to 120:291/566 of 5adzA

query
sites
5adzA

P

P

T

T

E

C

V

H

S

D

H

D

L

V

I

V

E

K

T

I

V

V

L

N

H

L

A

A

R

C

K

K

T

Y

K

N

T

L

S

C

L

I

N

I

I
x
P

V
x
I

G
|
G

T
|
T

K
x
S

C

V

F

S

Y

Y

G
|
G

-

L

-

M

-

C

-

P

-

A

-

D

E

E

E

T

P

R

S

T

G

I

E

I

P

S

C

L

D

D

V

T

R

S

R

Q

L

M

S

N

G

R

I

I

C

L

S

W

Y

V

E

D

P

E

S

N

E

N

L

L

V

T

V

A

T

H

A

V

R

E

A

A

G

G

T

I

P

T

L

G

E

Q

E

E

L

L

E

E

A

R

V

Q

L

L

A

K

E

E

H

S

N

G

Q

Y

Y

C

L

T

A

G

F

H

E

E

P
|
P

P
x
D

R
x
S

F

L

A

-

K

E

G

F

S
|
S

T
|
T

V

V

G

G

G
|
G

A
x
W

V

I

A
x
S

A
x
T

G

R

L
x
A

S
|
S

G

G

P

M

A

K

R

K

V

N

G

I

V

Y

G

G

S

N

I

I

R

E

D

D

F

L

V

V

L

V

G

H

A

M

T

K

M

V

I

V

N

T

G

P

K

R

G

G

E

-

L

V

L

I

T

E

F

K

G

S

G

C

Q

Q

V

G

M

P

K

R

N

M

V

S

A

T

G

G

Y

P

D

D

V

I

S

H

R

H

L

F

L

I

A

M

G

G

S

S

M
x
E

G
|
G

I

T

L

L

G

G

V
|
V

I
|
I

C

T

E

E

V

A

S

T

L

I

K

K

V

I

L

R

P

P

binding flavin-adenine dinucleotide: P142 (≠ I27), I143 (≠ V28), G144 (= G29), G145 (= G30), G146 (= G31), T147 (= T32), S148 (≠ K33), G152 (= G37), P210 (= P89), D211 (≠ P90), S212 (≠ R91), S216 (= S96), T217 (= T97), G220 (= G100), W221 (≠ A101), S223 (≠ A103), T224 (≠ A104), A226 (≠ L106), S227 (= S107), E276 (≠ M157), G277 (= G158), V281 (= V162), I282 (= I163)
binding (3S)-3-(2-fluorophenyl)-N-((2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)methyl)butanamide): D211 (≠ P90)

Sites not aligning to the query:

Query Sequence

>RR42_RS29880 FitnessBrowser__Cup4G11:RR42_RS29880
MTTIPTEVSHLIETVLHARKTKTSLNIVGGGTKCFYGEEPSGEPCDVRRLSGICSYEPSE
LVVTARAGTPLEELEAVLAEHNQYLAFEPPRFAKGSTVGGAVAAGLSGPARVGVGSIRDF
VLGATMINGKGELLTFGGQVMKNVAGYDVSRLLAGSMGILGVICEVSLKVLPIHSSRITL
FIERDEAGALSLLNGLTRQALPVNASAWHDGKLFLRLSGAASAVTEARKRLGGTELEPDE
ALSWWDAVRDHRHDFFSQSDAPLWRVSVPAVSQPFLAANQLIEWGGALRWLYTDDPIEDV
REMASSLGGHATLFRDPHHRSGVFTPPSDALFEIHRNLKQAFDPDGIFNVGRLYPGL

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory