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Comparing RR42_RS32650 FitnessBrowser__Cup4G11:RR42_RS32650 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
4npiA 1.94 angstroms x-ray crystal structure of NAD- and intermediate- bound alpha-aminomuconate-epsilon-semialdehyde dehydrogenase from pseudomonas fluorescens (see paper)
59% identity, 100% coverage: 2:484/484 of query aligns to 1:483/483 of 4npiA
- active site: N152 (= N153), K175 (= K176), E251 (= E252), C285 (= C286), E387 (= E388), E464 (= E465)
- binding (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoic acid: R103 (= R104), L157 (= L158), W160 (= W161), E251 (= E252), C285 (= C286), Y445 (≠ F446), R447 (= R448), F453 (= F454)
- binding nicotinamide-adenine-dinucleotide: I148 (≠ V149), S149 (≠ C150), P150 (= P151), W151 (= W152), K175 (= K176), E178 (= E179), G208 (= G209), G213 (= G214), E214 (≠ A215), F227 (= F228), G229 (= G230), E230 (= E231), T233 (= T234), G253 (= G254), C285 (= C286), K335 (= K336), E387 (= E388), F389 (= F390)
4i2rA 2.15 angstroms x-ray crystal structure of NAD- and alternative substrate-bound 2-aminomuconate 6-semialdehyde dehydrogenase from pseudomonas fluorescens (see paper)
59% identity, 100% coverage: 2:484/484 of query aligns to 1:483/483 of 4i2rA
- active site: N152 (= N153), K175 (= K176), E251 (= E252), C285 (= C286), E387 (= E388), E464 (= E465)
- binding (2E,4E)-2-hydroxy-6-oxohexa-2,4-dienoic acid: R103 (= R104), L157 (= L158), C285 (= C286), Y445 (≠ F446), R447 (= R448), F453 (= F454)
- binding nicotinamide-adenine-dinucleotide: I148 (≠ V149), S149 (≠ C150), W151 (= W152), N152 (= N153), K175 (= K176), E178 (= E179), G208 (= G209), F227 (= F228), T228 (= T229), G229 (= G230), E230 (= E231), T233 (= T234), E251 (= E252), L252 (= L253), G253 (= G254), C285 (= C286), E387 (= E388), F389 (= F390)
4i25A 2.00 angstroms x-ray crystal structure of NAD- and substrate-bound 2- aminomuconate 6-semialdehyde dehydrogenase from pseudomonas fluorescens (see paper)
59% identity, 100% coverage: 2:484/484 of query aligns to 1:483/483 of 4i25A
- active site: N152 (= N153), K175 (= K176), E251 (= E252), C285 (= C286), E387 (= E388), E464 (= E465)
- binding (2E,4E)-2-amino-6-oxohexa-2,4-dienoic acid: R103 (= R104), L157 (= L158), C285 (= C286), Y445 (≠ F446), R447 (= R448), F453 (= F454)
- binding nicotinamide-adenine-dinucleotide: I148 (≠ V149), S149 (≠ C150), P150 (= P151), W151 (= W152), N152 (= N153), K175 (= K176), E178 (= E179), G208 (= G209), G213 (= G214), F227 (= F228), T228 (= T229), G229 (= G230), E230 (= E231), T233 (= T234), E251 (= E252), L252 (= L253), C285 (= C286), E387 (= E388), F389 (= F390)
5kllA Crystal structure of 2-hydroxymuconate-6-semialdehyde derived tautomeric intermediate in 2-aminomuconate 6-semialdehyde dehydrogenase n169d (see paper)
59% identity, 100% coverage: 2:484/484 of query aligns to 1:483/483 of 5kllA
- active site: D152 (≠ N153), K175 (= K176), E251 (= E252), C285 (= C286), E387 (= E388), E464 (= E465)
- binding (3~{E},5~{E})-6-oxidanyl-2-oxidanylidene-hexa-3,5-dienoic acid: R103 (= R104), D152 (≠ N153), L157 (= L158), W160 (= W161), C285 (= C286), Y445 (≠ F446), R447 (= R448), F453 (= F454)
5kj5B Crystal structure of 2-aminomuconate 6-semialdehyde dehydrogenase n169d in complex with NAD+ (see paper)
59% identity, 100% coverage: 2:484/484 of query aligns to 2:484/484 of 5kj5B
- active site: D153 (≠ N153), K176 (= K176), E252 (= E252), C286 (= C286), E388 (= E388), E465 (= E465)
- binding nicotinamide-adenine-dinucleotide: I149 (≠ V149), S150 (≠ C150), P151 (= P151), W152 (= W152), D153 (≠ N153), L158 (= L158), K176 (= K176), G209 (= G209), K210 (≠ P210), G214 (= G214), F228 (= F228), T229 (= T229), G230 (= G230), E231 (= E231), T234 (= T234), E252 (= E252), L253 (= L253), C286 (= C286), E388 (= E388), F390 (= F390), F454 (= F454)
4ou2A A 2.15 angstroms x-ray crystal structure of e268a 2-aminomuconate 6- semialdehyde dehydrogenase catalytic intermediate from pseudomonas fluorescens (see paper)
59% identity, 100% coverage: 2:484/484 of query aligns to 1:483/483 of 4ou2A
- active site: N152 (= N153), K175 (= K176), A251 (≠ E252), C285 (= C286), E387 (= E388), E464 (= E465)
- binding (2Z,4E)-2,6-dihydroxyhexa-2,4-dienoic acid: R103 (= R104), L157 (= L158), C285 (= C286), Y445 (≠ F446), R447 (= R448), F453 (= F454)
- binding nicotinamide-adenine-dinucleotide: I148 (≠ V149), S149 (≠ C150), P150 (= P151), W151 (= W152), N152 (= N153), K175 (= K176), G208 (= G209), G213 (= G214), E214 (≠ A215), F227 (= F228), T228 (= T229), G229 (= G230), E230 (= E231), T233 (= T234), A251 (≠ E252), L252 (= L253), G253 (= G254), C285 (= C286), E387 (= E388), F389 (= F390)
4u3wA X-ray crystal structure of 2-aminomuconate 6-semialdehyde dehydrogenase from burkholderia cenocepacia
60% identity, 99% coverage: 4:484/484 of query aligns to 4:484/485 of 4u3wA
Q9H2A2 2-aminomuconic semialdehyde dehydrogenase; Aldehyde dehydrogenase 12; Aldehyde dehydrogenase family 8 member A1; EC 1.2.1.32 from Homo sapiens (Human) (see paper)
41% identity, 99% coverage: 4:483/484 of query aligns to 10:486/487 of Q9H2A2
- R109 (= R104) mutation to A: About 65-fold loss of catalytic efficiency.
- N155 (= N153) mutation to A: Complete loss of activity.
- R451 (= R448) mutation to A: Complete loss of activity.
5gtlA NADPH complex structure of aldehyde dehydrogenase from bacillus cereus
40% identity, 100% coverage: 2:484/484 of query aligns to 15:490/491 of 5gtlA
- active site: N165 (= N153), K188 (= K176), E263 (= E252), C297 (= C286), E394 (= E388), E471 (= E465)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: I161 (≠ V149), P163 (= P151), K188 (= K176), A190 (≠ S178), E191 (= E179), Q192 (≠ E180), G221 (= G209), G225 (= G214), G241 (= G230), S242 (≠ E231), T245 (= T234), L264 (= L253), C297 (= C286), E394 (= E388), F396 (= F390)
5gtkA NAD+ complex structure of aldehyde dehydrogenase from bacillus cereus
40% identity, 100% coverage: 2:484/484 of query aligns to 15:490/491 of 5gtkA
- active site: N165 (= N153), K188 (= K176), E263 (= E252), C297 (= C286), E394 (= E388), E471 (= E465)
- binding nicotinamide-adenine-dinucleotide: I161 (≠ V149), I162 (≠ C150), P163 (= P151), W164 (= W152), K188 (= K176), E191 (= E179), G221 (= G209), G225 (= G214), A226 (= A215), F239 (= F228), G241 (= G230), S242 (≠ E231), T245 (= T234), Y248 (≠ A237), L264 (= L253), C297 (= C286), Q344 (≠ H333), R347 (≠ K336), E394 (= E388), F396 (= F390)
Q9HTJ1 NAD/NADP-dependent betaine aldehyde dehydrogenase; BADH; EC 1.2.1.8 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 2 papers)
41% identity, 100% coverage: 1:484/484 of query aligns to 4:483/490 of Q9HTJ1
- GAWN 150:153 (≠ CPWN 150:153) binding
- K162 (= K162) active site, Charge relay system
- KPSE 176:179 (= KPSE 176:179) binding
- G209 (= G209) binding
- GTST 230:233 (≠ ETRT 231:234) binding
- E252 (= E252) active site, Proton acceptor
- C286 (= C286) binding covalent; modified: Cysteine sulfenic acid (-SOH)
- E387 (= E388) binding
- E464 (= E465) active site, Charge relay system
4cazA Crystal structure of betaine aldehyde dehydrogenase from pseudomonas aeruginosa in complex with nadh
41% identity, 100% coverage: 1:484/484 of query aligns to 3:482/489 of 4cazA
- active site: N152 (= N153), K175 (= K176), E251 (= E252), C285 (= C286), E386 (= E388), E463 (= E465)
- binding [[(2R,3S,4R,5R)-5-[(3R)-3-aminocarbonyl-3,4-dihydro-2H-pyridin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanidyl-phosphoryl] [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl phosphate: I148 (≠ V149), G149 (≠ C150), W151 (= W152), N152 (= N153), K175 (= K176), E178 (= E179), G208 (= G209), G212 (= G214), F226 (= F228), T227 (= T229), G228 (= G230), G229 (≠ E231), T232 (= T234), V236 (≠ I238), E251 (= E252), L252 (= L253), C285 (= C286), E386 (= E388), F388 (= F390)
2woxA Betaine aldehyde dehydrogenase from pseudomonas aeruginosa with NAD(p) h-catalytic thiol adduct. (see paper)
41% identity, 100% coverage: 1:484/484 of query aligns to 3:482/489 of 2woxA
- active site: N152 (= N153), K175 (= K176), E251 (= E252), C285 (= C286), E386 (= E388), E463 (= E465)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: I148 (≠ V149), G149 (≠ C150), W151 (= W152), N152 (= N153), K175 (= K176), S177 (= S178), E178 (= E179), G208 (= G209), G212 (= G214), F226 (= F228), T227 (= T229), G228 (= G230), G229 (≠ E231), T232 (= T234), V236 (≠ I238), E251 (= E252), L252 (= L253), C285 (= C286), E386 (= E388), F388 (= F390)
2wmeA Crystallographic structure of betaine aldehyde dehydrogenase from pseudomonas aeruginosa (see paper)
41% identity, 100% coverage: 1:484/484 of query aligns to 3:482/489 of 2wmeA
- active site: N152 (= N153), K175 (= K176), E251 (= E252), C285 (= C286), E386 (= E388), E463 (= E465)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G149 (≠ C150), W151 (= W152), K175 (= K176), S177 (= S178), E178 (= E179), G208 (= G209), G212 (= G214), F226 (= F228), G228 (= G230), G229 (≠ E231), T232 (= T234), V236 (≠ I238)
4o6rA Crystal structure of a putative aldehyde dehydrogenase from burkholderia cenocepacia
41% identity, 99% coverage: 7:484/484 of query aligns to 7:479/489 of 4o6rA
- active site: N150 (= N153), K173 (= K176), E248 (= E252), C282 (= C286), E383 (= E388), E460 (= E465)
- binding adenosine monophosphate: I146 (≠ V149), V147 (≠ C150), K173 (= K176), G206 (= G209), G210 (= G214), Q211 (≠ A215), F224 (= F228), G226 (= G230), S227 (≠ E231), T230 (= T234), R233 (≠ A237)
2d4eC Crystal structure of the hpcc from thermus thermophilus hb8
39% identity, 99% coverage: 6:484/484 of query aligns to 29:505/515 of 2d4eC
- active site: N173 (= N153), K196 (= K176), E271 (= E252), C305 (= C286), E409 (= E388), E486 (= E465)
- binding nicotinamide-adenine-dinucleotide: I169 (≠ V149), T170 (≠ C150), P171 (= P151), W172 (= W152), K196 (= K176), A198 (≠ S178), G229 (= G209), G233 (= G214), A234 (= A215), T248 (= T229), G249 (= G230), E250 (= E231), T253 (= T234), E271 (= E252), L272 (= L253), C305 (= C286), E409 (= E388), F411 (= F390), F475 (= F454)
8skfA Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (lattice translocation disorder)
40% identity, 100% coverage: 1:484/484 of query aligns to 11:490/497 of 8skfA
- binding calcium ion: T33 (≠ D21), I34 (≠ R22), D100 (= D89), V187 (≠ E180)
- binding nicotinamide-adenine-dinucleotide: I156 (≠ V149), G157 (≠ C150), A158 (≠ P151), W159 (= W152), K183 (= K176), E186 (= E179), G216 (= G209), G220 (= G214), T235 (= T229), G236 (= G230), G237 (≠ E231), S240 (≠ T234), K243 (≠ A237), E259 (= E252), C293 (= C286), F396 (= F390)
8vr1A Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (ctp bound)
40% identity, 100% coverage: 1:484/484 of query aligns to 2:481/488 of 8vr1A
8vr0A Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (gmp bound)
40% identity, 100% coverage: 1:484/484 of query aligns to 2:481/488 of 8vr0A
8vqzA Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (cmp bound)
40% identity, 100% coverage: 1:484/484 of query aligns to 2:481/488 of 8vqzA
Query Sequence
>RR42_RS32650 FitnessBrowser__Cup4G11:RR42_RS32650
MKEFKNFINGEWVATNRRFDDRNPVDNSLIARVHEAGQAEVDAAVAAAKQALRGPWGKMT
VARRVEILHAVADGINRRFDDFLQAEIADTGKPHSLASHVDIPRGAANFKVFADLIKNVP
TESFAMATPDGGEAINYAVRSPRGVIGVVCPWNLPLLLMTWKVGPALACGNTVVVKPSEE
TPATATLLGEVMNEAGVPPGVYNVVHGFGPDSAGAFLTAHPDVNGITFTGETRTGEAIMK
AAANGVRPVSFELGGKNAGIVFADADFDKAVAGITRSAFENSGQVCLGTERVYVQRPIFA
RFVAALKARAEALRIGRPNDEGVNMGPLVSLEHRDKVLSYYRKAADAGATVVTGGGVPEM
PGALAEGAWVQPTIWTGLPEDAAVIREEIFGPCCHIAPFDTEEEAIRLANDTPYGLAATV
WTSDLGTAHRMGSALEVGICWINAWFLRDLRTAFGGAKQSGIGREGGVHSLEFYTELRNV
CVKL
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory