Comparing RR42_RS33965 FitnessBrowser__Cup4G11:RR42_RS33965 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
4kp1A Crystal structure of ipm isomerase large subunit from methanococcus jannaschii (mj0499) (see paper)
32% identity, 67% coverage: 203:640/653 of query aligns to 3:417/423 of 4kp1A
4nqyA The reduced form of mj0499 (see paper)
31% identity, 67% coverage: 203:640/653 of query aligns to 2:404/409 of 4nqyA
P19414 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
31% identity, 50% coverage: 315:640/653 of query aligns to 164:502/778 of P19414
Sites not aligning to the query:
P39533 Homocitrate dehydratase, mitochondrial; Aconitase 2; EC 4.2.1.- from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
31% identity, 52% coverage: 315:653/653 of query aligns to 165:519/789 of P39533
Sites not aligning to the query:
O14289 3-isopropylmalate dehydratase; Alpha-IPM isomerase; IPMI; Isopropylmalate isomerase; EC 4.2.1.33 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
31% identity, 49% coverage: 318:640/653 of query aligns to 117:472/758 of O14289
Sites not aligning to the query:
1b0kA S642a:fluorocitrate complex of aconitase (see paper)
29% identity, 50% coverage: 315:641/653 of query aligns to 140:478/753 of 1b0kA
Sites not aligning to the query:
5acnA Structure of activated aconitase. Formation of the (4fe-4s) cluster in the crystal (see paper)
29% identity, 50% coverage: 315:641/653 of query aligns to 141:479/754 of 5acnA
Sites not aligning to the query:
P16276 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Sus scrofa (Pig) (see 3 papers)
29% identity, 50% coverage: 315:641/653 of query aligns to 168:506/781 of P16276
Sites not aligning to the query:
8acnA Crystal structures of aconitase with isocitrate and nitroisocitrate bound (see paper)
29% identity, 50% coverage: 315:641/653 of query aligns to 140:478/753 of 8acnA
Sites not aligning to the query:
1fghA Complex with 4-hydroxy-trans-aconitate (see paper)
29% identity, 50% coverage: 315:641/653 of query aligns to 140:478/753 of 1fghA
Sites not aligning to the query:
1amjA Steric and conformational features of the aconitase mechanism (see paper)
29% identity, 50% coverage: 315:641/653 of query aligns to 140:478/753 of 1amjA
Sites not aligning to the query:
1amiA Steric and conformational features of the aconitase mechanism (see paper)
29% identity, 50% coverage: 315:641/653 of query aligns to 140:478/753 of 1amiA
Sites not aligning to the query:
1acoA Crystal structure of aconitase with transaconitate bound (see paper)
29% identity, 50% coverage: 315:641/653 of query aligns to 140:478/753 of 1acoA
Sites not aligning to the query:
1nisA Crystal structure of aconitase with trans-aconitate and nitrocitrate bound (see paper)
29% identity, 50% coverage: 315:641/653 of query aligns to 140:478/753 of 1nisA
Sites not aligning to the query:
P20004 Aconitate hydratase, mitochondrial; Aconitase; Citrate hydro-lyase; EC 4.2.1.3 from Bos taurus (Bovine) (see 2 papers)
29% identity, 50% coverage: 315:641/653 of query aligns to 168:506/780 of P20004
Sites not aligning to the query:
Q9SIB9 Aconitate hydratase 3, mitochondrial; Aconitase 3; mACO1; Citrate hydro-lyase 3; EC 4.2.1.3 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
25% identity, 50% coverage: 314:641/653 of query aligns to 266:663/990 of Q9SIB9
Sites not aligning to the query:
P21399 Cytoplasmic aconitate hydratase; Aconitase; Citrate hydro-lyase; Ferritin repressor protein; Iron regulatory protein 1; IRP1; Iron-responsive element-binding protein 1; IRE-BP 1; EC 4.2.1.3 from Homo sapiens (Human) (see 2 papers)
25% identity, 50% coverage: 314:640/653 of query aligns to 170:566/889 of P21399
Sites not aligning to the query:
2b3xA Structure of an orthorhombic crystal form of human cytosolic aconitase (irp1) (see paper)
25% identity, 50% coverage: 314:640/653 of query aligns to 169:565/888 of 2b3xA
Sites not aligning to the query:
P09339 Aconitate hydratase A; ACN; Aconitase; Aconitate/2-methylaconitate hydratase; Iron-responsive protein-like; IRP-like; RNA-binding protein; EC 4.2.1.3; EC 4.2.1.- from Bacillus subtilis (strain 168) (see 2 papers)
25% identity, 50% coverage: 314:641/653 of query aligns to 180:580/909 of P09339
Sites not aligning to the query:
P36683 Aconitate hydratase B; ACN; Aconitase; (2R,3S)-2-methylisocitrate dehydratase; (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase; 2-methyl-cis-aconitate hydratase; Iron-responsive protein-like; IRP-like; RNA-binding protein; EC 4.2.1.3; EC 4.2.1.99 from Escherichia coli (strain K12) (see 2 papers)
27% identity, 50% coverage: 296:621/653 of query aligns to 440:800/865 of P36683
Sites not aligning to the query:
>RR42_RS33965 FitnessBrowser__Cup4G11:RR42_RS33965
MEATIRFDGRVLYLSQDPACVRAQLDGKPMTRAEAGPLRDNISTDEITPVTIMLTYDERL
GQFPYVGFQAGGEQPIGRDAIRNGGFAVTVAGKRYGKGSSRESSPLAELSAGIRLIVAES
FERIYQQNCDNIGILTTTDFTVLDRVLAGEAIPIEAFLAGRDALTRQVIRAGGLLAYSRA
ASWPAAGEGAQATQATGSAAPRTLVEKIIARHLLPGTPSAECGQGVFVAADWRFSHDYFT
GMCAHLMHRAFGKPATLREPDHIIAFQDHLVLAAQSFPHVRDGLLPGVANLMQGHSSFAH
DYPVRSHNALPGDVPGSEGICHALMAEQYALPGQVVVGTDSHTPHSGALGCLAFGAGATD
VANSWVTGYVRCKVPETLRVEVEGELAPGVSAKDIVLYLLQMDAIRSGGAIGVVFEYAGS
TVRALSIDERATLTNMVAELGGFTGIVEPDDKTVAFLKARRGVDFAIEDWMRSDAGATYR
DVIRIDAAAIAPMVARPGDPGNGIAANTLAQPVPVDIAYGGSCTAGKREDFDYYHEVLRW
GLEHGLKVSPRTRLFLQFGTLGVKAYCEARGYMDTFAAAGATLVMPGCGSCANCGPGAST
TSEQVTISAINRNFPGRSGPGQVWLASPYTVAASALAGQISTFGQLQASCAAP
Or try a new SitesBLAST search
SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory