SitesBLAST
Comparing RR42_RS34925 FitnessBrowser__Cup4G11:RR42_RS34925 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
5x5uA Crystal structure of alpha-ketoglutarate-semialdehyde dehydrogenase (kgsadh) complexed with NAD (see paper)
51% identity, 99% coverage: 2:473/475 of query aligns to 2:473/476 of 5x5uA
- active site: N151 (= N151), K174 (= K174), E249 (= E249), C283 (= C283), E380 (= E380), E457 (= E457)
- binding glycerol: D15 (≠ K15), A16 (≠ G16), A17 (≠ G17), G19 (≠ R19)
- binding nicotinamide-adenine-dinucleotide: P149 (= P149), P207 (= P207), A208 (≠ G208), S211 (= S211), G227 (= G227), S228 (= S228), V231 (= V231), R329 (= R329), R330 (= R330), E380 (= E380), F382 (= F382)
5x5tA Crystal structure of alpha-ketoglutarate semialdehyde dehydrogenase (kgsadh) from azospirillum brasilense (see paper)
51% identity, 99% coverage: 2:473/475 of query aligns to 2:473/476 of 5x5tA
P25526 Succinate-semialdehyde dehydrogenase [NADP(+)] GabD; SSDH; Glutarate-semialdehyde dehydrogenase; EC 1.2.1.79; EC 1.2.1.- from Escherichia coli (strain K12) (see paper)
43% identity, 99% coverage: 1:472/475 of query aligns to 8:478/482 of P25526
3jz4A Crystal structure of e. Coli NADP dependent enzyme (see paper)
43% identity, 99% coverage: 1:472/475 of query aligns to 7:477/481 of 3jz4A
- active site: N156 (= N151), K179 (= K174), E254 (= E249), C288 (= C283), E385 (= E380), E462 (= E457)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: P154 (= P149), W155 (= W150), K179 (= K174), A181 (≠ P176), S182 (≠ E177), A212 (≠ P207), G216 (≠ S211), G232 (= G227), S233 (= S228), I236 (≠ V231), C288 (= C283), K338 (≠ S333), E385 (= E380), F387 (= F382)
8c54A Cryo-em structure of nadh bound sla dehydrogenase rlgabd from rhizobium leguminosarum bv. Trifolii srd1565
41% identity, 99% coverage: 3:472/475 of query aligns to 3:477/482 of 8c54A
- binding 1,4-dihydronicotinamide adenine dinucleotide: I152 (≠ F147), T153 (= T148), P154 (= P149), K179 (= K174), A212 (≠ P207), K213 (≠ G208), F230 (= F225), T231 (= T226), G232 (= G227), S233 (= S228), V236 (= V231), W239 (≠ Q234), G256 (= G251)
8skfA Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (lattice translocation disorder)
38% identity, 98% coverage: 7:472/475 of query aligns to 16:486/497 of 8skfA
- binding calcium ion: T33 (≠ V24), I34 (= I25), D100 (= D91), V187 (≠ D178)
- binding nicotinamide-adenine-dinucleotide: I156 (≠ F147), G157 (≠ T148), A158 (≠ P149), W159 (= W150), K183 (= K174), E186 (= E177), G216 (≠ P207), G220 (≠ S211), T235 (= T226), G236 (= G227), G237 (≠ S228), S240 (≠ V231), K243 (≠ Q234), E259 (= E249), C293 (= C283), F396 (= F382)
P51649 Succinate-semialdehyde dehydrogenase, mitochondrial; Aldehyde dehydrogenase family 5 member A1; NAD(+)-dependent succinic semialdehyde dehydrogenase; EC 1.2.1.24 from Homo sapiens (Human) (see 5 papers)
39% identity, 95% coverage: 24:473/475 of query aligns to 78:531/535 of P51649
- C93 (≠ A39) to F: in SSADHD; 3% of activity; dbSNP:rs765561257
- G176 (= G122) to R: in SSADHD; <1% of activity; dbSNP:rs72552281
- H180 (≠ P126) to Y: 83% of activity; dbSNP:rs2760118
- P182 (≠ R128) to L: 48% of activity; dbSNP:rs3765310
- R213 (= R159) binding ; mutation to A: Reduces catalytic activity to less than 15% of wild-type.
- C223 (= C169) to Y: in SSADHD; 5% of activity; dbSNP:rs72552282
- KPAE 228:231 (≠ KGPE 174:177) binding
- T233 (≠ S179) to M: in SSADHD; 4% of activity; dbSNP:rs1326526453
- A237 (≠ V183) to S: 65% of activity; dbSNP:rs62621664
- N255 (= N201) to S: in SSADHD; 17% of activity; dbSNP:rs145087265
- G268 (≠ S211) to E: in SSADHD; <1% of activity; dbSNP:rs375628463
- GSTTTG 284:289 (≠ GSVPVG 227:232) binding
- R334 (= R277) binding ; mutation to A: Reduces catalytic activity to less than 15% of wild-type.
- N335 (= N278) to K: in SSADHD; 1% of activity; dbSNP:rs72552283
- C340 (= C283) modified: Disulfide link with 342, In inhibited form
- C342 (≠ S285) modified: Disulfide link with 340, In inhibited form; mutation to A: Loss of regulation by redox state.
- N372 (≠ D314) natural variant: N -> S
- P382 (= P324) to L: in SSADHD; 2% of activity
- V406 (= V348) to I: in dbSNP:rs143741652
- G409 (= G351) to D: in SSADHD; <1% of activity; dbSNP:rs118203984
- S498 (≠ A440) binding ; mutation to A: Reduces catalytic activity to less than 15% of wild-type.
Sites not aligning to the query:
- 36 G → R: no effect on succinate-semialdehyde dehydrogenase activity; dbSNP:rs4646832
- 533 G → R: in SSADHD; <1% of activity; dbSNP:rs72552284
8vr1A Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (ctp bound)
38% identity, 98% coverage: 7:472/475 of query aligns to 7:477/488 of 8vr1A
8vr0A Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (gmp bound)
38% identity, 98% coverage: 7:472/475 of query aligns to 7:477/488 of 8vr0A
8vqzA Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (cmp bound)
38% identity, 98% coverage: 7:472/475 of query aligns to 7:477/488 of 8vqzA
8vqwC Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (coa bound)
38% identity, 98% coverage: 7:472/475 of query aligns to 7:477/488 of 8vqwC
- binding coenzyme a: I147 (≠ F147), W150 (= W150), K174 (= K174), S176 (≠ P176), E177 (= E177), G207 (≠ P207), G211 (≠ S211), F225 (= F225), G227 (= G227), G228 (≠ S228), S231 (≠ V231), H331 (≠ R330), F387 (= F382)
8vj3A Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (fad bound)
38% identity, 98% coverage: 7:472/475 of query aligns to 7:477/488 of 8vj3A
8uzoA Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (adp bound)
38% identity, 98% coverage: 7:472/475 of query aligns to 7:477/488 of 8uzoA
8uznA Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (amp bound)
38% identity, 98% coverage: 7:472/475 of query aligns to 7:477/488 of 8uznA
- binding adenosine monophosphate: I147 (≠ F147), G148 (≠ T148), K174 (= K174), S176 (≠ P176), E177 (= E177), G207 (≠ P207), G211 (≠ S211), F225 (= F225), G228 (≠ S228), S231 (≠ V231), K234 (≠ Q234)
8uzmA Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (NADPH bound)
38% identity, 98% coverage: 7:472/475 of query aligns to 7:477/488 of 8uzmA
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G148 (≠ T148), W150 (= W150), K174 (= K174), S176 (≠ P176), E177 (= E177), G207 (≠ P207), G211 (≠ S211), F225 (= F225), T226 (= T226), G227 (= G227), G228 (≠ S228), S231 (≠ V231), E250 (= E249), G252 (= G251), C284 (= C283), E385 (= E380), F387 (= F382)
8uzkA Crystal structure of betaine aldehyde dehydrogenase (betb) from klebsiella aerogenes (NADP+ bound)
38% identity, 98% coverage: 7:472/475 of query aligns to 7:477/488 of 8uzkA
- binding nadp nicotinamide-adenine-dinucleotide phosphate: I147 (≠ F147), G148 (≠ T148), W150 (= W150), N151 (= N151), K174 (= K174), S176 (≠ P176), E177 (= E177), G207 (≠ P207), G211 (≠ S211), F225 (= F225), G227 (= G227), G228 (≠ S228), S231 (≠ V231), E250 (= E249), F387 (= F382)
5gtlA NADPH complex structure of aldehyde dehydrogenase from bacillus cereus
35% identity, 99% coverage: 1:472/475 of query aligns to 13:486/491 of 5gtlA
- active site: N165 (= N151), K188 (= K174), E263 (= E249), C297 (= C283), E394 (= E380), E471 (= E457)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: I161 (≠ F147), P163 (= P149), K188 (= K174), A190 (≠ P176), E191 (= E177), Q192 (≠ D178), G221 (≠ P207), G225 (≠ S211), G241 (= G227), S242 (= S228), T245 (≠ V231), L264 (= L250), C297 (= C283), E394 (= E380), F396 (= F382)
5gtkA NAD+ complex structure of aldehyde dehydrogenase from bacillus cereus
35% identity, 99% coverage: 1:472/475 of query aligns to 13:486/491 of 5gtkA
- active site: N165 (= N151), K188 (= K174), E263 (= E249), C297 (= C283), E394 (= E380), E471 (= E457)
- binding nicotinamide-adenine-dinucleotide: I161 (≠ F147), I162 (≠ T148), P163 (= P149), W164 (= W150), K188 (= K174), E191 (= E177), G221 (≠ P207), G225 (≠ S211), A226 (≠ T212), F239 (= F225), G241 (= G227), S242 (= S228), T245 (≠ V231), Y248 (≠ Q234), L264 (= L250), C297 (= C283), Q344 (≠ R330), R347 (≠ S333), E394 (= E380), F396 (= F382)
4cazA Crystal structure of betaine aldehyde dehydrogenase from pseudomonas aeruginosa in complex with nadh
36% identity, 99% coverage: 2:472/475 of query aligns to 3:478/489 of 4cazA
- active site: N152 (= N151), K175 (= K174), E251 (= E249), C285 (= C283), E386 (= E380), E463 (= E457)
- binding [[(2R,3S,4R,5R)-5-[(3R)-3-aminocarbonyl-3,4-dihydro-2H-pyridin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanidyl-phosphoryl] [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl phosphate: I148 (≠ F147), G149 (≠ T148), W151 (= W150), N152 (= N151), K175 (= K174), E178 (= E177), G208 (≠ P207), G212 (≠ S211), F226 (= F225), T227 (= T226), G228 (= G227), G229 (≠ S228), T232 (≠ V231), V236 (vs. gap), E251 (= E249), L252 (= L250), C285 (= C283), E386 (= E380), F388 (= F382)
2woxA Betaine aldehyde dehydrogenase from pseudomonas aeruginosa with NAD(p) h-catalytic thiol adduct. (see paper)
36% identity, 99% coverage: 2:472/475 of query aligns to 3:478/489 of 2woxA
- active site: N152 (= N151), K175 (= K174), E251 (= E249), C285 (= C283), E386 (= E380), E463 (= E457)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: I148 (≠ F147), G149 (≠ T148), W151 (= W150), N152 (= N151), K175 (= K174), S177 (≠ P176), E178 (= E177), G208 (≠ P207), G212 (≠ S211), F226 (= F225), T227 (= T226), G228 (= G227), G229 (≠ S228), T232 (≠ V231), V236 (vs. gap), E251 (= E249), L252 (= L250), C285 (= C283), E386 (= E380), F388 (= F382)
Query Sequence
>RR42_RS34925 FitnessBrowser__Cup4G11:RR42_RS34925
MYQDLALYIDGEFVKGGDRREQDVINPATQELLGKLPHANRGDLDRALAAAQRAFESWKK
TSPLERSKILRRVAELTRERAKDIGRNITLDQGKPLAEAIGEVMICAEHAEWHAEECRRI
YGRVIPPRQPNVRQIVVREPIGVCAAFTPWNFPFNQAIRKMVSAIGAGCTLILKGPEDSP
SAVVALAQLFHDAGLPPGVLNIVWGVPGEISTYLIESPIVRKISFTGSVPVGKQLAALAG
AHMKRVTMELGGHSPVLVFDDADIEPAAEMLARFKLRNAGQVCVSPTRFYVQEKAYDKFL
ARFTEVIGSIKVGDGLDDGTQMGPLAHERRIASMEQFLDDANHRGGKVVAGGKRIGDKGF
FFAPTVVTDLPDDAKLMVDEPFGPVAPVTRFKDVEEVLRRANSLPFGLASYVFTNSLKTA
TVVSNGLEAGMVNINHFGMALAETPFGGIKDSGIGSEGGQETFDGYLVTKFITQV
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory