SitesBLAST
Comparing RR42_RS36650 FitnessBrowser__Cup4G11:RR42_RS36650 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
8sgrA Isovaleryl-CoA dehydrogenase, mitochondrial (see paper)
27% identity, 92% coverage: 6:350/375 of query aligns to 13:365/393 of 8sgrA
- binding flavin-adenine dinucleotide: S135 (≠ L126), G140 (≠ R131), S141 (≠ Y132), W165 (≠ L156), T167 (≠ W158), R279 (= R262), F282 (= F265), I286 (≠ L269), F289 (= F272), Q347 (= Q332), C348 (≠ L333), G351 (= G336)
Sites not aligning to the query:
1ivhA Structure of human isovaleryl-coa dehydrogenase at 2.6 angstroms resolution: structural basis for substrate specificity (see paper)
27% identity, 92% coverage: 6:350/375 of query aligns to 9:361/387 of 1ivhA
- active site: M130 (≠ Y125), S131 (≠ L126), E249 (≠ G236)
- binding coenzyme a persulfide: S137 (≠ Y132), S185 (= S175), R186 (≠ N176), V239 (≠ L226), Y240 (≠ P227), M243 (≠ L230), E249 (≠ G236), R250 (≠ I237)
- binding flavin-adenine dinucleotide: L128 (= L123), M130 (≠ Y125), S131 (≠ L126), G136 (≠ R131), S137 (≠ Y132), W161 (≠ L156), T163 (≠ W158), R275 (= R262), F278 (= F265), F285 (= F272), M288 (≠ L275), Q343 (= Q332), C344 (≠ L333), G347 (= G336)
Sites not aligning to the query:
P26440 Isovaleryl-CoA dehydrogenase, mitochondrial; IVD; Butyryl-CoA dehydrogenase; EC 1.3.8.4; EC 1.3.8.1 from Homo sapiens (Human) (see 5 papers)
27% identity, 92% coverage: 6:350/375 of query aligns to 46:398/426 of P26440
- 165:174 (vs. 123:132, 40% identical) binding
- S174 (≠ Y132) binding
- WIT 198:200 (≠ LAW 156:158) binding
- SR 222:223 (≠ SN 175:176) binding
- G250 (vs. gap) to A: in IVA; uncertain significance
- Y277 (≠ P227) binding
- DLER 284:287 (≠ DHGI 234:237) binding
- E286 (≠ G236) active site, Proton acceptor; mutation to D: Residual isovaleryl-CoA dehydrogenase activity.; mutation to G: Loss of isovaleryl-CoA dehydrogenase activity. Does not affect isovaleryl-CoA dehydrogenase activity; when associated with 407-E.; mutation to Q: Loss of isovaleryl-CoA dehydrogenase activity.
- A291 (≠ C241) to V: in IVA; uncertain significance; dbSNP:rs886042098
- R312 (= R262) binding
- Q323 (= Q273) binding
- I379 (≠ V331) to T: in IVA; uncertain significance
- QCFGG 380:384 (≠ QLHGG 332:336) binding
- R398 (≠ K350) to Q: in IVA; uncertain significance; dbSNP:rs1477527791
Sites not aligning to the query:
- 1:32 modified: transit peptide, Mitochondrion
- 403 Y → N: in IVA; uncertain significance
- 407 A→E: Does not affect isovaleryl-CoA dehydrogenase activity; when associated with 286-D.
- 407:408 binding
- 409:411 binding
4l1fA Electron transferring flavoprotein of acidaminococcus fermentans: towards a mechanism of flavin-based electron bifurcation (see paper)
29% identity, 91% coverage: 1:340/375 of query aligns to 1:344/380 of 4l1fA
- active site: L125 (≠ Y125), T126 (≠ L126), G242 (= G236)
- binding coenzyme a persulfide: T132 (≠ Y132), H179 (≠ N176), F232 (≠ L226), M236 (≠ L230), E237 (≠ H231), L239 (≠ I233), D240 (= D234), R243 (≠ I237)
- binding flavin-adenine dinucleotide: F123 (≠ L123), L125 (≠ Y125), T126 (≠ L126), G131 (≠ R131), T132 (≠ Y132), F156 (≠ L156), I157 (≠ A157), T158 (≠ W158), R268 (= R262), Q270 (= Q264), F271 (= F265), I275 (≠ L269), F278 (= F272), L281 (= L275), Q336 (= Q332), I337 (≠ L333), G340 (= G336)
- binding 1,3-propandiol: L5 (≠ Y5), Q10 (= Q10)
Sites not aligning to the query:
2pg0A Crystal structure of acyl-coa dehydrogenase from geobacillus kaustophilus
27% identity, 92% coverage: 7:352/375 of query aligns to 7:357/380 of 2pg0A
- active site: M124 (≠ Y125), T125 (≠ L126), E243 (≠ G236)
- binding flavin-adenine dinucleotide: I122 (≠ L123), M124 (≠ Y125), T125 (≠ L126), G130 (≠ R131), S131 (≠ Y132), F155 (≠ L156), I156 (≠ A157), T157 (≠ W158), R269 (= R262), F272 (= F265), F279 (= F272), Q337 (= Q332), L338 (= L333), G340 (= G335), G341 (= G336)
Sites not aligning to the query:
4n5fA Crystal structure of a putative acyl-coa dehydrogenase with bound fadh2 from burkholderia cenocepacia j2315
29% identity, 95% coverage: 1:355/375 of query aligns to 2:362/378 of 4n5fA
Sites not aligning to the query:
4x28D Crystal structure of the chse4-chse5 complex from mycobacterium tuberculosis (see paper)
29% identity, 100% coverage: 1:374/375 of query aligns to 1:360/364 of 4x28D
6wy8C Tcur3481-tcur3483 steroid acad (see paper)
31% identity, 100% coverage: 1:374/375 of query aligns to 1:359/364 of 6wy8C
8sgsA Short-chain specific acyl-CoA dehydrogenase, mitochondrial (see paper)
25% identity, 97% coverage: 7:368/375 of query aligns to 6:369/381 of 8sgsA
- binding coenzyme a: S131 (≠ Y132), A133 (≠ P134), N177 (≠ S175), F231 (≠ L226), M235 (≠ L230), L238 (≠ I233), I312 (≠ Q307), E362 (≠ L359), G363 (= G360)
- binding flavin-adenine dinucleotide: F122 (≠ L123), L124 (≠ Y125), S125 (≠ L126), G130 (≠ R131), S131 (≠ Y132), W155 (≠ L156), T157 (vs. gap), R267 (= R262), F270 (= F265), L274 (= L269), L277 (≠ F272), Q335 (= Q332), I336 (≠ L333), G338 (= G335), G339 (= G336), I357 (≠ M354), I360 (≠ P357), Y361 (≠ L358), T364 (≠ D361), E366 (≠ D363)
7y0bA Crystal structure of human short-chain acyl-coa dehydrogenase
25% identity, 97% coverage: 7:368/375 of query aligns to 9:372/385 of 7y0bA
- binding (2S,3R,4R,5S,6R)-2-[4-chloranyl-3-[[4-[(3S)-oxolan-3-yl]oxyphenyl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol: M343 (= M337), T347 (≠ D341), E348 (= E342)
- binding flavin-adenine dinucleotide: F125 (≠ L123), L127 (≠ Y125), S128 (≠ L126), G133 (≠ R131), S134 (≠ Y132), W158 (≠ L156), T160 (vs. gap), R270 (= R262), F273 (= F265), L280 (≠ F272), V282 (≠ A274), Q338 (= Q332), I339 (≠ L333), G342 (= G336), I360 (≠ M354), Y364 (≠ L358), T367 (≠ D361), E369 (≠ D363), I370 (≠ V366)
Sites not aligning to the query:
P16219 Short-chain specific acyl-CoA dehydrogenase, mitochondrial; SCAD; Butyryl-CoA dehydrogenase; EC 1.3.8.1 from Homo sapiens (Human) (see 3 papers)
25% identity, 97% coverage: 7:368/375 of query aligns to 36:399/412 of P16219
- G90 (= G63) to S: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs121908005
- E104 (= E77) natural variant: Missing (in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs387906308)
- 152:161 (vs. 123:132, 30% identical) binding in other chain
- R171 (≠ E142) to W: 69% of wild-type acyl-CoA dehydrogenase activity; confers susceptibility to ethylmalonicaciduria; dbSNP:rs1800556
- WIT 185:187 (≠ L-- 156) binding in other chain
- A192 (≠ G160) to V: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs28940874
- G209 (≠ E177) to S: 86% of wild-type acyl-CoA dehydrogenase activity; confers susceptibility to ethylmalonicaciduria; dbSNP:rs1799958
- R297 (= R262) binding
- Q308 (= Q273) binding in other chain
- R325 (≠ L290) to W: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs121908006
- S353 (≠ A320) to L: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs28941773
- QILGG 365:369 (≠ QLHGG 332:336) binding
- R380 (≠ D347) to W: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs28940875
- TSE 394:396 (≠ DSD 361:363) binding in other chain
Sites not aligning to the query:
- 1:24 modified: transit peptide, Mitochondrion
7y0aC Crystal structure of human short-chain acyl-coa dehydrogenase
25% identity, 97% coverage: 7:368/375 of query aligns to 12:375/387 of 7y0aC
- binding flavin-adenine dinucleotide: F128 (≠ L123), L130 (≠ Y125), S131 (≠ L126), G136 (≠ R131), S137 (≠ Y132), W161 (≠ L156), T163 (vs. gap), T214 (≠ A203), R273 (= R262), F276 (= F265), L280 (= L269), L283 (≠ F272), V285 (≠ A274), Q341 (= Q332), I342 (≠ L333), G345 (= G336), I363 (≠ M354), Y367 (≠ L358), T370 (≠ D361), E372 (≠ D363)
Sites not aligning to the query:
1jqiA Crystal structure of rat short chain acyl-coa dehydrogenase complexed with acetoacetyl-coa (see paper)
26% identity, 93% coverage: 7:355/375 of query aligns to 9:363/384 of 1jqiA
- binding acetoacetyl-coenzyme a: L95 (≠ A91), F125 (≠ L123), S134 (≠ Y132), F234 (≠ L226), M238 (≠ L230), Q239 (≠ H231), L241 (≠ I233), D242 (= D234), R245 (≠ I237)
- binding flavin-adenine dinucleotide: F125 (≠ L123), L127 (≠ Y125), S128 (≠ L126), G133 (≠ R131), S134 (≠ Y132), W158 (≠ L156), T160 (vs. gap), R270 (= R262), F273 (= F265), L280 (≠ F272), Q338 (= Q332), I339 (≠ L333), G342 (= G336), I360 (≠ L352)
Sites not aligning to the query:
P15651 Short-chain specific acyl-CoA dehydrogenase, mitochondrial; SCAD; Butyryl-CoA dehydrogenase; EC 1.3.8.1 from Rattus norvegicus (Rat) (see 2 papers)
25% identity, 97% coverage: 7:368/375 of query aligns to 36:399/412 of P15651
- 152:161 (vs. 123:132, 30% identical) binding
- S161 (≠ Y132) binding
- WIT 185:187 (≠ L-- 156) binding
- DMGR 269:272 (≠ DHGI 234:237) binding
- R297 (= R262) binding
- QILGG 365:369 (≠ QLHGG 332:336) binding
- E392 (≠ L359) active site, Proton acceptor
- TSE 394:396 (≠ DSD 361:363) binding
Sites not aligning to the query:
- 1:24 modified: transit peptide, Mitochondrion
I6Y3Q0 Acyl-CoA dehydrogenase FadE27; ACAD; 3-oxocholest-4-en-26-oyl-CoA dehydrogenase beta subunit; EC 1.3.99.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
28% identity, 100% coverage: 1:374/375 of query aligns to 1:369/373 of I6Y3Q0
- R251 (= R262) binding
- H327 (≠ Q332) binding
- G331 (= G336) binding
6es9A Methylsuccinyl-coa dehydrogenase of paracoccus denitrificans with bound flavin adenine dinucleotide (see paper)
29% identity, 86% coverage: 46:367/375 of query aligns to 201:537/545 of 6es9A
- active site: F281 (≠ Y125), T282 (≠ L126), A408 (≠ G236)
- binding coenzyme a: F467 (≠ V295), W470 (≠ Q298)
- binding flavin-adenine dinucleotide: A279 (≠ L123), F281 (≠ Y125), T282 (≠ L126), G287 (≠ R131), S288 (≠ Y132), W312 (≠ L156), I313 (≠ A157), T314 (≠ W158), E374 (≠ A203), R434 (= R262), Q436 (= Q264), F437 (= F265), L441 (= L269), F444 (= F272), Q502 (= Q332), I503 (≠ L333), G505 (= G335), G506 (= G336), F528 (≠ L358), A531 (≠ D361), E533 (≠ D363), I534 (≠ F364)
Sites not aligning to the query:
5ol2F The electron transferring flavoprotein/butyryl-coa dehydrogenase complex from clostridium difficile (see paper)
26% identity, 98% coverage: 1:368/375 of query aligns to 1:369/378 of 5ol2F
- active site: L124 (≠ Y125), T125 (≠ L126), G241 (= G236)
- binding calcium ion: E29 (vs. gap), E33 (≠ R29), R35 (≠ K31)
- binding coenzyme a persulfide: L238 (≠ I233), R242 (≠ I237), E362 (≠ L359), G363 (= G360)
- binding flavin-adenine dinucleotide: F122 (≠ L123), L124 (≠ Y125), T125 (≠ L126), P127 (= P128), T131 (≠ Y132), F155 (≠ L156), I156 (≠ A157), T157 (≠ W158), E198 (≠ P196), R267 (= R262), F270 (= F265), L274 (= L269), F277 (= F272), Q335 (= Q332), L336 (= L333), G338 (= G335), G339 (= G336), Y361 (≠ L358), T364 (≠ D361), E366 (≠ D363)
Sites not aligning to the query:
4ktoA Crystal structure of a putative isovaleryl-coa dehydrogenase (psi- nysgrc-012251) from sinorhizobium meliloti 1021
28% identity, 92% coverage: 1:346/375 of query aligns to 6:347/377 of 4ktoA
- active site: M130 (≠ Y125), S131 (≠ L126), E239 (≠ G236)
- binding flavin-adenine dinucleotide: L128 (= L123), M130 (≠ Y125), S131 (≠ L126), M155 (≠ S155), W156 (≠ L156), T158 (≠ W158), R265 (= R262), F268 (= F265), I272 (≠ L269), F275 (= F272), M278 (≠ L275), Q333 (= Q332), A334 (≠ L333), G337 (= G336)
Sites not aligning to the query:
2vigB Crystal structure of human short-chain acyl coa dehydrogenase
25% identity, 97% coverage: 7:368/375 of query aligns to 3:359/371 of 2vigB
- active site: L121 (≠ Y125), S122 (≠ L126), G231 (= G236), E352 (≠ L359)
- binding coenzyme a persulfide: S128 (≠ Y132), F221 (≠ L226), M225 (≠ L230), Q226 (≠ H231), L228 (≠ I233), D229 (= D234), R232 (≠ I237), E352 (≠ L359), G353 (= G360), I357 (≠ V366)
- binding flavin-adenine dinucleotide: L121 (≠ Y125), S122 (≠ L126), G127 (≠ R131), S128 (≠ Y132), W152 (≠ L156), T154 (vs. gap), R257 (= R262), F260 (= F265), L264 (= L269), L267 (≠ F272), Q325 (= Q332), I326 (≠ L333), G329 (= G336), I347 (≠ M354), Y351 (≠ L358), T354 (≠ D361), E356 (≠ D363)
Sites not aligning to the query:
2jifA Structure of human short-branched chain acyl-coa dehydrogenase (acadsb)
26% identity, 93% coverage: 4:350/375 of query aligns to 5:354/381 of 2jifA
- active site: L125 (≠ Y125), S126 (≠ L126), G242 (= G236)
- binding coenzyme a persulfide: S132 (≠ Y132), S134 (≠ P134), Y178 (≠ S175), Y232 (≠ L226), I236 (≠ L230), L239 (≠ I233), N240 (≠ D234), R243 (≠ I237)
- binding flavin-adenine dinucleotide: F123 (≠ L123), L125 (≠ Y125), S126 (≠ L126), G131 (≠ R131), S132 (≠ Y132), W156 (≠ L156), I157 (≠ A157), S158 (≠ W158), K201 (≠ M198), T209 (vs. gap), R268 (= R262), F271 (= F265), L275 (= L269), F278 (= F272), L281 (= L275), E336 (≠ Q332), W337 (≠ L333), G340 (= G336)
Sites not aligning to the query:
Query Sequence
>RR42_RS36650 FitnessBrowser__Cup4G11:RR42_RS36650
MDFNYSEEQQMLADSLRRFIDTEYTFDKRRKSARGGGSLNRATWAQLAEMGVLGLTVPGE
YGGFGESAASQLVVQRELGRGLVLEPVTPTAVMATAVLSAYGSDAQKNDWLPAIAAGERV
VTLAYLEPTTRYRPETARASAERKGDGYVLNGNKSLAWHGEAADAFLLTARVCGSNELAL
FLVPGNAAGLTVHGYPTMDSLRAADLALQNVIVDASAMIGNAADGLPALLHGIDHGIAAL
CAEAAGAMEKLIEITAEYLRTRQQFGKPLAVFQALQHRMADMLVQKELALSMAYVAAQAL
DETDPAQRRRMLSAAKVTVAKAGRLVGQQAVQLHGGMGMTDELEVGDYFKRLTMIDPLLG
DSDFHVQRYGEVMAA
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory