SitesBLAST
Comparing SM_b20402 SM_b20402 alcohol dehydrogenase cytochrome c subunit precursor to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 6 hits to proteins with known functional sites (download)
8gy3A Cryo-em structure of membrane-bound aldehyde dehydrogenase from gluconobacter oxydans
39% identity, 94% coverage: 6:437/462 of query aligns to 1:429/440 of 8gy3A
- binding heme c: Y52 (≠ N57), C53 (= C58), C56 (= C61), H57 (= H62), S84 (≠ T86), I86 (= I88), W97 (= W99), F102 (= F104), L117 (= L119), F121 (= F123), F126 (= F128), R163 (= R165), C203 (= C204), C206 (= C207), H207 (= H208), A232 (= A233), P233 (≠ Y234), L235 (≠ I236), W245 (= W246), Y253 (= Y254), L254 (= L255), G263 (= G264), S264 (≠ V265), M269 (= M270), Y292 (≠ V292), C337 (= C346), C340 (= C349), H341 (= H350), P353 (≠ L361), L355 (≠ F363), N358 (≠ S366), N359 (≠ T367), V372 (= V380), I377 (≠ L385), G382 (= G390), Q383 (≠ E391), I386 (≠ A394), M388 (= M396), F391 (= F399)
- binding ubiquinone-10: E55 (≠ A60), T76 (= T78), F78 (= F80), Y118 (= Y120), P119 (= P121), I160 (≠ L162), G166 (≠ L168), Q167 (≠ A169), F169 (vs. gap), W170 (= W171), H202 (= H203), R210 (= R211), L213 (≠ F214)
8jejC Cryo-em structure of na-dithionite reduced membrane-bound fructose dehydrogenase from gluconobacter japonicus
36% identity, 81% coverage: 46:419/462 of query aligns to 1:384/413 of 8jejC
- binding heme c: C13 (= C58), C16 (= C61), H17 (= H62), T42 (= T86), I44 (= I88), F60 (= F104), L64 (≠ M108), L75 (= L119), Y76 (= Y120), M79 (≠ F123), P80 (= P124), Y84 (≠ F128), R122 (= R165), C162 (= C204), C165 (= C207), H166 (= H208), I186 (≠ A228), W189 (= W231), A191 (= A233), P192 (≠ Y234), I194 (= I236), W205 (= W246), Y213 (= Y254), R223 (≠ V265), M228 (= M270), V303 (≠ A345), C304 (= C346), C307 (= C349), H308 (= H350), Y320 (≠ N362), P321 (≠ F363), L323 (= L365), T327 (= T367), T328 (≠ A368), D336 (≠ N376), I341 (≠ V381), V345 (≠ L385), R347 (≠ P387), I354 (≠ A394), M356 (= M396), F359 (= F399), I376 (≠ L411)
- binding ubiquinone-10: M36 (≠ F80), P77 (= P121), S124 (≠ L167), W128 (= W171), C165 (= C207), L173 (≠ G215)
Sites not aligning to the query:
7w2jC Cryo-em structure of membrane-bound fructose dehydrogenase from gluconobacter japonicus
36% identity, 81% coverage: 46:419/462 of query aligns to 1:370/418 of 7w2jC
- binding heme c: C13 (= C58), C16 (= C61), H17 (= H62), T42 (= T86), I44 (= I88), Y55 (≠ W99), L75 (= L119), Y76 (= Y120), A78 (= A122), M79 (≠ F123), R122 (= R165), H161 (= H203), C162 (= C204), C165 (= C207), H166 (= H208), A191 (= A233), P192 (≠ Y234), R223 (≠ V265), P227 (= P269), M228 (= M270), V289 (≠ A345), C290 (= C346), C293 (= C349), H294 (= H350), Y305 (≠ L361), Y306 (≠ N362), P307 (≠ F363), L309 (= L365), N312 (≠ S366), T313 (= T367), T314 (≠ A368), D322 (≠ N376), I327 (≠ V381), V331 (≠ L385), R333 (≠ P387), I340 (≠ A394), M342 (= M396), P343 (= P397), F345 (= F399)
Q47945 Alcohol dehydrogenase (quinone), cytochrome c subunit; ADH; Alcohol dehydrogenase (quinone), subunit II; Cytochrome c-553; Cytochrome c553; Ethanol:Q2 reductase; G3-ADH subunit II; Quinohemoprotein-cytochrome c complex; Ubiquinol oxidase; EC 1.1.5.5 from Gluconobacter oxydans (strain 621H) (Gluconobacter suboxydans) (see paper)
37% identity, 84% coverage: 36:424/462 of query aligns to 33:422/478 of Q47945
- Q37 (≠ R40) modified: Pyrrolidone carboxylic acid
Sites not aligning to the query:
8gy2B Cryo-em structure of membrane-bound alcohol dehydrogenase from gluconobacter oxydans
36% identity, 82% coverage: 45:424/462 of query aligns to 5:384/433 of 8gy2B
- binding heme c: C18 (= C58), C21 (= C61), H22 (= H62), T46 (= T86), I48 (= I88), Y59 (≠ W99), L68 (≠ M108), R73 (≠ D113), V79 (≠ L119), Y80 (= Y120), M83 (≠ F123), F88 (= F128), R126 (= R165), H165 (= H203), C166 (= C204), C169 (= C207), H170 (= H208), I201 (≠ Q232), A202 (= A233), P203 (≠ Y234), L205 (≠ I236), W216 (= W246), F224 (≠ Y254), A234 (≠ V265), V235 (≠ S266), F236 (≠ R267), F236 (≠ R267), M239 (= M270), N301 (≠ A345), C302 (= C346), C305 (= C349), H306 (= H350), M316 (≠ Q356), F317 (vs. gap), P318 (vs. gap), L320 (≠ F358), P324 (≠ T367), G342 (vs. gap), S352 (= S393), V354 (= V395), M356 (= M396), F359 (= F399), M375 (= M415)
- binding ubiquinone-10: C21 (= C61), L34 (= L74), P39 (= P79), P81 (= P121), L129 (= L168), W132 (= W171), E168 (≠ A206), R173 (= R211), I197 (vs. gap), D241 (≠ E272)
Sites not aligning to the query:
8hddB Complex structure of catalytic, small, and a partial electron transfer subunits from burkholderia cepacia fad glucose dehydrogenase
35% identity, 25% coverage: 316:431/462 of query aligns to 1:115/121 of 8hddB
- binding protoporphyrin ix containing fe: C30 (= C346), C33 (= C349), H34 (= H350), Y46 (≠ L361), P47 (vs. gap), T54 (≠ A368), V66 (= V380), I67 (≠ V381), R73 (≠ P387), I80 (≠ A394), M82 (= M396), P83 (= P397)
Query Sequence
>SM_b20402 SM_b20402 alcohol dehydrogenase cytochrome c subunit precursor
MRALRVAIGIAAVILVAAAAFFLFAWRSEIPEDTTAAEARFAAELVAKGAQLAALGNCIA
CHTVPGRPAFAGGLALPTPFGTIYSTNITPDRETGIGGWSEAAFERAMREGVDREGSHLY
PAFPYEHFTRVSADDNRALYAFLMTRVAVKAEALENDLPFPLKFRPLLAGWKLLFLDSGE
REPDPGQSDAWNRGRYLAEGLGHCGACHTPRNPFGAEDRDRHFGGGEAEGWQAYAINTES
KAPIPWDEQSLAFYLRNGWHEFHGVSRGPMAEVTGNLAFLPDSDIAAIATYVRSIMGAPT
PEREQRAAQLREAFEGQRPEQAADSQRSPVSASGSQPGEAIYLAACASCHEGGRRQPFGG
LNFELSTAVNAPNPQNIVNVVLFGLPPADGEASAVMPAFRHLLNDQQVADLLAYMRERFS
EEPPWAGLVEQTARTRSGTYKVAVRPSDGIERAPHHVGAEED
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory