Comparing SM_b20581 FitnessBrowser__Smeli:SM_b20581 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
Q88JU3 3-dehydroshikimate dehydratase; DSD; EC 4.2.1.118 from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see paper)
48% identity, 99% coverage: 1:620/629 of query aligns to 1:625/635 of Q88JU3
5hmqD Xylose isomerase-like tim barrel/4-hydroxyphenylpyruvate dioxygenase fusion protein
48% identity, 99% coverage: 1:620/629 of query aligns to 3:622/624 of 5hmqD
7xntA Crystal structure of pfhppd-y13161 complex
30% identity, 51% coverage: 287:609/629 of query aligns to 10:329/341 of 7xntA
Sites not aligning to the query:
1cjxA Crystal structure of pseudomonas fluorescens hppd (see paper)
30% identity, 51% coverage: 287:609/629 of query aligns to 7:333/352 of 1cjxA
Sites not aligning to the query:
7xntC Crystal structure of pfhppd-y13161 complex
29% identity, 51% coverage: 287:609/629 of query aligns to 9:313/320 of 7xntC
Sites not aligning to the query:
7x8eA Crystal structure of pfhppd-y13287 complex
30% identity, 51% coverage: 287:609/629 of query aligns to 9:325/341 of 7x8eA
Sites not aligning to the query:
7yvvA Acmp1, r-4-hydroxymandelate synthase
30% identity, 42% coverage: 356:619/629 of query aligns to 70:334/335 of 7yvvA
2r5vA Hydroxymandelate synthase crystal structure (see paper)
32% identity, 29% coverage: 429:609/629 of query aligns to 149:332/346 of 2r5vA
Sites not aligning to the query:
O52791 4-hydroxymandelate synthase; HMS; HmaS; 4-hydroxyphenylpyruvate dioxygenase II; EC 1.13.11.46 from Amycolatopsis orientalis (Nocardia orientalis) (see paper)
32% identity, 29% coverage: 429:609/629 of query aligns to 151:334/357 of O52791
1t47A Structure of fe2-hppd bound to ntbc (see paper)
28% identity, 40% coverage: 356:609/629 of query aligns to 81:348/362 of 1t47A
Sites not aligning to the query:
5ec3A Structural insight into the catalyitc mechanism of human 4- hydroxyphenylpyruvate dioxygenase
23% identity, 42% coverage: 356:622/629 of query aligns to 81:370/376 of 5ec3A
8im2A Crystal structure of human hppd complexed with ntbc (see paper)
23% identity, 42% coverage: 356:622/629 of query aligns to 83:372/374 of 8im2A
8im3A Crystal structure of human hppd complexed with compound a10 (see paper)
23% identity, 40% coverage: 356:609/629 of query aligns to 83:357/371 of 8im3A
Sites not aligning to the query:
3zgjB S221m v223f y359a mutant of 4-hydroxymandelate synthase from streptomyces coelicolor (see paper)
28% identity, 50% coverage: 295:609/629 of query aligns to 12:330/343 of 3zgjB
P32755 4-hydroxyphenylpyruvate dioxygenase; 4-hydroxyphenylpyruvic acid oxidase; 4HPPD; HPD; HPPDase; F Alloantigen; F protein; EC 1.13.11.27 from Rattus norvegicus (Rat) (see 2 papers)
23% identity, 42% coverage: 356:622/629 of query aligns to 89:378/393 of P32755
Sites not aligning to the query:
Q02110 4-hydroxyphenylpyruvate dioxygenase; 4-hydroxyphenylpyruvic acid oxidase; 4HPPD; HPD; HPPDase; EC 1.13.11.27 from Sus scrofa (Pig) (see paper)
24% identity, 43% coverage: 356:627/629 of query aligns to 89:390/393 of Q02110
Sites not aligning to the query:
1sqiA Structural basis for inhibitor selectivity revealed by crystal structures of plant and mammalian 4-hydroxyphenylpyruvate dioxygenases (see paper)
23% identity, 40% coverage: 356:609/629 of query aligns to 82:340/343 of 1sqiA
Sites not aligning to the query:
1sqiB Structural basis for inhibitor selectivity revealed by crystal structures of plant and mammalian 4-hydroxyphenylpyruvate dioxygenases (see paper)
23% identity, 40% coverage: 356:609/629 of query aligns to 83:339/342 of 1sqiB
Sites not aligning to the query:
1i6nA 1.8 a crystal structure of ioli protein with a binding zinc atom (see paper)
25% identity, 24% coverage: 113:262/629 of query aligns to 121:269/278 of 1i6nA
7x7lA Crystal structure of zmhppd-y13161 complex
28% identity, 39% coverage: 356:598/629 of query aligns to 95:343/364 of 7x7lA
Sites not aligning to the query:
>SM_b20581 FitnessBrowser__Smeli:SM_b20581
MKTSIATVSISGTLSEKLAAVAASGFDGVEIFENDFLTFDGSPAEVGRMVRDHGLEVTLF
QPFRDFEGLPEPHRSRAFDRAERKFDVMQELGTELMLVCSSVSPLALGGIDRAADDLREL
GERAARRGLRVGYEALAWGRHVNDHRDAWEIVRRADHPNIGLILDSFHTLSRNIDLRSIR
SIPGDRIFIVQLADAPRIEMDLLYLSRHFRNMPGEGDLPVVDFMQAVAATGYDGALSLEI
FNDQFRGGSPRAIAEDGHRSLVYLMDRVRRREPVAKGALAMPDRVEVLGVEFVEFTADRA
EAETLGSLLGTMGFHAVASHREKSVTLWRQGRDHGGVNIVINTEQQGFAHSSYLVHGASA
YAVGLKVPDASAAIERSRALGAEIFLPEANEGEGAMAAIRGIGGGLIYFLDEADDVWSRE
FVWSGATPQGASPLLAIDHVAQSMQAEELPSWLLFYTSILDADKLAEVDIVDPAGLIRSQ
VVENASGTLRLTLNGADNHRTLAGHFIAESFGSGVQHVAFRTDDIFAAADHMLRSGFRPL
AISRNYYDDIEVRFGLEPDFVDRLRDESILYDRDEDGEYFQIYGPTYGEGFFFEIVERRA
GYRGYGAANAPFRIAAQKRSLRPAGMPAL
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory