SitesBLAST
Comparing SM_b21143 FitnessBrowser__Smeli:SM_b21143 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
6kgyB Hocl-induced flavoprotein disulfide reductase rcla from escherichia coli (see paper)
38% identity, 96% coverage: 17:468/473 of query aligns to 1:438/441 of 6kgyB
- active site: C43 (= C58), C48 (= C63), T51 (= T66), Y168 (= Y195), E172 (= E199), H426 (= H456), E431 (= E461)
- binding flavin-adenine dinucleotide: I9 (= I26), G12 (= G29), E33 (= E50), Q34 (≠ R51), M38 (≠ L53), G41 (= G56), T42 (= T57), G47 (= G62), C48 (= C63), A99 (= A131), N126 (= N154), T127 (≠ V155), G128 (= G156), G291 (= G322), D292 (= D323), F299 (= F330), T300 (= T331), Y301 (≠ H332), S303 (= S334), F333 (≠ Y363)
6kyyA Cu(ii) complex of hocl-induced flavoprotein disulfide reductase rcla from escherichia coli (see paper)
38% identity, 94% coverage: 23:468/473 of query aligns to 2:429/432 of 6kyyA
- active site: C39 (= C58), C44 (= C63), T47 (= T66), Y159 (= Y195), E163 (= E199), H417 (= H456), E422 (= E461)
- binding copper (ii) ion: C39 (= C58), C44 (= C63), H226 (≠ G262), H229 (≠ E269), T291 (= T331)
- binding flavin-adenine dinucleotide: F7 (≠ A28), G8 (= G29), E29 (= E50), Q30 (≠ R51), M34 (≠ L53), T38 (= T57), C39 (= C58), C44 (= C63), K48 (= K67), A95 (= A131), N117 (= N154), T118 (≠ V155), G119 (= G156), I160 (= I196), R243 (= R283), D283 (= D323), F290 (= F330), T291 (= T331), S294 (= S334)
8ajjA Crystal structure of the disulfide reductase mera from staphylococcus aureus (see paper)
33% identity, 95% coverage: 21:468/473 of query aligns to 2:437/442 of 8ajjA
- binding flavin-adenine dinucleotide: G10 (= G29), E31 (= E50), Q32 (≠ R51), M36 (≠ L53), G39 (= G56), T40 (= T57), C41 (= C58), C46 (= C63), K50 (= K67), A97 (= A131), N126 (= N154), T127 (≠ V155), G128 (= G156), I169 (= I196), N255 (= N286), G290 (= G322), D291 (= D323), Q297 (≠ A329), F298 (= F330), T299 (= T331), Y300 (≠ H332), S302 (= S334)
- binding histidine: D353 (vs. gap), Y354 (vs. gap)
Sites not aligning to the query:
8ajkB Crystal structure of a c43s variant from the disulfide reductase mera from staphylococcus aureus (see paper)
33% identity, 95% coverage: 19:468/473 of query aligns to 3:440/447 of 8ajkB
- binding flavin-adenine dinucleotide: G11 (= G27), G13 (= G29), E34 (= E50), Q35 (≠ R51), M39 (≠ L53), G42 (= G56), T43 (= T57), G48 (= G62), C49 (= C63), K53 (= K67), K99 (≠ H130), A100 (= A131), N129 (= N154), T130 (≠ V155), G131 (= G156), G293 (= G322), D294 (= D323), Q300 (≠ A329), F301 (= F330), T302 (= T331), Y303 (≠ H332), S305 (= S334)
P16171 Mercuric reductase; Hg(II) reductase; EC 1.16.1.1 from Bacillus cereus (see paper)
30% identity, 90% coverage: 18:442/473 of query aligns to 167:584/631 of P16171
- Y264 (≠ W117) mutation to F: 30-fold decrease in activity. 300-fold decrease in activity; when associated with F-605.
Sites not aligning to the query:
- 605 Y→F: 10-fold decrease in activity. 300-fold decrease in activity; when associated with F-264.; Y→H: 2-fold decrease in activity.
2eq6A Crystal structure of lipoamide dehydrogenase from thermus thermophilus hb8
33% identity, 94% coverage: 19:461/473 of query aligns to 2:442/460 of 2eq6A
- active site: V37 (≠ F54), C41 (= C58), C46 (= C63), T49 (= T66), A176 (≠ Y195), E180 (= E199), H435 (= H454), H437 (= H456), E442 (= E461)
- binding flavin-adenine dinucleotide: I9 (= I26), G10 (= G27), G12 (= G29), P13 (≠ Q30), G14 (≠ A31), E33 (= E50), A34 (≠ R51), G39 (= G56), V40 (≠ T57), C41 (= C58), G45 (= G62), C46 (= C63), K50 (= K67), F111 (≠ H130), A112 (= A131), A135 (≠ N154), T136 (≠ V155), G137 (= G156), S155 (≠ T174), R269 (≠ N286), D306 (= D323), L312 (≠ A329), L313 (≠ F330), A314 (≠ T331), H315 (= H332), Y344 (= Y363)
Sites not aligning to the query:
6uziC Crystal structure of dihydrolipoyl dehydrogenase from elizabethkingia anophelis nuhp1
31% identity, 95% coverage: 17:463/473 of query aligns to 4:455/470 of 6uziC
- active site: C45 (= C58), C50 (= C63), S53 (≠ T66), V187 (≠ Y195), E191 (= E199), H448 (= H456), E453 (= E461)
- binding flavin-adenine dinucleotide: I12 (= I26), G13 (= G27), G15 (= G29), P16 (≠ Q30), G17 (≠ A31), E36 (≠ I49), K37 (≠ E50), G43 (= G56), T44 (= T57), C45 (= C58), G49 (= G62), C50 (= C63), S53 (≠ T66), K54 (= K67), V117 (≠ H130), G118 (≠ A131), T147 (≠ V155), G148 (= G156), I188 (= I196), R276 (= R283), D316 (= D323), M322 (≠ A329), L323 (≠ F330), A324 (≠ T331)
- binding zinc ion: H448 (= H456), E453 (= E461)
1ebdA Dihydrolipoamide dehydrogenase complexed with the binding domain of the dihydrolipoamide acetylase (see paper)
31% identity, 93% coverage: 22:462/473 of query aligns to 5:446/455 of 1ebdA
- active site: P13 (≠ Q30), L37 (≠ F54), C41 (= C58), C46 (= C63), S49 (≠ T66), N74 (≠ P91), V75 (= V92), Y180 (= Y195), E184 (= E199), S320 (≠ Y335), H438 (= H454), H440 (= H456), E445 (= E461)
- binding flavin-adenine dinucleotide: G10 (= G27), G12 (= G29), P13 (≠ Q30), V32 (≠ I49), E33 (= E50), K34 (≠ R51), G39 (= G56), V40 (≠ T57), C41 (= C58), G45 (= G62), C46 (= C63), K50 (= K67), E112 (≠ H130), A113 (= A131), T141 (≠ V155), G142 (= G156), Y180 (= Y195), I181 (= I196), R268 (= R283), D308 (= D323), A314 (= A329), L315 (≠ F330), A316 (≠ T331)
P11959 Dihydrolipoyl dehydrogenase; Dihydrolipoamide dehydrogenase; E3 component of pyruvate complex; EC 1.8.1.4 from Geobacillus stearothermophilus (Bacillus stearothermophilus) (see paper)
31% identity, 93% coverage: 22:462/473 of query aligns to 11:452/470 of P11959
- 39:47 (vs. 50:58, 44% identical) binding
- K56 (= K67) binding
- D314 (= D323) binding
- A322 (≠ T331) binding
5x1yB Structure of mercuric reductase from lysinibacillus sphaericus (see paper)
29% identity, 95% coverage: 20:466/473 of query aligns to 3:436/454 of 5x1yB
- active site: A13 (≠ Q30), V37 (≠ F54), C41 (= C58), C46 (= C63), S49 (≠ T66), A74 (≠ P91), G75 (≠ V92), Y178 (= Y195), E182 (= E199), A318 (≠ Y335)
- binding flavin-adenine dinucleotide: I9 (= I26), G12 (= G29), I32 (= I49), E33 (= E50), R34 (= R51), G39 (= G56), T40 (= T57), C41 (= C58), G45 (= G62), C46 (= C63), K50 (= K67), A114 (= A131), T138 (≠ V155), G139 (= G156), Y178 (= Y195), R266 (= R283), G305 (= G322), D306 (= D323), F313 (= F330), V314 (≠ T331), A317 (≠ S334)
Sites not aligning to the query:
D9J041 Mercuric reductase; Hg(II) reductase; EC 1.16.1.1 from Lysinibacillus sphaericus (Bacillus sphaericus) (see paper)
29% identity, 96% coverage: 15:466/473 of query aligns to 79:517/546 of D9J041
- C122 (= C58) modified: Disulfide link with 127, Redox-active
- C127 (= C63) modified: Disulfide link with 122, Redox-active
2yquB Crystal structures and evolutionary relationship of two different lipoamide dehydrogenase(e3s) from thermus thermophilus
34% identity, 94% coverage: 21:463/473 of query aligns to 2:441/455 of 2yquB
- active site: P11 (≠ Q30), L36 (≠ F54), C40 (= C58), C45 (= C63), S48 (≠ T66), G72 (≠ P91), V73 (= V92), V177 (≠ Y195), E181 (= E199), S314 (≠ N336), H432 (= H454), H434 (= H456), E439 (= E461)
- binding carbonate ion: A310 (≠ H332), S314 (≠ N336), S423 (≠ P445), D426 (≠ M448)
- binding flavin-adenine dinucleotide: G8 (= G27), G10 (= G29), P11 (≠ Q30), G12 (≠ A31), E31 (= E50), K32 (≠ R51), G38 (= G56), T39 (= T57), C40 (= C58), R42 (≠ N60), G44 (= G62), C45 (= C63), K49 (= K67), T110 (≠ H130), A111 (= A131), T137 (≠ V155), G138 (= G156), I178 (= I196), Y265 (≠ N286), G301 (= G322), D302 (= D323), M308 (≠ F330), L309 (≠ T331), A310 (≠ H332), H311 (≠ T333)
2yquA Crystal structures and evolutionary relationship of two different lipoamide dehydrogenase(e3s) from thermus thermophilus
34% identity, 94% coverage: 21:463/473 of query aligns to 2:441/455 of 2yquA
- active site: P11 (≠ Q30), L36 (≠ F54), C40 (= C58), C45 (= C63), S48 (≠ T66), G72 (≠ P91), V73 (= V92), V177 (≠ Y195), E181 (= E199), S314 (≠ N336), H432 (= H454), H434 (= H456), E439 (= E461)
- binding flavin-adenine dinucleotide: G8 (= G27), G10 (= G29), P11 (≠ Q30), G12 (≠ A31), E31 (= E50), K32 (≠ R51), G38 (= G56), T39 (= T57), C40 (= C58), R42 (≠ N60), G44 (= G62), C45 (= C63), K49 (= K67), T110 (≠ H130), A111 (= A131), T137 (≠ V155), G138 (= G156), S157 (≠ N175), I178 (= I196), Y265 (≠ N286), G301 (= G322), D302 (= D323), M308 (≠ F330), L309 (≠ T331), A310 (≠ H332)
2eq7A Crystal structure of lipoamide dehydrogenase from thermus thermophilus hb8 with psbdo
33% identity, 94% coverage: 21:463/473 of query aligns to 2:441/452 of 2eq7A
- active site: P11 (≠ Q30), L36 (≠ F54), C40 (= C58), C45 (= C63), S48 (≠ T66), G72 (≠ P91), V73 (= V92), V177 (≠ Y195), E181 (= E199), S314 (≠ N336), H432 (= H454), H434 (= H456), E439 (= E461)
- binding flavin-adenine dinucleotide: G10 (= G29), P11 (≠ Q30), G12 (≠ A31), E31 (= E50), K32 (≠ R51), G38 (= G56), T39 (= T57), C40 (= C58), R42 (≠ N60), G44 (= G62), C45 (= C63), K49 (= K67), T110 (≠ H130), A111 (= A131), T137 (≠ V155), G138 (= G156), S157 (≠ N175), I178 (= I196), R262 (= R283), Y265 (≠ N286), D302 (= D323), M308 (≠ F330), L309 (≠ T331), A310 (≠ H332), H311 (≠ T333), Y341 (= Y363)
- binding nicotinamide-adenine-dinucleotide: W146 (≠ L164), G174 (= G192), G176 (≠ S194), V177 (≠ Y195), I178 (= I196), E197 (= E215), Y198 (≠ K216), V231 (≠ C249), V260 (≠ T281), G261 (= G282), R262 (= R283), M308 (≠ F330), L309 (≠ T331), V339 (≠ A361)
P18925 Dihydrolipoyl dehydrogenase; Dihydrolipoamide dehydrogenase; E3 component of pyruvate complex; EC 1.8.1.4 from Azotobacter vinelandii (see 2 papers)
30% identity, 95% coverage: 17:463/473 of query aligns to 1:458/477 of P18925
- 34:49 (vs. 50:58, 31% identical) binding
- C49 (= C58) modified: Disulfide link with 54, Redox-active
- C54 (= C63) modified: Disulfide link with 49, Redox-active
- K58 (= K67) binding
- D319 (= D323) binding
- A327 (≠ H332) binding
5u8uD Dihydrolipoamide dehydrogenase (lpdg) from pseudomonas aeruginosa (see paper)
30% identity, 95% coverage: 17:463/473 of query aligns to 3:460/477 of 5u8uD
- active site: P16 (≠ Q30), L47 (≠ F54), C51 (= C58), C56 (= C63), S59 (≠ T66), G85 (≠ P91), V86 (= V92), V193 (≠ Y195), E197 (= E199), S333 (≠ Y335), F451 (≠ H454), H453 (= H456), E458 (= E461)
- binding flavin-adenine dinucleotide: I12 (= I26), G15 (= G29), P16 (≠ Q30), G17 (≠ A31), E36 (= E50), K37 (≠ R51), G49 (= G56), T50 (= T57), C51 (= C58), G55 (= G62), C56 (= C63), K60 (= K67), H123 (= H130), G124 (≠ A131), A152 (≠ N154), S153 (≠ V155), G154 (= G156), I194 (= I196), R281 (= R283), G320 (= G322), D321 (= D323), M327 (≠ A329), L328 (≠ F330), A329 (≠ T331), H330 (= H332), H453 (= H456), P454 (= P457)
Sites not aligning to the query:
P14218 Dihydrolipoyl dehydrogenase; Dihydrolipoamide dehydrogenase; E3 component of 2-oxoglutarate dehydrogenase complex; EC 1.8.1.4 from Pseudomonas fluorescens (see 2 papers)
29% identity, 95% coverage: 17:463/473 of query aligns to 1:458/478 of P14218
- M1 (= M17) modified: Initiator methionine, Removed
- 34:49 (vs. 50:58, 31% identical) binding
- C49 (= C58) modified: Disulfide link with 54, Redox-active
- C54 (= C63) modified: Disulfide link with 49, Redox-active
- K58 (= K67) binding
- G122 (≠ A131) binding
- D319 (= D323) binding
- A327 (≠ T331) binding
3urhB Crystal structure of a dihydrolipoamide dehydrogenase from sinorhizobium meliloti 1021
30% identity, 94% coverage: 21:463/473 of query aligns to 1:452/465 of 3urhB
- active site: Y35 (≠ F54), C39 (= C58), C44 (= C63), S47 (≠ T66), V183 (≠ Y195), E187 (= E199), H443 (= H454), H445 (= H456), E450 (= E461)
- binding flavin-adenine dinucleotide: I6 (= I26), G7 (= G27), G9 (= G29), P10 (≠ Q30), G11 (≠ A31), E30 (= E50), K31 (vs. gap), G37 (= G56), T38 (= T57), C39 (= C58), G43 (= G62), C44 (= C63), K48 (= K67), T111 (≠ H130), G112 (≠ A131), A140 (≠ N154), T141 (≠ V155), G142 (= G156), I184 (= I196), R273 (= R283), G312 (= G322), D313 (= D323), M319 (≠ F330), L320 (≠ T331), A321 (≠ H332), H322 (≠ T333)
3ladA Refined crystal structure of lipoamide dehydrogenase from azotobacter vinelandii at 2.2 angstroms resolution. A comparison with the structure of glutathione reductase (see paper)
30% identity, 94% coverage: 18:463/473 of query aligns to 1:457/472 of 3ladA
- active site: L44 (≠ F54), C48 (= C58), C53 (= C63), S56 (≠ T66), V190 (≠ Y195), E194 (= E199), F448 (≠ H454), H450 (= H456), E455 (= E461)
- binding flavin-adenine dinucleotide: I9 (= I26), G10 (= G27), G12 (= G29), P13 (≠ Q30), E33 (= E50), K34 (≠ R51), G46 (= G56), T47 (= T57), C48 (= C58), G52 (= G62), C53 (= C63), H120 (= H130), G121 (≠ A131), A149 (≠ N154), S150 (≠ V155), G151 (= G156), I191 (= I196), R278 (= R283), D318 (= D323), L325 (≠ T331), A326 (≠ H332)
5u8wA Dihydrolipoamide dehydrogenase (lpdg) from pseudomonas aeruginosa bound to nadh (see paper)
29% identity, 94% coverage: 18:463/473 of query aligns to 1:457/473 of 5u8wA
- active site: P13 (≠ Q30), L44 (≠ F54), C48 (= C58), C53 (= C63), S56 (≠ T66), G82 (≠ P91), V83 (= V92), V190 (≠ Y195), E194 (= E199), S330 (≠ Y335), F448 (≠ H454), H450 (= H456), E455 (= E461)
- binding flavin-adenine dinucleotide: I9 (= I26), G12 (= G29), P13 (≠ Q30), G14 (≠ A31), E33 (= E50), K34 (≠ R51), G46 (= G56), T47 (= T57), C48 (= C58), G52 (= G62), C53 (= C63), K57 (= K67), H120 (= H130), G121 (≠ A131), A149 (≠ N154), S150 (≠ V155), G151 (= G156), S170 (≠ N175), G317 (= G322), D318 (= D323), M324 (≠ A329), L325 (≠ F330), A326 (≠ T331), H327 (= H332), Y357 (= Y363), H450 (= H456), P451 (= P457)
- binding 1,4-dihydronicotinamide adenine dinucleotide: I186 (≠ V191), G189 (≠ S194), V190 (≠ Y195), I191 (= I196), E194 (= E199), E210 (= E215), A211 (≠ K216), L212 (≠ G217), A275 (= A280), V276 (≠ T281), G277 (= G282), R278 (= R283), M324 (≠ A329), L325 (≠ F330), V355 (≠ Y360), Y357 (= Y363)
Sites not aligning to the query:
Query Sequence
>SM_b21143 FitnessBrowser__Smeli:SM_b21143
MWTTLPPGASISPEVVMNKHFDAVIIGAGQAGPSLAGRLSGVGKTVALIERKLFGGTCVN
TGCMPTKAMVASAYAIHTARRGAEYGMTTGPVSVDFGRVMARKEKVRLDARSGVEKWLKG
MKNCTVFEGHARFEGPREVRIGDELISGERIFVNVGGRAAVADLPGVNDVPYLTNSSIMD
LAELPEHLVVVGGSYIGLEFAQMFRRFGSDVTVIEKGARLIGREDPEVSDAIREILENEG
VRIRTNAECIRFSNHADSVAVGVDCTSGEPEVSGSHVLLATGRHPNTDDLGLDKAGVKTD
ERGYIEVDDSLRTNVPHIFAMGDCNGRGAFTHTSYNDFEIVAANLIDNDPRRVSDRIQTY
ALYIDPPLGRAGMTETEARKKGHKLLVGTRPMTRVGRAVEKGETQGFMKVIVDAETDEIL
GASILGTGGDEAVQSILDVMYAKKPYTMIARAVHIHPTVSELIPTVFGDLSSA
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory