SitesBLAST
Comparing SMa0958 FitnessBrowser__Smeli:SMa0958 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P09114 Acetolactate synthase 2, chloroplastic; ALS II; Acetohydroxy-acid synthase II; Acetolactate synthase II; EC 2.2.1.6 from Nicotiana tabacum (Common tobacco) (see paper)
31% identity, 95% coverage: 18:557/570 of query aligns to 101:640/664 of P09114
- P191 (≠ E105) mutation to A: In S4-Hra; highly resistant to sulfonylurea herbicides; when associated with L-568.
- W568 (vs. gap) mutation to L: In S4-Hra; highly resistant to sulfonylurea herbicides; when associated with A-191.
7egvA Acetolactate synthase from trichoderma harzianum with inhibitor harzianic acid (see paper)
31% identity, 94% coverage: 17:553/570 of query aligns to 16:549/590 of 7egvA
- active site: Y28 (≠ L31), G30 (≠ S33), G31 (≠ A34), A32 (≠ V35), I33 (= I36), E54 (= E52), T77 (≠ Q75), F116 (= F114), Q117 (= Q115), K166 (≠ A164), E220 (≠ H225), M256 (≠ R266), V283 (≠ G293), V400 (vs. gap), L425 (= L430), G426 (≠ A431), M428 (≠ L433), Q483 (≠ L488), M485 (≠ F490), V486 (≠ Q491), W489 (≠ A494), L511 (= L516), G516 (= G521), I517 (≠ C522)
- binding flavin-adenine dinucleotide: R156 (= R154), G209 (= G215), Q210 (≠ G216), G211 (= G217), T236 (= T241), L237 (≠ N242), H238 (≠ M243), G276 (= G286), S277 (≠ T287), R278 (= R288), D280 (≠ N290), R282 (≠ N292), V283 (≠ G293), E309 (≠ D310), I310 (≠ V311), D328 (= D328), V329 (≠ A329), M405 (= M409), G423 (≠ R428), G424 (= G429)
- binding (2S)-3-methyl-2-[[(2S,4R)-1-methyl-4-[(2E,4E)-octa-2,4-dienoyl]-3,5-bis(oxidanylidene)pyrrolidin-2-yl]methyl]-2-oxidanyl-butanoic acid: F493 (≠ K498), Y494 (≠ F499)
- binding magnesium ion: D453 (= D458), N480 (= N485), E482 (≠ I487)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: P29 (= P32), E54 (= E52), Q117 (= Q115), V400 (vs. gap), G401 (≠ S405), Q402 (≠ Y406), H403 (≠ S407), G426 (≠ A431), M428 (≠ L433), D453 (= D458), A454 (≠ G459), S455 (≠ G460), E482 (≠ I487), Q483 (≠ L488), G484 (= G489), M485 (≠ F490), V486 (≠ Q491)
1t9cA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl (see paper)
30% identity, 96% coverage: 8:553/570 of query aligns to 8:555/596 of 1t9cA
- active site: Y29 (≠ L31), G31 (≠ S33), G32 (≠ A34), A33 (≠ V35), I34 (= I36), E55 (= E52), T78 (≠ Q75), F117 (= F114), Q118 (= Q115), E119 (≠ D116), K167 (≠ A164), R227 (≠ H225), M263 (≠ S267), V290 (≠ G293), V406 (≠ A404), L431 (= L430), G432 (≠ A431), M434 (≠ L433), D459 (= D458), N486 (= N485), E488 (≠ I487), Q489 (≠ L488), M491 (≠ F490), V492 (≠ Q491), W495 (≠ A494), L517 (= L516), G522 (= G521), L523 (≠ C522)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (≠ A34), V107 (= V104), P108 (≠ E105), F117 (= F114), K167 (≠ A164), D288 (≠ Q291), R289 (≠ N292), W495 (≠ A494)
- binding flavin-adenine dinucleotide: R157 (= R154), G216 (= G215), A217 (≠ G216), G218 (= G217), N221 (vs. gap), T243 (= T241), L244 (≠ N242), Q245 (≠ M243), L261 (= L259), M263 (≠ S267), H264 (≠ L268), G283 (= G286), A284 (≠ T287), R285 (= R288), D287 (≠ N290), R289 (≠ N292), V290 (≠ G293), E316 (≠ D310), V317 (= V311), N321 (≠ E315), G334 (= G327), D335 (= D328), A336 (= A329), M411 (= M409), G429 (≠ R428), G430 (= G429)
- binding magnesium ion: D459 (= D458), N486 (= N485), E488 (≠ I487)
Sites not aligning to the query:
1t9dA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
30% identity, 96% coverage: 8:553/570 of query aligns to 8:555/596 of 1t9dA
- active site: Y29 (≠ L31), G31 (≠ S33), G32 (≠ A34), A33 (≠ V35), I34 (= I36), E55 (= E52), T78 (≠ Q75), F117 (= F114), Q118 (= Q115), E119 (≠ D116), K167 (≠ A164), R227 (≠ H225), M263 (≠ S267), V290 (≠ G293), V406 (≠ A404), L431 (= L430), G432 (≠ A431), M434 (≠ L433), D459 (= D458), N486 (= N485), E488 (≠ I487), Q489 (≠ L488), M491 (≠ F490), V492 (≠ Q491), W495 (≠ A494), L517 (= L516), G522 (= G521), L523 (≠ C522)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (≠ A34), A33 (≠ V35), V107 (= V104), P108 (≠ E105), F117 (= F114), K167 (≠ A164), M263 (≠ S267), D288 (≠ Q291), R289 (≠ N292), W495 (≠ A494)
- binding flavin-adenine dinucleotide: R157 (= R154), G216 (= G215), A217 (≠ G216), G218 (= G217), N221 (vs. gap), T243 (= T241), L244 (≠ N242), Q245 (≠ M243), M260 (≠ V258), L261 (= L259), H264 (≠ L268), G283 (= G286), A284 (≠ T287), R285 (= R288), D287 (≠ N290), R289 (≠ N292), V290 (≠ G293), E316 (≠ D310), V317 (= V311), N321 (≠ E315), G334 (= G327), D335 (= D328), A336 (= A329), Q410 (≠ S408), M411 (= M409), G429 (≠ R428), G430 (= G429)
- binding magnesium ion: D459 (= D458), N486 (= N485), E488 (≠ I487)
- binding 2,5-dimethyl-pyrimidin-4-ylamine: E55 (= E52), P81 (= P78), Q118 (= Q115), G432 (≠ A431), M434 (≠ L433), M464 (≠ H463)
Sites not aligning to the query:
1t9aA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl (see paper)
30% identity, 96% coverage: 8:553/570 of query aligns to 9:556/597 of 1t9aA
- active site: Y30 (≠ L31), G32 (≠ S33), G33 (≠ A34), A34 (≠ V35), I35 (= I36), E56 (= E52), T79 (≠ Q75), F118 (= F114), Q119 (= Q115), E120 (≠ D116), K168 (≠ A164), R228 (≠ H225), M264 (≠ S267), V291 (≠ G293), V407 (≠ A404), L432 (= L430), G433 (≠ A431), M435 (≠ L433), D460 (= D458), N487 (= N485), E489 (≠ I487), Q490 (≠ L488), M492 (≠ F490), V493 (≠ Q491), W496 (≠ A494), L518 (= L516), G523 (= G521), L524 (≠ C522)
- binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: G33 (≠ A34), V108 (= V104), P109 (≠ E105), F118 (= F114), K168 (≠ A164), M264 (≠ S267), D289 (≠ Q291), R290 (≠ N292), M492 (≠ F490), V493 (≠ Q491), W496 (≠ A494)
- binding flavin-adenine dinucleotide: R158 (= R154), G217 (= G215), A218 (≠ G216), G219 (= G217), N222 (vs. gap), T244 (= T241), L245 (≠ N242), Q246 (≠ M243), L262 (= L259), M264 (≠ S267), H265 (≠ L268), G284 (= G286), A285 (≠ T287), R286 (= R288), D288 (≠ N290), R290 (≠ N292), V291 (≠ G293), E317 (≠ D310), V318 (= V311), N322 (≠ E315), G335 (= G327), D336 (= D328), A337 (= A329), Q411 (≠ S408), M412 (= M409), G430 (≠ R428), G431 (= G429)
- binding magnesium ion: D460 (= D458), N487 (= N485), E489 (≠ I487)
- binding propyl trihydrogen diphosphate: V407 (≠ A404), G408 (≠ S405), Q409 (≠ Y406), H410 (≠ S407), M435 (≠ L433), G459 (= G457), D460 (= D458), A461 (≠ G459), S462 (≠ G460), N487 (= N485), E489 (≠ I487), Q490 (≠ L488), G491 (= G489), M492 (≠ F490)
- binding 5-{[ethyl(methyl)amino]methyl}-2-methyl-5,6-dihydropyrimidin-4-amine: G433 (≠ A431), M435 (≠ L433), M465 (≠ H463)
Sites not aligning to the query:
P09342 Acetolactate synthase 1, chloroplastic; ALS I; Acetohydroxy-acid synthase I; Acetolactate synthase I; EC 2.2.1.6 from Nicotiana tabacum (Common tobacco) (see 2 papers)
31% identity, 95% coverage: 18:557/570 of query aligns to 104:643/667 of P09342
- C161 (≠ V72) modified: Disulfide link with 307
- P194 (≠ E105) mutation to Q: In C3; highly resistant to sulfonylurea herbicides.
- C307 (= C220) modified: Disulfide link with 161
5wkcA Saccharomyces cerevisiae acetohydroxyacid synthase in complex with the herbicide penoxsulam (see paper)
30% identity, 96% coverage: 8:553/570 of query aligns to 8:550/591 of 5wkcA
- active site: Y29 (≠ L31), G31 (≠ S33), G32 (≠ A34), A33 (≠ V35), I34 (= I36), E55 (= E52), T78 (≠ Q75), F117 (= F114), Q118 (= Q115), E119 (≠ D116), K167 (≠ A164), R222 (≠ H225), M258 (≠ S267), V285 (≠ G293), V401 (≠ A404), L426 (= L430), G427 (≠ A431), M429 (≠ L433), D454 (= D458), N481 (= N485), E483 (≠ I487), Q484 (≠ L488), M486 (≠ F490), V487 (≠ Q491), W490 (≠ A494), L512 (= L516), G517 (= G521), L518 (≠ C522)
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V401 (≠ A404), G402 (≠ S405), Q403 (≠ Y406), H404 (≠ S407), G427 (≠ A431), M429 (≠ L433), G453 (= G457), D454 (= D458), A455 (≠ G459), S456 (≠ G460), M459 (≠ H463), N481 (= N485), E483 (≠ I487), Q484 (≠ L488), G485 (= G489), M486 (≠ F490), V487 (≠ Q491)
- binding ethaneperoxoic acid: G32 (≠ A34), Q118 (= Q115)
- binding flavin-adenine dinucleotide: R157 (= R154), G211 (= G215), A212 (≠ G216), G213 (= G217), N216 (vs. gap), T238 (= T241), L239 (≠ N242), Q240 (≠ M243), L256 (= L259), M258 (≠ S267), G278 (= G286), A279 (≠ T287), R280 (= R288), R284 (≠ N292), V285 (≠ G293), E311 (≠ D310), V312 (= V311), N316 (≠ E315), D330 (= D328), A331 (= A329), M406 (= M409), G424 (≠ R428)
- binding magnesium ion: D454 (= D458), N481 (= N485), E483 (≠ I487)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: G32 (≠ A34), A33 (≠ V35), V107 (= V104), F117 (= F114), K167 (≠ A164), M258 (≠ S267), R284 (≠ N292), M486 (≠ F490), W490 (≠ A494)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: P30 (= P32), E55 (= E52)
Sites not aligning to the query:
6u9dB Saccharomyces cerevisiae acetohydroxyacid synthase (see paper)
30% identity, 96% coverage: 8:553/570 of query aligns to 12:566/607 of 6u9dB
- active site: Y33 (≠ L31), G35 (≠ S33), G36 (≠ A34), A37 (≠ V35), I38 (= I36), E59 (= E52), T82 (≠ Q75), F121 (= F114), Q122 (= Q115), E123 (≠ D116), K171 (≠ A164), M274 (≠ S267), V301 (≠ G293), V417 (≠ A404), G443 (≠ A431), M445 (≠ L433), D470 (= D458), N497 (= N485), E499 (≠ I487), Q500 (≠ L488), M502 (≠ F490), V503 (≠ Q491), W506 (≠ A494)
- binding methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate: G36 (≠ A34), V111 (= V104), P112 (≠ E105), F121 (= F114), K171 (≠ A164), D299 (≠ Q291), R300 (≠ N292), M502 (≠ F490), W506 (≠ A494)
- binding flavin-adenine dinucleotide: R161 (= R154), A228 (≠ G216), G229 (= G217), N232 (vs. gap), T254 (= T241), L255 (≠ N242), Q256 (≠ M243), L272 (= L259), M274 (≠ S267), G294 (= G286), R296 (= R288), D298 (≠ N290), R300 (≠ N292), V301 (≠ G293), E327 (≠ D310), V328 (= V311), N332 (≠ E315), D346 (= D328), A347 (= A329), M422 (= M409), G440 (≠ R428), G441 (= G429)
- binding magnesium ion: D470 (= D458), N497 (= N485)
- binding thiamine diphosphate: E59 (= E52), P85 (= P78), V417 (≠ A404), G418 (≠ S405), Q419 (≠ Y406), H420 (≠ S407), G443 (≠ A431), M445 (≠ L433), A471 (≠ G459), S472 (≠ G460), N497 (= N485), E499 (≠ I487), Q500 (≠ L488), G501 (= G489), M502 (≠ F490), V503 (≠ Q491)
P07342 Acetolactate synthase catalytic subunit, mitochondrial; Acetohydroxy-acid synthase catalytic subunit; AHAS; ALS; EC 2.2.1.6 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
30% identity, 96% coverage: 8:553/570 of query aligns to 92:646/687 of P07342
- R241 (= R154) binding
- 355:376 (vs. 268:288, 41% identical) binding
- 407:426 (vs. 310:328, 30% identical) binding
1t9bB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
30% identity, 96% coverage: 8:553/570 of query aligns to 8:554/595 of 1t9bB
- active site: Y29 (≠ L31), G31 (≠ S33), G32 (≠ A34), A33 (≠ V35), I34 (= I36), E55 (= E52), T78 (≠ Q75), F117 (= F114), Q118 (= Q115), E119 (≠ D116), K167 (≠ A164), R226 (≠ H225), M262 (≠ S267), V289 (≠ G293), V405 (≠ A404), L430 (= L430), G431 (≠ A431), M433 (≠ L433), D458 (= D458), N485 (= N485), E487 (≠ I487), Q488 (≠ L488), M490 (≠ F490), V491 (≠ Q491), W494 (≠ A494), L516 (= L516), G521 (= G521), L522 (≠ C522)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: V107 (= V104), P108 (≠ E105), D287 (≠ Q291), R288 (≠ N292), M490 (≠ F490), W494 (≠ A494)
- binding flavin-adenine dinucleotide: R157 (= R154), G215 (= G215), A216 (≠ G216), G217 (= G217), N220 (vs. gap), T242 (= T241), L243 (≠ N242), Q244 (≠ M243), M259 (≠ V258), L260 (= L259), M262 (≠ S267), H263 (≠ L268), G282 (= G286), A283 (≠ T287), R284 (= R288), D286 (≠ N290), R288 (≠ N292), V289 (≠ G293), E315 (≠ D310), V316 (= V311), N320 (≠ E315), G333 (= G327), D334 (= D328), A335 (= A329), Q409 (≠ S408), M410 (= M409), G428 (≠ R428), G429 (= G429)
- binding magnesium ion: D458 (= D458), N485 (= N485), E487 (≠ I487)
Sites not aligning to the query:
3ea4A Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron-ester (see paper)
30% identity, 95% coverage: 18:557/570 of query aligns to 21:560/582 of 3ea4A
- active site: Y32 (vs. gap), G34 (vs. gap), G35 (= G28), A36 (≠ Q29), S37 (= S30), E58 (= E52), T81 (≠ Q75), F120 (= F114), Q121 (= Q115), E122 (≠ D116), K170 (≠ A164), M265 (≠ V258), V292 (≠ G293), V399 (≠ A404), G425 (≠ A431), M427 (≠ L433), D452 (= D458), N479 (= N485), H481 (≠ I487), L482 (= L488), M484 (≠ F490), V485 (≠ Q491), W488 (≠ A494), H557 (≠ P554)
- binding methyl 2-{[(4-methylpyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: D290 (≠ Q291), R291 (≠ N292), W488 (≠ A494)
- binding flavin-adenine dinucleotide-n5-isobutyl ketone: R160 (= R154), G221 (= G215), G222 (= G216), G223 (= G217), T245 (= T241), L246 (≠ N242), M247 (= M243), L263 (≠ A256), G264 (= G257), M265 (≠ V258), H266 (≠ L259), G285 (= G286), R287 (= R288), D289 (≠ N290), R291 (≠ N292), D309 (= D310), I310 (≠ V311), G327 (= G327), D328 (= D328), V329 (≠ A329), M404 (= M409), G422 (≠ R428)
- binding magnesium ion: D452 (= D458), N479 (= N485), H481 (≠ I487)
- binding 2-[(2e)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-hydroxyethylidene)-4-methyl-2,3-dihydro-1,3-thiazol-5-yl]ethyltrihydrogen diphosphate: V399 (≠ A404), G400 (≠ S405), Q401 (≠ Y406), H402 (≠ S407), M427 (≠ L433), G451 (= G457), D452 (= D458), G453 (= G459), S454 (≠ G460), N479 (= N485), H481 (≠ I487), L482 (= L488), G483 (= G489), M484 (≠ F490), V485 (≠ Q491)
Sites not aligning to the query:
3e9yA Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron (see paper)
30% identity, 95% coverage: 18:557/570 of query aligns to 21:560/582 of 3e9yA
- active site: Y32 (vs. gap), G34 (vs. gap), G35 (= G28), A36 (≠ Q29), S37 (= S30), E58 (= E52), T81 (≠ Q75), F120 (= F114), Q121 (= Q115), E122 (≠ D116), K170 (≠ A164), M265 (≠ V258), V292 (≠ G293), V399 (≠ A404), G425 (≠ A431), M427 (≠ L433), D452 (= D458), N479 (= N485), H481 (≠ I487), L482 (= L488), M484 (≠ F490), V485 (≠ Q491), W488 (≠ A494), H557 (≠ P554)
- binding N-[(4-methylpyrimidin-2-yl)carbamoyl]-2-nitrobenzenesulfonamide: D290 (≠ Q291), R291 (≠ N292), W488 (≠ A494)
- binding flavin-adenine dinucleotide-n5-isobutyl ketone: R160 (= R154), G221 (= G215), G222 (= G216), G223 (= G217), T245 (= T241), L246 (≠ N242), M247 (= M243), L263 (≠ A256), G285 (= G286), R287 (= R288), D289 (≠ N290), R291 (≠ N292), D309 (= D310), I310 (≠ V311), G327 (= G327), D328 (= D328), V329 (≠ A329), M404 (= M409), G422 (≠ R428)
- binding magnesium ion: D452 (= D458), N479 (= N485), H481 (≠ I487)
- binding 2-[(2e)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-hydroxyethylidene)-4-methyl-2,3-dihydro-1,3-thiazol-5-yl]ethyltrihydrogen diphosphate: V399 (≠ A404), G400 (≠ S405), Q401 (≠ Y406), H402 (≠ S407), M427 (≠ L433), G451 (= G457), G453 (= G459), S454 (≠ G460), N479 (= N485), H481 (≠ I487), L482 (= L488), G483 (= G489), M484 (≠ F490), V485 (≠ Q491)
Sites not aligning to the query:
1n0hA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorimuron ethyl (see paper)
30% identity, 96% coverage: 8:553/570 of query aligns to 10:558/599 of 1n0hA
- active site: Y31 (≠ L31), G33 (≠ S33), G34 (≠ A34), A35 (≠ V35), I36 (= I36), E57 (= E52), T80 (≠ Q75), F119 (= F114), Q120 (= Q115), E121 (≠ D116), K169 (≠ A164), R230 (≠ H225), M266 (≠ S267), V293 (≠ G293), V409 (≠ A404), L434 (= L430), G435 (≠ A431), M437 (≠ L433), D462 (= D458), N489 (= N485), E491 (≠ I487), Q492 (≠ L488), M494 (≠ F490), V495 (≠ Q491), W498 (≠ A494), L520 (= L516), G525 (= G521), L526 (≠ C522)
- binding 4-{[(4'-amino-2'-methylpyrimidin-5'-yl)methyl]amino}pent-3-enyl diphosphate: V409 (≠ A404), G410 (≠ S405), Q411 (≠ Y406), H412 (≠ S407), G435 (≠ A431), M437 (≠ L433), G461 (= G457), D462 (= D458), A463 (≠ G459), S464 (≠ G460), M467 (≠ H463), N489 (= N485), E491 (≠ I487), Q492 (≠ L488), G493 (= G489), V495 (≠ Q491)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: G34 (≠ A34), A35 (≠ V35), V109 (= V104), P110 (≠ E105), F119 (= F114), K169 (≠ A164), M266 (≠ S267), D291 (≠ Q291), R292 (≠ N292), V495 (≠ Q491), W498 (≠ A494)
- binding flavin-adenine dinucleotide: R159 (= R154), G219 (= G215), A220 (≠ G216), G221 (= G217), N224 (vs. gap), T246 (= T241), L247 (≠ N242), Q248 (≠ M243), L264 (= L259), G265 (= G260), M266 (≠ S267), H267 (≠ L268), G286 (= G286), A287 (≠ T287), R288 (= R288), D290 (≠ N290), R292 (≠ N292), V293 (≠ G293), E319 (≠ D310), V320 (= V311), N324 (≠ E315), G337 (= G327), D338 (= D328), A339 (= A329), M414 (= M409), G432 (≠ R428), G433 (= G429)
- binding magnesium ion: D462 (= D458), N489 (= N485), E491 (≠ I487)
- binding thiamine diphosphate: Y31 (≠ L31), E57 (= E52), P83 (= P78)
Sites not aligning to the query:
6deoA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron methyl (see paper)
29% identity, 94% coverage: 17:553/570 of query aligns to 19:552/593 of 6deoA
- active site: Y31 (≠ Q29), G33 (≠ P32), G34 (≠ S33), A35 (= A34), I36 (≠ V35), E57 (= E52), T80 (≠ Q75), F119 (= F114), Q120 (= Q115), E121 (≠ D116), K169 (≠ A164), K224 (≠ H225), M260 (≠ L262), V287 (≠ G293), V403 (≠ A404), L428 (= L430), G429 (≠ A431), M431 (≠ L433), D456 (= D458), N483 (= N485), E485 (≠ I487), Q486 (≠ L488), M488 (≠ F490), V489 (≠ Q491), W492 (≠ A494), L514 (= L516), N519 (≠ G521), V520 (≠ C522)
- binding flavin-adenine dinucleotide: R159 (= R154), G213 (= G215), A214 (≠ G216), G215 (= G217), N218 (≠ H219), T240 (= T241), L241 (≠ N242), Q242 (≠ M243), L258 (= L259), G280 (= G286), A281 (≠ T287), R282 (= R288), D284 (≠ N290), R286 (≠ N292), V287 (≠ G293), E313 (≠ D310), I314 (≠ V311), N318 (≠ E315), D332 (= D328), V333 (≠ A329), M408 (= M409), G426 (≠ R428)
- binding methyl 2-{[(4-iodo-6-methoxypyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: M260 (≠ L262), D285 (≠ Q291), R286 (≠ N292), M488 (≠ F490), W492 (≠ A494)
- binding magnesium ion: D456 (= D458), N483 (= N485), E485 (≠ I487)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V403 (≠ A404), G404 (≠ S405), Q405 (≠ Y406), H406 (≠ S407), G429 (≠ A431), M431 (≠ L433), G455 (= G457), D456 (= D458), A457 (≠ G459), S458 (≠ G460), M461 (≠ H463), N483 (= N485), E485 (≠ I487), Q486 (≠ L488), G487 (= G489), M488 (≠ F490), V489 (≠ Q491)
5k2oA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, pyrithiobac (see paper)
30% identity, 95% coverage: 18:557/570 of query aligns to 22:561/585 of 5k2oA
- active site: Y33 (vs. gap), G35 (vs. gap), G36 (= G28), A37 (≠ Q29), S38 (= S30), E59 (= E52), T82 (≠ Q75), F121 (= F114), Q122 (= Q115), E123 (≠ D116), K171 (≠ A164), M266 (≠ V258), V293 (≠ G293), V400 (≠ A404), G426 (≠ A431), M428 (≠ L433), D453 (= D458), N480 (= N485), H482 (≠ I487), L483 (= L488), M485 (≠ F490), V486 (≠ Q491), W489 (≠ A494), H558 (≠ P554)
- binding 2-chloranyl-6-(4,6-dimethoxypyrimidin-2-yl)sulfanyl-benzoic acid: M266 (≠ V258), R292 (≠ N292), W489 (≠ A494)
- binding flavin-adenine dinucleotide: R161 (= R154), G222 (= G215), G223 (= G216), G224 (= G217), T246 (= T241), L247 (≠ N242), M248 (= M243), L264 (≠ A256), G286 (= G286), R288 (= R288), D290 (≠ N290), V293 (≠ G293), D310 (= D310), I311 (≠ V311), D329 (= D328), V330 (≠ A329), Q404 (≠ S408), M405 (= M409), G423 (≠ R428)
- binding magnesium ion: D453 (= D458), N480 (= N485), H482 (≠ I487)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (≠ A404), G401 (≠ S405), Q402 (≠ Y406), H403 (≠ S407), M428 (≠ L433), D453 (= D458), G454 (= G459), S455 (≠ G460), N480 (= N485), H482 (≠ I487), L483 (= L488), G484 (= G489), M485 (≠ F490), V486 (≠ Q491)
Sites not aligning to the query:
P17597 Acetolactate synthase, chloroplastic; AtALS; Acetohydroxy-acid synthase; Protein CHLORSULFURON RESISTANT 1; EC 2.2.1.6 from Arabidopsis thaliana (Mouse-ear cress) (see 8 papers)
30% identity, 95% coverage: 18:557/570 of query aligns to 107:646/670 of P17597
- A122 (≠ Q29) mutation to V: Reduced catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
- M124 (≠ L31) mutation to E: Reduced catalytic activity. Resistant to imidazolinone herbicides and reduced sensitivity to sulfonylurea herbicides.; mutation to I: No effect on catalytic activity. Increased resistance to imidazolinone herbicides.
- E144 (= E52) binding
- S186 (= S94) binding
- P197 (≠ E105) mutation to S: In csr1-1/GH50; resistant to sulfonylurea but not to imidazolinone herbicides.
- R199 (≠ D107) mutation R->A,E: No effect on catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
- Q207 (= Q115) binding
- K220 (= K128) binding
- R246 (= R154) binding ; binding
- K256 (≠ A164) binding
- G308 (= G216) binding
- TL 331:332 (≠ TN 241:242) binding
- C340 (vs. gap) modified: Cysteine sulfinic acid (-SO2H)
- LGMH 349:352 (≠ AGVL 256:259) binding
- GVRFD 371:375 (≠ GTRTN 286:290) binding
- DR 376:377 (≠ QN 291:292) binding
- DI 395:396 (≠ DV 310:311) binding
- DV 414:415 (≠ DA 328:329) binding
- QH 487:488 (≠ YS 406:407) binding
- GG 508:509 (≠ RG 428:429) binding
- GAM 511:513 (≠ AGL 431:433) binding
- D538 (= D458) binding
- DGS 538:540 (≠ DGG 458:460) binding
- N565 (= N485) binding
- NQHLGM 565:570 (≠ NGILGF 485:490) binding
- H567 (≠ I487) binding
- W574 (≠ A494) binding ; mutation to L: Increased catalytic activity. Resistant to imidazolinone and sulfonylurea herbicides.; mutation to S: Slightly decreased catalytic activity. Resistant to imidazolinone and sulfonylurea herbicides.
Sites not aligning to the query:
- 653 binding ; S→A: No effect on catalytic activity or sensitivity to herbicides.; S→F: No effect on catalytic activity. Resistant to imidazolinone herbicides and also slightly sulfonylurea-resistant.; S→N: In csr1-2/GH90; no effect on catalytic activity. Resistant to imidazolinone but not to sulfonylurea herbicides.; S→T: No effect on catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
7tzzA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase p197t mutant in complex with bispyribac-sodium (see paper)
30% identity, 95% coverage: 18:557/570 of query aligns to 22:561/582 of 7tzzA
- binding 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid: M266 (≠ V258), R292 (≠ N292), W489 (≠ A494)
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V400 (≠ A404), G401 (≠ S405), Q402 (≠ Y406), H403 (≠ S407), G426 (≠ A431), M428 (≠ L433), G452 (= G457), D453 (= D458), G454 (= G459), S455 (≠ G460), L483 (= L488), G484 (= G489), M485 (≠ F490), V486 (≠ Q491)
- binding flavin-adenine dinucleotide: R161 (= R154), G222 (= G215), G223 (= G216), G224 (= G217), T246 (= T241), L247 (≠ N242), M248 (= M243), M263 (≠ S255), L264 (≠ A256), M266 (≠ V258), H267 (≠ L259), G286 (= G286), R288 (= R288), V293 (≠ G293), D310 (= D310), I311 (≠ V311), D329 (= D328), V330 (≠ A329), M405 (= M409), G423 (≠ R428)
- binding magnesium ion: A37 (≠ Q29), T82 (≠ Q75), S83 (≠ N76), Q122 (= Q115), Y381 (≠ R385), D453 (= D458), M458 (≠ H463), Q461 (≠ A466), N480 (= N485), H482 (≠ I487), K533 (≠ P530)
Sites not aligning to the query:
8et4A Crystal structure of wild-type arabidopsis thaliana acetohydroxyacid synthase in complex with amidosulfuron (see paper)
30% identity, 95% coverage: 18:557/570 of query aligns to 22:561/582 of 8et4A
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V400 (≠ A404), G401 (≠ S405), Q402 (≠ Y406), H403 (≠ S407), G426 (≠ A431), M428 (≠ L433), G452 (= G457), D453 (= D458), G454 (= G459), S455 (≠ G460), M458 (≠ H463), N480 (= N485), H482 (≠ I487), L483 (= L488), G484 (= G489), M485 (≠ F490), V486 (≠ Q491)
- binding flavin-adenine dinucleotide: R161 (= R154), G222 (= G215), G223 (= G216), G224 (= G217), T246 (= T241), L247 (≠ N242), M248 (= M243), L264 (≠ A256), M266 (≠ V258), H267 (≠ L259), G286 (= G286), V287 (≠ T287), R288 (= R288), D290 (≠ N290), R292 (≠ N292), V293 (≠ G293), D310 (= D310), I311 (≠ V311), D329 (= D328), V330 (≠ A329), M405 (= M409), G423 (≠ R428)
- binding magnesium ion: F370 (≠ V374), D453 (= D458), M458 (≠ H463), Q461 (≠ A466), N480 (= N485), H482 (≠ I487), K533 (≠ P530)
- binding N-{[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]sulfamoyl}-N-methylmethanesulfonamide: M266 (≠ V258), R292 (≠ N292), M485 (≠ F490), W489 (≠ A494)
Sites not aligning to the query:
5wj1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a triazolopyrimidine herbicide, penoxsulam (see paper)
30% identity, 95% coverage: 18:557/570 of query aligns to 22:561/582 of 5wj1A
- active site: Y33 (vs. gap), G35 (vs. gap), G36 (= G28), A37 (≠ Q29), S38 (= S30), E59 (= E52), T82 (≠ Q75), F121 (= F114), Q122 (= Q115), E123 (≠ D116), K171 (≠ A164), M266 (≠ V258), V293 (≠ G293), V400 (≠ A404), G426 (≠ A431), M428 (≠ L433), D453 (= D458), N480 (= N485), H482 (≠ I487), L483 (= L488), M485 (≠ F490), V486 (≠ Q491), W489 (≠ A494), H558 (≠ P554)
- binding flavin-adenine dinucleotide: R161 (= R154), G222 (= G215), G223 (= G216), G224 (= G217), T246 (= T241), L247 (≠ N242), M248 (= M243), M263 (≠ S255), L264 (≠ A256), G286 (= G286), R288 (= R288), V293 (≠ G293), D310 (= D310), I311 (≠ V311), D329 (= D328), V330 (≠ A329), M405 (= M409), G423 (≠ R428), G424 (= G429)
- binding magnesium ion: D453 (= D458), N480 (= N485), H482 (≠ I487)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: M266 (≠ V258), D291 (≠ Q291), R292 (≠ N292), M485 (≠ F490), W489 (≠ A494)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (≠ A404), G401 (≠ S405), Q402 (≠ Y406), H403 (≠ S407), M428 (≠ L433), D453 (= D458), G454 (= G459), S455 (≠ G460), M458 (≠ H463), N480 (= N485), H482 (≠ I487), L483 (= L488), G484 (= G489), M485 (≠ F490), V486 (≠ Q491)
Sites not aligning to the query:
5k6tA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, propoxycarbazone-sodium (see paper)
30% identity, 95% coverage: 18:557/570 of query aligns to 22:561/582 of 5k6tA
- active site: Y33 (vs. gap), G35 (vs. gap), G36 (= G28), A37 (≠ Q29), S38 (= S30), E59 (= E52), T82 (≠ Q75), F121 (= F114), Q122 (= Q115), E123 (≠ D116), K171 (≠ A164), M266 (≠ V258), V293 (≠ G293), V400 (≠ A404), G426 (≠ A431), M428 (≠ L433), D453 (= D458), N480 (= N485), H482 (≠ I487), L483 (= L488), M485 (≠ F490), V486 (≠ Q491), W489 (≠ A494), H558 (≠ P554)
- binding methyl 2-[(4-methyl-5-oxidanylidene-3-propoxy-1,2,4-triazol-1-yl)carbonylsulfamoyl]benzoate: H267 (≠ L259), R292 (≠ N292), M485 (≠ F490), W489 (≠ A494)
- binding flavin-adenine dinucleotide: R161 (= R154), G222 (= G215), G223 (= G216), G224 (= G217), T246 (= T241), L247 (≠ N242), M248 (= M243), L264 (≠ A256), G286 (= G286), R288 (= R288), D290 (≠ N290), R292 (≠ N292), V293 (≠ G293), D310 (= D310), I311 (≠ V311), D329 (= D328), V330 (≠ A329), Q404 (≠ S408), M405 (= M409), G423 (≠ R428)
- binding magnesium ion: D453 (= D458), N480 (= N485), H482 (≠ I487)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V400 (≠ A404), G401 (≠ S405), Q402 (≠ Y406), H403 (≠ S407), G426 (≠ A431), M428 (≠ L433), G452 (= G457), G454 (= G459), S455 (≠ G460), N480 (= N485), H482 (≠ I487), L483 (= L488), G484 (= G489)
Sites not aligning to the query:
Query Sequence
>SMa0958 FitnessBrowser__Smeli:SMa0958
MTQQNPNVTVAQRIANILRRHGVEFIFGQSLPSAVILAAEAIGIRQIAYRQENMGGAMAD
GYARVSGKVGVVAAQNGPAATLLVPPLAEALKASVPIVALVQDVERDQTDRNAFQDLDQI
ALFQSCTKWVRRVTVPERIDDYVDAAFTAAASGRAGPAALLLPADLLRAEAKSPAVVRSK
QLGHWPLDRVRPSDDALAEVASLIAAAHAPIIIAGGGVHCGGATHELAALQQEACLPVFT
TNMGKGAVDEYHPLSAGVLGSLVGPRSLGRYSYGLVEDADLVILIGTRTNQNGTDTWRQI
PSSARVVHIDVDPVEIGRNYEAIRLVGDARESLAALRAALTRVDLTRRHGDRARLEECIA
QYWKGFELDRHDVVTSRSRPIRPERVMAELQDLLTGDVTVVADASYSSMWVLGQLRARAS
GMRFITPRGLAGLGWGVPLAIGAKVARPGKPVIAVVGDGGFAHSWAELETMVRMKLPVTI
VVLNNGILGFQRDAETVKFGTYTTACHFAEVDHAKLAEACGCPAVRVEDPGELAFHLHRG
MDQGPLLIEVMTDPAAHPPLSLFAKMDEAA
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory