SitesBLAST
Comparing SMa2037 FitnessBrowser__Smeli:SMa2037 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
O33819 4-hydroxybenzoyl-CoA reductase subunit alpha; 4-HBCR subunit alpha; EC 1.1.7.1 from Thauera aromatica (see paper)
33% identity, 98% coverage: 14:750/750 of query aligns to 10:764/769 of O33819
1rm6A Structure of 4-hydroxybenzoyl-coa reductase from thauera aromatica (see paper)
33% identity, 98% coverage: 14:750/750 of query aligns to 2:756/761 of 1rm6A
- active site: Q206 (= Q230), T241 (= T265), Y318 (vs. gap), L322 (vs. gap), R350 (= R370), E718 (= E712), G719 (≠ T713)
- binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): G235 (= G259), G236 (= G260), F237 (= F261), G238 (= G262), R350 (= R370), I473 (≠ V480), G474 (= G481), Q475 (vs. gap), G476 (= G482), Y513 (≠ D519), S514 (≠ G520), S515 (= S521), V517 (≠ G523), T518 (= T524), L646 (≠ V639), N647 (≠ H640), V651 (= V644), Q654 (= Q647), K714 (≠ R708), E715 (≠ G709), A716 (≠ V710), S717 (≠ G711), E718 (= E712)
1n63B Crystal structure of the cu,mo-co dehydrogenase (codh); carbon monoxide reduced state (see paper)
28% identity, 97% coverage: 4:729/750 of query aligns to 4:776/805 of 1n63B
- active site: Q236 (= Q230), V271 (≠ T265), P348 (≠ A336), I354 (≠ T342), R383 (= R370), C384 (≠ A371), E759 (= E712), S760 (≠ T713)
- binding cu(i)-s-mo(iv)(=o)oh cluster: G268 (= G262), A381 (= A368), R383 (= R370), C384 (≠ A371), Y564 (≠ D519), G565 (= G520), E759 (= E712)
- binding pterin cytosine dinucleotide: G266 (= G260), F267 (= F261), R383 (= R370), Q524 (≠ V480), G525 (= G481), Q526 (vs. gap), H528 (≠ S483), T531 (≠ S486), T563 (= T518), Y564 (≠ D519), S566 (= S521), S568 (≠ G523), T569 (= T524), C682 (≠ A635), I686 (≠ V639), I690 (≠ Y643), I691 (≠ V644), Q694 (= Q647), K755 (≠ R708), G756 (= G709), V757 (= V710), E759 (= E712)
P19919 Carbon monoxide dehydrogenase large chain; CO dehydrogenase subunit L; CO-DH L; EC 1.2.5.3 from Afipia carboxidovorans (strain ATCC 49405 / DSM 1227 / KCTC 32145 / OM5) (Oligotropha carboxidovorans) (see 2 papers)
28% identity, 97% coverage: 4:729/750 of query aligns to 8:780/809 of P19919
- C388 (≠ A371) binding
- E763 (= E712) binding
1zxiB Reconstituted co dehydrogenase from oligotropha carboxidovorans (see paper)
28% identity, 97% coverage: 4:729/750 of query aligns to 3:775/804 of 1zxiB
- active site: Q235 (= Q230), V270 (≠ T265), P347 (≠ A336), I353 (≠ T342), R382 (= R370), C383 (≠ A371), E758 (= E712), S759 (≠ T713)
- binding copper (ii) ion: C383 (≠ A371), S384 (≠ P372), E758 (= E712)
- binding cu(i)-s-mo(vi)(=o)oh cluster: F266 (= F261), G267 (= G262), A380 (= A368), Y381 (= Y369), R382 (= R370), C383 (≠ A371), Y563 (≠ D519), G564 (= G520), E758 (= E712)
- binding pterin cytosine dinucleotide: G265 (= G260), F266 (= F261), R382 (= R370), Q523 (≠ V480), G524 (= G481), Q525 (vs. gap), H527 (≠ S483), T530 (≠ S486), T562 (= T518), Y563 (≠ D519), S565 (= S521), S567 (≠ G523), T568 (= T524), C681 (≠ A635), I685 (≠ V639), I689 (≠ Y643), I690 (≠ V644), Q693 (= Q647), K754 (≠ R708), G755 (= G709), V756 (= V710), E758 (= E712)
1n62B Crystal structure of the mo,cu-co dehydrogenase (codh), n- butylisocyanide-bound state (see paper)
28% identity, 97% coverage: 4:729/750 of query aligns to 3:775/804 of 1n62B
- active site: Q235 (= Q230), V270 (≠ T265), P347 (≠ A336), I353 (≠ T342), R382 (= R370), C383 (≠ A371), E758 (= E712), S759 (≠ T713)
- binding cu(i)-s-mo(iv)(=o)o-nbic cluster: G267 (= G262), V379 (≠ A367), A380 (= A368), R382 (= R370), C383 (≠ A371), F385 (vs. gap), Y563 (≠ D519), G564 (= G520), E758 (= E712)
- binding pterin cytosine dinucleotide: G265 (= G260), F266 (= F261), R382 (= R370), Q523 (≠ V480), G524 (= G481), Q525 (vs. gap), H527 (≠ S483), T530 (≠ S486), T562 (= T518), Y563 (≠ D519), G564 (= G520), S565 (= S521), S567 (≠ G523), T568 (= T524), C681 (≠ A635), I685 (≠ V639), I689 (≠ Y643), I690 (≠ V644), Q693 (= Q647), K754 (≠ R708), G755 (= G709), V756 (= V710), G757 (= G711), E758 (= E712)
1n60B Crystal structure of the cu,mo-co dehydrogenase (codh); cyanide- inactivated form (see paper)
28% identity, 97% coverage: 4:729/750 of query aligns to 2:774/803 of 1n60B
- active site: Q234 (= Q230), V269 (≠ T265), P346 (≠ A336), I352 (≠ T342), R381 (= R370), C382 (≠ A371), E757 (= E712), S758 (≠ T713)
- binding pterin cytosine dinucleotide: G264 (= G260), F265 (= F261), R381 (= R370), Q522 (≠ V480), G523 (= G481), Q524 (vs. gap), H526 (≠ S483), T529 (≠ S486), T561 (= T518), Y562 (≠ D519), G563 (= G520), S564 (= S521), S566 (≠ G523), T567 (= T524), C680 (≠ A635), I684 (≠ V639), I688 (≠ Y643), I689 (≠ V644), Q692 (= Q647), K753 (≠ R708), G754 (= G709), V755 (= V710), E757 (= E712)
- binding mo(vi)(=o)(oh)2 cluster: F265 (= F261), G266 (= G262), Y562 (≠ D519), G563 (= G520), E757 (= E712)
1n5wB Crystal structure of the cu,mo-co dehydrogenase (codh); oxidized form (see paper)
28% identity, 97% coverage: 4:729/750 of query aligns to 3:775/804 of 1n5wB
- active site: Q235 (= Q230), V270 (≠ T265), P347 (≠ A336), I353 (≠ T342), R382 (= R370), C383 (≠ A371), E758 (= E712), S759 (≠ T713)
- binding cu(i)-s-mo(vi)(=o)oh cluster: G267 (= G262), A380 (= A368), R382 (= R370), C383 (≠ A371), Y563 (≠ D519), G564 (= G520), E758 (= E712)
- binding pterin cytosine dinucleotide: G265 (= G260), F266 (= F261), R382 (= R370), Q523 (≠ V480), G524 (= G481), Q525 (vs. gap), H527 (≠ S483), T530 (≠ S486), T562 (= T518), Y563 (≠ D519), S565 (= S521), S567 (≠ G523), T568 (= T524), C681 (≠ A635), I685 (≠ V639), I689 (≠ Y643), I690 (≠ V644), Q693 (= Q647), K754 (≠ R708), G755 (= G709), V756 (= V710), E758 (= E712)
7dqxD Crystal structure of xanthine dehydrogenase family protein
27% identity, 98% coverage: 15:746/750 of query aligns to 6:764/770 of 7dqxD
- binding pterin cytosine dinucleotide: G247 (= G259), S248 (≠ G260), F249 (= F261), R363 (= R370), V491 (= V480), G492 (= G481), Q493 (vs. gap), G494 (= G482), V498 (≠ S486), S530 (≠ T518), W531 (≠ D519), S532 (≠ G520), S533 (= S521), R534 (= R522), S535 (≠ G523), T536 (= T524), T658 (≠ Y643), T659 (≠ V644), Q662 (= Q647), G725 (= G709), L726 (≠ V710), G727 (= G711), E728 (= E712)
1ffvB Carbon monoxide dehydrogenase from hydrogenophaga pseudoflava (see paper)
28% identity, 99% coverage: 4:749/750 of query aligns to 1:791/797 of 1ffvB
- active site: Q231 (= Q230), V266 (≠ T265), P343 (vs. gap), I349 (vs. gap), R378 (= R370), C379 (≠ A371), E751 (= E712), S752 (≠ T713)
- binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): G260 (= G259), G261 (= G260), F262 (= F261), G263 (= G262), A376 (= A368), R378 (= R370), C379 (≠ A371), Q516 (≠ V480), G517 (= G481), Q518 (vs. gap), H520 (≠ S483), T523 (≠ S486), Y556 (≠ D519), G557 (= G520), S558 (= S521), S560 (≠ G523), T561 (= T524), C674 (≠ A635), I678 (≠ V639), I683 (≠ V644), Q686 (= Q647), K747 (≠ R708), G748 (= G709), V749 (= V710), A750 (≠ G711), E751 (= E712)
1ffuB Carbon monoxide dehydrogenase from hydrogenophaga pseudoflava which lacks the mo-pyranopterin moiety of the molybdenum cofactor (see paper)
28% identity, 99% coverage: 4:749/750 of query aligns to 1:791/797 of 1ffuB
- active site: Q231 (= Q230), V266 (≠ T265), P343 (vs. gap), I349 (vs. gap), R378 (= R370), C379 (≠ A371), E751 (= E712), S752 (≠ T713)
- binding cytidine-5'-diphosphate: Q518 (vs. gap), H520 (≠ S483), T523 (≠ S486), S558 (= S521), S560 (≠ G523), T561 (= T524), C674 (≠ A635), T676 (≠ K637), I678 (≠ V639), I683 (≠ V644), K747 (≠ R708), G748 (= G709), V749 (= V710), A750 (≠ G711)
1t3qB Crystal structure of quinoline 2-oxidoreductase from pseudomonas putida 86 (see paper)
28% identity, 98% coverage: 14:749/750 of query aligns to 13:783/786 of 1t3qB
- active site: Q224 (= Q230), A259 (≠ T265), E336 (vs. gap), V343 (≠ T342), R371 (= R370), E743 (= E712), S744 (≠ T713)
- binding pterin cytosine dinucleotide: G254 (= G260), F255 (= F261), R371 (= R370), S506 (≠ V480), G507 (= G481), Q508 (vs. gap), H510 (≠ S483), T513 (≠ S486), Y545 (≠ F525), S547 (= S527), G549 (≠ M529), A550 (= A530), C666 (≠ A635), I670 (≠ V639), I674 (≠ Y643), V675 (= V644), Q678 (= Q647), K739 (≠ R708), G740 (= G709), M741 (≠ V710), G742 (= G711)
P19913 Carbon monoxide dehydrogenase large chain; CO dehydrogenase subunit L; CO-DH L; EC 1.2.5.3 from Hydrogenophaga pseudoflava (Pseudomonas carboxydoflava) (see paper)
28% identity, 99% coverage: 10:749/750 of query aligns to 11:797/803 of P19913
- R384 (= R370) modified: 4-hydroxyarginine
5y6qC Crystal structure of an aldehyde oxidase from methylobacillus sp. Ky4400 (see paper)
28% identity, 97% coverage: 21:745/750 of query aligns to 13:748/748 of 5y6qC
- active site: Q204 (= Q230), P239 (vs. gap), A310 (= A336), V316 (≠ T342), R344 (= R370), E715 (= E712), L716 (≠ T713)
- binding pterin cytosine dinucleotide: G233 (= G259), G234 (= G260), F235 (= F261), I461 (≠ V480), G462 (= G481), T463 (vs. gap), G464 (= G482), I468 (≠ S486), G500 (≠ D519), S502 (= S521), Q503 (≠ R522), L504 (≠ F525), A505 (≠ S526), R638 (≠ K637), Y640 (≠ V639), N641 (≠ H640), Q648 (= Q647), K711 (≠ R708), V713 (= V710), G714 (= G711), E715 (= E712)
Q0QLF2 Nicotinate dehydrogenase large molybdopterin subunit; NDH; Nicotinic acid hydroxylase large molybdopterin subunit; NAH; EC 1.17.1.5 from Eubacterium barkeri (Clostridium barkeri) (see 2 papers)
31% identity, 56% coverage: 10:431/750 of query aligns to 3:413/425 of Q0QLF2
Sites not aligning to the query:
- 1 modified: Initiator methionine, Removed
- 2:425 modified: mature protein, Nicotinate dehydrogenase large molybdopterin subunit
3hrdE Crystal structure of nicotinate dehydrogenase (see paper)
31% identity, 56% coverage: 10:431/750 of query aligns to 2:412/420 of 3hrdE
- active site: Q207 (= Q230), L242 (≠ T265), R318 (≠ M341), H322 (≠ A345), R350 (= R370)
- binding calcium ion: T206 (= T229), N208 (≠ G231), D212 (≠ Y235), K241 (= K264), L242 (≠ T265), D243 (≠ H266)
- binding pterin cytosine dinucleotide: G237 (= G260), F238 (= F261), R350 (= R370)
- binding selenium atom: F238 (= F261), A348 (= A368), F349 (≠ Y369), R350 (= R370)
3hrdA Crystal structure of nicotinate dehydrogenase (see paper)
31% identity, 56% coverage: 10:431/750 of query aligns to 2:412/420 of 3hrdA
- active site: Q207 (= Q230), L242 (≠ T265), R318 (≠ M341), H322 (≠ A345), R350 (= R370)
- binding pterin cytosine dinucleotide: G236 (= G259), G237 (= G260), F238 (= F261), R350 (= R370)
- binding magnesium ion: T206 (= T229), N208 (≠ G231), D212 (≠ Y235), K241 (= K264), L242 (≠ T265), D243 (≠ H266), T305 (≠ C328), Y308 (= Y331), A309 (= A332), S346 (≠ T366)
- binding nicotinic acid: A314 (≠ E337), R318 (≠ M341), F352 (≠ P372)
- binding selenium atom: F238 (= F261), G239 (= G262), A348 (= A368), F349 (≠ Y369), R350 (= R370)
4usaA Aldehyde oxidoreductase from desulfovibrio gigas (mop), soaked with trans-cinnamaldehyde (see paper)
27% identity, 98% coverage: 16:750/750 of query aligns to 177:907/907 of 4usaA
- active site: I390 (≠ Q230), F425 (≠ T265), R501 (vs. gap), F505 (≠ T342), R533 (= R370), E869 (= E712), L870 (≠ T713)
- binding bicarbonate ion: R460 (≠ T300), A531 (= A368), F532 (≠ Y369), Y535 (≠ P372), Q539 (≠ M376)
- binding hydrocinnamic acid: I255 (vs. gap), F425 (≠ T265), F494 (≠ W335), L497 (≠ V338), Y535 (≠ P372), L626 (≠ F455)
- binding magnesium ion: E899 (≠ P742), E903 (≠ A746)
- binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): T420 (≠ G260), F421 (= F261), G422 (= G262), R533 (= R370), W650 (≠ T477), H653 (≠ G481), G654 (= G482), Q655 (≠ S483), G656 (≠ R484), S695 (≠ T518), G696 (≠ D519), G697 (= G520), Q700 (≠ G523), Q701 (≠ T524), C799 (≠ V639), N800 (≠ H640), T804 (≠ V644), Q807 (= Q647), S865 (≠ R708), G866 (= G709), V867 (= V710), G868 (= G711), E869 (= E712)
Sites not aligning to the query:
- binding fe2/s2 (inorganic) cluster: 38, 40, 41, 43, 45, 46, 48, 58, 60, 100, 101, 103, 137, 139
- binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 99, 139
4us9A Aldehyde oxidoreductase from desulfovibrio gigas (mop), soaked with 3- phenylpropionaldehyde (see paper)
27% identity, 98% coverage: 16:750/750 of query aligns to 177:907/907 of 4us9A
- active site: I390 (≠ Q230), F425 (≠ T265), R501 (vs. gap), F505 (≠ T342), R533 (= R370), E869 (= E712), L870 (≠ T713)
- binding 3-phenylpropanal: I255 (vs. gap), F257 (vs. gap), P258 (vs. gap), H752 (= H596)
- binding bicarbonate ion: R460 (≠ T300), L498 (vs. gap), A531 (= A368), F532 (≠ Y369), Y535 (≠ P372), Q539 (≠ M376), R890 (= R733), Y892 (≠ L735)
- binding magnesium ion: E899 (≠ P742), E903 (≠ A746)
- binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): T420 (≠ G260), F421 (= F261), G422 (= G262), R533 (= R370), W650 (≠ T477), H653 (≠ G481), G654 (= G482), Q655 (≠ S483), G656 (≠ R484), S695 (≠ T518), G696 (≠ D519), G697 (= G520), Q700 (≠ G523), Q701 (≠ T524), C799 (≠ V639), N800 (≠ H640), T804 (≠ V644), Q807 (= Q647), S865 (≠ R708), G866 (= G709), V867 (= V710), G868 (= G711), E869 (= E712)
Sites not aligning to the query:
- binding fe2/s2 (inorganic) cluster: 38, 40, 41, 43, 45, 46, 48, 58, 60, 100, 101, 103, 137, 139
- binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 99, 139
4us8A Aldehyde oxidoreductase from desulfovibrio gigas (mop), soaked with benzaldehyde (see paper)
27% identity, 98% coverage: 16:750/750 of query aligns to 177:907/907 of 4us8A
- active site: I390 (≠ Q230), F425 (≠ T265), R501 (vs. gap), F505 (≠ T342), R533 (= R370), E869 (= E712), L870 (≠ T713)
- binding bicarbonate ion: R460 (≠ T300), L498 (vs. gap), A531 (= A368), F532 (≠ Y369), Y535 (≠ P372), Q539 (≠ M376)
- binding benzaldehyde: I255 (vs. gap), I255 (vs. gap), L394 (≠ V234), F425 (≠ T265), F425 (≠ T265), F425 (≠ T265), F425 (≠ T265), L497 (≠ V338), L497 (≠ V338), R501 (vs. gap), A531 (= A368), Y535 (≠ P372), Y535 (≠ P372), L626 (≠ F455), L626 (≠ F455), L626 (≠ F455), P694 (≠ M517), G696 (≠ D519), G697 (= G520)
- binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): T420 (≠ G260), F421 (= F261), G422 (= G262), R533 (= R370), H653 (≠ G481), G654 (= G482), Q655 (≠ S483), G656 (≠ R484), S695 (≠ T518), G696 (≠ D519), G697 (= G520), Q700 (≠ G523), Q701 (≠ T524), C799 (≠ V639), N800 (≠ H640), T804 (≠ V644), Q807 (= Q647), S865 (≠ R708), G866 (= G709), V867 (= V710), G868 (= G711), E869 (= E712)
Sites not aligning to the query:
- binding fe2/s2 (inorganic) cluster: 38, 40, 41, 43, 45, 46, 48, 58, 60, 100, 101, 103, 137, 139
- binding (molybdopterin-cytosine dinucleotide-s,s)-dioxo-aqua-molybdenum(v): 99, 139
Query Sequence
>SMa2037 FitnessBrowser__Smeli:SMa2037
MNFDPSHSKRSFSSVGTRPIRPDGVDKVTGRARYGADFNMPGQLVGRILRSPHAHAIIRK
IDTLKAAQLPGVKAVLTAADLPDLTDGDAAMYDILDNCMARKKALYDGHAVAAVAAIDAR
TAKQALKLIEVEYELLPHVTDVDQAFAPDAPLINDTIFTTGVDPKPDRPSNVSMRSQFGH
GDVDAGMARADFVVERTFKTEQTHQGYIEPHACVASVSSDGTADLWVCTQGHFVYRQHCA
QLLGMDASKLRVTSSEIGGGFGGKTHVWAEPVALALSRKAGRPVKLVMTRDEVFRASGPT
SATSIDVKIGALKDGTIIAADATLRYSCGPYAGAWAEVGAMTAFACYKLENVRTVGYEVL
VNRPKTAAYRAPSAPMAAFAVESAIDELAKKVGMNPIDFRIRNAAQEGTKASYGPVYGPI
GIGPTLEAVKNHPHMKAPLGRNQGRGMACGFWFNFGGQTCTDLNIGMDGTVSLAVGTVDV
GGSRASLSLVAAEELGIDYSQVRTVIADTSSLGYNDMTDGSRGTFSSSMATISAARNAIK
ILRERAAQMWDIPVEDVTWEKGHAVAKGETHGNLPKLSLKEIAAASGTTGGPIAGHSEIV
ADGAGVSFATHICDIEVDPETGATKVLRYTVVQDAGKAVHPTYVEGQYQGGAAQGIGWAL
NEEYIYGNDGRLQNAGFLDYRIPVCSDLPMIDTQILEIPNPNHPYGVRGVGETSIVPPLA
AVANAVSNAVGVRMLHIPMSPPRILAALEA
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory