Comparing SMc00497 FitnessBrowser__Smeli:SMc00497 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 7 hits to proteins with known functional sites (download)
6p3hC Crystal structure of ligu(k66m) bound to substrate (see paper)
66% identity, 99% coverage: 4:351/352 of query aligns to 3:350/352 of 6p3hC
6p3jB Crystal structure of ligu (see paper)
65% identity, 99% coverage: 4:351/352 of query aligns to 8:347/352 of 6p3jB
Sites not aligning to the query:
Q8EJW4 2-methyl-aconitate isomerase; Cis-trans isomerase; EC 5.3.3.- from Shewanella oneidensis (strain MR-1) (see paper)
33% identity, 98% coverage: 6:350/352 of query aligns to 12:392/397 of Q8EJW4
5k87A Crystal structure of malonate bound to methylaconitate isomerase prpf from shewanella oneidensis (see paper)
33% identity, 98% coverage: 6:350/352 of query aligns to 8:384/389 of 5k87A
2pvzA Crystal structure of methylaconitate isomerase prpf from shewanella oneidensis (see paper)
38% identity, 72% coverage: 6:259/352 of query aligns to 8:278/387 of 2pvzA
Sites not aligning to the query:
2pw0A Crystal structure of trans-aconitate bound to methylaconitate isomerase prpf from shewanella oneidensis (see paper)
38% identity, 72% coverage: 6:259/352 of query aligns to 7:276/385 of 2pw0A
Sites not aligning to the query:
2pw0B Crystal structure of trans-aconitate bound to methylaconitate isomerase prpf from shewanella oneidensis (see paper)
40% identity, 62% coverage: 6:223/352 of query aligns to 8:228/341 of 2pw0B
Sites not aligning to the query:
>SMc00497 FitnessBrowser__Smeli:SMc00497
MTPDGIACMMMRGGTSKGAYFLADDLPADAGERDRLLLRIMGSPDPRQIDGIGGADPLTS
KVAVVRASARPDFDVDFLFLQVFVDQALVSDSQNCGNILAGVGAFAVERGLVEAAEGETA
IRIYMENTSQSAVARIRTANGRPVYAGDASIDGVPTPAAPVYLTFTDAAGSSCGALLPTG
SAANEIEGVACTLIDNGMPVVVMRAADFGLTGYESREELEANESVKARIERIRLAAGPLM
NLGDVMKKSVPKMTLVALPVNGGAIMTRSFIPHRVHASIGVFGALSVATACLLPNSPAAS
LAILPEGEEKTVAVEHPTGRMEILLRLDNAGSVEECSFLRTARKLFDGRVFA
Or try a new SitesBLAST search
SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory