Comparing SMc01126 SMc01126 malic enzyme to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
6zngF Maeb full-length acetyl-coa bound state (see paper)
48% identity, 98% coverage: 17:759/761 of query aligns to 6:743/753 of 6zngF
P76558 NADP-dependent malic enzyme; NADP-ME; EC 1.1.1.40 from Escherichia coli (strain K12) (see paper)
47% identity, 98% coverage: 17:761/761 of query aligns to 7:756/759 of P76558
6zn7A Maeb malic enzyme domain apoprotein (see paper)
63% identity, 53% coverage: 17:417/761 of query aligns to 5:405/405 of 6zn7A
6zn4A Maeb malic enzyme domain apoprotein (see paper)
63% identity, 53% coverage: 17:417/761 of query aligns to 5:405/406 of 6zn4A
5ceeA Malic enzyme from candidatus phytoplasma aywb in complex with NAD and mg2+ (see paper)
47% identity, 49% coverage: 44:416/761 of query aligns to 29:387/387 of 5ceeA
2a9fA Crystal structure of a putative malic enzyme ((s)-malate:nad+ oxidoreductase (decarboxylating))
51% identity, 45% coverage: 29:371/761 of query aligns to 18:354/383 of 2a9fA
2dvmA NAD complex structure of ph1275 protein from pyrococcus horikoshii
45% identity, 53% coverage: 17:416/761 of query aligns to 3:398/438 of 2dvmA
2haeD Crystal structure of a putative malic enzyme (malate oxidoreductase)
42% identity, 52% coverage: 18:409/761 of query aligns to 1:373/373 of 2haeD
2haeB Crystal structure of a putative malic enzyme (malate oxidoreductase)
42% identity, 52% coverage: 18:409/761 of query aligns to 1:373/373 of 2haeB
1xcoD Crystal structure of a phosphotransacetylase from bacillus subtilis in complex with acetylphosphate (see paper)
30% identity, 43% coverage: 436:759/761 of query aligns to 3:324/325 of 1xcoD
6ioxA Crystal structure of porphyromonas gingivalis phosphotransacetylase in complex with acetyl-coa (see paper)
31% identity, 43% coverage: 435:759/761 of query aligns to 2:334/339 of 6ioxA
Q8ZND6 Phosphate acetyltransferase; Phosphotransacetylase; EC 2.3.1.222; EC 2.3.1.8 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
30% identity, 45% coverage: 419:759/761 of query aligns to 373:709/714 of Q8ZND6
Sites not aligning to the query:
2af3C Phosphotransacetylase from methanosarcina thermophila soaked with coenzyme a (see paper)
27% identity, 42% coverage: 440:760/761 of query aligns to 4:328/332 of 2af3C
P38503 Phosphate acetyltransferase; Phosphotransacetylase; EC 2.3.1.8 from Methanosarcina thermophila (see 2 papers)
27% identity, 42% coverage: 440:760/761 of query aligns to 5:329/333 of P38503
Sites not aligning to the query:
P16243 NADP-dependent malic enzyme, chloroplastic; NADP-ME; EC 1.1.1.40 from Zea mays (Maize) (see 3 papers)
28% identity, 52% coverage: 34:427/761 of query aligns to 185:624/636 of P16243
Sites not aligning to the query:
6w29A Trypanosoma cruzi malic enzyme in complex with inhibitor (mec013) (see paper)
28% identity, 38% coverage: 77:366/761 of query aligns to 133:483/545 of 6w29A
Sites not aligning to the query:
6w59A Trypanosoma cruzi malic enzyme in complex with inhibitor (mec063) (see paper)
28% identity, 38% coverage: 77:366/761 of query aligns to 131:481/544 of 6w59A
Sites not aligning to the query:
6w56A Trypanosoma cruzi malic enzyme in complex with inhibitor (mec062) (see paper)
28% identity, 38% coverage: 77:366/761 of query aligns to 131:481/544 of 6w56A
Sites not aligning to the query:
6w49A Trypanosoma cruzi malic enzyme in complex with inhibitor (mec010) (see paper)
28% identity, 38% coverage: 77:366/761 of query aligns to 131:481/543 of 6w49A
Sites not aligning to the query:
7x11A Crystal structure of me1 in complex with NADPH (see paper)
28% identity, 37% coverage: 79:362/761 of query aligns to 144:482/564 of 7x11A
>SMc01126 SMc01126 malic enzyme
MPGIDKTDRAMTSVTAQEALDFHSQGRPGKLEISPTKPMATQRDLSLAYSPGVAVPVKAI
ADDPATAYDYTARGNMVAVISNGTAILGLGNLGALASKPVMEGKAVLFKRFADVDSIDLE
VDTENVDEFVNCVRFLGPSFGGINLEDIKAPDCFIIEQRLREVMDIPVFHDDQHGTAIIA
AAGLVNALTLTGRDFKTAKLVCNGAGAAAIACIELIKAMGFNPENIILCDTKGVIYKGRT
DGMNQWKSAHAVETDRRTLAEALDGADVFFGLSAKGALSADMVRSMGARPIIFAMANPDP
EITPEEVALIRDDAIVATGRSDYPNQVNNVLGFPYIFRGALDVRASTINDAMKIAAAEAL
ANLAKEDVPDDVAAAYQGNRPRFGPQYIIPVPFDPRLISAIPMAVAKAAMETGVARKPIE
DLKAYGQQLSARRDPIASTLQRIVERVRRQPKRIVFAEGEEVQMMRSAIAYANQQLGTAL
LLGREEVMRETAEREGIDLDRAGIQIVNARLSKRVGAYTDFLYSRLQRKGYLFRDVQRLI
NTDRNHFAASMVALGDADGMVTGLTRNYSTALEDVRRCIDPKPGHRVIGVSIALCRGRTV
LVADTAVHDMPTSEELADIAEEAAGLAKRLGYVPRVAMLAYSTFGHPSGERSERVREAVK
ILDRRRVDFEYDGEMAADVALNARVMEQYPFCRLSGTANVLVMPAFHSASISTKMLQELG
GSTVIGPLLVGLDKSVQIASMSAKDSDLVNLAAIAAYNAGT
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory