SitesBLAST
Comparing SMc01431 FitnessBrowser__Smeli:SMc01431 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
6denA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron ethyl (see paper)
45% identity, 96% coverage: 8:573/592 of query aligns to 14:580/599 of 6denA
- active site: Y35 (= Y29), G37 (= G31), G38 (= G32), A39 (= A33), I40 (≠ V34), E61 (= E55), T84 (= T78), F123 (= F117), Q124 (= Q118), E125 (= E119), K173 (= K167), K230 (≠ H229), M266 (= M265), V293 (≠ I292), V409 (= V401), L434 (= L426), G435 (= G427), M437 (= M429), D462 (= D454), N489 (= N481), E491 (≠ Y483), Q492 (≠ M484), M494 (= M486), V495 (= V487), W498 (= W490), L520 (= L513), N525 (≠ G518), V526 (≠ G519)
- binding flavin-adenine dinucleotide: R163 (= R157), G219 (= G217), A220 (≠ G218), G221 (= G219), N224 (= N222), T246 (= T245), L247 (= L246), Q248 (≠ M247), L264 (= L263), G286 (= G285), A287 (= A286), R288 (= R287), D290 (= D289), R292 (= R291), V293 (≠ I292), E319 (≠ D309), I320 (= I310), N324 (≠ S314), D338 (= D328), V339 (= V329), M414 (= M406), G432 (= G424)
- binding ethyl 2-{[(4-iodo-6-methoxypyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: M266 (= M265), D291 (= D290), R292 (= R291), W498 (= W490)
- binding magnesium ion: D462 (= D454), N489 (= N481), E491 (≠ Y483)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V409 (= V401), G410 (= G402), Q411 (= Q403), H412 (= H404), G435 (= G427), M437 (= M429), G461 (= G453), D462 (= D454), A463 (= A455), S464 (= S456), N489 (= N481), E491 (≠ Y483), Q492 (≠ M484), G493 (= G485), M494 (= M486), V495 (= V487)
6demA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide bensulfuron methyl (see paper)
45% identity, 96% coverage: 8:573/592 of query aligns to 12:578/597 of 6demA
- active site: Y33 (= Y29), G35 (= G31), G36 (= G32), A37 (= A33), I38 (≠ V34), E59 (= E55), T82 (= T78), F121 (= F117), Q122 (= Q118), E123 (= E119), K171 (= K167), K228 (≠ H229), M264 (= M265), V291 (≠ I292), V407 (= V401), L432 (= L426), G433 (= G427), M435 (= M429), D460 (= D454), N487 (= N481), E489 (≠ Y483), Q490 (≠ M484), M492 (= M486), V493 (= V487), W496 (= W490), L518 (= L513), N523 (≠ G518), V524 (≠ G519)
- binding methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate: M264 (= M265), D289 (= D290), R290 (= R291), M492 (= M486), W496 (= W490), A567 (≠ S562)
- binding flavin-adenine dinucleotide: R161 (= R157), G217 (= G217), A218 (≠ G218), G219 (= G219), N222 (= N222), T244 (= T245), L245 (= L246), Q246 (≠ M247), L262 (= L263), G284 (= G285), A285 (= A286), R286 (= R287), D288 (= D289), R290 (= R291), V291 (≠ I292), E317 (≠ D309), I318 (= I310), N322 (≠ S314), D336 (= D328), V337 (= V329), M412 (= M406), G430 (= G424)
- binding magnesium ion: D460 (= D454), N487 (= N481), E489 (≠ Y483)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V407 (= V401), G408 (= G402), Q409 (= Q403), H410 (= H404), M435 (= M429), G459 (= G453), D460 (= D454), A461 (= A455), S462 (= S456), M465 (= M459), N487 (= N481), E489 (≠ Y483), Q490 (≠ M484), G491 (= G485), M492 (= M486), V493 (= V487)
6delA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide chlorimuron ethyl (see paper)
45% identity, 96% coverage: 8:573/592 of query aligns to 12:578/597 of 6delA
- active site: Y33 (= Y29), G35 (= G31), G36 (= G32), A37 (= A33), I38 (≠ V34), E59 (= E55), T82 (= T78), F121 (= F117), Q122 (= Q118), E123 (= E119), K171 (= K167), K228 (≠ H229), M264 (= M265), V291 (≠ I292), V407 (= V401), L432 (= L426), G433 (= G427), M435 (= M429), D460 (= D454), N487 (= N481), E489 (≠ Y483), Q490 (≠ M484), M492 (= M486), V493 (= V487), W496 (= W490), L518 (= L513), N523 (≠ G518), V524 (≠ G519)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: D289 (= D290), R290 (= R291), W496 (= W490)
- binding flavin-adenine dinucleotide: R161 (= R157), G217 (= G217), A218 (≠ G218), G219 (= G219), N222 (= N222), T244 (= T245), L245 (= L246), Q246 (≠ M247), L262 (= L263), G284 (= G285), A285 (= A286), R286 (= R287), D288 (= D289), R290 (= R291), V291 (≠ I292), E317 (≠ D309), I318 (= I310), N322 (≠ S314), D336 (= D328), V337 (= V329), M412 (= M406), G430 (= G424)
- binding (3Z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl](formyl)amino}-3-sulfanylpent-3-en-1-yl trihydrogen diphosphate: V407 (= V401), G408 (= G402), Q409 (= Q403), H410 (= H404), G433 (= G427), M435 (= M429), G459 (= G453), D460 (= D454), A461 (= A455), S462 (= S456), M465 (= M459), N487 (= N481), E489 (≠ Y483), Q490 (≠ M484), G491 (= G485), M492 (= M486), V493 (= V487)
- binding magnesium ion: D460 (= D454), N487 (= N481), E489 (≠ Y483)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V407 (= V401), G408 (= G402), Q409 (= Q403), H410 (= H404), G433 (= G427), M435 (= M429), G459 (= G453), D460 (= D454), A461 (= A455), S462 (= S456), M465 (= M459), N487 (= N481), E489 (≠ Y483), Q490 (≠ M484), G491 (= G485), M492 (= M486), V493 (= V487)
6deqA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide penoxsulam (see paper)
45% identity, 96% coverage: 8:573/592 of query aligns to 14:582/601 of 6deqA
- active site: Y35 (= Y29), G37 (= G31), G38 (= G32), A39 (= A33), I40 (≠ V34), E61 (= E55), T84 (= T78), F123 (= F117), Q124 (= Q118), E125 (= E119), K173 (= K167), K232 (≠ H229), M268 (= M265), V295 (≠ I292), V411 (= V401), L436 (= L426), G437 (= G427), M439 (= M429), D464 (= D454), N491 (= N481), E493 (≠ Y483), Q494 (≠ M484), M496 (= M486), V497 (= V487), W500 (= W490), L522 (= L513), N527 (≠ G518), V528 (≠ G519)
- binding flavin-adenine dinucleotide: R163 (= R157), G221 (= G217), A222 (≠ G218), G223 (= G219), N226 (= N222), T248 (= T245), L249 (= L246), Q250 (≠ M247), L266 (= L263), G288 (= G285), A289 (= A286), R290 (= R287), D292 (= D289), R294 (= R291), V295 (≠ I292), E321 (≠ D309), I322 (= I310), D340 (= D328), V341 (= V329), M416 (= M406), G434 (= G424)
- binding magnesium ion: D464 (= D454), N491 (= N481), E493 (≠ Y483)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: M268 (= M265), R294 (= R291), M496 (= M486), V497 (= V487), W500 (= W490), A571 (≠ S562)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V411 (= V401), G412 (= G402), Q413 (= Q403), H414 (= H404), M439 (= M429), G463 (= G453), D464 (= D454), A465 (= A455), S466 (= S456), N491 (= N481), E493 (≠ Y483), Q494 (≠ M484), G495 (= G485), M496 (= M486), V497 (= V487)
1t9bB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
46% identity, 95% coverage: 8:570/592 of query aligns to 8:573/595 of 1t9bB
- active site: Y29 (= Y29), G31 (= G31), G32 (= G32), A33 (= A33), I34 (≠ V34), E55 (= E55), T78 (= T78), F117 (= F117), Q118 (= Q118), E119 (= E119), K167 (= K167), R226 (≠ Q226), M262 (= M265), V289 (≠ I292), V405 (= V401), L430 (= L426), G431 (= G427), M433 (= M429), D458 (= D454), N485 (= N481), E487 (≠ Y483), Q488 (≠ M484), M490 (= M486), V491 (= V487), W494 (= W490), L516 (= L513), G521 (= G518), L522 (≠ G519), K555 (≠ N552)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: V107 (= V107), P108 (= P108), D287 (= D290), R288 (= R291), M490 (= M486), W494 (= W490)
- binding flavin-adenine dinucleotide: R157 (= R157), G215 (= G217), A216 (≠ G218), G217 (= G219), N220 (= N222), T242 (= T245), L243 (= L246), Q244 (≠ M247), M259 (= M262), L260 (= L263), M262 (= M265), H263 (= H266), G282 (= G285), A283 (= A286), R284 (= R287), D286 (= D289), R288 (= R291), V289 (≠ I292), E315 (≠ D309), V316 (≠ I310), N320 (≠ S314), G333 (= G327), D334 (= D328), A335 (≠ V329), Q409 (= Q405), M410 (= M406), G428 (= G424), G429 (= G425)
- binding magnesium ion: D458 (= D454), N485 (= N481), E487 (≠ Y483)
6deoA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide iodomuron methyl (see paper)
44% identity, 96% coverage: 8:578/592 of query aligns to 10:579/593 of 6deoA
- active site: Y31 (= Y29), G33 (= G31), G34 (= G32), A35 (= A33), I36 (≠ V34), E57 (= E55), T80 (= T78), F119 (= F117), Q120 (= Q118), E121 (= E119), K169 (= K167), K224 (≠ H229), M260 (= M265), V287 (≠ I292), V403 (= V401), L428 (= L426), G429 (= G427), M431 (= M429), D456 (= D454), N483 (= N481), E485 (≠ Y483), Q486 (≠ M484), M488 (= M486), V489 (= V487), W492 (= W490), L514 (= L513), N519 (≠ G518), V520 (≠ G519)
- binding flavin-adenine dinucleotide: R159 (= R157), G213 (= G217), A214 (≠ G218), G215 (= G219), N218 (= N222), T240 (= T245), L241 (= L246), Q242 (≠ M247), L258 (= L263), G280 (= G285), A281 (= A286), R282 (= R287), D284 (= D289), R286 (= R291), V287 (≠ I292), E313 (≠ D309), I314 (= I310), N318 (≠ S314), D332 (= D328), V333 (= V329), M408 (= M406), G426 (= G424)
- binding methyl 2-{[(4-iodo-6-methoxypyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: M260 (= M265), D285 (= D290), R286 (= R291), M488 (= M486), W492 (= W490)
- binding magnesium ion: D456 (= D454), N483 (= N481), E485 (≠ Y483)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V403 (= V401), G404 (= G402), Q405 (= Q403), H406 (= H404), G429 (= G427), M431 (= M429), G455 (= G453), D456 (= D454), A457 (= A455), S458 (= S456), M461 (= M459), N483 (= N481), E485 (≠ Y483), Q486 (≠ M484), G487 (= G485), M488 (= M486), V489 (= V487)
6desA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide propoxycarbazone (see paper)
45% identity, 96% coverage: 8:573/592 of query aligns to 12:579/598 of 6desA
- active site: Y33 (= Y29), G35 (= G31), G36 (= G32), A37 (= A33), I38 (≠ V34), E59 (= E55), T82 (= T78), F121 (= F117), Q122 (= Q118), E123 (= E119), K171 (= K167), K229 (≠ H229), M265 (= M265), V292 (≠ I292), V408 (= V401), L433 (= L426), G434 (= G427), M436 (= M429), D461 (= D454), N488 (= N481), E490 (≠ Y483), Q491 (≠ M484), M493 (= M486), V494 (= V487), W497 (= W490), L519 (= L513), N524 (≠ G518), V525 (≠ G519)
- binding methyl 2-[(4-methyl-5-oxidanylidene-3-propoxy-1,2,4-triazol-1-yl)carbonylsulfamoyl]benzoate: M265 (= M265), D290 (= D290), R291 (= R291), W497 (= W490)
- binding flavin-adenine dinucleotide: R161 (= R157), G218 (= G217), A219 (≠ G218), G220 (= G219), N223 (= N222), T245 (= T245), L246 (= L246), Q247 (≠ M247), L263 (= L263), G285 (= G285), A286 (= A286), R287 (= R287), D289 (= D289), R291 (= R291), V292 (≠ I292), E318 (≠ D309), I319 (= I310), N323 (≠ S314), D337 (= D328), V338 (= V329), Q412 (= Q405), M413 (= M406), G431 (= G424)
- binding magnesium ion: D461 (= D454), N488 (= N481), E490 (≠ Y483)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V408 (= V401), G409 (= G402), Q410 (= Q403), H411 (= H404), G434 (= G427), M436 (= M429), G460 (= G453), D461 (= D454), A462 (= A455), S463 (= S456), N488 (= N481), E490 (≠ Y483), Q491 (≠ M484), G492 (= G485), M493 (= M486), V494 (= V487)
6depA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide sulfometuron methyl (see paper)
45% identity, 96% coverage: 8:573/592 of query aligns to 12:579/598 of 6depA
- active site: Y33 (= Y29), G35 (= G31), G36 (= G32), A37 (= A33), I38 (≠ V34), E59 (= E55), T82 (= T78), F121 (= F117), Q122 (= Q118), E123 (= E119), K171 (= K167), K229 (≠ H229), M265 (= M265), V292 (≠ I292), V408 (= V401), L433 (= L426), G434 (= G427), M436 (= M429), D461 (= D454), N488 (= N481), E490 (≠ Y483), Q491 (≠ M484), M493 (= M486), V494 (= V487), W497 (= W490), L519 (= L513), N524 (≠ G518), V525 (≠ G519)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D290 (= D290), R291 (= R291), M493 (= M486), W497 (= W490)
- binding flavin-adenine dinucleotide: R161 (= R157), G218 (= G217), A219 (≠ G218), G220 (= G219), N223 (= N222), T245 (= T245), L246 (= L246), Q247 (≠ M247), L263 (= L263), G264 (= G264), G285 (= G285), A286 (= A286), R287 (= R287), D289 (= D289), R291 (= R291), V292 (≠ I292), E318 (≠ D309), I319 (= I310), N323 (≠ S314), D337 (= D328), V338 (= V329), M413 (= M406), G431 (= G424)
- binding magnesium ion: D461 (= D454), N488 (= N481), E490 (≠ Y483)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V408 (= V401), G409 (= G402), Q410 (= Q403), H411 (= H404), G434 (= G427), M436 (= M429), G460 (= G453), D461 (= D454), A462 (= A455), S463 (= S456), M466 (= M459), N488 (= N481), E490 (≠ Y483), Q491 (≠ M484), G492 (= G485), M493 (= M486), V494 (= V487)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V408 (= V401), G409 (= G402), Q410 (= Q403), H411 (= H404), G434 (= G427), M436 (= M429), G460 (= G453), D461 (= D454), A462 (= A455), S463 (= S456), M466 (= M459), N488 (= N481), E490 (≠ Y483), Q491 (≠ M484), G492 (= G485), M493 (= M486), V494 (= V487)
P07342 Acetolactate synthase catalytic subunit, mitochondrial; Acetohydroxy-acid synthase catalytic subunit; AHAS; ALS; EC 2.2.1.6 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
46% identity, 95% coverage: 8:570/592 of query aligns to 92:665/687 of P07342
- R241 (= R157) binding
- 355:376 (vs. 266:287, 50% identical) binding
- 407:426 (vs. 309:328, 35% identical) binding
1n0hA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorimuron ethyl (see paper)
45% identity, 95% coverage: 8:570/592 of query aligns to 10:577/599 of 1n0hA
- active site: Y31 (= Y29), G33 (= G31), G34 (= G32), A35 (= A33), I36 (≠ V34), E57 (= E55), T80 (= T78), F119 (= F117), Q120 (= Q118), E121 (= E119), K169 (= K167), R230 (≠ Q226), M266 (= M265), V293 (≠ I292), V409 (= V401), L434 (= L426), G435 (= G427), M437 (= M429), D462 (= D454), N489 (= N481), E491 (≠ Y483), Q492 (≠ M484), M494 (= M486), V495 (= V487), W498 (= W490), L520 (= L513), G525 (= G518), L526 (≠ G519), K559 (≠ N552)
- binding 4-{[(4'-amino-2'-methylpyrimidin-5'-yl)methyl]amino}pent-3-enyl diphosphate: V409 (= V401), G410 (= G402), Q411 (= Q403), H412 (= H404), G435 (= G427), M437 (= M429), G461 (= G453), D462 (= D454), A463 (= A455), S464 (= S456), M467 (= M459), N489 (= N481), E491 (≠ Y483), Q492 (≠ M484), G493 (= G485), V495 (= V487)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: G34 (= G32), A35 (= A33), V109 (= V107), P110 (= P108), F119 (= F117), K169 (= K167), M266 (= M265), D291 (= D290), R292 (= R291), V495 (= V487), W498 (= W490)
- binding flavin-adenine dinucleotide: R159 (= R157), G219 (= G217), A220 (≠ G218), G221 (= G219), N224 (= N222), T246 (= T245), L247 (= L246), Q248 (≠ M247), L264 (= L263), G265 (= G264), M266 (= M265), H267 (= H266), G286 (= G285), A287 (= A286), R288 (= R287), D290 (= D289), R292 (= R291), V293 (≠ I292), E319 (≠ D309), V320 (≠ I310), N324 (≠ S314), G337 (= G327), D338 (= D328), A339 (≠ V329), M414 (= M406), G432 (= G424), G433 (= G425)
- binding magnesium ion: D462 (= D454), N489 (= N481), E491 (≠ Y483)
- binding thiamine diphosphate: Y31 (= Y29), E57 (= E55), P83 (= P81)
6derA Crystal structure of candida albicans acetohydroxyacid synthase in complex with the herbicide metosulam (see paper)
45% identity, 96% coverage: 8:573/592 of query aligns to 14:581/600 of 6derA
- active site: Y35 (= Y29), G37 (= G31), G38 (= G32), A39 (= A33), I40 (≠ V34), E61 (= E55), T84 (= T78), F123 (= F117), Q124 (= Q118), E125 (= E119), K173 (= K167), K231 (≠ H229), M267 (= M265), V294 (≠ I292), V410 (= V401), L435 (= L426), G436 (= G427), M438 (= M429), D463 (= D454), N490 (= N481), E492 (≠ Y483), Q493 (≠ M484), M495 (= M486), V496 (= V487), W499 (= W490), L521 (= L513), N526 (≠ G518), V527 (≠ G519)
- binding flavin-adenine dinucleotide: R163 (= R157), G220 (= G217), A221 (≠ G218), G222 (= G219), N225 (= N222), T247 (= T245), L248 (= L246), Q249 (≠ M247), L265 (= L263), H268 (= H266), G287 (= G285), A288 (= A286), R289 (= R287), D291 (= D289), R293 (= R291), V294 (≠ I292), E320 (≠ D309), I321 (= I310), N325 (≠ S314), G338 (= G327), D339 (= D328), V340 (= V329), Q414 (= Q405), M415 (= M406), G433 (= G424)
- binding Metosulam: R293 (= R291), M495 (= M486), W499 (= W490), A570 (≠ S562)
- binding magnesium ion: D463 (= D454), N490 (= N481), E492 (≠ Y483)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V410 (= V401), G411 (= G402), Q412 (= Q403), H413 (= H404), G436 (= G427), M438 (= M429), G462 (= G453), D463 (= D454), A464 (= A455), S465 (= S456), N490 (= N481), E492 (≠ Y483), Q493 (≠ M484), G494 (= G485), M495 (= M486), V496 (= V487)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V410 (= V401), G411 (= G402), Q412 (= Q403), H413 (= H404), G436 (= G427), M438 (= M429), G462 (= G453), D463 (= D454), A464 (= A455), S465 (= S456), M468 (= M459), N490 (= N481), E492 (≠ Y483), Q493 (≠ M484), G494 (= G485), V496 (= V487)
6u9dB Saccharomyces cerevisiae acetohydroxyacid synthase (see paper)
46% identity, 95% coverage: 8:570/592 of query aligns to 12:585/607 of 6u9dB
- active site: Y33 (= Y29), G35 (= G31), G36 (= G32), A37 (= A33), I38 (≠ V34), E59 (= E55), T82 (= T78), F121 (= F117), Q122 (= Q118), E123 (= E119), K171 (= K167), M274 (= M265), V301 (≠ I292), V417 (= V401), G443 (= G427), M445 (= M429), D470 (= D454), N497 (= N481), E499 (≠ Y483), Q500 (≠ M484), M502 (= M486), V503 (= V487), W506 (= W490)
- binding methyl 2-[(4,6-dimethoxypyrimidin-2-yl)carbamoylsulfamoylmethyl]benzoate: G36 (= G32), V111 (= V107), P112 (= P108), F121 (= F117), K171 (= K167), D299 (= D290), R300 (= R291), M502 (= M486), W506 (= W490)
- binding flavin-adenine dinucleotide: R161 (= R157), A228 (≠ G218), G229 (= G219), N232 (= N222), T254 (= T245), L255 (= L246), Q256 (≠ M247), L272 (= L263), M274 (= M265), G294 (= G285), R296 (= R287), D298 (= D289), R300 (= R291), V301 (≠ I292), E327 (≠ D309), V328 (≠ I310), N332 (≠ S314), D346 (= D328), A347 (≠ V329), M422 (= M406), G440 (= G424), G441 (= G425)
- binding magnesium ion: D470 (= D454), N497 (= N481)
- binding thiamine diphosphate: E59 (= E55), P85 (= P81), V417 (= V401), G418 (= G402), Q419 (= Q403), H420 (= H404), G443 (= G427), M445 (= M429), A471 (= A455), S472 (= S456), N497 (= N481), E499 (≠ Y483), Q500 (≠ M484), G501 (= G485), M502 (= M486), V503 (= V487)
1t9cA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl (see paper)
46% identity, 95% coverage: 8:570/592 of query aligns to 8:574/596 of 1t9cA
- active site: Y29 (= Y29), G31 (= G31), G32 (= G32), A33 (= A33), I34 (≠ V34), E55 (= E55), T78 (= T78), F117 (= F117), Q118 (= Q118), E119 (= E119), K167 (= K167), R227 (≠ Q226), M263 (= M265), V290 (≠ I292), V406 (= V401), L431 (= L426), G432 (= G427), M434 (= M429), D459 (= D454), N486 (= N481), E488 (≠ Y483), Q489 (≠ M484), M491 (= M486), V492 (= V487), W495 (= W490), L517 (= L513), G522 (= G518), L523 (≠ G519), K556 (≠ N552)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (= G32), V107 (= V107), P108 (= P108), F117 (= F117), K167 (= K167), D288 (= D290), R289 (= R291), W495 (= W490)
- binding flavin-adenine dinucleotide: R157 (= R157), G216 (= G217), A217 (≠ G218), G218 (= G219), N221 (= N222), T243 (= T245), L244 (= L246), Q245 (≠ M247), L261 (= L263), M263 (= M265), H264 (= H266), G283 (= G285), A284 (= A286), R285 (= R287), D287 (= D289), R289 (= R291), V290 (≠ I292), E316 (≠ D309), V317 (≠ I310), N321 (≠ S314), G334 (= G327), D335 (= D328), A336 (≠ V329), M411 (= M406), G429 (= G424), G430 (= G425)
- binding magnesium ion: D459 (= D454), N486 (= N481), E488 (≠ Y483)
5wkcA Saccharomyces cerevisiae acetohydroxyacid synthase in complex with the herbicide penoxsulam (see paper)
46% identity, 95% coverage: 8:570/592 of query aligns to 8:569/591 of 5wkcA
- active site: Y29 (= Y29), G31 (= G31), G32 (= G32), A33 (= A33), I34 (≠ V34), E55 (= E55), T78 (= T78), F117 (= F117), Q118 (= Q118), E119 (= E119), K167 (= K167), R222 (≠ Q226), M258 (= M265), V285 (≠ I292), V401 (= V401), L426 (= L426), G427 (= G427), M429 (= M429), D454 (= D454), N481 (= N481), E483 (≠ Y483), Q484 (≠ M484), M486 (= M486), V487 (= V487), W490 (= W490), L512 (= L513), G517 (= G518), L518 (≠ G519), K551 (≠ N552)
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V401 (= V401), G402 (= G402), Q403 (= Q403), H404 (= H404), G427 (= G427), M429 (= M429), G453 (= G453), D454 (= D454), A455 (= A455), S456 (= S456), M459 (= M459), N481 (= N481), E483 (≠ Y483), Q484 (≠ M484), G485 (= G485), M486 (= M486), V487 (= V487)
- binding ethaneperoxoic acid: G32 (= G32), Q118 (= Q118)
- binding flavin-adenine dinucleotide: R157 (= R157), G211 (= G217), A212 (≠ G218), G213 (= G219), N216 (= N222), T238 (= T245), L239 (= L246), Q240 (≠ M247), L256 (= L263), M258 (= M265), G278 (= G285), A279 (= A286), R280 (= R287), R284 (= R291), V285 (≠ I292), E311 (≠ D309), V312 (≠ I310), N316 (≠ S314), D330 (= D328), A331 (≠ V329), M406 (= M406), G424 (= G424)
- binding magnesium ion: D454 (= D454), N481 (= N481), E483 (≠ Y483)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: G32 (= G32), A33 (= A33), V107 (= V107), F117 (= F117), K167 (= K167), M258 (= M265), R284 (= R291), M486 (= M486), W490 (= W490)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: P30 (= P30), E55 (= E55)
1t9aA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl (see paper)
46% identity, 95% coverage: 8:570/592 of query aligns to 9:575/597 of 1t9aA
- active site: Y30 (= Y29), G32 (= G31), G33 (= G32), A34 (= A33), I35 (≠ V34), E56 (= E55), T79 (= T78), F118 (= F117), Q119 (= Q118), E120 (= E119), K168 (= K167), R228 (≠ Q226), M264 (= M265), V291 (≠ I292), V407 (= V401), L432 (= L426), G433 (= G427), M435 (= M429), D460 (= D454), N487 (= N481), E489 (≠ Y483), Q490 (≠ M484), M492 (= M486), V493 (= V487), W496 (= W490), L518 (= L513), G523 (= G518), L524 (≠ G519), K557 (≠ N552)
- binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: G33 (= G32), V108 (= V107), P109 (= P108), F118 (= F117), K168 (= K167), M264 (= M265), D289 (= D290), R290 (= R291), M492 (= M486), V493 (= V487), W496 (= W490)
- binding flavin-adenine dinucleotide: R158 (= R157), G217 (= G217), A218 (≠ G218), G219 (= G219), N222 (= N222), T244 (= T245), L245 (= L246), Q246 (≠ M247), L262 (= L263), M264 (= M265), H265 (= H266), G284 (= G285), A285 (= A286), R286 (= R287), D288 (= D289), R290 (= R291), V291 (≠ I292), E317 (≠ D309), V318 (≠ I310), N322 (≠ S314), G335 (= G327), D336 (= D328), A337 (≠ V329), Q411 (= Q405), M412 (= M406), G430 (= G424), G431 (= G425)
- binding magnesium ion: D460 (= D454), N487 (= N481), E489 (≠ Y483)
- binding propyl trihydrogen diphosphate: V407 (= V401), G408 (= G402), Q409 (= Q403), H410 (= H404), M435 (= M429), G459 (= G453), D460 (= D454), A461 (= A455), S462 (= S456), N487 (= N481), E489 (≠ Y483), Q490 (≠ M484), G491 (= G485), M492 (= M486)
- binding 5-{[ethyl(methyl)amino]methyl}-2-methyl-5,6-dihydropyrimidin-4-amine: G433 (= G427), M435 (= M429), M465 (= M459)
1t9dA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
46% identity, 95% coverage: 8:570/592 of query aligns to 8:574/596 of 1t9dA
- active site: Y29 (= Y29), G31 (= G31), G32 (= G32), A33 (= A33), I34 (≠ V34), E55 (= E55), T78 (= T78), F117 (= F117), Q118 (= Q118), E119 (= E119), K167 (= K167), R227 (≠ Q226), M263 (= M265), V290 (≠ I292), V406 (= V401), L431 (= L426), G432 (= G427), M434 (= M429), D459 (= D454), N486 (= N481), E488 (≠ Y483), Q489 (≠ M484), M491 (= M486), V492 (= V487), W495 (= W490), L517 (= L513), G522 (= G518), L523 (≠ G519), K556 (≠ N552)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (= G32), A33 (= A33), V107 (= V107), P108 (= P108), F117 (= F117), K167 (= K167), M263 (= M265), D288 (= D290), R289 (= R291), W495 (= W490)
- binding flavin-adenine dinucleotide: R157 (= R157), G216 (= G217), A217 (≠ G218), G218 (= G219), N221 (= N222), T243 (= T245), L244 (= L246), Q245 (≠ M247), M260 (= M262), L261 (= L263), H264 (= H266), G283 (= G285), A284 (= A286), R285 (= R287), D287 (= D289), R289 (= R291), V290 (≠ I292), E316 (≠ D309), V317 (≠ I310), N321 (≠ S314), G334 (= G327), D335 (= D328), A336 (≠ V329), Q410 (= Q405), M411 (= M406), G429 (= G424), G430 (= G425)
- binding magnesium ion: D459 (= D454), N486 (= N481), E488 (≠ Y483)
- binding 2,5-dimethyl-pyrimidin-4-ylamine: E55 (= E55), P81 (= P81), Q118 (= Q118), G432 (= G427), M434 (= M429), M464 (= M459)
1t9dB Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
45% identity, 95% coverage: 8:570/592 of query aligns to 7:560/582 of 1t9dB
- active site: Y28 (= Y29), G30 (= G31), G31 (= G32), A32 (= A33), I33 (≠ V34), E54 (= E55), T77 (= T78), F116 (= F117), Q117 (= Q118), E118 (= E119), K166 (= K167), R213 (≠ Q226), M249 (= M265), V276 (≠ I292), V392 (= V401), L417 (= L426), G418 (= G427), M420 (= M429), D445 (= D454), N472 (= N481), E474 (≠ Y483), Q475 (≠ M484), M477 (= M486), V478 (= V487), W481 (= W490), L503 (= L513), G508 (= G518), L509 (≠ G519), K542 (≠ N552)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G31 (= G32), A32 (= A33), V106 (= V107), P107 (= P108), F116 (= F117), K166 (= K167), M249 (= M265), D274 (= D290), R275 (= R291), W481 (= W490)
- binding flavin-adenine dinucleotide: R156 (= R157), G202 (= G217), A203 (≠ G218), G204 (= G219), N207 (= N222), T229 (= T245), L230 (= L246), Q231 (≠ M247), L247 (= L263), M249 (= M265), H250 (= H266), G269 (= G285), A270 (= A286), R271 (= R287), D273 (= D289), R275 (= R291), V276 (≠ I292), E302 (≠ D309), V303 (≠ I310), N307 (≠ S314), G320 (= G327), D321 (= D328), A322 (≠ V329), Q396 (= Q405), M397 (= M406), G415 (= G424), G416 (= G425)
- binding magnesium ion: D445 (= D454), N472 (= N481), E474 (≠ Y483)
- binding 2,5-dimethyl-pyrimidin-4-ylamine: E54 (= E55), P80 (= P81), G418 (= G427), M420 (= M429), M450 (= M459)
1t9bA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
45% identity, 95% coverage: 8:570/592 of query aligns to 8:561/583 of 1t9bA
- active site: Y29 (= Y29), G31 (= G31), G32 (= G32), A33 (= A33), I34 (≠ V34), E55 (= E55), T78 (= T78), F117 (= F117), Q118 (= Q118), E119 (= E119), K167 (= K167), R214 (≠ Q226), M250 (= M265), V277 (≠ I292), V393 (= V401), L418 (= L426), G419 (= G427), M421 (= M429), D446 (= D454), N473 (= N481), E475 (≠ Y483), Q476 (≠ M484), M478 (= M486), V479 (= V487), W482 (= W490), L504 (= L513), G509 (= G518), L510 (≠ G519), K543 (≠ N552)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: V107 (= V107), P108 (= P108), F117 (= F117), D275 (= D290), R276 (= R291), M478 (= M486), W482 (= W490)
- binding flavin-adenine dinucleotide: R157 (= R157), G203 (= G217), A204 (≠ G218), G205 (= G219), N208 (= N222), T230 (= T245), L231 (= L246), Q232 (≠ M247), M247 (= M262), L248 (= L263), M250 (= M265), H251 (= H266), G270 (= G285), A271 (= A286), R272 (= R287), D274 (= D289), R276 (= R291), V277 (≠ I292), E303 (≠ D309), V304 (≠ I310), N308 (≠ S314), D322 (= D328), A323 (≠ V329), Q397 (= Q405), M398 (= M406), G416 (= G424), G417 (= G425)
- binding magnesium ion: D446 (= D454), N473 (= N481), E475 (≠ Y483)
7egvA Acetolactate synthase from trichoderma harzianum with inhibitor harzianic acid (see paper)
46% identity, 96% coverage: 9:578/592 of query aligns to 8:576/590 of 7egvA
- active site: Y28 (= Y29), G30 (= G31), G31 (= G32), A32 (= A33), I33 (≠ V34), E54 (= E55), T77 (= T78), F116 (= F117), Q117 (= Q118), K166 (= K167), E220 (≠ Q226), M256 (= M265), V283 (≠ I292), V400 (= V401), L425 (= L426), G426 (= G427), M428 (= M429), Q483 (≠ M484), M485 (= M486), V486 (= V487), W489 (= W490), L511 (= L513), G516 (= G518), I517 (≠ G519)
- binding flavin-adenine dinucleotide: R156 (= R157), G209 (= G217), Q210 (≠ G218), G211 (= G219), T236 (= T245), L237 (= L246), H238 (≠ M247), G276 (= G285), S277 (≠ A286), R278 (= R287), D280 (= D289), R282 (= R291), V283 (≠ I292), E309 (≠ D309), I310 (= I310), D328 (= D328), V329 (= V329), M405 (= M406), G423 (= G424), G424 (= G425)
- binding (2S)-3-methyl-2-[[(2S,4R)-1-methyl-4-[(2E,4E)-octa-2,4-dienoyl]-3,5-bis(oxidanylidene)pyrrolidin-2-yl]methyl]-2-oxidanyl-butanoic acid: F493 (≠ L494), Y494 (≠ H495)
- binding magnesium ion: D453 (= D454), N480 (= N481), E482 (≠ Y483)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: P29 (= P30), E54 (= E55), Q117 (= Q118), V400 (= V401), G401 (= G402), Q402 (= Q403), H403 (= H404), G426 (= G427), M428 (= M429), D453 (= D454), A454 (= A455), S455 (= S456), E482 (≠ Y483), Q483 (≠ M484), G484 (= G485), M485 (= M486), V486 (= V487)
P17597 Acetolactate synthase, chloroplastic; AtALS; Acetohydroxy-acid synthase; Protein CHLORSULFURON RESISTANT 1; EC 2.2.1.6 from Arabidopsis thaliana (Mouse-ear cress) (see 8 papers)
44% identity, 95% coverage: 10:570/592 of query aligns to 99:661/670 of P17597
- A122 (= A33) mutation to V: Reduced catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
- M124 (≠ L35) mutation to E: Reduced catalytic activity. Resistant to imidazolinone herbicides and reduced sensitivity to sulfonylurea herbicides.; mutation to I: No effect on catalytic activity. Increased resistance to imidazolinone herbicides.
- E144 (= E55) binding
- S186 (= S97) binding
- P197 (= P108) mutation to S: In csr1-1/GH50; resistant to sulfonylurea but not to imidazolinone herbicides.
- R199 (≠ S110) mutation R->A,E: No effect on catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
- Q207 (= Q118) binding
- K220 (= K131) binding
- R246 (= R157) binding ; binding
- K256 (= K167) binding
- G308 (= G218) binding
- TL 331:332 (= TL 245:246) binding
- C340 (≠ A254) modified: Cysteine sulfinic acid (-SO2H)
- LGMH 349:352 (= LGMH 263:266) binding
- GVRFD 371:375 (≠ GARFD 285:289) binding
- DR 376:377 (= DR 290:291) binding
- DI 395:396 (= DI 309:310) binding
- DV 414:415 (= DV 328:329) binding
- QH 487:488 (= QH 403:404) binding
- GG 508:509 (= GG 424:425) binding
- GAM 511:513 (≠ GTM 427:429) binding
- D538 (= D454) binding
- DGS 538:540 (≠ DAS 454:456) binding
- N565 (= N481) binding
- NQHLGM 565:570 (≠ NQYMGM 481:486) binding
- H567 (≠ Y483) binding
- W574 (= W490) binding ; mutation to L: Increased catalytic activity. Resistant to imidazolinone and sulfonylurea herbicides.; mutation to S: Slightly decreased catalytic activity. Resistant to imidazolinone and sulfonylurea herbicides.
- S653 (= S562) binding ; mutation to A: No effect on catalytic activity or sensitivity to herbicides.; mutation to F: No effect on catalytic activity. Resistant to imidazolinone herbicides and also slightly sulfonylurea-resistant.; mutation to N: In csr1-2/GH90; no effect on catalytic activity. Resistant to imidazolinone but not to sulfonylurea herbicides.; mutation to T: No effect on catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
Query Sequence
>SMc01431 FitnessBrowser__Smeli:SMc01431
MSGTENQMTGAEIVLQALKDNGVEHIFGYPGGAVLPIYDEIFQQEDIQHILVRHEQGAGH
MAEGYARSTGKVGVMLVTSGPGATNAVTPLQDALMDSIPLVCISGQVPTSLIGSDAFQEC
DTIGITRPCTKHNWLVRDVNELARVIHEAFRVAQSGRPGPVVVDIPKDVQFATGTYTPPS
AVPTQKSYQPKTQGDLKKIEEAVALMKTARQPVIYSGGGVINSGPQAAHFLRELVELTGF
PITSTLMGLGAYPASGKNWLGMLGMHGTYEANLAMHDCDVMICIGARFDDRITGRLNAFS
PNSKKIHIDIDPSSINKNVRVDVPIIGDVAAVLEDMIRLWRAAAKTVDQTRLGDWWKSIS
KWRARNSLAYTPSADVIMPQYAIQRLYELTKDRDTYITTEVGQHQMWAAQFFGFEEPNRW
MTSGGLGTMGYGFPAAVGVQVAHPESLVIDIAGDASIQMCIQEMSCAVQYGLPVKIFILN
NQYMGMVRQWQQLLHGNRLSHSYTEAMPDFVKLAEAYGGVGIRCEKPGELDDAIRQMIDT
PAPVIFDCRVANLANCFPMIPSGKAHNEMLLPDEATDEVVANAIDAKGRQLV
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory