Comparing SMc01614 FitnessBrowser__Smeli:SMc01614 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P27876 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Bacillus subtilis (strain 168) (see paper)
40% identity, 95% coverage: 8:250/255 of query aligns to 6:249/253 of P27876
6bveA Triosephosphate isomerase of synechocystis in complex with 2- phosphoglycolic acid (see paper)
39% identity, 95% coverage: 6:248/255 of query aligns to 4:238/242 of 6bveA
P00943 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Geobacillus stearothermophilus (Bacillus stearothermophilus) (see 2 papers)
41% identity, 95% coverage: 8:249/255 of query aligns to 6:248/253 of P00943
1btmA Triosephosphate isomerase (tim) complexed with 2-phosphoglycolic acid (see paper)
41% identity, 95% coverage: 8:249/255 of query aligns to 5:247/251 of 1btmA
P36204 Bifunctional PGK/TIM; EC 2.7.2.3; EC 5.3.1.1 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
40% identity, 90% coverage: 6:235/255 of query aligns to 404:634/654 of P36204
Sites not aligning to the query:
3uwzA Crystal structure of staphylococcus aureus triosephosphate isomerase complexed with glycerol-2-phosphate (see paper)
37% identity, 95% coverage: 8:249/255 of query aligns to 7:251/254 of 3uwzA
3uwwA Crystal structure of staphylococcus aureus triosephosphate isomerase complexed with 3-phosphoglyceric acid (see paper)
37% identity, 95% coverage: 8:249/255 of query aligns to 7:251/254 of 3uwwA
3uwvA Crystal structure of staphylococcus aureus triosephosphate isomerase complexed with 2-phosphoglyceric acid (see paper)
37% identity, 95% coverage: 8:249/255 of query aligns to 8:252/255 of 3uwvA
3uwuA Crystal structure of staphylococcus aureus triosephosphate isomerase complexed with glycerol-3-phosphate (see paper)
37% identity, 95% coverage: 8:249/255 of query aligns to 6:250/253 of 3uwuA
Q6GIL6 Triosephosphate isomerase; TIM; TPI; Triose-phosphate isomerase; EC 5.3.1.1 from Staphylococcus aureus (strain MRSA252) (see paper)
37% identity, 95% coverage: 8:249/255 of query aligns to 6:250/253 of Q6GIL6
3uwzB Crystal structure of staphylococcus aureus triosephosphate isomerase complexed with glycerol-2-phosphate (see paper)
36% identity, 95% coverage: 8:249/255 of query aligns to 6:247/250 of 3uwzB
4y96A Crystal structure of triosephosphate isomerase from gemmata obscuriglobus (see paper)
38% identity, 95% coverage: 7:249/255 of query aligns to 5:247/250 of 4y96A
6neeB Crystal structure of a reconstructed ancestor of triosephosphate isomerase from eukaryotes (see paper)
37% identity, 98% coverage: 1:249/255 of query aligns to 1:249/252 of 6neeB
5zfxB Crystal structure of triosephosphate isomerase from opisthorchis viverrini (see paper)
40% identity, 90% coverage: 6:235/255 of query aligns to 3:232/248 of 5zfxB
6ooiC Crystal structure of triosephosphate isomerase from schistosoma mansoni in complex with 2pg (see paper)
37% identity, 90% coverage: 6:235/255 of query aligns to 10:239/255 of 6ooiC
Sites not aligning to the query:
Q07412 Triosephosphate isomerase; PfTIM; Triose-phosphate isomerase; EC 5.3.1.1 from Plasmodium falciparum (see 6 papers)
34% identity, 95% coverage: 7:249/255 of query aligns to 6:245/248 of Q07412
6oogA Crystal structure of triosephosphate isomerase from taenia solium in complex with 2pg (see paper)
37% identity, 90% coverage: 6:235/255 of query aligns to 7:236/252 of 6oogA
Sites not aligning to the query:
1o5xB Plasmodium falciparum tim complexed to 2-phosphoglycerate (see paper)
33% identity, 95% coverage: 7:249/255 of query aligns to 4:243/246 of 1o5xB
1o5xA Plasmodium falciparum tim complexed to 2-phosphoglycerate (see paper)
33% identity, 95% coverage: 7:249/255 of query aligns to 4:243/246 of 1o5xA
1m7pA Plasmodium falciparum triosephosphate isomerase (pftim) compled to substrate analog glycerol-3-phosphate (g3p). (see paper)
33% identity, 95% coverage: 7:249/255 of query aligns to 4:243/246 of 1m7pA
>SMc01614 FitnessBrowser__Smeli:SMc01614
MSKSGLWVGTSWKMNKTLAEAMVFADGLAAADDARDQRIQRFVIPPFTAARQVKERLKAT
SVKVGAQNMHWDDAGAWTGEISPVMLSDCDLDIVELGHSERREHFGETDRTVGLKTAAAV
KHGLVPLICIGETLAQREAGEADTVLKRQVEGAFAFLEGAARKAPVLLAYEPVWAIGVNG
IPATADYADARHRLIGEVAERALGVKVPVLYGGSVNPQNCEELILQPHIDGLFIGRSAWD
VGGYLDILQRVARAI
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory