SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing SMc02358 SMc02358 high-affinity branched-chain amino acid ABC transporter ATP-binding protein to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

1ji0A Crystal structure analysis of the abc transporter from thermotoga maritima
50% identity, 100% coverage: 1:234/235 of query aligns to 6:238/240 of 1ji0A

query
sites
1ji0A

M

V

L

L

D

E

V

V

T

Q

D

S

L

L

S

H

V

V

S

Y

Y
|
Y

G

G

A

A

I

I

R

H

A

A

V

I

R

K

S

G

I

I

S

D

F

L

T

K

L

V

R

P

K

R

G

G

E

Q

L

I

V

V

S

T

L

L

L

I

G

G

A

A

N

N

G
|
G

A

A

G
|
G

K
|
K

S
x
T

T

T

I

L

K

S

C

A

I

I

A

A

G

G

A

L

L

V

K

R

A

A

S

Q

G

K

G

G

T

K

I

I

T

I

L

F

E

N

G

G

K

Q

D

D

I

I

T

T

A

N

A

K

S

P

P

A

E

H

Q

V

V

I

V

N

R

R

A

M

G

G

L

I

A

A

T

L

V

V

P

P

E
|
E

T

G

R

R

D

R

V

I

F

F

P

P

D

E

L

L

T

T

V

V

A

Y

E

E

N

N

L

L

M

M

L

M

G

G

A

A

F

Y

I

-

H

N

R

R

R

K

D

D

Q

K

A

E

G

G

N

I

R

K

D

R

N

D

L

L

E

E

K

W

L

I

N

F

T

S

L

L

F

F

P

P

R

R

L

L

A

K

E

E

R

R

S

L

K

K

Q

Q

A

L

A

G

G

G

T

T

L

L

S

S

G

G

E

E

Q

Q

M

M

L

L

V

A

I

I

A

G

R

R

A

A

L

L

M

M

A

S

R

R

P

P

R

K

V

L

L

L

L

M

D

D

E
|
E

P

P

S

S

L

L

G

G

L

L

A

A

P

P

A

I

I

L

V

V

E

S

R

E

I

V

F

F

E

E

M

V

I

I

E

Q

T

K

L

I

K

N

K

Q

S

E

G

G

L

T

T

T

I

I

L

L

V

V

E

E

Q

Q

N

N

V

A

N

L

Q

G

A

A

L

L

A

K

V

V

A

A

D

H

R

Y

A

G

F

Y

V

V

M

L

R

E

L

T

G

G

A

Q

I

I

V

V

A

L

S

E

G

G

T

K

A

A

E

S

E

E

I

L

R

L

S

D

T

N

S

E

D

M

L

V

S

R

A

K

H

A

Y

Y

L

L

G

G

binding adenosine-5'-triphosphate: Y16 (= Y11), G42 (= G37), G44 (= G39), K45 (= K40), T46 (≠ S41), T47 (≠ S42), E88 (= E83), E165 (= E161)

1g6hA Crystal structure of the adp conformation of mj1267, an atp-binding cassette of an abc transporter (see paper)
32% identity, 90% coverage: 11:221/235 of query aligns to 14:236/254 of 1g6hA

query
sites
1g6hA

Y
x
F

G

G

A

E

I
x
F

R

K

A

A

V

L

R

D

S

G

I

V

S

S

F

I

T

S

L

V

R

N

K

K

G

G

E

D

L

V

V

T

S

L

L

I

G

G

A

P

N
|
N

G
|
G

A

S

G
|
G

K
|
K

S
|
S

S
x
T

T

L

I

I

K

N

C

V

I

I

A

T

G

G

A

F

L

L

K

K

A

A

S

D

G

E

G

G

T

R

I

V

T

Y

L

F

E

E

G

N

K

K

D

D

I

I

T

T

A

N

A

K

S

E

P

P

E

A

Q

E

V

L

V

Y

R

H

A

Y

G

G

L

I

A

V

T

R

V

T

P

F

E

Q

T

T

R

P

D

Q

V

P

F

L

P

K

D

E

L

M

T

T

V

V

A

L

E

E

N

N

L

L

M

L

L

I

G

G

-

E

-

I

-

C

-

P

-

G

-

E

-

S

-

P

-

L

-

N

A

S

F

L

I

F

H

Y

R

K

D

W

Q

I

A

P

G

K

N

E

R

E

D

E

N

M

L

V

E

E

K

K

L

A

N

F

T

K

L

I

-

L

-

E

F

F

P

L

R

K

L

L

A

S

E

H

R

L

S

Y

K

D

Q

R

A

K

A

A

G

G

T

E

L

L

S

S

G

G

E

Q

Q

M

Q

K

M

L

L

V

V

E

I

I

A

G

R

R

A

A

L

L

M

M

A

T

R

N

P

P

R

K

V

M

L

I

L

V

L

M

D

D

E

E

P

P

S

I

L

A

G

G

L

V

A

A

P

P

A

G

I

L

V

A

E

H

R

D

I

I

F

F

E

N

M

H

I

V

E

L

T

E

L

L

K

K

K

A

S

K

G

G

L

I

T

T

I

F

L

L

L

I

V

I

E

E

Q

H

N

R

V

L

N

D

Q

I

A

V

L

L

A

N

V

Y

A

I

D

D

R

H

A

L

F

Y

V

V

M

M

R

F

L

N

G

G

A

Q

I

I

V

I

A

A

S

E

G

G

T

R

A

G

E

E

binding adenosine-5'-diphosphate: F14 (≠ Y11), F17 (≠ I14), N39 (= N36), G40 (= G37), G42 (= G39), K43 (= K40), S44 (= S41), T45 (≠ S42)

6mjpA Lptb(e163q)fgc from vibrio cholerae (see paper)
33% identity, 100% coverage: 1:234/235 of query aligns to 2:235/240 of 6mjpA

query
sites
6mjpA

M

I

L

L

D

K

V

A

T

Q

D

H

L

L

S

A

V

K

S

S

Y

Y

G

K

A

K

I

R

R

K

A

V

V

V

R

S

S

D

I

V

S

S

F

L

T

Q

L

V

R

E

K

S

G

G

E

Q

L

I

V

V

S

G

L

L

G

G

A

P

N

N

G

G

A

A

G

G

K

K

S

T

T

S

I

F

K

Y

C

M

I

I

A

V

G

G

A

L

L

V

K

A

A

R

S

D

G

E

G

G

T

T

I

I

T

T

L

I

E

D

G

D

K

N

D

D

I

I

T

S

A

I

A

L

S

P

P

M

E

H

Q

S

V

R

V

S

R

R

A

M

G

G

L

I

A

G

T

Y

V

L

P

P

E

Q

T

E

R

A

D

S

V

I

F

F

P

R

D

K

L

L

T

S

V

V

A

E

E

D

N

N

L

I

M

M

L

-

G

-

A

A

F

V

I

L

H

Q

R

T

R

R

D

E

Q

E

A

L

G

T

N

H

R
x
E

D

E

N

R

L

Q

E
x
D

K

K

L

L

N

E

T

D

L

L

F

L

P

E

R

E

L

F

A

H

-

I

E

Q

R

H

S

I

K

R

Q

K

A

S

A

A

G

G

-

M

T

A

L

L

S

S

G

G

E

E

Q

R

M

R

L

V

V

E

I

I

A

A

R

R

A

A

L

L

M

A

A

A

R

N

P

P

R

Q

V

F

L

I

L

L

D

D

E

Q

P

P

S

F

L

A

G

G

L

V

A

D

P

P

A

I

I

S

V

V

E

I

R

D

I

I

F

K

E

K

M

I

I

I

E

E

T

H

L

L

K

R

K

D

S

R

G

G

L

L

T

G

I

V

L

L

L

I

V

T

E

D

Q

H

N

N

V

V

N

R

Q

E

A

T

L

L

A

D

V

V

A

C

D

E

R

K

A

A

F

Y

V

I

M

V

R

S

L

Q

G

G

A

R

I

L

V

I

A

A

S

E

G

G

T

T

A

P

E

Q

E

D

I

V

R

L

S

N

T

N

S

E

D

Q

L

V

S

K

A

Q

H

V

Y

Y

L

L

G

G

binding calcium ion: E111 (≠ R112), D115 (≠ E116)

1g9xB Characterization of the twinning structure of mj1267, an atp-binding cassette of an abc transporter (see paper)
31% identity, 94% coverage: 1:221/235 of query aligns to 4:236/253 of 1g9xB

query
sites
1g9xB

M

I

L

L

D

R

V

T

T

E

D

N

L

I

S

V

V

K

S

Y

Y
x
F

G

G

A

E

I
x
F

R

K

A

A

V

L

R

D

S

G

I

V

S

S

F

I

T

S

L

V

R

C

K

K

G

G

E

D

L

V

V

T

S

L

L

I

G

G

A

P

N

N

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

S
x
T

T

L

I

I

K

N

C

V

I

I

A

T

G

G

A

F

L

L

K

K

A

A

S

D

G

E

G

G

T

R

I

V

T

Y

L

F

E

E

G

N

K

K

D

D

I

I

T

T

A

N

A

K

S

E

P

P

E

A

Q

E

V

L

V

Y

R

H

A

Y

G

G

L

I

A

V

T

R

V

T

P

F

E

Q

T

T

R

P

D

Q

V

P

F

L

P

K

D

E

L

M

T

T

V

V

A

L

E

E

N

N

L

L

M

L

L

I

G

G

-

E

-

I

-

N

-

P

-

G

-

E

-

S

-

P

-

L

-

N

A

S

F

L

I

F

H

Y

R

K

D

W

Q

I

A

P

G

K

N

E

R

E

D

E

N

M

L

V

E

E

K

K

L

A

N

F

T

K

L

I

-

L

-

E

F

F

P

L

R

K

L

L

A

S

E

H

R

L

S

Y

K

D

Q

R

A

K

A

A

G

G

T

E

L

L

S

S

G

G

E

Q

Q

M

Q

K

M

L

L

V

V

E

I

I

A

G

R

R

A

A

L

L

M

M

A

T

R

N

P

P

R

K

V

M

L

I

L

V

L

M

D

D

E
|
E

P

P

S

I

L

A

G

G

L

V

A

A

P

P

A

G

I

L

V

A

E

H

R

D

I

I

F

F

E

N

M

H

I

V

E

L

T

E

L

L

K

K

K

A

S

K

G

G

L

I

T

T

I

F

L

L

L

I

V

I

E

E

Q

H

N

R

V

L

N

D

Q

I

A

V

L

L

A

N

V

Y

A

I

D

D

R

H

A

L

F

Y

V

V

M

M

R

F

L

N

G

G

A

Q

I

I

V

I

A

A

S

E

G

G

T

R

A

G

E

E

binding adenosine-5'-diphosphate: F14 (≠ Y11), F17 (≠ I14), G40 (= G37), S41 (≠ A38), G42 (= G39), K43 (= K40), S44 (= S41), T45 (≠ S42)
binding magnesium ion: S44 (= S41), E176 (= E161)

6s8nB Cryo-em structure of lptb2fgc in complex with lipopolysaccharide (see paper)
36% identity, 99% coverage: 2:234/235 of query aligns to 3:235/238 of 6s8nB

query
sites
6s8nB

L

L

D

T

V

A

T

K

D

N

L

L

S

A

V

K

S

A

Y

Y

G

K

A

G

I

R

R

R

A

V

V

V

R

E

S

D

I

V

S

S

F

L

T

T

L

V

R

N

K

S

G

G

E

E

L

I

V

V

S

G

L

L

G

G

A

P

N

N

G

G

A

A

G

G

K

K

S

T

T

T

I

F

K

Y

C

M

I

V

A

V

G

G

A

I

L

V

K

P

A

R

S

D

G

A

G

G

T

N

I

I

T

I

L

I

E

D

G

D

K

D

D

D

I

I

T

S

A

L

S

P

P

L

E

H

Q

A

V

R

V

A

R

R

A

R

G

G

L

I

A

G

T

Y

V

L

P

P

E

Q

T

E

R

A

D

S

V

I

F

F

P
x
R

D

R

L

L

T

S

V

V

A

Y

E

D

N

N

L

L

M

M

L

-

G

-

A

A

F

V

I

L

H

Q

R

I

R

R

D

D

Q

D

A

L

G

S

N

A

R

E

D

Q

N

R

L

E

E

D

K

R

L

A

N

N

T

E

L

L

F

M

P

E

R

E

L

F

A

H

-

I

E

E

R

H

S

L

K

R

Q

D

A

S

A
x
M

G
|
G

-
x
Q

T

S

L

L

S

S

G

G

E

E

Q

R

M

R

L

V

V

E

I

I

A

A

R

R

A

A

L

L

M

A

A

A

R

N

P

P

R

K

V

F

L

I

L

L

D

D

E

E

P

P

S

F

L

A

G

G

L

V

A

D

P

P

A

I

I

S

V

V

E

I

R

D

I

I

F

K

E

R

M

I

I

I

E

E

T

H

L

L

K

R

K

D

S

S

G

G

L

L

T

G

I

V

L

L

L

I

V

T

E

D

Q

H

N

N

V

V

N

R

Q

E

A

T

L

L

A

A

V

V

A

C

D

E

R

R

A

A

F

Y

V

I

M

V

R

S

L

Q

G

G

A

H

I

L

V

I

A

A

S

H

G

G

T

T

A

P

E

T

E

E

I

I

R

L

S

Q

T

D

S

E

D

H

L

V

S

K

A

R

H

V

Y

Y

L

L

G

G

binding 2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione: R90 (≠ P89), M133 (≠ A133), G134 (= G134), Q135 (vs. gap)

6s8gA Cryo-em structure of lptb2fgc in complex with amp-pnp (see paper)
36% identity, 99% coverage: 2:234/235 of query aligns to 3:235/238 of 6s8gA

query
sites
6s8gA

L

L

D

T

V

A

T

K

D

N

L

L

S

A

V

K

S

A

Y
|
Y

G

K

A

G

I
x
R

R

R

A

V

V

V

R

E

S

D

I

V

S

S

F

L

T

T

L

V

R

N

K

S

G

G

E

E

L

I

V

V

S

G

L

L

G

G

A

P

N
|
N

G

G

A

A

G
|
G

K
|
K

S
x
T

T

T

I

F

K

Y

C

M

I

V

A

V

G

G

A

I

L

V

K

P

A

R

S

D

G

A

G

G

T

N

I

I

T

I

L

I

E

D

G

D

K

D

D

D

I

I

T

S

A

L

S

P

P

L

E

H

Q

A

V

R

V

A

R

R

A

R

G

G

L

I

A

G

T

Y

V

L

P

P

E
x
Q

T

E

R

A

D

S

V

I

F

F

P

R

D

R

L

L

T

S

V

V

A

Y

E

D

N

N

L

L

M

M

L

-

G

-

A

A

F

V

I

L

H

Q

R

I

R

R

D

D

Q

D

A

L

G

S

N

A

R

E

D

Q

N

R

L

E

E

D

K

R

L

A

N

N

T

E

L

L

F

M

P

E

R

E

L

F

A

H

-

I

E

E

R

H

S

L

K

R

Q

D

A

S

A

M

G

G

-

Q

T
x
S

L

L

S
|
S

G

G

E
|
E

Q

R

M

R

L

V

V

E

I

I

A

A

R

R

A

A

L

L

M

A

A

A

R

N

P

P

R

K

V

F

L

I

L

L

D

D

E

E

P

P

S

F

L

A

G

G

L

V

A

D

P

P

A

I

I

S

V

V

E

I

R

D

I

I

F

K

E

R

M

I

I

I

E

E

T

H

L

L

K

R

K

D

S

S

G

G

L

L

T

G

I

V

L

L

L

I

V

T

E

D

Q

H

N

N

V

V

N

R

Q

E

A

T

L

L

A

A

V

V

A

C

D

E

R

R

A

A

F

Y

V

I

M

V

R

S

L

Q

G

G

A

H

I

L

V

I

A

A

S

H

G

G

T

T

A

P

E

T

E

E

I

I

R

L

S

Q

T

D

S

E

D

H

L

V

S

K

A

R

H

V

Y

Y

L

L

G

G

binding phosphoaminophosphonic acid-adenylate ester: Y12 (= Y11), R15 (≠ I14), N37 (= N36), G40 (= G39), K41 (= K40), T42 (≠ S41), T43 (≠ S42), Q84 (≠ E83), S136 (≠ T135), S138 (= S137), E141 (= E140)

6mhzA Vanadate trapped cryo-em structure of e.Coli lptb2fg transporter (see paper)
36% identity, 99% coverage: 2:234/235 of query aligns to 3:235/235 of 6mhzA

query
sites
6mhzA

L

L

D

T

V

A

T

K

D

N

L

L

S

A

V

K

S

A

Y
|
Y

G

K

A

G

I

R

R

R

A

V

V

V

R

E

S

D

I

V

S

S

F

L

T

T

L

V

R

N

K

S

G

G

E

E

L

I

V

V

S

G

L

L

G

G

A

P

N
|
N

G
|
G

A

A

G
|
G

K
|
K

S
x
T

T

T

I

F

K

Y

C

M

I

V

A

V

G

G

A

I

L

V

K

P

A

R

S

D

G

A

G

G

T

N

I

I

T

I

L

I

E

D

G

D

K

D

D

D

I

I

T

S

A

L

S

P

P

L

E

H

Q

A

V

R

V

A

R

R

A

R

G

G

L

I

A

G

T

Y

V

L

P

P

E
x
Q

T

E

R

A

D

S

V

I

F

F

P

R

D

R

L

L

T

S

V

V

A

Y

E

D

N

N

L

L

M

M

L

-

G

-

A

A

F

V

I

L

H

Q

R

I

R

R

D

D

Q

D

A

L

G

S

N

A

R

E

D

Q

N

R

L

E

E

D

K

R

L

A

N

N

T

E

L

L

F

M

P

E

R

E

L

F

A

H

-

I

E

E

R

H

S

L

K

R

Q

D

A

S

A

M

G

G

-

Q

T
x
S

L

L

S
|
S

G
|
G

E

E

Q

R

M

R

L

V

V

E

I

I

A

A

R

R

A

A

L

L

M

A

A

A

R

N

P

P

R

K

V

F

L

I

L

L

D

D

E
|
E

P

P

S

F

L

A

G
|
G

L

V

A

D

P

P

A

I

I

S

V

V

E

I

R

D

I

I

F

K

E

R

M

I

I

I

E

E

T

H

L

L

K

R

K

D

S

S

G

G

L

L

T

G

I

V

L

L

L

I

V

T

E

D

Q
x
H

N

N

V

V

N

R

Q

E

A

T

L

L

A

A

V

V

A

C

D

E

R

R

A

A

F

Y

V

I

M

V

R

S

L

Q

G

G

A

H

I

L

V

I

A

A

S

H

G

G

T

T

A

P

E

T

E

E

I

I

R

L

S

Q

T

D

S

E

D

H

L

V

S

K

A

R

H

V

Y

Y

L

L

G

G

binding adp orthovanadate: Y12 (= Y11), N37 (= N36), G38 (= G37), G40 (= G39), K41 (= K40), T42 (≠ S41), T43 (≠ S42), Q84 (≠ E83), S136 (≠ T135), S138 (= S137), G139 (= G138), G140 (= G139), E162 (= E161), G166 (= G165), H194 (≠ Q193)

6mbnA Lptb e163q in complex with atp (see paper)
35% identity, 99% coverage: 2:234/235 of query aligns to 4:236/241 of 6mbnA

query
sites
6mbnA

L

L

D

T

V

A

T

K

D

N

L

L

S

A

V

K

S

A

Y
|
Y

G

K

A

G

I
x
R

R

R

A
x
V

V

V

R

E

S

D

I

V

S

S

F

L

T

T

L

V

R

N

K

S

G

G

E

E

L

I

V

V

S

G

L

L

G

G

A

P

N
|
N

G
|
G

A

A

G
|
G

K
|
K

S
x
T

T

T

I

F

K

Y

C

M

I

V

A

V

G

G

A

I

L

V

K

P

A

R

S

D

G

A

G

G

T

N

I

I

T

I

L

I

E

D

G

D

K

D

D

D

I

I

T

S

A

L

S

P

P

L

E

H

Q

A

V

R

V

A

R

R

A

R

G

G

L

I

A

G

T

Y

V

L

P

P

E

Q

T

E

R

A

D

S

V

I

F

F

P

R

D

R

L

L

T

S

V

V

A

Y

E

D

N

N

L

L

M

M

L

-

G

-

A

A

F

V

I

L

H

Q

R

I

R

R

D

D

Q

D

A

L

G

S

N

A

R

E

D

Q

N

R

L

E

E

D

K

R

L

A

N

N

T

E

L

L

F

M

P

E

R

E

L

F

A

H

-

I

E

E

R

H

S

L

K

R

Q

D

A

S

A

M

G

G

-

Q

T

S

L

L

S

S

G

G

E

E

Q

R

M

R

L

V

V

E

I

I

A

A

R

R

A

A

L

L

M

A

A

A

R

N

P

P

R

K

V

F

L

I

L

L

D

D

E

Q

P

P

S

F

L

A

G

G

L

V

A

D

P

P

A

I

I

S

V

V

E

I

R

D

I

I

F

K

E

R

M

I

I

I

E

E

T

H

L

L

K

R

K

D

S

S

G

G

L

L

T

G

I

V

L

L

L

I

V

T

E

D

Q
x
H

N

N

V

V

N

R

Q

E

A

T

L

L

A

A

V

V

A

C

D

E

R

R

A

A

F

Y

V

I

M

V

R

S

L

Q

G

G

A

H

I

L

V

I

A

A

S

H

G

G

T

T

A

P

E

T

E

E

I

I

R

L

S

Q

T

D

S

E

D

H

L

V

S

K

A

R

H

V

Y

Y

L

L

G

G

binding adenosine-5'-triphosphate: Y13 (= Y11), R16 (≠ I14), V18 (≠ A16), N38 (= N36), G39 (= G37), G41 (= G39), K42 (= K40), T43 (≠ S41), T44 (≠ S42), H195 (≠ Q193)

6b89A E. Coli lptb in complex with adp and novobiocin (see paper)
35% identity, 99% coverage: 2:233/235 of query aligns to 3:234/234 of 6b89A

query
sites
6b89A

L

L

D

T

V

A

T

K

D

N

L

L

S

A

V

K

S

A

Y
|
Y

G

K

A

G

I
x
R

R

R

A
x
V

V

V

R

E

S

D

I

V

S

S

F

L

T

T

L

V

R

N

K

S

G

G

E

E

L

I

V

V

S

G

L

L

G

G

A

P

N
|
N

G
|
G

A

A

G
|
G

K
|
K

S
x
T

T

T

I

F

K

Y

C

M

I

V

A

V

G

G

A

I

L

V

K

P

A

R

S

D

G

A

G

G

T

N

I

I

T

I

L

I

E

D

G

D

K

D

D

D

I

I

T

S

A

L

S

P

P
x
L

E
x
H

Q

A

V

R

V

A

R

R

A

R

G

G

L

I

A

G

T

Y

V

L

P
|
P

E
x
Q

T

E

R
x
A

D
x
S

V

I

F
|
F

P
x
R

D
x
R

L
|
L

T

S

V

V

A

Y

E

D

N

N

L

L

M

M

L

-

G

-

A

A

F
x
V

I

L

H

Q

R

I

R

R

D

D

Q

D

A

L

G

S

N

A

R

E

D

Q

N

R

L

E

E

D

K

R

L

A

N

N

T

E

L

L

F

M

P

E

R

E

L

F

A

H

-

I

E

E

R

H

S

L

K

R

Q

D

A

S

A

M

G

G

-
x
Q

T

S

L

L

S

S

G

G

E

E

Q

R

M

R

L

V

V

E

I

I

A

A

R
|
R

A

A

L

L

M

A

A

A

R

N

P

P

R

K

V

F

L

I

L

L

D

D

E

E

P

P

S

F

L

A

G

G

L

V

A

D

P

P

A

I

I

S

V

V

E

I

R

D

I

I

F

K

E

R

M

I

I

I

E

E

T

H

L

L

K

R

K

D

S

S

G

G

L

L

T

G

I

V

L

L

L

I

V

T

E

D

Q

H

N

N

V

V

N

R

Q

E

A

T

L

L

A

A

V

V

A

C

D

E

R

R

A

A

F

Y

V

I

M

V

R

S

L

Q

G

G

A

H

I

L

V

I

A

A

S

H

G

G

T

T

A

P

E

T

E

E

I

I

R

L

S

Q

T

D

S

E

D

H

L

V

S

K

A

R

H

V

Y

Y

L

L

binding adenosine-5'-diphosphate: Y12 (= Y11), R15 (≠ I14), V17 (≠ A16), N37 (= N36), G38 (= G37), G40 (= G39), K41 (= K40), T42 (≠ S41), T43 (≠ S42)
binding magnesium ion: T42 (≠ S41), Q84 (≠ E83)
binding novobiocin: L71 (≠ P70), H72 (≠ E71), P83 (= P82), A86 (≠ R85), S87 (≠ D86), F89 (= F88), R90 (≠ P89), R91 (≠ D90), L92 (= L91), V101 (≠ F102), Q135 (vs. gap), R149 (= R148)

4p31A Crystal structure of a selenomethionine derivative of e. Coli lptb in complex with adp-magensium (see paper)
35% identity, 99% coverage: 2:233/235 of query aligns to 3:234/234 of 4p31A

query
sites
4p31A

L

L

D

T

V

A

T

K

D

N

L

L

S

A

V

K

S

A

Y
|
Y

G

K

A

G

I
x
R

R

R

A
x
V

V

V

R

E

S

D

I

V

S

S

F

L

T

T

L

V

R

N

K

S

G

G

E

E

L

I

V

V

S

G

L

L

G

G

A

P

N

N

G
|
G

A

A

G
|
G

K
|
K

S
x
T

T

T

I

F

K

Y

C

M

I

V

A

V

G

G

A

I

L

V

K

P

A

R

S

D

G

A

G

G

T

N

I

I

T

I

L

I

E

D

G

D

K

D

D

D

I

I

T

S

A

L

S

P

P

L

E

H

Q

A

V

R

V

A

R

R

A

R

G

G

L

I

A

G

T

Y

V

L

P

P

E
x
Q

T

E

R

A

D

S

V

I

F

F

P

R

D

R

L

L

T

S

V

V

A

Y

E

D

N

N

L

L

M

M

L

-

G

-

A

A

F

V

I

L

H

Q

R

I

R

R

D

D

Q

D

A

L

G

S

N

A

R

E

D

Q

N

R

L

E

E

D

K

R

L

A

N

N

T

E

L

L

F

M

P

E

R

E

L

F

A

H

-

I

E

E

R

H

S

L

K

R

Q

D

A

S

A

M

G

G

-

Q

T

S

L

L

S

S

G

G

E

E

Q

R

M

R

L

V

V

E

I

I

A

A

R

R

A

A

L

L

M

A

A

A

R

N

P

P

R

K

V

F

L

I

L

L

D

D

E

E

P

P

S

F

L

A

G

G

L

V

A

D

P

P

A

I

I

S

V

V

E

I

R

D

I

I

F

K

E

R

M

I

I

I

E

E

T

H

L

L

K

R

K

D

S

S

G

G

L

L

T

G

I

V

L

L

L

I

V

T

E

D

Q

H

N

N

V

V

N

R

Q

E

A

T

L

L

A

A

V

V

A

C

D

E

R

R

A

A

F

Y

V

I

M

V

R

S

L

Q

G

G

A

H

I

L

V

I

A

A

S

H

G

G

T

T

A

P

E

T

E

E

I

I

R

L

S

Q

T

D

S

E

D

H

L

V

S

K

A

R

H

V

Y

Y

L

L

binding adenosine-5'-diphosphate: Y12 (= Y11), R15 (≠ I14), V17 (≠ A16), G38 (= G37), G40 (= G39), K41 (= K40), T42 (≠ S41), T43 (≠ S42)
binding magnesium ion: T42 (≠ S41), Q84 (≠ E83)

P04983 Ribose import ATP-binding protein RbsA; EC 7.5.2.7 from Escherichia coli (strain K12) (see paper)
34% identity, 88% coverage: 16:221/235 of query aligns to 267:481/501 of P04983

query
sites
P04983

A

G

V

V

R

N

S

D

I

V

S

S

F

F

T

T

L

L

R

R

K

K

G

G

E

E

L

I

V

L

S

G

L

V

L

S

G

G

A

L

N

M

G

G

A

A

G

G

K

R

S

T

S

E

T

L

I

M

K

K

C

V

I

L

A

Y

G

G

A

A

L

L

K

P

A

R

S

T

G

S

G

G

T

Y

I

V

T

T

L

L

E

D

G

G

K

H

D

E

I

V

T

V

A

T

A

R

S

S

P

P

E

Q

Q

D

V

G

V

L

R

A

A

N

G

G

L

I

A

V

T

Y

V

I

P

S

E

E

T

D

R

R

D

K

-

R

-

D

-

G

V

L

F

V

P

L

D

G

L

M

T

S

V

V

A

K

E

E

N

N

L

M

M

S

L

L

-

T

-

A

-

L

-

R

-

Y

-

F

-

S

-

R

-

A

-

G

G

G

A

S

F

L

I

K

H

H

R

A

R

D

D

E

Q

Q

A

Q

G

A

N

V

R

S

D

D

N

F

L

I

E

R

K

L

L

F

N

N

T

V

L

K

F

T

P

P

R

S

L

M

A

-

E

-

R

-

S

-

K

E

Q

Q

A

A

A

I

G

G

T

L

L

L

S

S

G

G

E

N

Q

Q

M

K

L

V

V

A

I

I

A

A

R

R

A

G

L

L

M

M

A

T

R

R

P

P

R

K

V

V

L

L

L

I

L

L

D

D

E

E

P

P

S

T

L

R

G

G

L

V

A

D

P

V

A

G

I

A

V

K

E

K

R

E

I

I

F

Y

E

Q

M

L

I

I

E

N

T

Q

L

F

K

K

K

A

S

D

G

G

L

L

T

S

I

I

L

I

L

L

V

V

E

S

Q

S

N

E

V

M

N

P

Q

E

A

V

L

L

A

G

V

M

A

S

D

D

R

R

A

I

F

I

V

V

M

M

R

H

L

E

G

G

A

H

I

L

V

S

A

G

S

E

G

F

T

T

A

R

E

E

E

Q

Sites not aligning to the query:

43 K→R: Loss of transport.

6b8bA E. Coli lptb in complex with adp and a novobiocin derivative (see paper)
36% identity, 94% coverage: 2:222/235 of query aligns to 3:223/233 of 6b8bA

query
sites
6b8bA

L

L

D

T

V

A

T

K

D

N

L

L

S

A

V

K

S

A

Y
|
Y

G

K

A

G

I
x
R

R

R

A
x
V

V

V

R

E

S

D

I

V

S

S

F

L

T

T

L

V

R

N

K

S

G

G

E

E

L

I

V

V

S

G

L

L

G

G

A

P

N

N

G
|
G

A

A

G
|
G

K
|
K

S
x
T

T

T

I

F

K

Y

C

M

I

V

A

V

G

G

A

I

L

V

K

P

A

R

S

D

G

A

G

G

T

N

I

I

T

I

L

I

E

D

G

D

K

D

D

D

I

I

T

S

A

L

S

P

P

L

E

H

Q

A

V

R

V

A

R

R

A

R

G

G

L

I

A

G

T

Y

V

L

P

P

E

Q

T

E

R

A

D

S

V

I

F
|
F

P
x
R

D
x
R

L

L

T

S

V

V

A

Y

E

D

N

N

L

L

M

M

L

-

G

-

A

A

F

V

I

L

H

Q

R

I

R

R

D

D

Q

D

A

L

G

S

N

A

R

E

D

Q

N

R

L

E

E

D

K

R

L

A

N

N

T

E

L

L

F

M

P

E

R

E

L

F

A

H

-

I

E

E

R

H

S

L

K

R

Q

D

A

S

A

M

G

G

-

Q

T

S

L

L

S

S

G

G

E

E

Q

R

M

R

L

V

V

E

I

I

A

A

R

R

A

A

L

L

M

A

A

A

R

N

P

P

R

K

V

F

L

I

L

L

D

D

E

E

P

P

S

F

L

A

G

G

L

V

A

D

P

P

A

I

I

S

V

V

E

I

R

D

I

I

F

K

E

R

M

I

I

I

E

E

T

H

L

L

K

R

K

D

S

S

G

G

L

L

T

G

I

V

L

L

L

I

V

T

E

D

Q

H

N

N

V

V

N

R

Q

E

A

T

L

L

A

A

V

V

A

C

D

E

R

R

A

A

F

Y

V

I

M

V

R

S

L

Q

G

G

A

H

I

L

V

I

A

A

S

H

G

G

T

T

A

P

E

T

E

E

I

I

binding adenosine-5'-diphosphate: Y12 (= Y11), R15 (≠ I14), V17 (≠ A16), G38 (= G37), G40 (= G39), K41 (= K40), T42 (≠ S41), T43 (≠ S42)
binding (3s,5s,7s)-N-{7-[(3-O-carbamoyl-6-deoxy-5-methyl-4-O-methyl-beta-D-gulopyranosyl)oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl}tricyclo[3.3.1.1~3,7~]decane-1-carboxamide: F89 (= F88), R90 (≠ P89), R91 (≠ D90)

4ymuJ Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
31% identity, 99% coverage: 1:233/235 of query aligns to 1:236/240 of 4ymuJ

query
sites
4ymuJ

M

M

L

I

D

F

V

V

T

N

D

D

L

V

S

Y

V

K

S

N

Y
x
F

G

G

A

S

I

L

R

E

A
x
V

V

L

R

K

S

G

I

V

S

T

F

L

T

K

L

V

R

N

K

K

G

G

E

E

L

V

V

V

S

V

L

I

G

G

A

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

S
x
T

T

L

I

L

K

R

C

C

I

I

A

N

G

L

A

L

L

E

K

E

A

P

S

T

G

K

G

G

T

E

I

V

T

F

L

I

E

D

G

G

K

V

D

K

I

I

T

N

A

N

A

G

S

K

P

V

E

N

-

I

Q

N

V

K

V

V

R

R

A

Q

G

K

L

V

A

G

T

M

V

V

P

F

E

Q

T

H

R

F

D

N

V

L

F

F

P

P

D

H

L

L

T

T

V

A

A

I

E

E

N

N

L

I

M

T

L

L

G

A

A

P

F

V

I

-

H

-

R

-

R

K

D

V

Q

K

A

K

G

M

N

N

R

K

D

K

N

E

L

A

E

E

K

E

L

L

N

A

T

V

-

D

L

L

F

L

P

A

R

K

-

V

-

G

L

L

A

L

E

D

R

K

S

K

K

D

Q

Q

A

Y

A

P

G

I

T

K

L

L

S

S

G

G

E

Q

Q

K

Q

Q

M

R

L

L

V

A

I

I

A

A

R

R

A

A

L

L

M

A

A

M

R

Q

P

P

R

E

V

V

L

M

L

L

L

F

D

D

E
|
E

P

P

S

T

L

S

G

A

L

L

A

D

P

P

A

E

I

M

V

V

E

K

R

E

I

V

F

L

E

N

M

V

I

M

E

K

T

Q

L

L

K

A

K

N

S

E

G

G

L

M

T

T

I

M

L

V

V

V

E

T

Q
x
H

N

E

V

M

N

G

Q

F

A

A

L

R

A

E

V

V

A

G

D

D

R

R

A

V

F

I

V

F

M

M

R

D

L

D

G

G

A

V

I

I

V

V

A

E

S

E

G

G

T

T

A

P

E

E

I

I

-

F

-

Y

R

R

S

A

T

K

S

N

D

E

L

R

S

T

A

R

H

E

Y

F

L

L

binding adenosine-5'-triphosphate: F11 (≠ Y11), V16 (≠ A16), S36 (≠ N36), G37 (= G37), S38 (≠ A38), G39 (= G39), K40 (= K40), S41 (= S41), T42 (≠ S42), E162 (= E161), H194 (≠ Q193)
binding magnesium ion: S41 (= S41), E162 (= E161)

4yerA Crystal structure of an abc transporter atp-binding protein (tm_1403) from thermotoga maritima msb8 at 2.35 a resolution
33% identity, 94% coverage: 4:223/235 of query aligns to 7:224/285 of 4yerA

query
sites
4yerA

V

V

T

E

D

N

L

L

S

V

V

K

S

K

Y
x
F

G

G

A

D

I
x
F

R

E

A

A

V

V

R

K

S

G

I

V

S

S

F

F

T

S

L

V

R

K

K

K

G

G

E

E

L

I

V

F

S

A

L

F

L

L

G

G

A

P

N
|
N

G
|
G

A

A

G
|
G

K
|
K

S
x
T

T

T

I

I

K

H

C

M

I

L

A

T

G

T

A

L

L

L

K

K

A

P

S

T

G

S

G

G

T

K

I

A

T

W

L

V

E

A

G

G

K

H

D

D

I

V

T

L

A

K

A

E

S

P

P

R

E

E

Q

-

V

-

V

V

R

R

A

R

G

K

L

I

A

G

T

I

V

V

P

F

E

Q

T

D

R

Q

D

S

V

L

F

D

P

R

D

E

L

L

T

T

V

A

A

Y

E

E

N

N

L

M

M

-

L

-

G

-

A

-

F

Y

I

I

H

H

R

G

R

K

D

I

Q

Y

A

G

G

Y

N

G

R

G

D

E

N

K

L

L

E

K

K

K

-

R

-

I

-

L

L

E

N

L

T

L

L

E

F

F

P

V

R

E

L

L

A

L

E

E

R

F

S

K

K

D

Q

K

A

P

A

V

G

K

T
|
T

L
x
F

S
|
S

G

G

E

M

Q

A

Q

R

M

R

L

L

V

E

I

I

A

A

R

R

A

S

L

L

M

I

A

H

R

E

P

P

R

E

V

V

L

L

L

F

L

L

D

D

E

E

P

P

S

T

L

I

G

G

L

L

A

D

P

P

A

H

I

T

V

R

E

A

R

H

I

M

F

W

E

E

M

Y

I

I

E

S

T

K

L

M

K

K

-

E

S

H

G

N

L

M

T

T

I

I

L

F

L

L

V

T

E

T

Q

H

N

Y

V

M

N

D

Q

E

A

A

L

E

A

Q

V

L

A

A

D

D

R

R

A

V

F

A

V

I

M

I

R

D

L

H

G

G

A

K

I

I

V

I

A

A

S

L

G

G

T

T

A

P

E

T

E

E

I

L

R

K

binding adenosine-5'-diphosphate: F14 (≠ Y11), F17 (≠ I14), N39 (= N36), G40 (= G37), G42 (= G39), K43 (= K40), T44 (≠ S41), T45 (≠ S42), T135 (= T135), F136 (≠ L136), S137 (= S137)

P55339 ABC-type transporter ATP-binding protein EcsA from Bacillus subtilis (strain 168) (see paper)
32% identity, 95% coverage: 1:223/235 of query aligns to 3:222/247 of P55339

query
sites
P55339

M

L

L

L

D

S

V

V

T

K

D

D

L

L

S

T

V

G

S

G

Y

Y

G

T

A

R

I

N

R

P

A

V

V

L

R

K

S

N

I

V

S

S

F

F

T

T

L

L

R

E

K

P

G

N

E

Q

L

I

V

V

S

G

L

L

L

I

G

G

A

L

N

N

G

G

A

A

G

G

K

K

S

S

S

T

T

T

I

I

K

R

C

H

I

I

A

I

G

G

A

L

L

M

K

D

A

P

S

H

G

K

G

G

T

S

I

I

T

E

L

L

E

N

G

G

K

K

D

-

I

-

T

T

A

F

A

A

S

E

P

D

E

P

Q

E

V

G

V

Y

R

R

A

S

G

Q

L

F

A

T

T

Y

V

I

P

P

E

E

T

T

R

P

D

V

V

L

F

Y

P

E

D

E

L

L

T

T

V

L

A

M

E

E

N

H

L

L

M

E

L

L

G

T

A

A

F

M

I

A

H

Y

R

G

R

L

D

S

Q

K

A

E

G

T

N

M

R

E

D

K

N

R

L

L

E

P

K

P

L

L

N

L

T

K

L

E

F

F

P

-

R

R

L

M

A

E

E

K

R

R

S

L

K

K

Q

W

A

F

A

P

G

A

T

H

L

F

S

S

G

K

G

G

E

M

Q

K

Q

Q

M

K

L

V

V

M

I

I

A

M

R

C

A

A

L

F

M

L

A

A

R

E

P

P

R

A

V

L

L

Y

L

I

D

D

E

E

P

P

S

F

L

L

G
|
G

L

L

A

D

P

P

A

L

I

A

V

I

E

N

R

A

I

L

F

L

E

E

M

R

I

M

E

N

T

E

L

A

K

K

S

G

G

G

L

A

T

S

I

V

L

L

L

M

V

S

E

T

Q

H

N

I

V

L

N

A

Q

T

A

A

L

E

A

R

V

Y

A

C

D

D

R

S

A

F

F

I

V

I

M

L

R

H

L

N

G

G

A

E

I

V

V

R

A

A

S

R

G

G

T

T

A

L

E

S

E

E

I

L

R

R

G164 (= G165) mutation to E: In ecsA-26; exoamylase and other exoenzymes decrease, competence- and sporulation-deficient phenotype.

3d31A Modbc from methanosarcina acetivorans (see paper)
35% identity, 94% coverage: 1:222/235 of query aligns to 1:215/348 of 3d31A

query
sites
3d31A

M

M

L

I

D

E

V

I

T

E

D

S

L

L

S

S

V

R

S

K

Y

W

G

K

A

N

I

F

R

-

A

S

V

L

R

D

S

N

I

L

S

S

F

L

T

K

L

V

R

E

K

S

G

G

E

E

L

Y

V

F

S

V

L

I

L

L

G

G

A

P

N

T

G

G

A

A

G

G

K

K

S

T

S

L

T

F

I

L

K

E

C

L

I

I

A

A

G

G

A

F

L

H

K

V

A

P

S

D

G

S

G

G

T

R

I

I

T

L

L

L

E

D

G

G

K

K

D

D

I

V

T

T

A

D

A

L

S

S

P

P

E

E

Q

-

V

-

R

K

A

H

G

D

L

I

A

A

T

F

V

V

P

Y

E

Q

T

N

R

Y

D

S

V

L

F

F

P

P

D

H

L

M

T

N

V

V

A

K

E

K

N

N

L

L

M

E

L

F

G

G

A

M

F

R

I

M

H

K

R

K

-

I

R

K

D

D

Q

P

A

K

G

R

N

V

R

L

D

D

N

T

L

A

E

R

K

D

L

L

N

K

T

-

L

-

F

I

P

E

R

H

L

L

A

L

E

D

R

R

S

N

K

P

Q

L

A

-

G

-

T

T

L

L

S

S

G

G

E

E

Q

Q

M

R

L

V

V

A

I

L

A

A

R

R

A

A

L

L

M

V

A

T

R

N

P

P

R

K

V

I

L

L

D

D

E

E

P

P

S

L

L

S

G

A

L

L

A

D

P

P

A

R

I

T

V

Q

E

E

R

N

I

A

F

R

E

E

M

M

I

L

E

S

T

V

L

L

-

H

K

K

S

N

G

K

L

L

T

T

I

V

L

L

L

H

V

I

E

T

Q

H

N

D

V

Q

N

T

Q

E

A

A

L

R

A

I

V

M

A

A

D

D

R

R

A

I

F

A

V

V

M

V

R

M

L

D

G

G

A

K

I

L

V

I

A

Q

S

V

G

G

T

K

A

P

E

E

I

I

Sites not aligning to the query:

binding tungstate(vi)ion: 286, 320, 323, 340, 341, 342

3c4jA Abc protein artp in complex with atp-gamma-s
29% identity, 94% coverage: 1:222/235 of query aligns to 3:225/242 of 3c4jA

query
sites
3c4jA

M

M

L

I

D

D

V

V

T

H

D

Q

L

L

S

K

V

K

S

S

Y
x
F

G

G

A

S

I

L

R

E

A
x
V

V

L

R

K

S

G

I

I

S

N

F

V

T

H

L

I

R

R

K

E

G

G

E

E

L

V

V

V

S

V

L

V

L

I

G

G

A

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

S
x
T

T

F

I

L

K

R

C

C

I

L

A

N

G

L

A

L

L

E

K

D

A

F

S

D

G

E

G

G

T

E

I

I

T

I

L

I

E

D

G

G

K

I

D

N

I

L

T

K

A

A

A

K

S

D

P

T

E

N

-

L

Q

N

V

K

V

V

R

R

A

E

G

E

L

V

A

G

T

M

V

V

P

F

E

Q

T

R

R

F

D

N

V

L

F

F

P

P

D

H

L

M

T

T

V

V

A

L

E

N

N

N

L

I

M

T

L

L

G

A

A

P

F

M

I

K

H

V

R

R

R

K

-

W

-

P

D

R

Q

E

A

K

G

A

N

E

R

A

D

K

N

A

L

M

E

E

K

L

L

L

N

D

T

K

L

V

F

-

P

-

R

G

L

L

A

K

E

D

R

K

S

A

K

H

Q

A

A

Y

A

P

G

D

T

S

L

L

S

S

G

G

E

Q

Q

A

Q

Q

M

R

L

V

V

A

I

I

A

A

R

R

A

A

L

L

M

A

A

M

R

E

P

P

R

K

V

I

L

M

L

L

L

F

D

D

E

E

P

P

S

T

L

S

G

A

L

L

A

D

P

P

A

E

I

M

V

V

E

G

R

E

I

V

F

L

E

S

M

V

I

M

E

K

T

Q

L

L

K

A

K

N

S

E

G

G

L

M

T

T

I

M

L

V

V

V

E

T

Q

H

N

E

V

M

N

G

Q

F

A

A

L

R

A

E

V

V

A

G

D

D

R

R

A

V

F

L

V

F

M

M

R

D

L

G

G

G

A

Y

I

I

V

I

A

E

S

E

G

G

T

K

A

P

E

E

E

D

I

L

binding phosphothiophosphoric acid-adenylate ester: F13 (≠ Y11), V18 (≠ A16), S38 (≠ N36), G39 (= G37), S40 (≠ A38), G41 (= G39), K42 (= K40), S43 (= S41), T44 (≠ S42)

3c41J Abc protein artp in complex with amp-pnp/mg2+
29% identity, 94% coverage: 1:222/235 of query aligns to 3:225/242 of 3c41J

query
sites
3c41J

M

M

L

I

D

D

V

V

T

H

D

Q

L

L

S

K

V

K

S

S

Y
x
F

G

G

A

S

I

L

R

E

A
x
V

V

L

R

K

S

G

I

I

S

N

F

V

T

H

L

I

R

R

K

E

G

G

E

E

L

V

V

V

S

V

L

V

L

I

G

G

A

P

N
x
S

G
|
G

A

S

G
|
G

K
|
K

S
|
S

S
x
T

T

F

I

L

K

R

C

C

I

L

A

N

G

L

A

L

L

E

K

D

A

F

S

D

G

E

G

G

T

E

I

I

T

I

L

I

E

D

G

G

K

I

D

N

I

L

T

K

A

A

A

K

S

D

P

T

E

N

-

L

Q

N

V

K

V

V

R

R

A

E

G

E

L

V

A

G

T

M

V

V

P

F

E

Q

T

R

R

F

D

N

V

L

F

F

P

P

D

H

L

M

T

T

V

V

A

L

E

N

N

N

L

I

M

T

L

L

G

A

A

P

F

M

I

K

H

V

R

R

R

K

-

W

-

P

D

R

Q

E

A

K

G

A

N

E

R

A

D

K

N

A

L

M

E

E

K

L

L

L

N

D

T

K

L

V

F

-

P

-

R

G

L

L

A

K

E

D

R

K

S

A

K

H

Q

A

A

Y

A

P

G

D

T

S

L

L

S

S

G

G

E

Q

Q

A

Q

Q

M

R

L

V

V

A

I

I

A

A

R

R

A

A

L

L

M

A

A

M

R

E

P

P

R

K

V

I

L

M

L

L

L

F

D
|
D

E

E

P

P

S

T

L

S

G

A

L

L

A

D

P

P

A

E

I

M

V

V

E

G

R

E

I

V

F

L

E

S

M

V

I

M

E

K

T

Q

L

L

K

A

K

N

S

E

G

G

L

M

T

T

I

M

L

V

V

V

E

T

Q

H

N

E

V

M

N

G

Q

F

A

A

L

R

A

E

V

V

A

G

D

D

R

R

A

V

F

L

V

F

M

M

R

D

L

G

G

G

A

Y

I

I

V

I

A

E

S

E

G

G

T

K

A

P

E

E

E

D

I

L

binding phosphoaminophosphonic acid-adenylate ester: F13 (≠ Y11), V18 (≠ A16), S38 (≠ N36), G39 (= G37), G41 (= G39), K42 (= K40), S43 (= S41), T44 (≠ S42)
binding magnesium ion: S43 (= S41), D163 (= D160)

2olkA Abc protein artp in complex with adp-beta-s
29% identity, 94% coverage: 1:222/235 of query aligns to 3:225/242 of 2olkA

query
sites
2olkA

M

M

L

I

D

D

V

V

T

H

D

Q

L

L

S

K

V

K

S

S

Y
x
F

G

G

A

S

I

L

R

E

A
x
V

V

L

R

K

S

G

I

I

S

N

F

V

T

H

L

I

R

R

K

E

G

G

E

E

L

V

V

V

S

V

L

V

L

I

G

G

A

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

S
x
T

T

F

I

L

K

R

C

C

I

L

A

N

G

L

A

L

L

E

K

D

A

F

S

D

G

E

G

G

T

E

I

I

T

I

L

I

E

D

G

G

K

I

D

N

I

L

T

K

A

A

A

K

S

D

P

T

E

N

-

L

Q

N

V

K

V

V

R

R

A

E

G

E

L

V

A

G

T

M

V

V

P

F

E

Q

T

R

R

F

D

N

V

L

F

F

P

P

D

H

L

M

T

T

V

V

A

L

E

N

N

N

L

I

M

T

L

L

G

A

A

P

F

M

I

K

H

V

R

R

R

K

-

W

-

P

D

R

Q

E

A

K

G

A

N

E

R

A

D

K

N

A

L

M

E

E

K

L

L

L

N

D

T

K

L

V

F

-

P

-

R

G

L

L

A

K

E

D

R

K

S

A

K

H

Q

A

A

Y

A

P

G

D

T

S

L

L

S

S

G

G

E

Q

Q

A

Q

Q

M

R

L

V

V

A

I

I

A

A

R

R

A

A

L

L

M

A

A

M

R

E

P

P

R

K

V

I

L

M

L

L

L

F

D

D

E

E

P

P

S

T

L

S

G

A

L

L

A

D

P

P

A

E

I

M

V

V

E

G

R

E

I

V

F

L

E

S

M

V

I

M

E

K

T

Q

L

L

K

A

K

N

S

E

G

G

L

M

T

T

I

M

L

V

V

V

E

T

Q

H

N

E

V

M

N

G

Q

F

A

A

L

R

A

E

V

V

A

G

D

D

R

R

A

V

F

L

V

F

M

M

R

D

L

G

G

G

A

Y

I

I

V

I

A

E

S

E

G

G

T

K

A

P

E

E

E

D

I

L

binding 5'-o-[(r)-hydroxy(thiophosphonooxy)phosphoryl]adenosine: F13 (≠ Y11), V18 (≠ A16), S38 (≠ N36), G39 (= G37), S40 (≠ A38), G41 (= G39), K42 (= K40), S43 (= S41), T44 (≠ S42)

2oljA Abc protein artp in complex with adp/mg2+
29% identity, 94% coverage: 1:222/235 of query aligns to 3:225/242 of 2oljA

query
sites
2oljA

M

M

L

I

D

D

V

V

T

H

D

Q

L

L

S

K

V

K

S

S

Y
x
F

G

G

A

S

I

L

R

E

A
x
V

V

L

R

K

S

G

I

I

S

N

F

V

T

H

L

I

R

R

K

E

G

G

E

E

L

V

V

V

S

V

L

V

L

I

G

G

A

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

S
x
T

T

F

I

L

K

R

C

C

I

L

A

N

G

L

A

L

L

E

K

D

A

F

S

D

G

E

G

G

T

E

I

I

T

I

L

I

E

D

G

G

K

I

D

N

I

L

T

K

A

A

A

K

S

D

P

T

E

N

-

L

Q

N

V

K

V

V

R

R

A

E

G

E

L

V

A

G

T

M

V

V

P

F

E

Q

T

R

R

F

D

N

V

L

F

F

P

P

D

H

L

M

T

T

V

V

A

L

E

N

N

N

L

I

M

T

L

L

G

A

A

P

F

M

I

K

H

V

R

R

R

K

-

W

-

P

D

R

Q

E

A

K

G

A

N

E

R

A

D

K

N

A

L

M

E

E

K

L

L

L

N

D

T

K

L

V

F

-

P

-

R

G

L

L

A

K

E

D

R

K

S

A

K

H

Q

A

A

Y

A

P

G

D

T

S

L

L

S

S

G

G

E

Q

Q

A

Q

Q

M

R

L

V

V

A

I

I

A

A

R

R

A

A

L

L

M

A

A

M

R

E

P

P

R

K

V

I

L

M

L

L

L

F

D

D

E

E

P

P

S

T

L

S

G

A

L

L

A

D

P

P

A

E

I

M

V

V

E

G

R

E

I

V

F

L

E

S

M

V

I

M

E

K

T

Q

L

L

K

A

K

N

S

E

G

G

L

M

T

T

I

M

L

V

V

V

E

T

Q

H

N

E

V

M

N

G

Q

F

A

A

L

R

A

E

V

V

A

G

D

D

R

R

A

V

F

L

V

F

M

M

R

D

L

G

G

G

A

Y

I

I

V

I

A

E

S

E

G

G

T

K

A

P

E

E

E

D

I

L

binding adenosine-5'-diphosphate: F13 (≠ Y11), V18 (≠ A16), S38 (≠ N36), G39 (= G37), S40 (≠ A38), G41 (= G39), K42 (= K40), S43 (= S41), T44 (≠ S42)

Query Sequence

>SMc02358 SMc02358 high-affinity branched-chain amino acid ABC transporter ATP-binding protein
MLDVTDLSVSYGAIRAVRSISFTLRKGELVSLLGANGAGKSSTIKCIAGALKASGGTITL
EGKDITAASPEQVVRAGLATVPETRDVFPDLTVAENLMLGAFIHRRDQAGNRDNLEKLNT
LFPRLAERSKQAAGTLSGGEQQMLVIARALMARPRVLLLDEPSLGLAPAIVERIFEMIET
LKKSGLTILLVEQNVNQALAVADRAFVMRLGAIVASGTAEEIRSTSDLSAHYLGG

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory