SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing SMc02568 FitnessBrowser__Smeli:SMc02568 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 2 hits to proteins with known functional sites (download)

6j2lA Crystal structure of bi-functional enzyme (see paper)
46% identity, 81% coverage: 6:92/107 of query aligns to 114:200/200 of 6j2lA

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6j2lA

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binding zinc ion: E152 (= E44), E171 (= E63), D174 (= D66)

Sites not aligning to the query:

binding zinc ion: 79, 81, 83, 96, 103

6j2lB Crystal structure of bi-functional enzyme (see paper)
39% identity, 81% coverage: 6:92/107 of query aligns to 107:185/185 of 6j2lB

query
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6j2lB

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binding magnesium ion: E137 (= E44), E140 (= E47), E156 (= E63), D159 (= D66)

Sites not aligning to the query:

binding zinc ion: 78, 80, 82

Query Sequence

>SMc02568 FitnessBrowser__Smeli:SMc02568
MTDFTLSDLEKIVATRARAAPEESWTAKLVAAGQTKAAKKLGEEAVETVIAAIGEDRKNL
VDESADLLYHLMVVLNIAAVPLQDVMSELARRTSQSGLQEKANRQNP

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory