Comparing SMc02717 FitnessBrowser__Smeli:SMc02717 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P9WQB3 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
52% identity, 96% coverage: 18:562/569 of query aligns to 45:641/644 of P9WQB3
Sites not aligning to the query:
3hpzB Crystal structure of mycobacterium tuberculosis leua complexed with bromopyruvate
54% identity, 96% coverage: 18:562/569 of query aligns to 28:574/576 of 3hpzB
3figB Crystal structure of leucine-bound leua from mycobacterium tuberculosis (see paper)
54% identity, 96% coverage: 18:562/569 of query aligns to 28:574/577 of 3figB
3hq1A Crystal structure of mycobacterium tuberculosis leua complexed with citrate and mn2+
54% identity, 96% coverage: 18:562/569 of query aligns to 28:571/573 of 3hq1A
1sr9A Crystal structure of leua from mycobacterium tuberculosis (see paper)
54% identity, 96% coverage: 18:562/569 of query aligns to 28:571/573 of 1sr9A
3hpsA Crystal structure of mycobacterium tuberculosis leua complexed with ketoisocaproate (kic)
54% identity, 96% coverage: 18:562/569 of query aligns to 28:573/575 of 3hpsA
4ov4A Isopropylmalate synthase binding with ketoisovalerate (see paper)
27% identity, 63% coverage: 46:403/569 of query aligns to 9:340/379 of 4ov4A
4ov9A Structure of isopropylmalate synthase binding with alpha- isopropylmalate (see paper)
27% identity, 63% coverage: 46:403/569 of query aligns to 9:342/380 of 4ov9A
Q9FN52 Methylthioalkylmalate synthase 3, chloroplastic; 2-isopropylmalate synthase 2; Methylthioalkylmalate synthase-like; EC 2.3.3.17 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
26% identity, 71% coverage: 48:449/569 of query aligns to 92:497/503 of Q9FN52
Q9FG67 Methylthioalkylmalate synthase 1, chloroplastic; 2-isopropylmalate synthase 3; EC 2.3.3.17 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
24% identity, 68% coverage: 48:432/569 of query aligns to 92:473/506 of Q9FG67
Q9JZG1 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Neisseria meningitidis serogroup B (strain MC58) (see 2 papers)
24% identity, 91% coverage: 48:563/569 of query aligns to 14:502/517 of Q9JZG1
Sites not aligning to the query:
6e1jA Crystal structure of methylthioalkylmalate synthase (bjumam1.1) from brassica juncea (see paper)
27% identity, 68% coverage: 48:432/569 of query aligns to 25:406/409 of 6e1jA
3rmjB Crystal structure of truncated alpha-isopropylmalate synthase from neisseria meningitidis (see paper)
28% identity, 47% coverage: 48:313/569 of query aligns to 11:265/308 of 3rmjB
3ivtB Homocitrate synthase lys4 bound to 2-og (see paper)
24% identity, 59% coverage: 48:381/569 of query aligns to 37:338/400 of 3ivtB
O87198 Homocitrate synthase; HCS; EC 2.3.3.14 from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27) (see paper)
26% identity, 54% coverage: 43:351/569 of query aligns to 4:296/376 of O87198
Q9Y823 Homocitrate synthase, mitochondrial; HCS; EC 2.3.3.14 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 2 papers)
24% identity, 59% coverage: 48:381/569 of query aligns to 42:343/418 of Q9Y823
Sites not aligning to the query:
6ktqA Crystal structure of catalytic domain of homocitrate synthase from sulfolobus acidocaldarius (sahcs(dram)) in complex with alpha- ketoglutarate/zn2+/coa (see paper)
23% identity, 62% coverage: 48:397/569 of query aligns to 29:346/399 of 6ktqA
2zyfA Crystal structure of homocitrate synthase from thermus thermophilus complexed with magnesuim ion and alpha-ketoglutarate (see paper)
25% identity, 54% coverage: 43:351/569 of query aligns to 4:290/314 of 2zyfA
2ztjA Crystal structure of homocitrate synthase from thermus thermophilus complexed with alpha-ketoglutarate (see paper)
25% identity, 54% coverage: 43:351/569 of query aligns to 4:288/312 of 2ztjA
3ivsA Homocitrate synthase lys4 (see paper)
25% identity, 40% coverage: 154:381/569 of query aligns to 102:307/364 of 3ivsA
Sites not aligning to the query:
>SMc02717 FitnessBrowser__Smeli:SMc02717
MILKSHSIKTGMPEAAVKYQPYPQIVLPDRTWPSKAITEAPIWCSVDLRDGNQALVDPMG
HDRKARMFHLLLDMGFKEIEIGFPSASQTDYDFARWCVEEGNVSEDVSLQVLVQCRPELI
ARTFEALEGAHRPIVHFYNSTSELQRRVVFGKDVAGIKQIATDAAKMITDMAAKAGGGYR
FEYSPESFTGTELEVALEICNAVIEIVRPTADNKLIINLPSTVEMATPNIYADQIEWMCR
NLDNRENLIVSLHPHNDRGTGIAATELGLMAGADRVEGTLFGNGERTGNVDVVTLALNMF
TQGVDPKLDCSDIERIKEVYEYSNQMVIPERHPYVGELVYTAFSGSHQDAINKGMKAIKQ
ANKPTWEVPYLPIDPRDVGRSYEAIIRINSQSGKGGIAYILQEDYGINLPRNLQIEFREE
VQRITDEEGKELPSKRIHQRFIESYVEQPGARIKFVDHHTYPAGEHKGLRVVAAEITDGG
ETRQIEGKGTGPIDGFINALSIYLGIELSVADYSEHSLQHGSNAAAIAYVEVEYPGGKLF
GVGINTNIVAASLEAIVSAANRVLDVVGK
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory