SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing SMc04249 FitnessBrowser__Smeli:SMc04249 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 1 hits to proteins with known functional sites (download)

8b01B Cryo-em structure of the tripartite atp-independent periplasmic (trap) transporter siaqm from photobacterium profundum in a nanodisc (see paper)
28% identity, 36% coverage: 13:227/597 of query aligns to 1:204/427 of 8b01B

query
sites
8b01B

M

M

F

F

V

T

S

S

L

I

I

V

V

G

F

W

L

L

L

G

L

L

-

L

-

F

-

A

G

G

Y

M

P

P

V

V

A

G

F

F

S

S

L

L

A

I

A

F

N

V

G

G

L

L

L

A

F

F

F

L

I

V

I

-

G

-

V

-

E

-

L

-

A

-

P

-

L

L

S

T

D

E

S

S

I

T

N

G

L

I

S

-

W

-

P

-

L

-

L

-

N

N

A

F

L

A

P

A

E

Q

R

Q

F

M

W

I

G

G

V

G

M

L

S

D

N

N

D

F

T

T

L

L

L

L

A

A

I

V

P

P

F

F

F

F

T

V

F

L

M

T

G

G

I

H

V

L

L

M

E

N

R

S

S

A

G

G

M

I

A

T

E

E

D

R

L

I

L

F

D

N

T

F

I

A

G

K

Q

A

L

M

F

V

G

G

P

H

V

I

R

T

G

G

G

S

L

L

A

G

Y

H

A

V

V

N

I

I

F

L

V

A

G

S

A

L

L

L

L

F

A
x
S

A

G

T

M

T
x
S

G
|
G

V

S

V

A

A

L

A

A

S

D

V

A

I

G

A

G

M

L

G

G

L

Q

I

L

S

E

L

I

P

K

I

S

M

M

L

R

R

D

Y

A

G

K

Y

Y

D

D

R

D

R

D

I

F

A

A

S

G

G

G

V

L

I

T

A

A

A

A

S

S

G

C

T

I

L

I

A
x
G

Q

P

I

L

I
x
V

P
|
P

P
|
P

S

S

L

I

V

P

L

L

I

V

V

I

L

Y

A

G

D

V

Q

V

L

S

G

N

R

T

S

S

V

I

G

G

D

A

M

L

Y

F

A

L

G

A

A

G

L

A

I

I

P

P

G

G

L

L

V

-

L

-

T

-

G

-

L

L

Y

C

M

C

G

I

Y

A

I

L

L

C

L

I

M

M

T

T

F

Y

-

F

-

I

V

A

K

K

R

K

H

R

S

G

M

Y

P

M

A

T

L

L

P

P

L

R

E

A

A

S

R

R

binding sodium ion: S103 (≠ A124), S106 (≠ T127), G107 (= G128), G145 (≠ A166), V148 (≠ I169), P149 (= P170), P150 (= P171)

Sites not aligning to the query:

binding sodium ion: 325, 326, 366, 367, 369, 372, 373

Query Sequence

>SMc04249 FitnessBrowser__Smeli:SMc04249
MIEFVAENLAPIMFVSLIVFLLLGYPVAFSLAANGLLFFIIGVELAPLSDSINLSWPLLN
ALPERFWGVMSNDTLLAIPFFTFMGIVLERSGMAEDLLDTIGQLFGPVRGGLAYAVIFVG
ALLAATTGVVAASVIAMGLISLPIMLRYGYDRRIASGVIAASGTLAQIIPPSLVLIVLAD
QLGRSVGDMYAGALIPGLVLTGLYMGYILLMTFVKRHSMPALPLEARTLGSGVASLAIAL
LVACAIAYAAHVYLSPTQGENADILGATVGIIFIYLAALADRTLKINALSRLAQQVIIVL
IPPLALIFLVLGTIFLGIATPTEGGAMGAVGALVMAAGKGRLNMEVVRAALASTTRLSAF
VLFILIGARVFSLTFYGVNGHLWVEHLLTALPGGEIGFLIAVNVLVFFLAFFLDFFELAF
IIVPLLAPAADKLGIDLIWFGVLLGINMQTSFMHPPFGFALFYLRSVAARVPYLDRVTGK
MMQPVTTGQIYWGAVPFVCIQVVMVALTLMFPQMVLHYKGSGAAVDPSTIKIEVPGFGTG
GGGLTLPDNGGGLGLPGGLQLPGGSPLDGGGQQPAQPNTAPQQNNPAPDLSAPPSFN

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory