SitesBLAST
Comparing Synpcc7942_0139 FitnessBrowser__SynE:Synpcc7942_0139 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
P09114 Acetolactate synthase 2, chloroplastic; ALS II; Acetohydroxy-acid synthase II; Acetolactate synthase II; EC 2.2.1.6 from Nicotiana tabacum (Common tobacco) (see paper)
48% identity, 91% coverage: 14:567/612 of query aligns to 93:648/664 of P09114
- P191 (= P115) mutation to A: In S4-Hra; highly resistant to sulfonylurea herbicides; when associated with L-568.
- W568 (= W493) mutation to L: In S4-Hra; highly resistant to sulfonylurea herbicides; when associated with A-191.
P09342 Acetolactate synthase 1, chloroplastic; ALS I; Acetohydroxy-acid synthase I; Acetolactate synthase I; EC 2.2.1.6 from Nicotiana tabacum (Common tobacco) (see 2 papers)
47% identity, 91% coverage: 14:567/612 of query aligns to 96:651/667 of P09342
- C161 (= C82) modified: Disulfide link with 307
- P194 (= P115) mutation to Q: In C3; highly resistant to sulfonylurea herbicides.
- C307 (≠ A228) modified: Disulfide link with 161
3ea4A Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron-ester (see paper)
45% identity, 91% coverage: 10:567/612 of query aligns to 9:568/582 of 3ea4A
- active site: Y32 (= Y33), G34 (= G35), G35 (= G36), A36 (= A37), S37 (≠ I38), E58 (= E62), T81 (= T85), F120 (= F124), Q121 (= Q125), E122 (= E126), K170 (= K174), M265 (= M271), V292 (= V298), V399 (= V405), G425 (= G430), M427 (= M432), D452 (= D457), N479 (= N484), H481 (≠ W486), L482 (≠ Q487), M484 (= M489), V485 (= V490), W488 (= W493), H557 (≠ R556)
- binding methyl 2-{[(4-methylpyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: D290 (= D296), R291 (= R297), W488 (= W493), S567 (= S566)
- binding flavin-adenine dinucleotide-n5-isobutyl ketone: R160 (= R164), G221 (= G225), G222 (= G226), G223 (= G227), T245 (= T251), L246 (= L252), M247 (= M253), L263 (= L269), G264 (= G270), M265 (= M271), H266 (= H272), G285 (= G291), R287 (= R293), D289 (= D295), R291 (= R297), D309 (= D315), I310 (= I316), G327 (= G333), D328 (= D334), V329 (= V335), M404 (= M410), G422 (≠ A427)
- binding magnesium ion: D452 (= D457), N479 (= N484), H481 (≠ W486)
- binding 2-[(2e)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-hydroxyethylidene)-4-methyl-2,3-dihydro-1,3-thiazol-5-yl]ethyltrihydrogen diphosphate: V399 (= V405), G400 (= G406), Q401 (= Q407), H402 (= H408), M427 (= M432), G451 (= G456), D452 (= D457), G453 (≠ A458), S454 (= S459), N479 (= N484), H481 (≠ W486), L482 (≠ Q487), G483 (= G488), M484 (= M489), V485 (= V490)
3e9yA Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron (see paper)
45% identity, 91% coverage: 10:567/612 of query aligns to 9:568/582 of 3e9yA
- active site: Y32 (= Y33), G34 (= G35), G35 (= G36), A36 (= A37), S37 (≠ I38), E58 (= E62), T81 (= T85), F120 (= F124), Q121 (= Q125), E122 (= E126), K170 (= K174), M265 (= M271), V292 (= V298), V399 (= V405), G425 (= G430), M427 (= M432), D452 (= D457), N479 (= N484), H481 (≠ W486), L482 (≠ Q487), M484 (= M489), V485 (= V490), W488 (= W493), H557 (≠ R556)
- binding N-[(4-methylpyrimidin-2-yl)carbamoyl]-2-nitrobenzenesulfonamide: D290 (= D296), R291 (= R297), W488 (= W493), S567 (= S566)
- binding flavin-adenine dinucleotide-n5-isobutyl ketone: R160 (= R164), G221 (= G225), G222 (= G226), G223 (= G227), T245 (= T251), L246 (= L252), M247 (= M253), L263 (= L269), G285 (= G291), R287 (= R293), D289 (= D295), R291 (= R297), D309 (= D315), I310 (= I316), G327 (= G333), D328 (= D334), V329 (= V335), M404 (= M410), G422 (≠ A427)
- binding magnesium ion: D452 (= D457), N479 (= N484), H481 (≠ W486)
- binding 2-[(2e)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-hydroxyethylidene)-4-methyl-2,3-dihydro-1,3-thiazol-5-yl]ethyltrihydrogen diphosphate: V399 (= V405), G400 (= G406), Q401 (= Q407), H402 (= H408), M427 (= M432), G451 (= G456), G453 (≠ A458), S454 (= S459), N479 (= N484), H481 (≠ W486), L482 (≠ Q487), G483 (= G488), M484 (= M489), V485 (= V490)
P17597 Acetolactate synthase, chloroplastic; AtALS; Acetohydroxy-acid synthase; Protein CHLORSULFURON RESISTANT 1; EC 2.2.1.6 from Arabidopsis thaliana (Mouse-ear cress) (see 8 papers)
45% identity, 91% coverage: 10:567/612 of query aligns to 95:654/670 of P17597
- A122 (= A37) mutation to V: Reduced catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
- M124 (≠ L39) mutation to E: Reduced catalytic activity. Resistant to imidazolinone herbicides and reduced sensitivity to sulfonylurea herbicides.; mutation to I: No effect on catalytic activity. Increased resistance to imidazolinone herbicides.
- E144 (= E62) binding
- S186 (= S104) binding
- P197 (= P115) mutation to S: In csr1-1/GH50; resistant to sulfonylurea but not to imidazolinone herbicides.
- R199 (≠ T117) mutation R->A,E: No effect on catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
- Q207 (= Q125) binding
- K220 (= K138) binding
- R246 (= R164) binding ; binding
- K256 (= K174) binding
- G308 (= G226) binding
- TL 331:332 (= TL 251:252) binding
- C340 (≠ E260) modified: Cysteine sulfinic acid (-SO2H)
- LGMH 349:352 (= LGMH 269:272) binding
- GVRFD 371:375 (≠ GARFD 291:295) binding
- DR 376:377 (= DR 296:297) binding
- DI 395:396 (= DI 315:316) binding
- DV 414:415 (= DV 334:335) binding
- QH 487:488 (= QH 407:408) binding
- GG 508:509 (≠ AG 427:428) binding
- GAM 511:513 (≠ GTM 430:432) binding
- D538 (= D457) binding
- DGS 538:540 (≠ DAS 457:459) binding
- N565 (= N484) binding
- NQHLGM 565:570 (≠ NGWQGM 484:489) binding
- H567 (≠ W486) binding
- W574 (= W493) binding ; mutation to L: Increased catalytic activity. Resistant to imidazolinone and sulfonylurea herbicides.; mutation to S: Slightly decreased catalytic activity. Resistant to imidazolinone and sulfonylurea herbicides.
- S653 (= S566) binding ; mutation to A: No effect on catalytic activity or sensitivity to herbicides.; mutation to F: No effect on catalytic activity. Resistant to imidazolinone herbicides and also slightly sulfonylurea-resistant.; mutation to N: In csr1-2/GH90; no effect on catalytic activity. Resistant to imidazolinone but not to sulfonylurea herbicides.; mutation to T: No effect on catalytic activity. Resistant to imidazolinone herbicides but not to sulfonylurea herbicides.
8et4A Crystal structure of wild-type arabidopsis thaliana acetohydroxyacid synthase in complex with amidosulfuron (see paper)
45% identity, 91% coverage: 10:567/612 of query aligns to 10:569/582 of 8et4A
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V400 (= V405), G401 (= G406), Q402 (= Q407), H403 (= H408), G426 (= G430), M428 (= M432), G452 (= G456), D453 (= D457), G454 (≠ A458), S455 (= S459), M458 (= M462), N480 (= N484), H482 (≠ W486), L483 (≠ Q487), G484 (= G488), M485 (= M489), V486 (= V490)
- binding flavin-adenine dinucleotide: R161 (= R164), G222 (= G225), G223 (= G226), G224 (= G227), T246 (= T251), L247 (= L252), M248 (= M253), L264 (= L269), M266 (= M271), H267 (= H272), G286 (= G291), V287 (≠ A292), R288 (= R293), D290 (= D295), R292 (= R297), V293 (= V298), D310 (= D315), I311 (= I316), D329 (= D334), V330 (= V335), M405 (= M410), G423 (≠ A427)
- binding magnesium ion: F370 (≠ I376), D453 (= D457), M458 (= M462), Q461 (= Q465), N480 (= N484), H482 (≠ W486), K533 (≠ P531)
- binding N-{[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]sulfamoyl}-N-methylmethanesulfonamide: M266 (= M271), R292 (= R297), M485 (= M489), W489 (= W493), S568 (= S566)
5wj1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a triazolopyrimidine herbicide, penoxsulam (see paper)
45% identity, 91% coverage: 10:567/612 of query aligns to 10:569/582 of 5wj1A
- active site: Y33 (= Y33), G35 (= G35), G36 (= G36), A37 (= A37), S38 (≠ I38), E59 (= E62), T82 (= T85), F121 (= F124), Q122 (= Q125), E123 (= E126), K171 (= K174), M266 (= M271), V293 (= V298), V400 (= V405), G426 (= G430), M428 (= M432), D453 (= D457), N480 (= N484), H482 (≠ W486), L483 (≠ Q487), M485 (= M489), V486 (= V490), W489 (= W493), H558 (≠ R556)
- binding flavin-adenine dinucleotide: R161 (= R164), G222 (= G225), G223 (= G226), G224 (= G227), T246 (= T251), L247 (= L252), M248 (= M253), M263 (= M268), L264 (= L269), G286 (= G291), R288 (= R293), V293 (= V298), D310 (= D315), I311 (= I316), D329 (= D334), V330 (= V335), M405 (= M410), G423 (≠ A427), G424 (= G428)
- binding magnesium ion: D453 (= D457), N480 (= N484), H482 (≠ W486)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: M266 (= M271), D291 (= D296), R292 (= R297), M485 (= M489), W489 (= W493), S568 (= S566)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (= V405), G401 (= G406), Q402 (= Q407), H403 (= H408), M428 (= M432), D453 (= D457), G454 (≠ A458), S455 (= S459), M458 (= M462), N480 (= N484), H482 (≠ W486), L483 (≠ Q487), G484 (= G488), M485 (= M489), V486 (= V490)
5k6tA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, propoxycarbazone-sodium (see paper)
45% identity, 91% coverage: 10:567/612 of query aligns to 10:569/582 of 5k6tA
- active site: Y33 (= Y33), G35 (= G35), G36 (= G36), A37 (= A37), S38 (≠ I38), E59 (= E62), T82 (= T85), F121 (= F124), Q122 (= Q125), E123 (= E126), K171 (= K174), M266 (= M271), V293 (= V298), V400 (= V405), G426 (= G430), M428 (= M432), D453 (= D457), N480 (= N484), H482 (≠ W486), L483 (≠ Q487), M485 (= M489), V486 (= V490), W489 (= W493), H558 (≠ R556)
- binding methyl 2-[(4-methyl-5-oxidanylidene-3-propoxy-1,2,4-triazol-1-yl)carbonylsulfamoyl]benzoate: H267 (= H272), R292 (= R297), M485 (= M489), W489 (= W493), S568 (= S566)
- binding flavin-adenine dinucleotide: R161 (= R164), G222 (= G225), G223 (= G226), G224 (= G227), T246 (= T251), L247 (= L252), M248 (= M253), L264 (= L269), G286 (= G291), R288 (= R293), D290 (= D295), R292 (= R297), V293 (= V298), D310 (= D315), I311 (= I316), D329 (= D334), V330 (= V335), Q404 (= Q409), M405 (= M410), G423 (≠ A427)
- binding magnesium ion: D453 (= D457), N480 (= N484), H482 (≠ W486)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V400 (= V405), G401 (= G406), Q402 (= Q407), H403 (= H408), G426 (= G430), M428 (= M432), G452 (= G456), G454 (≠ A458), S455 (= S459), N480 (= N484), H482 (≠ W486), L483 (≠ Q487), G484 (= G488)
5k6rA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, thiencarbazone-methyl (see paper)
45% identity, 91% coverage: 10:567/612 of query aligns to 10:569/582 of 5k6rA
- active site: Y33 (= Y33), G35 (= G35), G36 (= G36), A37 (= A37), S38 (≠ I38), E59 (= E62), T82 (= T85), F121 (= F124), Q122 (= Q125), E123 (= E126), K171 (= K174), M266 (= M271), V293 (= V298), V400 (= V405), G426 (= G430), M428 (= M432), D453 (= D457), N480 (= N484), H482 (≠ W486), L483 (≠ Q487), M485 (= M489), V486 (= V490), W489 (= W493), H558 (≠ R556)
- binding methyl 4-[(3-methoxy-4-methyl-5-oxidanylidene-1,2,4-triazol-1-yl)carbonylsulfamoyl]-5-methyl-thiophene-3-carboxylate: R292 (= R297), W489 (= W493), S568 (= S566)
- binding flavin-adenine dinucleotide: R161 (= R164), G222 (= G225), G223 (= G226), G224 (= G227), T246 (= T251), L247 (= L252), M248 (= M253), L264 (= L269), M266 (= M271), G286 (= G291), R288 (= R293), R292 (= R297), V293 (= V298), D310 (= D315), I311 (= I316), G328 (= G333), D329 (= D334), V330 (= V335), M405 (= M410), G423 (≠ A427)
- binding magnesium ion: D453 (= D457), N480 (= N484), H482 (≠ W486)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V400 (= V405), G401 (= G406), Q402 (= Q407), H403 (= H408), G426 (= G430), M428 (= M432), D453 (= D457), G454 (≠ A458), S455 (= S459), M458 (= M462), N480 (= N484), H482 (≠ W486), L483 (≠ Q487), G484 (= G488), M485 (= M489), V486 (= V490)
1z8nA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with an imidazolinone herbicide, imazaquin (see paper)
45% identity, 91% coverage: 10:567/612 of query aligns to 10:569/582 of 1z8nA
- active site: Y33 (= Y33), G35 (= G35), G36 (= G36), A37 (= A37), S38 (≠ I38), E59 (= E62), T82 (= T85), F121 (= F124), Q122 (= Q125), E123 (= E126), K171 (= K174), M266 (= M271), V293 (= V298), V400 (= V405), G426 (= G430), M428 (= M432), D453 (= D457), N480 (= N484), H482 (≠ W486), L483 (≠ Q487), M485 (= M489), V486 (= V490), W489 (= W493), H558 (≠ R556)
- binding 2-(4-isopropyl-4-methyl-5-oxo-4,5-dihydro-1h-imidazol-2-yl)quinoline-3-carboxylic acid: K135 (= K138), R161 (= R164), Y191 (= Y196), R194 (≠ T199), D291 (= D296), R292 (= R297), D312 (= D317), W489 (= W493), G569 (= G567)
- binding flavin-adenine dinucleotide: R161 (= R164), G222 (= G225), G224 (= G227), T246 (= T251), L247 (= L252), M248 (= M253), L264 (= L269), G265 (= G270), M266 (= M271), H267 (= H272), G286 (= G291), V287 (≠ A292), R288 (= R293), D290 (= D295), R292 (= R297), V293 (= V298), D310 (= D315), I311 (= I316), D329 (= D334), V330 (= V335), M405 (= M410), G423 (≠ A427), G424 (= G428)
- binding magnesium ion: D453 (= D457), N480 (= N484)
- binding thiamine diphosphate: V400 (= V405), G401 (= G406), Q402 (= Q407), H403 (= H408), G426 (= G430), M428 (= M432), G452 (= G456), G454 (≠ A458), S455 (= S459), N480 (= N484), H482 (≠ W486), L483 (≠ Q487), G484 (= G488), M485 (= M489), V486 (= V490)
1yi1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl (see paper)
45% identity, 91% coverage: 10:567/612 of query aligns to 10:569/582 of 1yi1A
- active site: Y33 (= Y33), G35 (= G35), G36 (= G36), A37 (= A37), S38 (≠ I38), E59 (= E62), T82 (= T85), F121 (= F124), Q122 (= Q125), E123 (= E126), K171 (= K174), M266 (= M271), V293 (= V298), V400 (= V405), G426 (= G430), M428 (= M432), D453 (= D457), N480 (= N484), H482 (≠ W486), L483 (≠ Q487), M485 (= M489), V486 (= V490), W489 (= W493), H558 (≠ R556)
- binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: D291 (= D296), R292 (= R297), W489 (= W493), S568 (= S566)
- binding flavin-adenine dinucleotide: R161 (= R164), G223 (= G226), G224 (= G227), T246 (= T251), L247 (= L252), M248 (= M253), M263 (= M268), L264 (= L269), G265 (= G270), M266 (= M271), H267 (= H272), G286 (= G291), V287 (≠ A292), R288 (= R293), D290 (= D295), V293 (= V298), D310 (= D315), I311 (= I316), D329 (= D334), V330 (= V335), M405 (= M410), G423 (≠ A427), G424 (= G428)
- binding magnesium ion: D453 (= D457), N480 (= N484), H482 (≠ W486)
1yi0A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl (see paper)
45% identity, 91% coverage: 10:567/612 of query aligns to 10:569/582 of 1yi0A
- active site: Y33 (= Y33), G35 (= G35), G36 (= G36), A37 (= A37), S38 (≠ I38), E59 (= E62), T82 (= T85), F121 (= F124), Q122 (= Q125), E123 (= E126), K171 (= K174), M266 (= M271), V293 (= V298), V400 (= V405), G426 (= G430), M428 (= M432), D453 (= D457), N480 (= N484), H482 (≠ W486), L483 (≠ Q487), M485 (= M489), V486 (= V490), W489 (= W493), H558 (≠ R556)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D291 (= D296), R292 (= R297), W489 (= W493), S568 (= S566)
- binding flavin-adenine dinucleotide: R161 (= R164), G222 (= G225), G223 (= G226), G224 (= G227), T246 (= T251), L247 (= L252), M248 (= M253), L264 (= L269), G265 (= G270), M266 (= M271), H267 (= H272), G286 (= G291), V287 (≠ A292), R288 (= R293), D290 (= D295), R292 (= R297), V293 (= V298), D310 (= D315), I311 (= I316), G328 (= G333), D329 (= D334), V330 (= V335), M405 (= M410), G423 (≠ A427), G424 (= G428)
- binding magnesium ion: D453 (= D457), N480 (= N484), H482 (≠ W486)
1yhzA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
45% identity, 91% coverage: 10:567/612 of query aligns to 10:569/582 of 1yhzA
- active site: Y33 (= Y33), G35 (= G35), G36 (= G36), A37 (= A37), S38 (≠ I38), E59 (= E62), T82 (= T85), F121 (= F124), Q122 (= Q125), E123 (= E126), K171 (= K174), M266 (= M271), V293 (= V298), V400 (= V405), G426 (= G430), M428 (= M432), D453 (= D457), N480 (= N484), H482 (≠ W486), L483 (≠ Q487), M485 (= M489), V486 (= V490), W489 (= W493), H558 (≠ R556)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: D291 (= D296), R292 (= R297), M485 (= M489), W489 (= W493), S568 (= S566)
- binding flavin-adenine dinucleotide: R161 (= R164), G223 (= G226), G224 (= G227), T246 (= T251), L247 (= L252), M248 (= M253), L264 (= L269), M266 (= M271), H267 (= H272), G286 (= G291), V287 (≠ A292), R288 (= R293), D290 (= D295), V293 (= V298), D310 (= D315), I311 (= I316), D329 (= D334), V330 (= V335), Q404 (= Q409), M405 (= M410), G423 (≠ A427), G424 (= G428)
- binding magnesium ion: D453 (= D457), N480 (= N484), H482 (≠ W486)
1yhyA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
45% identity, 91% coverage: 10:567/612 of query aligns to 10:569/582 of 1yhyA
- active site: Y33 (= Y33), G35 (= G35), G36 (= G36), A37 (= A37), S38 (≠ I38), E59 (= E62), T82 (= T85), F121 (= F124), Q122 (= Q125), E123 (= E126), K171 (= K174), M266 (= M271), V293 (= V298), V400 (= V405), G426 (= G430), M428 (= M432), D453 (= D457), N480 (= N484), H482 (≠ W486), L483 (≠ Q487), M485 (= M489), V486 (= V490), W489 (= W493), H558 (≠ R556)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D291 (= D296), R292 (= R297), V486 (= V490), W489 (= W493), S568 (= S566)
- binding flavin-adenine dinucleotide: R161 (= R164), G222 (= G225), G223 (= G226), G224 (= G227), T246 (= T251), L247 (= L252), M248 (= M253), L264 (= L269), G265 (= G270), M266 (= M271), H267 (= H272), G286 (= G291), V287 (≠ A292), R288 (= R293), D290 (= D295), V293 (= V298), D310 (= D315), I311 (= I316), D329 (= D334), V330 (= V335), Q404 (= Q409), M405 (= M410), G423 (≠ A427), G424 (= G428)
- binding magnesium ion: D453 (= D457), N480 (= N484), H482 (≠ W486)
1ybhA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide chlorimuron ethyl (see paper)
45% identity, 91% coverage: 10:567/612 of query aligns to 10:569/582 of 1ybhA
- active site: Y33 (= Y33), G35 (= G35), G36 (= G36), A37 (= A37), S38 (≠ I38), E59 (= E62), T82 (= T85), F121 (= F124), Q122 (= Q125), E123 (= E126), K171 (= K174), M266 (= M271), V293 (= V298), V400 (= V405), G426 (= G430), M428 (= M432), D453 (= D457), N480 (= N484), H482 (≠ W486), L483 (≠ Q487), M485 (= M489), V486 (= V490), W489 (= W493), H558 (≠ R556)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: M266 (= M271), D291 (= D296), R292 (= R297), M485 (= M489), W489 (= W493), S568 (= S566)
- binding flavin-adenine dinucleotide: R161 (= R164), G223 (= G226), G224 (= G227), T246 (= T251), L247 (= L252), M248 (= M253), L264 (= L269), M266 (= M271), H267 (= H272), G286 (= G291), V287 (≠ A292), R288 (= R293), D290 (= D295), V293 (= V298), D310 (= D315), I311 (= I316), D329 (= D334), V330 (= V335), Q404 (= Q409), M405 (= M410), G423 (≠ A427), G424 (= G428)
- binding magnesium ion: D453 (= D457), N480 (= N484), H482 (≠ W486)
5k2oA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, pyrithiobac (see paper)
45% identity, 91% coverage: 10:567/612 of query aligns to 10:569/585 of 5k2oA
- active site: Y33 (= Y33), G35 (= G35), G36 (= G36), A37 (= A37), S38 (≠ I38), E59 (= E62), T82 (= T85), F121 (= F124), Q122 (= Q125), E123 (= E126), K171 (= K174), M266 (= M271), V293 (= V298), V400 (= V405), G426 (= G430), M428 (= M432), D453 (= D457), N480 (= N484), H482 (≠ W486), L483 (≠ Q487), M485 (= M489), V486 (= V490), W489 (= W493), H558 (≠ R556)
- binding 2-chloranyl-6-(4,6-dimethoxypyrimidin-2-yl)sulfanyl-benzoic acid: M266 (= M271), R292 (= R297), W489 (= W493), S568 (= S566)
- binding flavin-adenine dinucleotide: R161 (= R164), G222 (= G225), G223 (= G226), G224 (= G227), T246 (= T251), L247 (= L252), M248 (= M253), L264 (= L269), G286 (= G291), R288 (= R293), D290 (= D295), V293 (= V298), D310 (= D315), I311 (= I316), D329 (= D334), V330 (= V335), Q404 (= Q409), M405 (= M410), G423 (≠ A427)
- binding magnesium ion: D453 (= D457), N480 (= N484), H482 (≠ W486)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (= V405), G401 (= G406), Q402 (= Q407), H403 (= H408), M428 (= M432), D453 (= D457), G454 (≠ A458), S455 (= S459), N480 (= N484), H482 (≠ W486), L483 (≠ Q487), G484 (= G488), M485 (= M489), V486 (= V490)
5k3sA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, bispyribac-sodium (see paper)
45% identity, 91% coverage: 10:567/612 of query aligns to 10:569/583 of 5k3sA
- active site: Y33 (= Y33), G35 (= G35), G36 (= G36), A37 (= A37), S38 (≠ I38), E59 (= E62), T82 (= T85), F121 (= F124), Q122 (= Q125), E123 (= E126), K171 (= K174), M266 (= M271), V293 (= V298), V400 (= V405), G426 (= G430), M428 (= M432), D453 (= D457), N480 (= N484), H482 (≠ W486), L483 (≠ Q487), M485 (= M489), V486 (= V490), W489 (= W493), H558 (≠ R556)
- binding 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid: R292 (= R297), M485 (= M489), W489 (= W493), G569 (= G567)
- binding flavin-adenine dinucleotide: R161 (= R164), G222 (= G225), G223 (= G226), G224 (= G227), T246 (= T251), L247 (= L252), M248 (= M253), L264 (= L269), M266 (= M271), G286 (= G291), R288 (= R293), D290 (= D295), V293 (= V298), D310 (= D315), I311 (= I316), D329 (= D334), V330 (= V335), M405 (= M410), G423 (≠ A427)
- binding magnesium ion: D453 (= D457), N480 (= N484), H482 (≠ W486)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (= V405), G401 (= G406), Q402 (= Q407), H403 (= H408), G426 (= G430), M428 (= M432), D453 (= D457), G454 (≠ A458), S455 (= S459), N480 (= N484), H482 (≠ W486), L483 (≠ Q487), G484 (= G488), M485 (= M489), V486 (= V490)
7tzzA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase p197t mutant in complex with bispyribac-sodium (see paper)
45% identity, 91% coverage: 10:567/612 of query aligns to 10:569/582 of 7tzzA
- binding 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid: M266 (= M271), R292 (= R297), W489 (= W493), S568 (= S566)
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V400 (= V405), G401 (= G406), Q402 (= Q407), H403 (= H408), G426 (= G430), M428 (= M432), G452 (= G456), D453 (= D457), G454 (≠ A458), S455 (= S459), L483 (≠ Q487), G484 (= G488), M485 (= M489), V486 (= V490)
- binding flavin-adenine dinucleotide: R161 (= R164), G222 (= G225), G223 (= G226), G224 (= G227), T246 (= T251), L247 (= L252), M248 (= M253), M263 (= M268), L264 (= L269), M266 (= M271), H267 (= H272), G286 (= G291), R288 (= R293), V293 (= V298), D310 (= D315), I311 (= I316), D329 (= D334), V330 (= V335), M405 (= M410), G423 (≠ A427)
- binding magnesium ion: A37 (= A37), T82 (= T85), S83 (= S86), Q122 (= Q125), Y381 (≠ Q387), D453 (= D457), M458 (= M462), Q461 (= Q465), N480 (= N484), H482 (≠ W486), K533 (≠ P531)
6lpiB Crystal structure of ahas holo-enzyme (see paper)
44% identity, 93% coverage: 7:574/612 of query aligns to 1:539/539 of 6lpiB
- active site: I27 (≠ Y33), G29 (= G35), G30 (= G36), S31 (≠ A37), I32 (= I38), E53 (= E62), C76 (≠ T85), F115 (= F124), Q116 (= Q125), E117 (= E126), K165 (= K174), M256 (= M271), A283 (≠ V298), V375 (= V405), G401 (= G430), M403 (= M432), D428 (= D457), N455 (= N484), A457 (≠ W486), L458 (≠ Q487), L460 (≠ M489), V461 (= V490), Q464 (≠ W493)
- binding flavin-adenine dinucleotide: R155 (= R164), G212 (= G225), G213 (= G226), G214 (= G227), T236 (= T251), L237 (= L252), M238 (= M253), L254 (= L269), M256 (= M271), H257 (= H272), G276 (= G291), A277 (= A292), R278 (= R293), D280 (= D295), R282 (= R297), A283 (≠ V298), D300 (= D315), I301 (= I316), D319 (= D334), V320 (= V335), M380 (= M410), G398 (≠ A427)
- binding magnesium ion: D428 (= D457), N455 (= N484)
- binding thiamine diphosphate: E53 (= E62), C76 (≠ T85), P79 (= P88), G376 (= G406), Q377 (= Q407), H378 (= H408), G401 (= G430), M403 (= M432), G427 (= G456), D428 (= D457), G429 (≠ A458), S430 (= S459), M433 (= M462), N455 (= N484), A457 (≠ W486), L458 (≠ Q487), G459 (= G488), L460 (≠ M489), V461 (= V490)
1t9cA Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl (see paper)
43% identity, 91% coverage: 13:567/612 of query aligns to 9:567/596 of 1t9cA
- active site: Y29 (= Y33), G31 (= G35), G32 (= G36), A33 (= A37), I34 (= I38), E55 (= E62), T78 (= T85), F117 (= F124), Q118 (= Q125), E119 (= E126), K167 (= K174), R227 (vs. gap), M263 (= M271), V290 (= V298), V406 (= V405), L431 (= L429), G432 (= G430), M434 (= M432), D459 (= D457), N486 (= N484), E488 (≠ W486), Q489 (= Q487), M491 (= M489), V492 (= V490), W495 (= W493), L517 (= L517), G522 (= G522), L523 (≠ I523), K556 (≠ R556)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: G32 (= G36), V107 (= V114), P108 (= P115), F117 (= F124), K167 (= K174), D288 (= D296), R289 (= R297), W495 (= W493)
- binding flavin-adenine dinucleotide: R157 (= R164), G216 (= G225), A217 (≠ G226), G218 (= G227), N221 (≠ T230), T243 (= T251), L244 (= L252), Q245 (≠ M253), L261 (= L269), M263 (= M271), H264 (= H272), G283 (= G291), A284 (= A292), R285 (= R293), D287 (= D295), R289 (= R297), V290 (= V298), E316 (≠ D315), V317 (≠ I316), N321 (≠ E320), G334 (= G333), D335 (= D334), A336 (≠ V335), M411 (= M410), G429 (≠ A427), G430 (= G428)
- binding magnesium ion: D459 (= D457), N486 (= N484), E488 (≠ W486)
Query Sequence
>Synpcc7942_0139 FitnessBrowser__SynE:Synpcc7942_0139
VQLQTVTIQQRATGAYALIDSLCQHGVKHIFGYPGGAILPIYDELHRAEAAGRVQHILVR
HEQGAVHAADAYSRATGEVGVCFATSGPGATNLVTGIATAQMDSIPMVVVTGQVPRTAIG
TDAFQETDIYGITLPIVKHSYVVRDPRDMARIVAEAFHIAQSGRPGPVLIDVPKDVGTEE
FDYVPVAPGDIRLPGYRPTTRGNPRQIAQAIALVKVARRPLLYVGGGAITAGAHAELRAF
AERFQLPVTTTLMGKGAFDERHPLALGMLGMHGTAYANFAVSECDLLIAVGARFDDRVTG
KLDEFASKAQVIHVDIDPAEVGKNRVPEVPIVGDVRQVLNELLARAEEQISADDATRTQP
WLDRIAYWKREYPLQIPYYADVLSPQQVIHSLGEAAPDAYFTTDVGQHQMWAAQFIKNGP
RRWISSAGLGTMGFGMPAAMGAQMALPDDTVICVAGDASILMNIQELGTLAQYNIPIKVV
VVNNGWQGMVRQWQEAFYDERYSNSNMERGMPDFVKLAEAFGIKGMRVSHPDELQAAIAE
MLAFDGPVFLDAIVKRDENCYPMVPSGHSNAQMLGLPKDPTLDLDLAIATCSSCGAKTLP
SHKFCPDCGAKL
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory