Comparing Synpcc7942_0143 FitnessBrowser__SynE:Synpcc7942_0143 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
6cfoB Human pyruvate dehydrogenase e1 component complex with covalent tdp adduct acetyl phosphinate (see paper)
46% identity, 97% coverage: 8:323/326 of query aligns to 8:329/330 of 6cfoB
6cerD Human pyruvate dehydrogenase complex e1 component v138m mutation (see paper)
46% identity, 97% coverage: 8:323/326 of query aligns to 9:330/331 of 6cerD
P11177 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial; PDHE1-B; EC 1.2.4.1 from Homo sapiens (Human) (see 6 papers)
46% identity, 97% coverage: 8:323/326 of query aligns to 37:358/359 of P11177
Sites not aligning to the query:
Q5SLR3 2-oxoisovalerate dehydrogenase subunit beta; Branched-chain alpha-keto acid dehydrogenase E1 component beta chain; BCKDH E1-beta; EC 1.2.4.4 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
48% identity, 92% coverage: 1:299/326 of query aligns to 1:301/324 of Q5SLR3
1umdD Branched-chain 2-oxo acid dehydrogenase (e1) from thermus thermophilus hb8 with 4-methyl-2-oxopentanoate as an intermediate (see paper)
48% identity, 90% coverage: 6:299/326 of query aligns to 5:300/323 of 1umdD
1umcD Branched-chain 2-oxo acid dehydrogenase (e1) from thermus thermophilus hb8 with 4-methylpentanoate (see paper)
48% identity, 90% coverage: 6:299/326 of query aligns to 5:300/323 of 1umcD
1umbD Branched-chain 2-oxo acid dehydrogenase (e1) from thermus thermophilus hb8 in holo-form (see paper)
48% identity, 90% coverage: 6:299/326 of query aligns to 5:300/323 of 1umbD
3dv0D Snapshots of catalysis in the e1 subunit of the pyruvate dehydrogenase multi-enzyme complex (see paper)
43% identity, 91% coverage: 2:299/326 of query aligns to 1:300/324 of 3dv0D
3dv0B Snapshots of catalysis in the e1 subunit of the pyruvate dehydrogenase multi-enzyme complex (see paper)
43% identity, 91% coverage: 2:299/326 of query aligns to 1:300/324 of 3dv0B
3dufD Snapshots of catalysis in the e1 subunit of the pyruvate dehydrogenase multi-enzyme complex (see paper)
43% identity, 91% coverage: 2:299/326 of query aligns to 1:300/324 of 3dufD
1w85B The crystal structure of pyruvate dehydrogenase e1 bound to the peripheral subunit binding domain of e2 (see paper)
43% identity, 91% coverage: 2:299/326 of query aligns to 1:300/324 of 1w85B
1qs0B Crystal structure of pseudomonas putida 2-oxoisovalerate dehydrogenase (branched-chain alpha-keto acid dehydrogenase, e1b) (see paper)
43% identity, 97% coverage: 6:322/326 of query aligns to 7:336/338 of 1qs0B
1dtwB Human branched-chain alpha-keto acid dehydrogenase (see paper)
39% identity, 90% coverage: 6:299/326 of query aligns to 7:303/326 of 1dtwB
P21953 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial; Branched-chain alpha-keto acid dehydrogenase E1 component beta chain; BCKDE1B; BCKDH E1-beta; EC 1.2.4.4 from Homo sapiens (Human) (see 2 papers)
39% identity, 90% coverage: 6:299/326 of query aligns to 73:369/392 of P21953
2j9fD Human branched-chain alpha-ketoacid dehydrogenase-decarboxylase e1b (see paper)
39% identity, 90% coverage: 6:299/326 of query aligns to 10:306/329 of 2j9fD
6yakDDD C-terminal component of the split chain transketolase (see paper)
28% identity, 94% coverage: 21:325/326 of query aligns to 20:310/311 of 6yakDDD
6rjbB Human transketolase variant t382e (see paper)
26% identity, 86% coverage: 43:323/326 of query aligns to 348:620/622 of 6rjbB
Sites not aligning to the query:
4kxxA Human transketolase in covalent complex with donor ketose d- sedoheptulose-7-phosphate (see paper)
26% identity, 86% coverage: 43:323/326 of query aligns to 349:621/621 of 4kxxA
Sites not aligning to the query:
6ha3A Human transketolase variant e160q in covalent complex with donor ketose d-fructose-6-phosphate (see paper)
26% identity, 86% coverage: 43:323/326 of query aligns to 348:620/620 of 6ha3A
Sites not aligning to the query:
8waaA Human transketolase soaked with donor ketose d-xylulose
26% identity, 86% coverage: 43:323/326 of query aligns to 348:620/620 of 8waaA
Sites not aligning to the query:
>Synpcc7942_0143 FitnessBrowser__SynE:Synpcc7942_0143
MAETFMFNALRAAIDEEMARDPNVFVLGEDVGHYGGSYKVTKDLYQKYGDFRLLDTPIAE
NGFTGMAVGAAMTGLRPIVEGMNMGFLLLAFNQIANNAMLRYTSGGNFTIPIVFRGPGGV
GRQLGAEHSQRLEAYFHAVPGLKIVACSTPYNAKGLLKAAIRDNNPVLFFEHVLLYNLKE
DLPDEEYICPLDKAEIVRPGKDVTVLTYSRMRYHCLQAVKTLEKEGFDPEVIDLISLKPF
DFEAIEASVRKTHRVVIVEECMKTGGIAAELSAAIMERCFDELDAPVVRLSSQDIPTPYN
GKLENLTIVQPEQIVAAVKDLLTAKV
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory