SitesBLAST

P0AC81 Lactoylglutathione lyase; Aldoketomutase; Glyoxalase I; Glx I; Ketone-aldehyde mutase; Methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase; EC 4.4.1.5 from Escherichia coli (strain K12) (see paper)
62% identity, 95% coverage: 1:130/137 of query aligns to 1:130/135 of P0AC81

query
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P0AC81

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H5 (= H5) binding
E56 (= E56) binding
H74 (= H74) binding in other chain
E122 (= E122) binding in other chain

4mttA Ni- and zn-bound gloa2 at low resolution (see paper)
61% identity, 93% coverage: 1:128/137 of query aligns to 1:128/128 of 4mttA

query
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4mttA

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active site: H5 (= H5), E56 (= E56), H74 (= H74), E122 (= E122)
binding zinc ion: H5 (= H5), E56 (= E56)

6bnnA Crystal structure of v278e-glyoxalase i mutant from zea mays in space group p4(1)2(1)2 (see paper)
54% identity, 91% coverage: 2:125/137 of query aligns to 16:139/282 of 6bnnA

query
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6bnnA

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active site: H19 (= H5), E70 (= E56), H88 (= H74), E136 (= E122)
binding cobalt (ii) ion: H88 (= H74), E136 (= E122)
binding glutathione: R112 (= R98), V117 (≠ M103), K118 (= K104)

Sites not aligning to the query:

5d7zA Crystal structure of glyoxalase i from zea mays (see paper)
54% identity, 91% coverage: 2:125/137 of query aligns to 10:133/281 of 5d7zA

query
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5d7zA

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active site: H13 (= H5), E64 (= E56), H82 (= H74), E130 (= E122)

Sites not aligning to the query:

binding nickel (ii) ion: 276, 281

Q948T6 Lactoylglutathione lyase; Aldoketomutase; Allergen Glb33; Glyoxalase I; Glx I; Glyoxylase I 11; OsGLYI-11; OsGLYI11; Ketone-aldehyde mutase; Methylglyoxalase; PP33; S-D-lactoylglutathione methylglyoxal lyase; Allergen Ory s Glyoxalase I; EC 4.4.1.5 from Oryza sativa subsp. japonica (Rice) (see paper)
52% identity, 93% coverage: 2:129/137 of query aligns to 24:152/291 of Q948T6

query
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Q948T6

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E78 (= E56) mutation to Q: No effect on the activity.
E145 (= E122) mutation to Q: Loss of activity.

Sites not aligning to the query:

209 E→D: Loss of activity.

2c21A Specificity of the trypanothione-dependednt leishmania major glyoxalase i: structure and biochemical comparison with the human enzyme (see paper)
49% identity, 97% coverage: 2:134/137 of query aligns to 3:130/139 of 2c21A

query
sites
2c21A

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active site: H6 (= H5), E57 (= E56), H75 (= H74), E118 (= E122)
binding nickel (ii) ion: H6 (= H5), E57 (= E56), H75 (= H74), E118 (= E122)

P50107 Glyoxalase I; Glx I; Aldoketomutase; Ketone-aldehyde mutase; Methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase; actoylglutathione lyase; EC 4.4.1.5 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
41% identity, 92% coverage: 2:127/137 of query aligns to 182:323/326 of P50107

query
sites
P50107

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E318 (= E122) active site, Proton donor/acceptor

Sites not aligning to the query:

163 active site, Proton donor/acceptor

Q9CPU0 Lactoylglutathione lyase; Aldoketomutase; Glyoxalase I; Glx I; Ketone-aldehyde mutase; Methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase; EC 4.4.1.5 from Mus musculus (Mouse) (see paper)
36% identity, 90% coverage: 3:125/137 of query aligns to 32:176/184 of Q9CPU0

query
sites
Q9CPU0

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Q34 (≠ H5) binding
E100 (= E56) binding
H127 (= H74) binding in other chain
E173 (= E122) binding in other chain

6l0uB Crystal structure of mouse glyoxalase i complexed with a small molecule inhibitor
36% identity, 90% coverage: 3:125/137 of query aligns to 25:169/177 of 6l0uB

query
sites
6l0uB

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G

D

N

A

S

-

D

-

P

-
x
R

-

G

Y

F

G

G

H
|
H

I

I

A

G

I

I

G

A

V

V

D

P

D

D

I

V

Y

Y

A

S

T

A

C

C

E

K

A

R

I

F

R

E

A

E

R

L

G

G

G

V

K

K

I

F

S

V

R
x
K

E

K

P

P

-

D

-
x
D

G
|
G

P

K

M

M

K

K

H

G

G

-

S

-

T

-

V

-

I

L

A

A

F

F

V

I

E

Q

D

D

P

P

D

D

G

G

Y

Y

K
x
W

V

I

E
|
E

L

I

I

L

Q

N

active site: Q27 (≠ H5), E93 (= E56), H120 (= H74), E166 (= E122)
binding N-[4-(trifluoromethyloxy)phenyl]-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carbothioamide: R116 (vs. gap), K144 (≠ R98), D148 (vs. gap), G149 (= G101), W164 (≠ K120)
binding zinc ion: Q27 (≠ H5), E93 (= E56), H120 (= H74), E166 (= E122)

4kykB Crystal structure of mouse glyoxalase i complexed with indomethacin (see paper)
36% identity, 90% coverage: 3:125/137 of query aligns to 25:169/177 of 4kykB

query
sites
4kykB

L

L

L

Q

H
x
Q

T

T

M

M

L

L

R

R

V

I

G

K

D

D

L

P

E

K

R

K

S

S

L

L

Q

D

F

F

Y

Y

C

T

E

R

I

V

L

L

G

G

M

L

Q

T

L

L

R

Q

R

K

K

L

D

D

Y

F

P

P

G

A

G

M

E

K

F

F

T

S

L

L

A

Y

F

F

V

L

G

A

Y

Y

G

E

E

D

E

K

A

N

D

D

-

I

-

P

-

K

-

D

-

K

-

S

-

E

-

K

-

T

-

A

-

W

-

T

-

F

-

S

-

R

H

K

T

A

V

T

L

L

E
|
E

L

L

T

T

Y

H

N

N

W

W

G

G

K

T

E

E

-

D

-

E

-

T

-

Q

Q

S

Y

Y

E

H

L

N

G

G

D

N

A

S

-

D

-

P

-

R

-

G

Y

F

G

G

H
|
H

I

I

A

G

I

I

G

A

V

V

D

P

D

D

I

V

Y

Y

A

S

T

A

C

C

E

K

A

R

I

F

R

E

A

E

R

L

G

G

G

V

K

K

I

F

S

V

R
x
K

E

K

P

P

-

D

G

G

P
x
K

M
|
M

K

K

H

G

G

-

S

-

T

-

V

-

I
x
L

A

A

F
|
F

V

I

E

Q

D

D

P

P

D

D

G

G

Y

Y

K

W

V

I

E
|
E

L

I

I

L

Q

N

active site: Q27 (≠ H5), E93 (= E56), H120 (= H74), E166 (= E122)
binding indomethacin: K144 (≠ R98), K150 (≠ P102), M151 (= M103), L154 (≠ I110), F156 (= F112)
binding zinc ion: Q27 (≠ H5), E93 (= E56), H120 (= H74), E166 (= E122)

2za0A Crystal structure of mouse glyoxalase i complexed with methyl-gerfelin (see paper)
36% identity, 90% coverage: 3:125/137 of query aligns to 29:173/180 of 2za0A

query
sites
2za0A

L

L

L

Q

H
x
Q

T

T

M

M

L

L

R

R

V

I

G

K

D

D

L

P

E

K

R

K

S

S

L

L

Q

D

F

F

Y

Y

C

T

E

R

I

V

L

L

G

G

M

L

Q

T

L

L

R

Q

R

K

K

L

D

D

Y

F

P

P

G

A

G

M

E

K

F
|
F

T

S

L
|
L

A

Y

F

F

V

L

G

A

Y

Y

G

E

E

D

E

K

A

N

D

D

-

I

-

P

-

K

-

D

-

K

-

S

-

E

-

K

-

T

-

A

-

W

-

T

-
x
F

-

S

-

R

H

K

T

A

V

T

L

L

E
|
E

L

L

T

T

Y

H

N

N

W

W

G

G

K

T

E

E

-

D

-

E

-

T

-

Q

Q

S

Y

Y

E

H

L

N

G

G

D

N

A

S

-

D

-

P

-

R

-

G

Y

F

G

G

H
|
H

I

I

A

G

I

I

G

A

V

V

D

P

D

D

I

V

Y

Y

A

S

T

A

C

C

E

K

A

R

I

F

R

E

A

E

R

L

G

G

G

V

K

K

I

F

S

V

R

K

E

K

P

P

-

D

G

G

P

K

M
|
M

K

K

H

G

G

-

S

-

T

-

V

-

I

L

A

A

F

F

V

I

E

Q

D

D

P

P

D

D

G

G

Y

Y

K

W

V

I

E
|
E

L

I

I

L

Q

N

active site: Q31 (≠ H5), E97 (= E56), H124 (= H74), E170 (= E122)
binding methyl 4-(2,3-dihydroxy-5-methylphenoxy)-2-hydroxy-6-methylbenzoate: Q31 (≠ H5), F65 (= F39), L67 (= L41), F90 (vs. gap), E97 (= E56), H124 (= H74), M155 (= M103), E170 (= E122)
binding zinc ion: Q31 (≠ H5), E97 (= E56), H124 (= H74), E170 (= E122)

4kyhA Crystal structure of mouse glyoxalase i complexed with zopolrestat (see paper)
36% identity, 90% coverage: 3:125/137 of query aligns to 27:171/177 of 4kyhA

query
sites
4kyhA

L

L

L

Q

H
x
Q

T

T

M
|
M

L

L

R
|
R

V

I

G

K

D

D

L

P

E

K

R

K

S

S

L

L

Q

D

F

F

Y

Y

C

T

E

R

I

V

L

L

G

G

M

L

Q

T

L

L

R

Q

R

K

K

L

D

D

Y

F

P

P

G

A

G

M

E

K

F
|
F

T

S

L

L

A

Y

F

F

V

L

G

A

Y

Y

G

E

E

D

E

K

A

N

D

D

-

I

-

P

-

K

-

D

-

K

-

S

-

E

-

K

-

T

-

A

-

W

-

T

-

F

-

S

-

R

H

K

T

A

V

T

L

L

E
|
E

L

L

T
|
T

Y

H

N
|
N

W

W

G

G

K

T

E

E

-

D

-

E

-

T

-

Q

Q

S

Y

Y

E

H

L

N

G

G

D

N

A

S

-

D

-

P

-

R

-

G

Y

F

G

G

H
|
H

I

I

A

G

I

I

G

A

V

V

D

P

D

D

I

V

Y

Y

A

S

T

A

C

C

E

K

A

R

I

F

R

E

A

E

R

L

G

G

G

V

K

K

I

F

S

V

R

K

E

K

P

P

-

D

G

G

P

K

M

M

K

K

H

G

G

-

S

-

T

-

V

-

I

L

A

A

F

F

V

I

E

Q

D

D

P

P

D

D

G

G

Y

Y

K

W

V

I

E
|
E

L

I

I

L

Q

N

active site: Q29 (≠ H5), E95 (= E56), H122 (= H74), E168 (= E122)
binding zinc ion: Q29 (≠ H5), E95 (= E56), H122 (= H74), E168 (= E122)
binding 3,4-dihydro-4-oxo-3-((5-trifluoromethyl-2-benzothiazolyl)methyl)-1-phthalazine acetic acid: M31 (= M7), R33 (= R9), F63 (= F39), E95 (= E56), T97 (= T58), N99 (= N60)

4kykA Crystal structure of mouse glyoxalase i complexed with indomethacin (see paper)
36% identity, 90% coverage: 3:125/137 of query aligns to 27:171/179 of 4kykA

query
sites
4kykA

L

L

L

Q

H
x
Q

T

T

M

M

L

L

R

R

V

I

G

K

D

D

L

P

E

K

R

K

S

S

L

L

Q

D

F

F

Y

Y

C

T

E

R

I

V

L

L

G

G

M

L

Q

T

L

L

R

Q

R

K

K

L

D

D

Y

F

P

P

G

A

G

M

E

K

F

F

T

S

L

L

A

Y

F

F

V

L

G

A

Y

Y

G

E

E

D

E

K

A

N

D

D

-

I

-

P

-

K

-

D

-

K

-

S

-

E

-

K

-

T

-

A

-

W

-

T

-

F

-

S

-

R

H

K

T

A

V

T

L

L

E
|
E

L

L

T

T

Y

H

N

N

W

W

G

G

K

T

E

E

-

D

-

E

-

T

-

Q

Q

S

Y

Y

E

H

L

N

G

G

D

N

A

S

-

D

-

P

-

R

-

G

Y

F

G

G

H
|
H

I

I

A

G

I

I

G

A

V

V

D

P

D

D

I

V

Y

Y

A

S

T

A

C

C

E

K

A

R

I

F

R

E

A

E

R

L

G

G

G

V

K

K

I

F

S

V

R

K

E

K

P

P

-

D

G

G

P

K

M

M

K

K

H

G

G

-

S

-

T

-

V

-

I

L

A

A

F

F

V

I

E

Q

D

D

P

P

D

D

G

G

Y

Y

K

W

V

I

E
|
E

L

I

I

L

Q

N

active site: Q29 (≠ H5), E95 (= E56), H122 (= H74), E168 (= E122)
binding zinc ion: Q29 (≠ H5), E95 (= E56), H122 (= H74), E168 (= E122)

4x2aA Crystal structure of mouse glyoxalase i complexed with baicalein (see paper)
36% identity, 90% coverage: 3:125/137 of query aligns to 18:162/167 of 4x2aA

query
sites
4x2aA

L

L

L

Q

H
x
Q

T

T

M

M

L

L

R

R

V

I

G

K

D

D

L

P

E

K

R

K

S

S

L

L

Q

D

F

F

Y

Y

C

T

E

R

I

V

L

L

G

G

M

L

Q

T

L

L

R

Q

R

K

K

L

D

D

Y
x
F

P

P

G

A

G

M

E

K

F

F

T

S

L
|
L

A

Y

F

F

V

L

G

A

Y

Y

G

E

E

D

E

K

A

N

D

D

-

I

-

P

-

K

-

D

-

K

-

S

-

E

-

K

-

T

-

A

-

W

-

T

-
x
F

-

S

-

R

H

K

T

A

V

T

L

L

E
|
E

L

L

T

T

Y

H

N

N

W

W

G

G

K

T

E

E

-

D

-

E

-

T

-

Q

Q

S

Y

Y

E

H

L

N

G

G

D

N

A

S

-

D

-

P

-

R

-

G

Y

F

G

G

H
|
H

I

I

A

G

I

I

G

A

V

V

D

P

D

D

I

V

Y

Y

A

S

T

A

C

C

E

K

A

R

I

F

R

E

A

E

R

L

G

G

G

V

K

K

I

F

S

V

R

K

E

K

P

P

-

D

G

G

P

K

M
|
M

K

K

H

G

G

-

S

-

T

-

V

-

I

L

A

A

F

F

V

I

E

Q

D

D

P

P

D

D

G

G

Y

Y

K

W

V

I

E
|
E

L

I

I

L

Q

N

active site: Q20 (≠ H5), E86 (= E56), H113 (= H74), E159 (= E122)
binding 5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one: Q20 (≠ H5), F49 (≠ Y34), L56 (= L41), F79 (vs. gap), E86 (= E56), H113 (= H74), M144 (= M103), E159 (= E122)
binding zinc ion: Q20 (≠ H5), E86 (= E56), H113 (= H74), E159 (= E122)

Sites not aligning to the query:

binding 5,6,7-trihydroxy-2-phenyl-4H-chromen-4-one: 166, 167

4pv5A Crystal structure of mouse glyoxalase i in complexed with 18-beta- glycyrrhetinic acid (see paper)
36% identity, 90% coverage: 3:125/137 of query aligns to 20:164/170 of 4pv5A

query
sites
4pv5A

L

L

L

Q

H
x
Q

T

T

M

M

L

L

R

R

V

I

G

K

D

D

L

P

E

K

R

K

S

S

L

L

Q

D

F

F

Y

Y

C

T

E

R

I

V

L

L

G

G

M

L

Q

T

L

L

R

Q

R

K

K

L

D

D

Y

F

P

P

G

A

G

M

E

K

F

F

T

S

L

L

A

Y

F

F

V

L

G

A

Y

Y

G

E

E

D

E

K

A

N

D

D

-

I

-

P

-

K

-

D

-

K

-

S

-

E

-

K

-

T

-

A

-

W

-

T

-

F

-

S

-

R

H

K

T

A

V

T

L

L

E
|
E

L

L

T

T

Y

H

N

N

W

W

G

G

K

T

E

E

-

D

-

E

-

T

-

Q

Q

S

Y

Y

E

H

L

N

G

G

D

N

A

S

-

D

-

P

-
x
R

-

G

Y

F

G

G

H
|
H

I

I

A

G

I

I

G

A

V

V

D

P

D

D

I

V

Y

Y

A

S

T

A

C

C

E

K

A

R

I

F

R

E

A

E

R

L

G

G

G

V

K

K

I

F

S

V

R
x
K

E

K

P

P

-

D

G

G

P

K

M

M

K

K

H

G

G

-

S

-

T

-

V

-

I

L

A

A

F

F

V

I

E

Q

D

D

P

P

D

D

G

G

Y

Y

K

W

V

I

E
|
E

L

I

I

L

Q

N

active site: Q22 (≠ H5), E88 (= E56), H115 (= H74), E161 (= E122)
binding (3beta,5beta,14beta)-3-hydroxy-11-oxoolean-12-en-29-oic acid: R111 (vs. gap), K139 (≠ R98)
binding zinc ion: Q22 (≠ H5), E88 (= E56)

4opnA Crystal structure of mouse glyoxalase i complexed with mah
36% identity, 90% coverage: 3:125/137 of query aligns to 24:168/172 of 4opnA

query
sites
4opnA

L

L

L

Q

H
x
Q

T

T

M

M

L

L

R
|
R

V

I

G

K

D

D

L

P

E

K

R

K

S

S

L

L

Q

D

F

F

Y

Y

C

T

E

R

I

V

L

L

G

G

M

L

Q

T

L

L

R

Q

R

K

K

L

D

D

Y

F

P

P

G

A

G

M

E

K

F
|
F

T

S

L

L

A

Y

F

F

V

L

G

A

Y

Y

G

E

E

D

E

K

A

N

D

D

-

I

-

P

-

K

-

D

-

K

-

S

-

E

-

K

-

T

-

A

-

W

-

T

-
x
F

-

S

-

R

H

K

T

A

V

T

L

L

E
|
E

L

L

T
|
T

Y

H

N
|
N

W

W

G

G

K

T

E

E

-

D

-

E

-

T

-

Q

Q

S

Y

Y

E

H

L

N

G

G

D

N

A

S

-

D

-

P

-
x
R

-

G

Y

F

G

G

H
|
H

I

I

A

G

I

I

G

A

V

V

D

P

D

D

I

V

Y

Y

A

S

T

A

C

C

E

K

A

R

I

F

R

E

A

E

R

L

G

G

G

V

K

K

I

F

S

V

R
x
K

E

K

P

P

-

D

G

G

P
x
K

M
|
M

K

K

H

G

G

-

S

-

T

-

V

-

I
x
L

A

A

F

F

V

I

E

Q

D

D

P

P

D

D

G

G

Y

Y

K

W

V

I

E
|
E

L

I

I

L

Q

N

active site: Q26 (≠ H5), E92 (= E56), H119 (= H74), E165 (= E122)
binding L-gamma-glutamyl-N-(3-ethynylphenyl)-N-hydroxy-L-glutaminylglycine: Q26 (≠ H5), R30 (= R9), F60 (= F39), F85 (vs. gap), E92 (= E56), T94 (= T58), N96 (= N60), R115 (vs. gap), H119 (= H74), K143 (≠ R98), K149 (≠ P102), M150 (= M103), L153 (≠ I110), E165 (= E122)
binding zinc ion: Q26 (≠ H5), E92 (= E56)

Sites not aligning to the query:

binding L-gamma-glutamyl-N-(3-ethynylphenyl)-N-hydroxy-L-glutaminylglycine: 172

Q04760 Lactoylglutathione lyase; Aldoketomutase; Glyoxalase I; Glx I; Ketone-aldehyde mutase; Methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase; EC 4.4.1.5 from Homo sapiens (Human) (see 12 papers)
36% identity, 91% coverage: 3:127/137 of query aligns to 32:178/184 of Q04760

query
sites
Q04760

L

L

L

Q

H
x
Q

T

T

M

M

L

L

R

R

V

V

G

K

D

D

L

P

E

K

R

K

S
|
S

L

L

Q

D

F

F

Y

Y

C

T

E

R

I

V

L

L

G

G

M

M

Q

T

L

L

L

I

R

Q

R

K

K
x
C

D

D

Y

F

P

P

G

I

G

M

E

K

F

F

T
x
S

L

L

A

Y

F

F

V

L

G

A

Y

Y

G

E

E

D

E

K

A

N

D

D

-

I

-

P

-

K

-

E

-

K

-

D

-

E

-

K

-

I

-

A

-

W

-

A

-

L

-
x
S

-

R

H

K

T

A

V
x
T

L

L

E
|
E

L

L

T
|
T

Y

H

N

N

W

W

G

G

K
x
T

E

E

-

D

-
x
E

-

T

-

Q

Q

S

Y

Y

E

H

L

N

G

G

D

N

A

S

-

D

-

P

-

R

-

G

Y

F

G

G

H
|
H

I

I

A

G

I

I

G

A

V

V

D

P

D

D

I

V

Y

Y

A

S

T

A

C
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C

E

K

A

R

I

F

R

E

A

E

R

L

G

G

G

V

K

K

I

F

S

V

R

K

E

K

P

P

-

D

G

G

P

K

M

M

K

K

H

G

G

-

S

-

T

-

V

-

I

L

A

A

F

F

V

I

E

Q

D

D

P

P

D

D

G

G

Y

Y

K

W

V

I

E
|
E

L

I

I

L

Q

N

T

P

G

N

Q34 (≠ H5) binding ; mutation to E: Reduces enzyme activity by 99%.
S45 (= S16) mutation to A: No effect on phosphorylation.
C61 (≠ K32) modified: Disulfide link with 139, Alternate; mutation to A: No effect on NO-mediated modification.
S69 (≠ T40) mutation to A: No effect on phosphorylation.
S94 (vs. gap) mutation to A: No effect on phosphorylation.
T98 (≠ V54) mutation to A: No effect on phosphorylation.
E100 (= E56) binding ; mutation to Q: Reduces enzyme activity by over 99%.
T102 (= T58) mutation to A: No effect on phosphorylation.
T107 (≠ K63) modified: Phosphothreonine; mutation to A: Loss of phosphorylation.
E111 (vs. gap) to A: in dbSNP:rs4746
H127 (= H74) binding in other chain
C139 (= C86) modified: S-glutathionyl cysteine; alternate; modified: Disulfide link with 61, Alternate; mutation to A: Impaired NO-mediated modification. Loss of NO-mediated modification; when associated with A-19 or A-20.
E173 (= E122) active site, Proton donor/acceptor; binding in other chain; mutation to Q: Abolishes enzyme activity.

Sites not aligning to the query:

1 modified: Initiator methionine, Removed
2 modified: N-acetylalanine
19 modified: Disulfide link with 20; C → Y: in dbSNP:rs17855424; C→A: No effect on NO-mediated modification. Impaired NO-mediated modification; when associated with A-20. Loss of NO-mediated modification; when associated with A-139.
20 modified: Disulfide link with 19; C→A: No effect on NO-mediated modification. Impaired NO-mediated modification; when associated with A-19. Loss of NO-mediated modification; when associated with A-139.

7wt0A Human glyoxalase i (with c-ter his tag) in complex with tlsc702 (see paper)
36% identity, 91% coverage: 3:127/137 of query aligns to 31:177/185 of 7wt0A

query
sites
7wt0A

L

L

L

Q

H
x
Q

T

T

M

M

L

L

R

R

V

V

G

K

D

D

L

P

E

K

R

K

S

S

L

L

Q

D

F

F

Y

Y

C

T

E

R

I

V

L

L

G

G

M

M

Q

T

L

L

L

I

R

Q

R

K

K
x
C

D

D

Y
x
F

P

P

G

I

G

M

E

K

F

F

T

S

L
|
L

A

Y

F
|
F

V

L

G

A

Y

Y

G

E

E

D

E

K

A

N

D

D

-

I

-

P

-

K

-

E

-

K

-

D

-

E

-

K

-

I

-

A

-

W

-

A

-
x
L

-

S

-

R

H

K

T

A

V

T

L

L

E
|
E

L

L

T

T

Y

H

N

N

W

W

G

G

K

T

E

E

-

D

-

E

-

T

-

Q

Q

S

Y

Y

E

H

L

N

G

G

D

N

A

S

-

D

-

P

-

R

-

G

Y

F

G

G

H
|
H

I

I

A

G

I

I

G

A

V

V

D

P

D

D

I

V

Y

Y

A

S

T

A

C

C

E

K

A

R

I

F

R

E

A

E

R

L

G

G

G

V

K

K

I

F

S

V

R
x
K

E

K

P

P

-

D

G

G

P

K

M
|
M

K

K

H

G

G

-

S

-

T

-

V

-

I
x
L

A

A

F
|
F

V

I

E

Q

D

D

P

P

D

D

G

G

Y

Y

K

W

V

I

E
|
E

L

I

I

L

Q

N

T

P

G

N

binding (~{E})-3-(1,3-benzothiazol-2-yl)-4-(4-methoxyphenyl)but-3-enoic acid: C60 (≠ K32), F62 (≠ Y34), L69 (= L41), F71 (= F43), L92 (vs. gap), E99 (= E56), H126 (= H74), K150 (≠ R98), M157 (= M103), L160 (≠ I110), F162 (= F112), E172 (= E122)
binding zinc ion: Q33 (≠ H5), E99 (= E56), H126 (= H74), E172 (= E122)

Sites not aligning to the query:

binding (~{E})-3-(1,3-benzothiazol-2-yl)-4-(4-methoxyphenyl)but-3-enoic acid: 179, 183

Query Sequence

>Synpcc7942_0638 FitnessBrowser__SynE:Synpcc7942_0638
MRLLHTMLRVGDLERSLQFYCEILGMQLLRRKDYPGGEFTLAFVGYGEEADHTVLELTYN
WGKEQYELGDAYGHIAIGVDDIYATCEAIRARGGKISREPGPMKHGSTVIAFVEDPDGYK
VELIQTGTSGASAQPAA

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory