SitesBLAST
Comparing Synpcc7942_0842 FitnessBrowser__SynE:Synpcc7942_0842 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
3o0hB Crystal structure of glutathione reductase from bartonella henselae
44% identity, 100% coverage: 2:445/446 of query aligns to 1:445/459 of 3o0hB
- active site: S13 (= S14), I37 (≠ V38), C41 (= C42), C46 (= C47), K49 (= K50), D74 (≠ Q75), P75 (= P76), Y177 (= Y176), E181 (= E180), I314 (= I312), A433 (= A433), H435 (= H435), E440 (= E440)
- binding flavin-adenine dinucleotide: I9 (= I10), G10 (= G11), G12 (= G13), S13 (= S14), G14 (= G15), A32 (= A33), E33 (= E34), E34 (≠ T35), T40 (= T41), C41 (= C42), G45 (= G46), C46 (= C47), K49 (= K50), R112 (≠ H113), A113 (= A114), T139 (≠ A138), G140 (= G139), Y177 (= Y176), R262 (= R261), N265 (≠ W264), G301 (= G299), D302 (= D300), Q308 (≠ N306), L309 (= L307), T310 (= T308)
Sites not aligning to the query:
4dnaA Crystal structure of putative glutathione reductase from sinorhizobium meliloti 1021
46% identity, 100% coverage: 2:445/446 of query aligns to 1:447/461 of 4dnaA
- active site: Y37 (≠ V38), C41 (= C42), C46 (= C47), K49 (= K50), Y178 (= Y176), E182 (= E180), A435 (= A433), H437 (= H435), E442 (= E440)
- binding flavin-adenine dinucleotide: I9 (= I10), G10 (= G11), G11 (≠ A12), G12 (= G13), G14 (= G15), E33 (= E34), E34 (≠ T35), G39 (= G40), T40 (= T41), C41 (= C42), G45 (= G46), C46 (= C47), K49 (= K50), R112 (≠ H113), A113 (= A114), V139 (≠ A138), G140 (= G139), Y178 (= Y176), R264 (= R261), G303 (= G299), D304 (= D300), Q310 (≠ N306), L311 (= L307), T312 (= T308)
Sites not aligning to the query:
D0VWY5 Glutathione amide reductase; GAR; EC 1.8.1.16 from Marichromatium gracile (Chromatium gracile) (see 2 papers)
43% identity, 100% coverage: 1:445/446 of query aligns to 1:447/463 of D0VWY5
- M1 (= M1) modified: Initiator methionine, Removed
- T2 (≠ S2) binding
- Q3 (≠ F3) binding
- H4 (≠ D4) binding
- SG 14:15 (= SG 14:15) binding
- E34 (= E34) binding
- T41 (= T41) binding
- C42 (= C42) modified: Disulfide link with 47, Redox-active
- C47 (= C47) modified: Disulfide link with 42, Redox-active
- K50 (= K50) binding ; binding
- HA 113:114 (= HA 113:114) binding
- 174:180 (vs. 174:180, 71% identical) binding
- LE 197:198 (≠ RR 197:198) binding
- V230 (= V230) binding
- G261 (= G260) binding
- D302 (= D300) binding
- Q308 (≠ N306) binding
- QLT 308:310 (≠ NLT 306:308) binding
- V341 (≠ A338) binding
- H437 (= H435) active site, Proton acceptor; binding
Sites not aligning to the query:
- 2:463 modified: mature protein, Glutathione amide reductase
2rabA Structure of glutathione amide reductase from chromatium gracile in complex with NAD (see paper)
43% identity, 99% coverage: 5:445/446 of query aligns to 4:443/451 of 2rabA
- active site: S13 (= S14), L37 (≠ V38), C41 (= C42), C46 (= C47), K49 (= K50), Y173 (= Y176), E177 (= E180), I310 (= I312), A431 (= A433), H433 (= H435), E438 (= E440)
- binding flavin-adenine dinucleotide: G10 (= G11), G12 (= G13), S13 (= S14), G14 (= G15), I32 (≠ A33), E33 (= E34), S34 (≠ T35), T40 (= T41), G45 (= G46), C46 (= C47), K49 (= K50), H110 (= H113), A111 (= A114), T135 (≠ A138), G136 (= G139), R258 (= R261), G297 (= G299), D298 (= D300), Q304 (≠ N306), L305 (= L307), T306 (= T308)
- binding nicotinamide-adenine-dinucleotide: K49 (= K50), I169 (= I172), G172 (= G175), Y173 (= Y176), I174 (= I177), E177 (= E180), A193 (≠ I196), L194 (≠ R197), E195 (≠ R198), V227 (= V230), V256 (≠ T259), G257 (= G260), Q304 (≠ N306), V337 (≠ A338)
2r9zB Glutathione amide reductase from chromatium gracile (see paper)
43% identity, 99% coverage: 5:445/446 of query aligns to 4:445/453 of 2r9zB
- active site: S13 (= S14), L37 (≠ V38), C41 (= C42), C46 (= C47), K49 (= K50), G74 (≠ P76), Y174 (= Y176), E178 (= E180), I312 (= I312), A433 (= A433), H435 (= H435), E440 (= E440)
- binding flavin-adenine dinucleotide: G12 (= G13), S13 (= S14), G14 (= G15), I32 (≠ A33), E33 (= E34), S34 (≠ T35), G39 (= G40), T40 (= T41), C41 (= C42), G45 (= G46), C46 (= C47), K49 (= K50), H111 (= H113), A112 (= A114), T136 (≠ A138), G137 (= G139), I175 (= I177), R260 (= R261), G299 (= G299), D300 (= D300), Q306 (≠ N306), L307 (= L307), T308 (= T308)
6n7fA 1.90 angstrom resolution crystal structure of glutathione reductase from streptococcus pyogenes in complex with fad.
42% identity, 100% coverage: 1:445/446 of query aligns to 2:450/451 of 6n7fA
- active site: C43 (= C42), C48 (= C47), K51 (= K50), Y178 (= Y176), E182 (= E180), H440 (= H435), E445 (= E440)
- binding flavin-adenine dinucleotide: I11 (= I10), G12 (= G11), G14 (= G13), S15 (= S14), A16 (≠ G15), A34 (= A33), E35 (= E34), G36 (≠ T35), K37 (≠ D36), G41 (= G40), T42 (= T41), C43 (= C42), G47 (= G46), C48 (= C47), K51 (= K50), Y115 (≠ H113), A116 (= A114), T140 (≠ A138), G141 (= G139), Y178 (= Y176), I179 (= I177), R264 (= R261), G303 (= G299), D304 (= D300), L311 (= L307), T312 (= T308)
- binding riboflavin: G36 (≠ T35), K37 (≠ D36), Y115 (≠ H113), G270 (= G267)
5v36A 1.88 angstrom resolution crystal structure of glutathione reductase from streptococcus mutans ua159 in complex with fad
42% identity, 100% coverage: 1:445/446 of query aligns to 2:450/451 of 5v36A
- active site: V39 (= V38), C43 (= C42), C48 (= C47), K51 (= K50), Y178 (= Y176), E182 (= E180), A438 (= A433), H440 (= H435), E445 (= E440)
- binding beta-D-fructopyranose: Y411 (≠ K406), G412 (≠ D407), D414 (≠ A409)
- binding flavin-adenine dinucleotide: I11 (= I10), G14 (= G13), S15 (= S14), G16 (= G15), E35 (= E34), G36 (≠ T35), G41 (= G40), T42 (= T41), C43 (= C42), G47 (= G46), C48 (= C47), K51 (= K50), Y115 (≠ H113), A116 (= A114), T140 (≠ A138), G141 (= G139), Y178 (= Y176), I179 (= I177), R264 (= R261), F271 (≠ L268), G303 (= G299), D304 (= D300), L311 (= L307), T312 (= T308)
P06715 Glutathione reductase; GR; GRase; EC 1.8.1.7 from Escherichia coli (strain K12) (see paper)
42% identity, 100% coverage: 1:445/446 of query aligns to 1:449/450 of P06715
- C42 (= C42) modified: Disulfide link with 47, Redox-active
- C47 (= C47) modified: Disulfide link with 42, Redox-active
1gerB The structure of glutathione reductase from escherichia coli at 1.86 angstroms resolution: comparison with the enzyme from human erythrocytes (see paper)
41% identity, 95% coverage: 21:445/446 of query aligns to 20:448/449 of 1gerB
- active site: L37 (≠ V38), C41 (= C42), C46 (= C47), K49 (= K50), Y176 (= Y176), E180 (= E180), A436 (= A433), H438 (= H435), E443 (= E440)
- binding flavin-adenine dinucleotide: E33 (= E34), A34 (≠ T35), G39 (= G40), T40 (= T41), C41 (= C42), G45 (= G46), C46 (= C47), K49 (= K50), F113 (≠ H113), A114 (= A114), T138 (≠ A138), Y176 (= Y176), I177 (= I177), R262 (= R261), G301 (= G299), D302 (= D300), E308 (≠ N306), L309 (= L307), T310 (= T308)
Sites not aligning to the query:
1getA Anatomy of an engineered NAD-binding site (see paper)
41% identity, 95% coverage: 21:445/446 of query aligns to 19:447/448 of 1getA
- active site: L36 (≠ V38), C40 (= C42), C45 (= C47), K48 (= K50), Y175 (= Y176), E179 (= E180), A435 (= A433), H437 (= H435), E442 (= E440)
- binding flavin-adenine dinucleotide: E32 (= E34), A33 (≠ T35), G38 (= G40), T39 (= T41), C40 (= C42), G44 (= G46), C45 (= C47), K48 (= K50), F112 (≠ H113), A113 (= A114), T137 (≠ A138), I176 (= I177), R261 (= R261), G300 (= G299), D301 (= D300), E307 (≠ N306), L308 (= L307), T309 (= T308)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: A173 (≠ G174), G174 (= G175), Y175 (= Y176), I176 (= I177), E179 (= E180), R196 (= R197), R202 (≠ Q203), I259 (≠ T259), G260 (= G260), E307 (≠ N306), L308 (= L307), V340 (≠ A338)
Sites not aligning to the query:
5vdnA 1.55 angstrom resolution crystal structure of glutathione reductase from yersinia pestis in complex with fad
42% identity, 99% coverage: 5:445/446 of query aligns to 4:448/449 of 5vdnA
- active site: L37 (≠ V38), C41 (= C42), C46 (= C47), K49 (= K50), Y176 (= Y176), E180 (= E180), A436 (= A433), H438 (= H435), E443 (= E440)
- binding beta-D-fructopyranose: K35 (≠ D36), T40 (= T41), G140 (= G140), D157 (≠ R157)
- binding flavin-adenine dinucleotide: I9 (= I10), G12 (= G13), S13 (= S14), G14 (= G15), E33 (= E34), A34 (≠ T35), G39 (= G40), T40 (= T41), C41 (= C42), G45 (= G46), C46 (= C47), K49 (= K50), F113 (≠ H113), A114 (= A114), T138 (≠ A138), G139 (= G139), Y176 (= Y176), I177 (= I177), R262 (= R261), G301 (= G299), D302 (= D300), E308 (≠ N306), L309 (= L307), T310 (= T308)
2hqmA Crystal structure of glutathione reductase glr1 from the yeast saccharomyces cerevisiae (see paper)
40% identity, 99% coverage: 5:445/446 of query aligns to 3:460/461 of 2hqmA
- active site: L36 (≠ V38), C40 (= C42), C45 (= C47), K48 (= K50), Y186 (= Y176), E190 (= E180), A448 (= A433), H450 (= H435), E455 (= E440)
- binding flavin-adenine dinucleotide: G9 (= G11), G11 (= G13), S12 (= S14), G13 (= G15), E32 (= E34), A33 (≠ T35), G38 (= G40), T39 (= T41), C40 (= C42), G44 (= G46), C45 (= C47), K48 (= K50), W117 (≠ H113), A118 (= A114), T147 (≠ A138), G148 (= G139), Y186 (= Y176), I187 (= I177), R273 (= R261), H276 (≠ W264), G311 (= G299), D312 (= D300), E318 (≠ N306), L319 (= L307), T320 (= T308)
- binding glutathione: E217 (≠ Q207), C218 (≠ E208), N221 (≠ E211), N383 (≠ R368), R401 (≠ L386), K403 (= K388)
1geuA Anatomy of an engineered NAD-binding site (see paper)
41% identity, 95% coverage: 21:445/446 of query aligns to 19:447/448 of 1geuA
- active site: L36 (≠ V38), C40 (= C42), C45 (= C47), K48 (= K50), Y175 (= Y176), E179 (= E180), A435 (= A433), H437 (= H435), E442 (= E440)
- binding flavin-adenine dinucleotide: E32 (= E34), A33 (≠ T35), K34 (≠ D36), G38 (= G40), T39 (= T41), C40 (= C42), G44 (= G46), C45 (= C47), K48 (= K50), F112 (≠ H113), A113 (= A114), T137 (≠ A138), G300 (= G299), D301 (= D300), L308 (= L307), T309 (= T308)
- binding nicotinamide-adenine-dinucleotide: Y175 (= Y176), I176 (= I177), E179 (= E180), E195 (≠ I196), M196 (≠ R197), F197 (≠ R198), A258 (= A258), I259 (≠ T259), G260 (= G260), E307 (≠ N306), L308 (= L307), V340 (≠ A338)
Sites not aligning to the query:
5grtA Human glutathione reductase a34e, r37w mutant, glutathionylspermidine complex (see paper)
39% identity, 99% coverage: 5:445/446 of query aligns to 4:460/461 of 5grtA
- active site: L37 (≠ V38), C41 (= C42), C46 (= C47), K49 (= K50), Y180 (= Y176), E184 (= E180), A448 (= A433), H450 (= H435), E455 (= E440)
- binding flavin-adenine dinucleotide: I9 (= I10), G12 (= G13), G14 (= G15), V32 (≠ A33), E33 (= E34), S34 (≠ T35), G39 (= G40), T40 (= T41), C41 (= C42), G45 (= G46), C46 (= C47), K49 (= K50), H112 (= H113), A113 (= A114), T139 (≠ A138), Y180 (= Y176), G313 (= G299), D314 (= D300), L320 (≠ N306), L321 (= L307), T322 (= T308)
- binding glutathionylspermidine disulfide: S13 (= S14), E17 (≠ A18), C41 (= C42), V42 (= V43), Y89 (≠ E90), L93 (= L94), I96 (≠ L97), Y97 (≠ H98), T322 (= T308), I326 (= I312)
4grtA Human glutathione reductase a34e, r37w mutant, mixed disulfide between trypanothione and the enzyme (see paper)
39% identity, 99% coverage: 5:445/446 of query aligns to 4:460/461 of 4grtA
- active site: L37 (≠ V38), C41 (= C42), C46 (= C47), K49 (= K50), Y180 (= Y176), E184 (= E180), A448 (= A433), H450 (= H435), E455 (= E440)
- binding flavin-adenine dinucleotide: I9 (= I10), G10 (= G11), G11 (≠ A12), G12 (= G13), S13 (= S14), G14 (= G15), V32 (≠ A33), E33 (= E34), S34 (≠ T35), H35 (≠ D36), G39 (= G40), T40 (= T41), G45 (= G46), C46 (= C47), K49 (= K50), H112 (= H113), A113 (= A114), T139 (≠ A138), G140 (= G139), Y180 (= Y176), G313 (= G299), D314 (= D300), L320 (≠ N306), L321 (= L307), T322 (= T308), A325 (= A311)
- binding bis(gamma-glutamyl-cysteinyl-glycinyl)spermidine: S13 (= S14), L16 (= L17), E17 (≠ A18), C41 (= C42), V42 (= V43), V47 (= V48), L93 (= L94), Y97 (≠ H98), I326 (= I312)
3grtA Human glutathione reductase a34e, r37w mutant, oxidized trypanothione complex (see paper)
39% identity, 99% coverage: 5:445/446 of query aligns to 4:460/461 of 3grtA
- active site: L37 (≠ V38), C41 (= C42), C46 (= C47), K49 (= K50), Y180 (= Y176), E184 (= E180), A448 (= A433), H450 (= H435), E455 (= E440)
- binding flavin-adenine dinucleotide: I9 (= I10), G10 (= G11), G12 (= G13), S13 (= S14), G14 (= G15), V32 (≠ A33), E33 (= E34), S34 (≠ T35), T40 (= T41), C41 (= C42), G45 (= G46), C46 (= C47), K49 (= K50), H112 (= H113), A113 (= A114), T139 (≠ A138), G140 (= G139), Y180 (= Y176), G313 (= G299), D314 (= D300), L321 (= L307), T322 (= T308)
- binding 2-amino-4-[4-(4-amino-4-carboxy-butyrylamino)-5,8,19,22-tetraoxo-1,2-dithia-6,9,13,18,21-pentaaza-cyclotetracos-23-ylcarbamoyl]-butyric acid: S13 (= S14), E17 (≠ A18), W20 (≠ K21), V42 (= V43), L93 (= L94), Y97 (≠ H98), T322 (= T308), I326 (= I312)
2grtA Human glutathione reductase a34e, r37w mutant, oxidized glutathione complex (see paper)
39% identity, 99% coverage: 5:445/446 of query aligns to 4:460/461 of 2grtA
- active site: L37 (≠ V38), C41 (= C42), C46 (= C47), K49 (= K50), Y180 (= Y176), E184 (= E180), A448 (= A433), H450 (= H435), E455 (= E440)
- binding flavin-adenine dinucleotide: I9 (= I10), G12 (= G13), S13 (= S14), G14 (= G15), E33 (= E34), S34 (≠ T35), G39 (= G40), T40 (= T41), C41 (= C42), V44 (≠ R45), G45 (= G46), C46 (= C47), K49 (= K50), H112 (= H113), A113 (= A114), T139 (≠ A138), G140 (= G139), Y180 (= Y176), G313 (= G299), D314 (= D300), L321 (= L307), T322 (= T308)
- binding oxidized glutathione disulfide: E17 (≠ A18), W20 (≠ K21), V42 (= V43), L93 (= L94), I96 (≠ L97), Y97 (≠ H98)
6i7nA Trypanothione reductase from leismania infantum in complex with trl156 (see paper)
39% identity, 100% coverage: 1:445/446 of query aligns to 2:472/490 of 6i7nA
- active site: C53 (= C42), C58 (= C47), K61 (= K50), Y199 (= Y176), E203 (= E180), H462 (= H435), E467 (= E440)
- binding flavin-adenine dinucleotide: G12 (= G11), G14 (= G13), S15 (= S14), G16 (= G15), D36 (≠ E34), A47 (vs. gap), A48 (vs. gap), G51 (= G40), T52 (= T41), C53 (= C42), G57 (= G46), C58 (= C47), K61 (= K50), G128 (≠ A114), A160 (= A137), T161 (≠ A138), G162 (= G139), R288 (= R261), D328 (= D300), L335 (= L307), T336 (= T308), A339 (= A311)
Sites not aligning to the query:
6i7nB Trypanothione reductase from leismania infantum in complex with trl156 (see paper)
39% identity, 100% coverage: 1:445/446 of query aligns to 1:471/488 of 6i7nB
- active site: C52 (= C42), C57 (= C47), K60 (= K50), Y198 (= Y176), E202 (= E180), H461 (= H435), E466 (= E440)
- binding flavin-adenine dinucleotide: G11 (= G11), G15 (= G15), D35 (≠ E34), A46 (vs. gap), A47 (vs. gap), G50 (= G40), T51 (= T41), C52 (= C42), G56 (= G46), C57 (= C47), K60 (= K50), G127 (≠ A114), A159 (= A137), T160 (≠ A138), G161 (= G139), Y198 (= Y176), R287 (= R261), G326 (= G299), D327 (= D300), M333 (≠ N306), L334 (= L307), T335 (= T308)
- binding ~{N}-(4-azanylbutyl)-~{N}-(2-azanyl-2-oxidanylidene-ethyl)-7-(3-azanyl-3-oxidanylidene-propyl)-4-(dimethylamino)-2-(2-naphthalen-2-ylethylamino)pyrrolo[2,3-d]pyrimidine-6-carboxamide: L17 (= L17), E18 (≠ A18), Y110 (≠ H98)
Sites not aligning to the query:
6er5A X-ray structure of trypanothione reductase from leishmania infantum in complex with 2-(diethylamino)ethyl 4-((3-(4-nitrophenyl)-3- oxopropyl)amino)benzoate (see paper)
39% identity, 100% coverage: 1:445/446 of query aligns to 1:471/488 of 6er5A
- active site: C52 (= C42), C57 (= C47), K60 (= K50), Y198 (= Y176), E202 (= E180), H461 (= H435), E466 (= E440)
- binding 2-(diethylamino)ethyl 4-((3-(4-nitrophenyl)-3-oxopropyl)amino)benzoate: Y221 (≠ I196), R222 (= R197), R228 (≠ Q203), I285 (≠ T259)
- binding flavin-adenine dinucleotide: G11 (= G11), G13 (= G13), G15 (= G15), V34 (≠ A33), D35 (≠ E34), V36 (≠ T35), A46 (vs. gap), A47 (vs. gap), G50 (= G40), T51 (= T41), C52 (= C42), G56 (= G46), C57 (= C47), K60 (= K50), G127 (≠ A114), T160 (≠ A138), Y198 (= Y176), R287 (= R261), R290 (≠ W264), G326 (= G299), D327 (= D300), M333 (≠ N306), L334 (= L307), T335 (= T308)
Sites not aligning to the query:
Query Sequence
>Synpcc7942_0842 FitnessBrowser__SynE:Synpcc7942_0842
MSFDYDLLVIGAGSGGLAASKRAASYGAKVAIAETDLVGGTCVIRGCVPKKLMVYASSFA
SQYHYAEAYGWSAVQPQFSWPKLIAAIDAEVNRLSRLHISLLEKAGVDLILGHAQFVDEH
RLQVGDRQVTAAKILIAAGGRPIKLPIPGGELAITSREMFHLPEQPQRFAVIGGGYIGCE
FAGILRSLGSEVTQIIRRDRILQGFDQELREAVQTGMSQHGVQFRTGVTVERIDQTETGL
QLSYSDGSQQIVDQVLMATGREPWLEGLNLDAAGVAIEGRRIAVDAWSRTNQPHIFAVGD
CTDRVNLTPVAIAEGRAFADTEFGQKPRQISYENIASAVFSQPEACSVGLSEEAAKAEYG
EERIRVYRSRFRPMFYTLPQAEERVLMKLVVETESDRVLGAHMVGKDAAEIIQSVAIAVT
MGATKADFDATMALHPTSAEEFVTMP
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory