Comparing Synpcc7942_1372 FitnessBrowser__SynE:Synpcc7942_1372 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
8g3hA Structure of cobalamin-dependent methionine synthase (meth) in a resting state (see paper)
49% identity, 72% coverage: 9:870/1190 of query aligns to 6:839/841 of 8g3hA
P13009 Methionine synthase; 5-methyltetrahydrofolate--homocysteine methyltransferase; Methionine synthase, vitamin-B12-dependent; MS; EC 2.1.1.13 from Escherichia coli (strain K12) (see 5 papers)
32% identity, 99% coverage: 16:1189/1190 of query aligns to 16:1191/1227 of P13009
Sites not aligning to the query:
Q99707 Methionine synthase; MS; 5-methyltetrahydrofolate--homocysteine methyltransferase; Cobalamin-dependent methionine synthase; Vitamin-B12 dependent methionine synthase; EC 2.1.1.13 from Homo sapiens (Human) (see 6 papers)
32% identity, 99% coverage: 13:1189/1190 of query aligns to 27:1229/1265 of Q99707
8sseA Methionine synthase, c-terminal fragment, cobalamin and reactivation domains from thermus thermophilus hb8
42% identity, 45% coverage: 652:1189/1190 of query aligns to 1:505/507 of 8sseA
4cczA Crystal structure of human 5-methyltetrahydrofolate-homocysteine methyltransferase, the homocysteine and folate binding domains
34% identity, 51% coverage: 13:613/1190 of query aligns to 11:598/611 of 4cczA
5vooA Methionine synthase folate-binding domain with methyltetrahydrofolate from thermus thermophilus hb8 (see paper)
48% identity, 24% coverage: 351:635/1190 of query aligns to 1:281/282 of 5vooA
3ivaA Structure of the b12-dependent methionine synthase (meth) c-teminal half with adohcy bound (see paper)
31% identity, 45% coverage: 653:1189/1190 of query aligns to 9:541/576 of 3ivaA
3bulA E. Coli i690c/g743c meth c-terminal fragment (649-1227) (see paper)
31% identity, 45% coverage: 653:1189/1190 of query aligns to 9:541/577 of 3bulA
1q8jA Cobalamin-dependent methionine synthase (1-566) from thermotoga maritima (cd2+, hcy, methyltetrahydrofolate complex) (see paper)
30% identity, 48% coverage: 16:588/1190 of query aligns to 15:538/559 of 1q8jA
3bofA Cobalamin-dependent methionine synthase (1-566) from thermotoga maritima complexed with zn2+ and homocysteine (see paper)
30% identity, 48% coverage: 16:588/1190 of query aligns to 15:538/560 of 3bofA
3k13C Structure of the pterin-binding domain metr of 5- methyltetrahydrofolate-homocysteine methyltransferase from bacteroides thetaiotaomicron
40% identity, 22% coverage: 351:614/1190 of query aligns to 3:271/287 of 3k13C
1bmtA How a protein binds b12: a 3.O angstrom x-ray structure of the b12- binding domains of methionine synthase (see paper)
37% identity, 18% coverage: 653:872/1190 of query aligns to 9:229/246 of 1bmtA
2ycjA Methyltransferase bound with methyltetrahydrofolate (see paper)
35% identity, 20% coverage: 352:587/1190 of query aligns to 10:237/271 of 2ycjA
2yciX Methyltransferase native (see paper)
35% identity, 20% coverage: 352:587/1190 of query aligns to 10:237/271 of 2yciX
2yckX Methyltransferase bound with tetrahydrofolate (see paper)
35% identity, 20% coverage: 352:587/1190 of query aligns to 11:238/272 of 2yckX
4djfA Crystal structure of folate-bound corrinoid iron-sulfur protein (cfesp) in complex with its methyltransferase (metr), co-crystallized with folate and ti(iii) citrate reductant (see paper)
33% identity, 20% coverage: 352:590/1190 of query aligns to 1:231/262 of 4djfA
4djeA Crystal structure of folate-bound corrinoid iron-sulfur protein (cfesp) in complex with its methyltransferase (metr), co-crystallized with folate (see paper)
33% identity, 20% coverage: 352:590/1190 of query aligns to 1:231/262 of 4djeA
4djdA Crystal structure of folate-free corrinoid iron-sulfur protein (cfesp) in complex with its methyltransferase (metr) (see paper)
33% identity, 20% coverage: 352:590/1190 of query aligns to 1:231/262 of 4djdA
2e7fA 5-methyltetrahydrofolate corrinoid/iron sulfur protein methyltransferase complexed with methyltetrahydrofolate to 2.2 angsrom resolution (see paper)
33% identity, 20% coverage: 352:590/1190 of query aligns to 1:231/262 of 2e7fA
Q46389 5-methyltetrahydrofolate:corrinoid/iron-sulfur protein co-methyltransferase; 5-methyltetrahydrofolate corrinoid/iron sulfur protein methyltransferase; MeTr; EC 2.1.1.258 from Moorella thermoacetica (Clostridium thermoaceticum) (see 2 papers)
33% identity, 20% coverage: 352:590/1190 of query aligns to 1:231/262 of Q46389
>Synpcc7942_1372 FitnessBrowser__SynE:Synpcc7942_1372
MQSLFLDRLHSPERPVLVFDGGMGTTLQFQNLTAEDFGGPETEGCNEWLIRTKPEAIATV
HRQFLEAGADVIETDTFGATSIVLAEYGLEDHAYALNVEAAKLAKAIAAEFSTPEKPRFV
AGSMGPTTKLPTLGHIGYDEMKASFAEQARGLWEGGVDLFIVETCQDVLQIKAALNGIAE
IFSEKGDRRPLMVSVTMETTGTMLVGSDVAAMLAILEPYPIDILGLNCATGPDRMVEHIK
YLSEHSPFVISCIPNAGIPENVGGHAHYRLTPMELRMALHRFVEDLGVQVIGGCCGTKPE
HIAQLAEVATQLQAKDRPVRRDRDHQQRQPFNYVPSAASIYGTTPYIQDNSFLIIGERLN
ASGSKKVRELLNEEDWDGLVAIARSQVKEGAHVLDVNVDYVGRDGERDMGELVSRLVTNV
NLPLMLDSTEWQKMEAGLKKAGGKCILNSTNYEDGDERFFKVLELAKQYGAGIVVGTIDE
EGMARTAEKKFAIAQRAYRDALEFGIPAHEIFYDPLALPISTGIEEDRGNGRETIESIRL
IRENLPGVHILLGVSNISFGLNPAARIVLNSVFLHDACEAGMDGAIVSAAKILPLSKIDE
KPLQVCRDLIGDRRRFENGICVYDPLTELTTLFEGVSAKEARASGPSLADLPLEERLKQH
IIDGERIGLDQALATALEQYPPLEIINTFLLDGMKVVGDLFGSGQMQLPFVLQSAETMKS
AVAYLEPFMDKEETNDSGKGTFLIATVKGDVHDIGKNLVDIILTNNGYKVVNIGIKQPVE
NIIQAYRDCNADCIAMSGLLVKSTAFMKENLATFNEEGISVPVILGGAALTPKFVYEDCQ
QTYKGQVIYGKDAFADLHFMDQLMAAKSKDQWDDQLGFLDEQGQPLQVAAIASEAAEPTE
SRESVAEVVIDLERSEAVAVDIDRPTPPFWGSKILGPDEIPFAEVFSYLDRQALFVGQWQ
FRKPKEQSREEYDAFIAEKVEPILQQWTTRILAEDLLEPQVVYGYFPCVAVGNSLQLFDP
NDRDRPTARFDFPRQRSLRRLCIADFFAPEELGIQDVFPMQAVTVGHKATEFAAQLFAGD
QYSDYLYFHGLAVQLAEALAEWTHARIRRELGYGSLEPESLRDILAQRYQGSRYSFGYPA
CPNVADSRIQLELLEADRIGMSMDESEQLYPEQSTTAIVAYHPAAKYFSA
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory