SitesBLAST
Comparing Synpcc7942_2117 FitnessBrowser__SynE:Synpcc7942_2117 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
3h0mA Structure of tRNA-dependent amidotransferase gatcab from aquifex aeolicus (see paper)
55% identity, 99% coverage: 3:477/479 of query aligns to 6:476/478 of 3h0mA
- active site: K72 (= K75), S147 (= S150), S148 (= S151), S166 (= S169), T168 (= T171), G169 (= G172), G170 (= G173), S171 (= S174), Q174 (= Q177)
- binding glutamine: M122 (= M125), G123 (= G126), D167 (= D170), T168 (= T171), G169 (= G172), G170 (= G173), S171 (= S174), F199 (≠ Y202), Y302 (= Y302), R351 (= R351), D418 (= D418)
3h0lA Structure of tRNA-dependent amidotransferase gatcab from aquifex aeolicus (see paper)
55% identity, 99% coverage: 3:477/479 of query aligns to 6:476/478 of 3h0lA
- active site: K72 (= K75), S147 (= S150), S148 (= S151), S166 (= S169), T168 (= T171), G169 (= G172), G170 (= G173), S171 (= S174), Q174 (= Q177)
- binding asparagine: G123 (= G126), S147 (= S150), G169 (= G172), G170 (= G173), S171 (= S174), Y302 (= Y302), R351 (= R351), D418 (= D418)
2f2aA Structure of tRNA-dependent amidotransferase gatcab complexed with gln (see paper)
53% identity, 98% coverage: 3:473/479 of query aligns to 7:479/485 of 2f2aA
- active site: K79 (= K75), S154 (= S150), S155 (= S151), S173 (= S169), T175 (= T171), G176 (= G172), G177 (= G173), S178 (= S174), Q181 (= Q177)
- binding glutamine: G130 (= G126), S154 (= S150), D174 (= D170), T175 (= T171), G176 (= G172), S178 (= S174), F206 (≠ Y202), Y309 (= Y302), Y310 (= Y303), R358 (= R351), D425 (= D418)
2dqnA Structure of tRNA-dependent amidotransferase gatcab complexed with asn (see paper)
53% identity, 98% coverage: 3:473/479 of query aligns to 7:479/485 of 2dqnA
- active site: K79 (= K75), S154 (= S150), S155 (= S151), S173 (= S169), T175 (= T171), G176 (= G172), G177 (= G173), S178 (= S174), Q181 (= Q177)
- binding asparagine: M129 (= M125), G130 (= G126), T175 (= T171), G176 (= G172), S178 (= S174), Y309 (= Y302), Y310 (= Y303), R358 (= R351), D425 (= D418)
3kfuE Crystal structure of the transamidosome (see paper)
51% identity, 99% coverage: 6:477/479 of query aligns to 4:465/468 of 3kfuE
4n0iA Crystal structure of s. Cerevisiae mitochondrial gatfab in complex with glutamine (see paper)
38% identity, 83% coverage: 65:460/479 of query aligns to 28:443/450 of 4n0iA
- active site: K38 (= K75), S116 (= S150), S117 (= S151), T135 (≠ S169), T137 (= T171), G138 (= G172), G139 (= G173), S140 (= S174), L143 (≠ Q177)
- binding glutamine: G89 (= G126), T137 (= T171), G138 (= G172), S140 (= S174), Y168 (= Y202), Y271 (= Y302), Y272 (= Y303), R320 (= R351), D404 (= D418)
Q7XJJ7 Fatty acid amide hydrolase; AtFAAH; N-acylethanolamine amidohydrolase; EC 3.5.1.99 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
31% identity, 97% coverage: 4:468/479 of query aligns to 131:589/607 of Q7XJJ7
- K205 (= K75) mutation to A: Loss of activity.
- SS 281:282 (= SS 150:151) mutation to AA: Loss of activity.
- GGGS 302:305 (≠ TGGS 171:174) binding
- S305 (= S174) mutation to A: Loss of activity.
- R307 (= R176) mutation to A: Loss of activity.
- S360 (≠ H229) mutation to A: No effect.
6diiH Structure of arabidopsis fatty acid amide hydrolase in complex with methyl linolenyl fluorophosphonate (see paper)
31% identity, 97% coverage: 4:468/479 of query aligns to 131:589/616 of 6diiH
- binding methyl-9Z,12Z,15Z-octadecatrienylphosphonofluoridate: G255 (≠ A124), T258 (≠ S127), S281 (= S150), G302 (≠ T171), G303 (= G172), S305 (= S174), S472 (≠ T356), I532 (≠ A409), M539 (= M420)
Sites not aligning to the query:
3a1iA Crystal structure of rhodococcus sp. N-771 amidase complexed with benzamide (see paper)
34% identity, 84% coverage: 66:468/479 of query aligns to 86:498/508 of 3a1iA
- active site: K95 (= K75), S170 (= S150), S171 (= S151), G189 (≠ S169), Q191 (≠ T171), G192 (= G172), G193 (= G173), A194 (≠ S174), I197 (≠ Q177)
- binding benzamide: F145 (≠ M125), S146 (≠ G126), G147 (≠ S127), Q191 (≠ T171), G192 (= G172), G193 (= G173), A194 (≠ S174), W327 (≠ Y302)
6c6gA An unexpected vestigial protein complex reveals the evolutionary origins of an s-triazine catabolic enzyme. Inhibitor bound complex. (see paper)
35% identity, 93% coverage: 17:461/479 of query aligns to 16:442/457 of 6c6gA