SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing U31H_SCYTH / A0A0A0VBR5 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 2 hits to proteins with known functional sites (download)

A0A0A0VBR5 U3-scytotoxin-Sth1h; U3-SYTX-Sth1h; U3-Sth1h from Scytodes thoracica (Spitting spider) (Aranea thoracica) (see paper)
100% identity, 100% coverage: 1:71/71 of query aligns to 1:71/71 of A0A0A0VBR5

query
sites
A0A0A0VBR5

M

M

S

S

Q

Q

N

N

S

S

I

I

T

T

S

S

Y

Y

K

K

M

M

G

G

F

F

A

A

K

K

H

H

F

F

F

F

L

L

F

F

A

A

V

V

L

L

L

L

C

C

A

A

T

T

A

A

M

M

Y

Y

S

S

V

V

A

A

E

E

P

P

A

A

Q

Q

E

E

R

R

L

L

I

I

E

E

S

S

I

I

A

A

C
|
C

M

M

Q

Q

K

K

G

G

L

L

P

P

C
|
C

M

M

E

E

H

H

V

V

D

D

C
|
C

C
|
C

H

H

G

G

V

V

C
|
C

D

D

S

S

L

L

F

F

C
|
C

L

L

Y

Y

C46 (= C46) modified: Disulfide link with 60
C53 (= C53) modified: Disulfide link with 64
C59 (= C59) modified: Disulfide link with 69
C60 (= C60) modified: Disulfide link with 46
C64 (= C64) modified: Disulfide link with 53
C69 (= C69) modified: Disulfide link with 59

A0A0A0V662 U3-scytotoxin-Sth1a; U3-SYTX-Sth1a; U3-Sth1a from Scytodes thoracica (Spitting spider) (Aranea thoracica) (see 2 papers)
78% identity, 83% coverage: 11:69/71 of query aligns to 1:59/60 of A0A0A0V662

query
sites
A0A0A0V662

M

M

G

G

F

F

A

A

K

K

H

Q

F

F

F

F

L

F

F

L

A

A

V

V

L

L

L

L

C

S

A

A

T

A

A

V

M

M

Y

C

S

S

V

M

A

A

E
|
E

P
|
P

A
|
A

Q
|
Q

E
|
E

R
|
R

L
|
L

I
|
I

E
|
E

S
|
S

I
|
I

A
|
A

C
|
C

M
x
I

Q
|
Q

K
|
K

G
|
G

L
|
L

P
|
P

C
|
C

M
|
M

E
|
E

H
|
H

V
x
S

D
|
D

C
|
C

C
|
C

H
x
R

G
|
G

V
|
V

C
|
C

D
x
E

S
x
A

L
|
L

F
|
F

C
|
C

EPAQER 24:29 (= EPAQER 34:39) modified: propeptide
C36 (= C46) modified: Disulfide link with 50
C43 (= C53) modified: Disulfide link with 54
C49 (= C59) modified: Disulfide link with 59
C50 (= C60) modified: Disulfide link with 36
C54 (= C64) modified: Disulfide link with 43
C59 (= C69) modified: Disulfide link with 49

Sites not aligning to the query:

30:60 modified: mature protein, U3-scytotoxin-Sth1a

Query Sequence

>U31H_SCYTH / A0A0A0VBR5
MSQNSITSYKMGFAKHFFLFAVLLCATAMYSVAEPAQERLIESIACMQKGLPCMEHVDCC
HGVCDSLFCLY

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory