SitesBLAST
Comparing WP_002720536.1 NCBI__GCF_000015985.1:WP_002720536.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
3i6vA Crystal structure of a periplasmic his/glu/gln/arg/opine family- binding protein from silicibacter pomeroyi in complex with lysine
78% identity, 91% coverage: 23:241/241 of query aligns to 1:218/218 of 3i6vA
- binding lysine: E7 (= E29), Y10 (= Y32), W48 (= W70), G66 (= G88), M67 (= M89), S68 (= S90), R73 (= R95), Q107 (= Q130), T110 (= T133), I111 (= I134), Q112 (= Q135)
P02911 Lysine/arginine/ornithine-binding periplasmic protein; LAO-binding protein from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 4 papers)
33% identity, 97% coverage: 1:234/241 of query aligns to 1:253/260 of P02911
- D33 (≠ E29) binding L-arginine; binding L-lysine; binding L-ornithine; mutation to A: Decreases arginine and histidine binding affinity.
- Y36 (= Y32) mutation to A: Shows a drastic decrease in arginine and histidine binding affinity.
- D52 (≠ E48) mutation to A: Shows a drastic decrease in arginine and histidine binding affinity.
- C60 (= C56) modified: Disulfide link with 67
- C67 (= C63) modified: Disulfide link with 60
- F74 (≠ W70) mutation to A: Shows a drastic decrease in arginine and histidine binding affinity.
- S91 (≠ A87) binding L-arginine; binding L-ornithine; mutation to A: Has no effect on the arginine and histidine binding affinity.
- S92 (≠ G88) binding L-arginine; binding L-lysine; binding L-ornithine; mutation to A: Decreases arginine and histidine binding affinity.
- S94 (= S90) binding L-arginine; binding L-lysine; binding L-ornithine; mutation to A: Decreases arginine and histidine binding affinity.
- R99 (= R95) binding L-arginine; binding L-lysine; binding L-ornithine; mutation to A: Shows a drastic decrease in arginine and histidine binding affinity.
- L139 (≠ Q130) mutation to K: Changes ligand specificity. Can bind glutamine. Still able to bind basic amino acids, however, with 1000-fold less affinity for arginine.; mutation to Q: Does not affect ligand preference.
- T143 (≠ I134) binding L-arginine; binding L-lysine; binding L-ornithine
- D183 (= D170) binding L-arginine; binding L-ornithine; mutation to A: Shows a drastic decrease in arginine and histidine binding affinity.
4zv2A An ancestral arginine-binding protein bound to glutamine (see paper)
32% identity, 89% coverage: 23:236/241 of query aligns to 5:225/225 of 4zv2A
5otaA Structure of the periplasmic binding protein (pbp) noct from agrobacterium tumefaciens c58 in complex with octopinic acid (see paper)
32% identity, 90% coverage: 22:237/241 of query aligns to 2:251/254 of 5otaA
- binding (2~{S})-5-azanyl-2-[[(2~{R})-1-oxidanyl-1-oxidanylidene-propan-2-yl]amino]pentanoic acid: E9 (= E29), Y12 (= Y32), W50 (= W70), A68 (≠ G88), G70 (≠ S90), R75 (= R95), M90 (vs. gap), Q138 (= Q130), T141 (= T133), S142 (≠ I134), H143 (≠ Q135), S180 (≠ D170)
5ot9A Structure of the periplasmic binding protein (pbp) noct from a.Tumefaciens c58 in complex with histopine. (see paper)
32% identity, 90% coverage: 22:237/241 of query aligns to 2:251/254 of 5ot9A
- binding Histopine: E9 (= E29), Y12 (= Y32), W50 (= W70), A67 (= A87), A68 (≠ G88), R75 (= R95), M90 (vs. gap), Q138 (= Q130), T141 (= T133), S142 (≠ I134), H143 (≠ Q135), S180 (≠ D170)
4powA Structure of the pbp noct in complex with pyronopaline (see paper)
32% identity, 90% coverage: 22:237/241 of query aligns to 2:251/254 of 4powA
- binding 1-[(1S)-4-carbamimidamido-1-carboxybutyl]-5-oxo-D-proline: E9 (= E29), Y12 (= Y32), W50 (= W70), A67 (= A87), A68 (≠ G88), G70 (≠ S90), R75 (= R95), M90 (vs. gap), Q138 (= Q130), T141 (= T133), S142 (≠ I134), H143 (≠ Q135), S180 (≠ D170)
5otcA Structure of the periplasmic binding protein (pbp) noct from agrobacterium tumefaciens c58 in complex with noroctopinic acid. (see paper)
32% identity, 90% coverage: 22:237/241 of query aligns to 2:251/256 of 5otcA
- binding (2~{S})-5-azanyl-2-(2-hydroxy-2-oxoethylamino)pentanoic acid: E9 (= E29), Y12 (= Y32), W50 (= W70), A68 (≠ G88), G70 (≠ S90), R75 (= R95), Q138 (= Q130), T141 (= T133), S142 (≠ I134), H143 (≠ Q135), S180 (≠ D170)
5ovzA High resolution structure of the pbp noct in complex with nopaline (see paper)
32% identity, 90% coverage: 22:237/241 of query aligns to 3:252/259 of 5ovzA
- binding N-[(1S)-4-carbamimidamido-1-carboxybutyl]-D-glutamic acid: E10 (= E29), Y13 (= Y32), W51 (= W70), A68 (= A87), A69 (≠ G88), G71 (≠ S90), R76 (= R95), M91 (vs. gap), Q139 (= Q130), T142 (= T133), S143 (≠ I134), H144 (≠ Q135), S181 (≠ D170), V213 (= V198)
5itoA Structure of the periplasmic binding protein m117n-noct from a. Tumefaciens in complex with octopine (see paper)
32% identity, 90% coverage: 22:237/241 of query aligns to 3:252/255 of 5itoA
- binding octopine: E10 (= E29), Y13 (= Y32), W51 (= W70), A68 (= A87), A69 (≠ G88), G71 (≠ S90), R76 (= R95), Q139 (= Q130), T142 (= T133), S143 (≠ I134), H144 (≠ Q135), S181 (≠ D170)
4zv1A An ancestral arginine-binding protein bound to arginine (see paper)
32% identity, 88% coverage: 23:235/241 of query aligns to 5:226/226 of 4zv1A
- binding arginine: E11 (= E29), F14 (≠ Y32), F52 (≠ W70), A69 (= A87), G70 (= G88), M71 (= M89), T72 (≠ S90), R77 (= R95), Q117 (= Q130), S120 (≠ T133), T121 (≠ I134), D161 (= D170)
5owfA Structure of a lao-binding protein mutant with glutamine (see paper)
32% identity, 88% coverage: 22:234/241 of query aligns to 1:228/235 of 5owfA
1lstA Three-dimensional structures of the periplasmic lysine-, arginine-, ornithine-binding protein with and without a ligand (see paper)
32% identity, 88% coverage: 22:234/241 of query aligns to 4:231/238 of 1lstA
1lahE Structural bases for multiple ligand specificity of the periplasmic lysine-, arginine-, ornithine-binding protein (see paper)
32% identity, 88% coverage: 22:234/241 of query aligns to 4:231/238 of 1lahE
1lagE Structural bases for multiple ligand specificity of the periplasmic lysine-, arginine-, ornithine-binding protein (see paper)
32% identity, 88% coverage: 22:234/241 of query aligns to 4:231/238 of 1lagE
- binding histidine: Y14 (= Y32), F52 (≠ W70), S69 (≠ A87), S70 (≠ G88), L71 (≠ M89), S72 (= S90), R77 (= R95), L117 (≠ Q130), S120 (≠ T133), Q122 (= Q135), D161 (= D170)
1lafE Structural bases for multiple ligand specificity of the periplasmic lysine-, arginine-, ornithine-binding protein (see paper)
32% identity, 88% coverage: 22:234/241 of query aligns to 4:231/238 of 1lafE
- binding arginine: D11 (≠ E29), Y14 (= Y32), F52 (≠ W70), S69 (≠ A87), S70 (≠ G88), S72 (= S90), R77 (= R95), L117 (≠ Q130), S120 (≠ T133), T121 (≠ I134), Q122 (= Q135), D161 (= D170)
P02910 Histidine-binding periplasmic protein; HBP from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 2 papers)
33% identity, 90% coverage: 22:238/241 of query aligns to 26:257/260 of P02910
- E40 (≠ N36) mutation to K: Decrease in ATPase-inducing activity and histidine transport; when associated with K-47.
- K42 (≠ I38) mutation to E: Increases ATPase-inducing activity and histidine transport; when associated with K-47.
- E47 (= E43) mutation to K: Decrease in ATPase-inducing activity and histidine transport; when associated with K-40. Increases ATPase-inducing activity and histidine transport; when associated with E-42.
- D171 (≠ A158) mutation D->A,N: Strong decrease in ATPase-inducing activity and histidine transport.
- R176 (≠ E163) mutation R->D,S: Strong decrease in ATPase-inducing activity and histidine transport.
- D178 (= D165) mutation to A: Slight decrease in ATPase-inducing activity and histidine transport.
Sites not aligning to the query:
1hslA Refined 1.89 angstroms structure of the histidine-binding protein complexed with histidine and its relationship with many other active transport(slash)chemosensory receptors (see paper)
33% identity, 90% coverage: 22:238/241 of query aligns to 4:235/238 of 1hslA
P0AEU0 Histidine-binding periplasmic protein; HBP from Escherichia coli (strain K12) (see 3 papers)
33% identity, 90% coverage: 22:238/241 of query aligns to 26:257/260 of P0AEU0
- C60 (= C56) modified: Disulfide link with 67
- C67 (= C63) modified: Disulfide link with 60
- S91 (≠ A87) binding L-histidine
- S92 (≠ G88) binding L-histidine
- S94 (= S90) binding L-histidine
- R99 (= R95) binding L-histidine
- T143 (≠ I134) binding L-histidine
- D183 (= D170) binding L-histidine
Sites not aligning to the query:
8hqrA Crystal structure of the arginine-/lysine-binding protein sar11_1210 from 'candidatus pelagibacter ubique' htcc1062 bound to arginine
32% identity, 89% coverage: 24:237/241 of query aligns to 10:264/267 of 8hqrA
- binding arginine: E15 (= E29), Y18 (= Y32), W56 (= W70), A73 (= A87), G74 (= G88), S76 (= S90), R81 (= R95), E94 (vs. gap), Q143 (= Q130), T146 (= T133), I147 (= I134)
5orgA Structure of the periplasmic binding protein (pbp) occj from a. Tumefaciens b6 in complex with octopine. (see paper)
29% identity, 90% coverage: 21:238/241 of query aligns to 3:254/257 of 5orgA
- binding octopine: E11 (= E29), Y14 (= Y32), W52 (= W70), A69 (= A87), A70 (≠ G88), M71 (= M89), S72 (= S90), R77 (= R95), N92 (vs. gap), Q140 (= Q130), T143 (= T133), T144 (≠ I134), N183 (≠ D170)
Query Sequence
>WP_002720536.1 NCBI__GCF_000015985.1:WP_002720536.1
MKKLILTTALVALAAGAAVAQQTVRMGTEGAYPPYNFINDKGEVDGYERELGDELCKRAN
LTCTWVKNDWDSIVPNLQSGNYDTIMAGMSITEEREKVIDFTQNYIPPLASAYASTSPDA
DIEGGVVAAQTGTIQAAHVAESGATLLEFATGEETVAAVRNGEADAVFADKDFLVPFVNE
SSGEFTFVGEDVPLGGGVGMGLRKSDTELKEKFNAAIQSMKDDGTINAMIKKWFGDDIQT
F
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory