SitesBLAST
Comparing WP_002723784.1 NCBI__GCF_000015985.1:WP_002723784.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
8jwmB Crystal structure of akrtyl-NADP-tylosin complex (see paper)
41% identity, 97% coverage: 1:328/339 of query aligns to 1:331/331 of 8jwmB
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G19 (= G19), M21 (= M21), D48 (= D57), Y53 (= Y62), N161 (= N162), Q186 (= Q187), W214 (= W215), S215 (= S216), P216 (= P217), L217 (= L218), G219 (= G220), G220 (= G221), R235 (vs. gap), R236 (≠ K232), A237 (= A233), I287 (= I287), G289 (= G289), R291 (≠ K291), Q295 (= Q295), S298 (≠ D298)
- binding tylosin: Y53 (= Y62), W55 (≠ G64), H130 (= H131), C192 (≠ A193), E193 (≠ G194), R195 (≠ D196), G240 (= G236), R241 (= R237), Q250 (≠ V246), E253 (≠ D249), Q254 (≠ R250), R257 (≠ A257), E317 (≠ R317), I318 (vs. gap), P320 (vs. gap)
8hw0A The structure of akr6d1
37% identity, 96% coverage: 1:326/339 of query aligns to 1:326/329 of 8hw0A
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G19 (= G19), W21 (vs. gap), Q27 (= Q35), D49 (= D57), Y54 (= Y62), R123 (≠ G132), S152 (= S161), Q178 (= Q187), W207 (= W215), S208 (= S216), P209 (= P217), L210 (= L218), S212 (≠ G220), K218 (= K226), S227 (≠ G236), R228 (= R237), I285 (= I287), G287 (= G289), S289 (≠ K291), Q293 (= Q295), D296 (= D298), N297 (= N299)
8jwoL Crystal structure of akrtyl-tylosin complex (see paper)
40% identity, 97% coverage: 1:328/339 of query aligns to 1:311/311 of 8jwoL
8jwkD The second purified state crystal structure of akrtyl (see paper)
40% identity, 97% coverage: 1:328/339 of query aligns to 1:314/314 of 8jwkD
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G19 (= G19), M21 (= M21), D48 (= D57), Y53 (= Y62), H130 (= H131), Q186 (= Q187), W214 (= W215), S215 (= S216), P216 (= P217), L217 (= L218), I270 (= I287), G272 (= G289), R274 (≠ K291), Q278 (= Q295), S281 (≠ D298)
8jwkH The second purified state crystal structure of akrtyl (see paper)
40% identity, 97% coverage: 1:328/339 of query aligns to 1:307/307 of 8jwkH
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G19 (= G19), M21 (= M21), D48 (= D57), Y53 (= Y62), H129 (= H131), N160 (= N162), Q185 (= Q187), W213 (= W215), S214 (= S216), P215 (= P217), L216 (= L218), G218 (= G220), I263 (= I287), G265 (= G289), R267 (≠ K291), Q271 (= Q295), S274 (≠ D298)
6ow0A Crystal structure of mithramycin 3-side chain keto-reductase mtmw in complex with NAD+ and peg (see paper)
37% identity, 93% coverage: 1:316/339 of query aligns to 1:313/323 of 6ow0A
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G19 (= G19), L21 (≠ M21), D49 (= D57), Y54 (= Y62), S151 (= S161), Y204 (≠ W215), F205 (≠ S216), L207 (= L218), Q209 (≠ G220), G210 (= G221), T213 (≠ S224), K215 (= K226), R227 (≠ E230), V284 (≠ I287), G286 (= G289), Q292 (= Q295), N296 (= N299)
Q13303 Voltage-gated potassium channel subunit beta-2; K(+) channel subunit beta-2; Kv-beta-2; hKvbeta2; EC 1.1.1.- from Homo sapiens (Human) (see 2 papers)
39% identity, 89% coverage: 3:305/339 of query aligns to 39:339/367 of Q13303
- T56 (= T20) binding NADP(+)
- W57 (vs. gap) binding NADP(+)
- Q63 (= Q35) binding NADP(+)
- D85 (= D57) binding NADP(+)
- Y90 (= Y62) mutation to F: No effect on its activity in promoting KCNA4 channel closure.
- S112 (≠ D84) modified: Phosphoserine
- S188 (= S161) binding NADP(+)
- R189 (≠ N162) binding NADP(+)
- Q214 (= Q187) binding NADP(+)
- W243 (= W215) binding NADP(+)
- S244 (= S216) binding NADP(+)
- P245 (= P217) binding NADP(+)
- L246 (= L218) binding NADP(+)
- A247 (= A219) binding NADP(+)
- C248 (≠ G220) binding NADP(+)
- K254 (= K226) binding NADP(+)
- R264 (= R238) binding NADP(+)
- S325 (≠ K291) binding NADP(+)
- Q329 (= Q295) binding NADP(+)
- E332 (≠ D298) binding NADP(+)
- N333 (= N299) binding NADP(+)
Sites not aligning to the query:
- 31 modified: Phosphoserine
7wf3C Composite map of human kv1.3 channel in apo state with beta subunits (see paper)
39% identity, 89% coverage: 3:305/339 of query aligns to 6:306/328 of 7wf3C
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G22 (= G19), R156 (≠ N162), W210 (= W215), S211 (= S216), P212 (= P217), L213 (= L218), C215 (≠ G220), K221 (= K226), R231 (= R238), Q296 (= Q295), E299 (≠ D298), N300 (= N299)
3eauA Voltage-dependent k+ channel beta subunit in complex with cortisone (see paper)
38% identity, 89% coverage: 3:305/339 of query aligns to 5:305/327 of 3eauA
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G21 (= G19), W23 (vs. gap), Q29 (= Q35), D51 (= D57), Y56 (= Y62), K84 (= K90), S154 (= S161), Q180 (= Q187), W209 (= W215), S210 (= S216), P211 (= P217), L212 (= L218), A213 (= A219), C214 (≠ G220), G215 (= G221), K220 (= K226), R230 (= R238), L287 (≠ I287), L288 (≠ V288), G289 (= G289), S291 (≠ K291), Q295 (= Q295), E298 (≠ D298), N299 (= N299)
- binding 17,21-dihydroxypregna-1,4-diene-3,11,20-trione: W23 (vs. gap), V55 (= V61), Y56 (= Y62), W87 (≠ G93), N124 (≠ H131), R155 (≠ N162), I174 (≠ A181), I177 (≠ L184), I202 (≠ T208)
1exbA Structure of the cytoplasmic beta subunit-t1 assembly of voltage- dependent k channels (see paper)
38% identity, 89% coverage: 3:305/339 of query aligns to 4:304/326 of 1exbA
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G20 (= G19), W22 (vs. gap), Q28 (= Q35), D50 (= D57), Y55 (= Y62), S153 (= S161), R154 (≠ N162), Q179 (= Q187), W208 (= W215), S209 (= S216), P210 (= P217), L211 (= L218), C213 (≠ G220), G214 (= G221), S217 (= S224), K219 (= K226), S228 (≠ R237), R229 (= R238), L286 (≠ I287), G288 (= G289), S290 (≠ K291), Q294 (= Q295), E297 (≠ D298), N298 (= N299)
P62483 Voltage-gated potassium channel subunit beta-2; K(+) channel subunit beta-2; Kv-beta-2; EC 1.1.1.- from Rattus norvegicus (Rat) (see 11 papers)
38% identity, 89% coverage: 3:305/339 of query aligns to 39:339/367 of P62483
- T56 (= T20) binding NADP(+)
- W57 (vs. gap) binding NADP(+)
- Q63 (= Q35) binding NADP(+)
- D85 (= D57) binding NADP(+)
- Y90 (= Y62) mutation to F: Abolishes enzyme activity, but has no effect on NADPH binding.
- S112 (≠ D84) modified: Phosphoserine
- N158 (≠ H131) binding NADP(+)
- S188 (= S161) binding NADP(+)
- R189 (≠ N162) binding NADP(+)
- Q214 (= Q187) binding NADP(+)
- W243 (= W215) binding NADP(+)
- S244 (= S216) binding NADP(+)
- P245 (= P217) binding NADP(+)
- L246 (= L218) binding NADP(+)
- A247 (= A219) binding NADP(+)
- C248 (≠ G220) binding NADP(+)
- K254 (= K226) binding NADP(+)
- Y262 (≠ G236) binding NADP(+)
- R264 (= R238) binding NADP(+)
- G323 (= G289) binding NADP(+)
- S325 (≠ K291) binding NADP(+)
- Q329 (= Q295) binding NADP(+)
- E332 (≠ D298) binding NADP(+)
- N333 (= N299) binding NADP(+)
Sites not aligning to the query:
- 9 modified: Phosphoserine; S→A: Impairs interaction with MAPRE1 and association with microtubules.
- 20 modified: Phosphoserine; S→A: No effect on interaction with MAPRE1 and association with microtubules.
- 31 S→A: Impairs interaction with MAPRE1 and association with microtubules.
P62482 Voltage-gated potassium channel subunit beta-2; K(+) channel subunit beta-2; Kv-beta-2; Neuroimmune protein F5; EC 1.1.1.- from Mus musculus (Mouse) (see 2 papers)
38% identity, 89% coverage: 3:305/339 of query aligns to 39:339/367 of P62482
- Y90 (= Y62) mutation to F: No detectable phenotype.
- S112 (≠ D84) modified: Phosphoserine
Sites not aligning to the query:
- 20 modified: Phosphoserine
6ow0B Crystal structure of mithramycin 3-side chain keto-reductase mtmw in complex with NAD+ and peg (see paper)
36% identity, 93% coverage: 1:316/339 of query aligns to 1:289/301 of 6ow0B
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G19 (= G19), L21 (≠ M21), Y50 (= Y62), H117 (= H131), S147 (= S161), Y200 (≠ W215), F201 (≠ S216), L203 (= L218), Q205 (≠ G220), T209 (≠ S224), Q268 (= Q295), N272 (= N299)
P63144 Voltage-gated potassium channel subunit beta-1; K(+) channel subunit beta-1; Kv-beta-1; EC 1.1.1.- from Rattus norvegicus (Rat) (see paper)
37% identity, 90% coverage: 1:305/339 of query aligns to 71:373/401 of P63144
- K152 (= K90) mutation to M: Loss of enzyme activity.
Q14722 Voltage-gated potassium channel subunit beta-1; K(+) channel subunit beta-1; Kv-beta-1; EC 1.1.1.- from Homo sapiens (Human) (see paper)
36% identity, 90% coverage: 1:305/339 of query aligns to 89:391/419 of Q14722
- Y307 (= Y227) mutation to F: Reduces affinity for NADPH.
- R316 (= R238) mutation to E: Nearly abolishes NADPH binding.
Q9P7U2 Putative aryl-alcohol dehydrogenase C977.14c; EC 1.1.1.- from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
33% identity, 95% coverage: 3:323/339 of query aligns to 9:346/351 of Q9P7U2
- S113 (≠ G96) modified: Phosphoserine
Q3L181 Perakine reductase; EC 1.1.1.317 from Rauvolfia serpentina (Serpentine wood) (Ophioxylon serpentinum) (see paper)
31% identity, 94% coverage: 5:321/339 of query aligns to 5:311/337 of Q3L181
- D52 (= D57) mutation to A: 99% loss of activity.
- Y57 (= Y62) mutation to A: 99% loss of activity.
- K84 (= K90) mutation to A: Total loss of activity.
- H126 (= H131) mutation to A: 98% loss of activity.
P46336 Aldo-keto reductase IolS; AKR11A; Vegetative protein 147; VEG147; EC 1.1.1.- from Bacillus subtilis (strain 168) (see paper)
33% identity, 94% coverage: 1:320/339 of query aligns to 1:310/310 of P46336
1pz0A Structure of NADPH-dependent family 11 aldo-keto reductase akr11a(holo) (see paper)
33% identity, 93% coverage: 5:320/339 of query aligns to 4:309/311 of 1pz0A
- active site: D52 (= D57), Y57 (= Y62), N91 (≠ G98), H124 (= H131)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: H124 (= H131), Q174 (= Q187), Y202 (≠ W215), F203 (≠ S216), P204 (= P217), L205 (= L218), S207 (≠ G220), G208 (= G221), A211 (≠ S224), K213 (= K226)
4aubB The complex structure of the bacterial aldo-keto reductase akr14a1 with NADP and citrate (see paper)
32% identity, 94% coverage: 1:317/339 of query aligns to 11:319/335 of 4aubB
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G29 (= G19), W31 (= W30), D59 (= D57), Y64 (= Y62), H136 (= H131), Q191 (= Q187), F220 (≠ W215), T221 (≠ S216), P222 (= P217), L223 (= L218), Q225 (≠ G220), G226 (= G221), K231 (= K226), R241 (= R237), R244 (≠ F243), L288 (≠ I287), G290 (= G289), S292 (≠ K291), Q296 (= Q295), E299 (≠ D298), N300 (= N299)
Sites not aligning to the query:
Query Sequence
>WP_002723784.1 NCBI__GCF_000015985.1:WP_002723784.1
MRYRRLGPSGLFVSELCLGTMTFGGSDGIWGQIGQLGQDEADALVRTALDAGINFIDTAN
VYAGGESERILGRSLRNLGVRREDVVIATKVLGPMGAGVNARGASRVHILDQCKASLERL
QLDHIDLYQIHGFDAETPIVETLEALDTLVRHGHVRYIGLSNWAAWQVMKAVGIAEARRL
APILSLQAYYTLAGRDLEREVVPMLKDTGMGLMVWSPLAGGFLSGKYDREGKAADGRRAA
FDFPPVDKDRGWTVIEAMRPIAEAKGSSVAQVALAWLLHQEAVTSVIVGAKRVDQLADNI
AATEVRLEAEDLAALDRASALAPEYPGWMLERQRSYRAR
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory