SitesBLAST
Comparing WP_004302132.1 NCBI__GCF_000310185.1:WP_004302132.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
4ryaA Crystal structure of abc transporter solute binding protein avi_3567 from agrobacterium vitis s4, target efi-510645, with bound d-mannitol
49% identity, 94% coverage: 27:442/442 of query aligns to 1:417/417 of 4ryaA
5iaiA Crystal structure of abc transporter solute binding protein arad_9887 from agrobacterium radiobacter k84, target efi-510945 in complex with ribitol
26% identity, 93% coverage: 24:433/442 of query aligns to 2:397/399 of 5iaiA
Q7LYW7 Trehalose/maltose-binding protein MalE; TMBP from Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C) (see paper)
27% identity, 87% coverage: 48:433/442 of query aligns to 66:444/450 of Q7LYW7
- T84 (≠ V62) binding alpha,alpha-trehalose
- R89 (≠ S67) binding alpha,alpha-trehalose
- D110 (= D85) binding alpha,alpha-trehalose
- Y161 (= Y137) binding alpha,alpha-trehalose
- D163 (≠ E139) binding alpha,alpha-trehalose
- Y217 (≠ G190) binding alpha,alpha-trehalose
- E279 (≠ G248) binding alpha,alpha-trehalose
- W297 (≠ T266) binding alpha,alpha-trehalose
- Y299 (≠ A268) binding alpha,alpha-trehalose
- G334 (≠ A303) binding alpha,alpha-trehalose
- W335 (= W304) binding alpha,alpha-trehalose
- W371 (= W342) binding alpha,alpha-trehalose
- R404 (≠ S386) binding alpha,alpha-trehalose
Sites not aligning to the query:
- 57 binding alpha,alpha-trehalose
1eu8A Structure of trehalose maltose binding protein from thermococcus litoralis (see paper)
26% identity, 93% coverage: 25:433/442 of query aligns to 1:403/407 of 1eu8A
- binding alpha-D-glucopyranose: G12 (≠ D36), E16 (vs. gap), T43 (≠ V62), T45 (≠ L64), R48 (≠ S67), D69 (= D85), Y120 (= Y137), D122 (≠ E139), G178 (≠ I192), E238 (≠ G248), W256 (≠ T266), Y258 (≠ A268), G292 (≠ W302), G293 (≠ A303), W294 (= W304), R363 (≠ S386)
5ci5A Crystal structure of an abc transporter solute binding protein from thermotoga lettingae tmo (tlet_1705, target efi-510544) bound with alpha-d-tagatose
26% identity, 75% coverage: 95:424/442 of query aligns to 70:380/393 of 5ci5A
Sites not aligning to the query:
6dtqA Maltose bound t. Maritima male3 (see paper)
27% identity, 61% coverage: 110:378/442 of query aligns to 86:348/391 of 6dtqA
Sites not aligning to the query:
1eljA The crystal structure of liganded maltodextrin-binding protein from pyrococcus furiosus (see paper)
26% identity, 55% coverage: 23:265/442 of query aligns to 1:229/380 of 1eljA
Sites not aligning to the query:
A9CEY9 Sulfoquinovosyl glycerol-binding protein SmoF; SQGro-binding protein SmoF; SQ monooxygenase cluster protein F from Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58)) (see 2 papers)
22% identity, 88% coverage: 49:437/442 of query aligns to 52:416/416 of A9CEY9
- S71 (= S67) binding 3-(6-sulfo-alpha-D-quinovosyl)glycerol
- D95 (≠ G90) binding 3-(6-sulfo-alpha-D-quinovosyl)glycerol
- D141 (≠ E139) binding 3-(6-sulfo-alpha-D-quinovosyl)glycerol
- G194 (vs. gap) binding 3-(6-sulfo-alpha-D-quinovosyl)glycerol
- T248 (≠ Y247) binding 3-(6-sulfo-alpha-D-quinovosyl)glycerol
- G303 (≠ A303) binding 3-(6-sulfo-alpha-D-quinovosyl)glycerol; binding 6-sulfo-D-quinovose
- W304 (= W304) binding 3-(6-sulfo-alpha-D-quinovosyl)glycerol; binding 6-sulfo-D-quinovose
- R373 (≠ P384) binding 3-(6-sulfo-alpha-D-quinovosyl)glycerol; binding 6-sulfo-D-quinovose
Sites not aligning to the query:
- 40 binding 3-(6-sulfo-alpha-D-quinovosyl)glycerol
- 41 binding 6-sulfo-D-quinovose
7ofyA Crystal structure of sq binding protein from agrobacterium tumefaciens in complex with sulfoquinovosyl glycerol (sqgro) (see paper)
22% identity, 81% coverage: 80:437/442 of query aligns to 57:388/389 of 7ofyA
- binding [(2S,3S,4S,5R,6S)-6-[(2R)-2,3-bis(oxidanyl)propoxy]-3,4,5-tris(oxidanyl)oxan-2-yl]methanesulfonic acid: D67 (≠ G90), D113 (≠ E139), G166 (vs. gap), T220 (≠ Y247), W238 (≠ P265), Y240 (≠ V267), G274 (≠ W302), G275 (≠ A303), W276 (= W304), R345 (≠ P384)
Sites not aligning to the query:
7qhvAAA Sulfoquinovosyl binding protein (see paper)
22% identity, 81% coverage: 80:437/442 of query aligns to 56:386/390 of 7qhvAAA
- binding [(2~{S},3~{S},4~{S},5~{R},6~{S})-6-[(2~{S})-3-butanoyloxy-2-heptanoyloxy-propoxy]-3,4,5-tris(oxidanyl)oxan-2-yl]methanesulfonic acid: D66 (≠ G90), F109 (≠ Y137), D111 (≠ E139), E163 (vs. gap), G164 (vs. gap), A217 (≠ G246), T218 (≠ Y247), D219 (≠ G248), W236 (≠ P265), G272 (≠ W302), G273 (≠ A303), W274 (= W304), R343 (≠ P384)
Sites not aligning to the query:
- binding [(2~{S},3~{S},4~{S},5~{R},6~{S})-6-[(2~{S})-3-butanoyloxy-2-heptanoyloxy-propoxy]-3,4,5-tris(oxidanyl)oxan-2-yl]methanesulfonic acid: 9, 10, 40, 41, 42
7yzsAAA Sulfoquinovosyl binding protein (see paper)
23% identity, 65% coverage: 80:365/442 of query aligns to 55:329/384 of 7yzsAAA
Sites not aligning to the query:
7yzuA Crystal structure of the sulfoquinovosyl binding protein smof complexed with sqme (see paper)
22% identity, 88% coverage: 49:436/442 of query aligns to 21:382/382 of 7yzuA
- binding [(2S,3S,4S,5R,6S)-6-methoxy-3,4,5-tris(oxidanyl)oxan-2-yl]methanesulfonic acid: T39 (vs. gap), S40 (= S67), D64 (≠ G90), D110 (≠ E139), E162 (vs. gap), G163 (vs. gap), T215 (≠ Y247), W233 (≠ P265), G269 (≠ W302), G270 (≠ A303), W271 (= W304), R340 (≠ P384)
Sites not aligning to the query:
3k02A Crystal structures of the gach receptor of streptomyces glaucescens gla.O in the unliganded form and in complex with acarbose and an acarbose homolog. Comparison with acarbose-loaded maltose binding protein of salmonella typhimurium. (see paper)
25% identity, 60% coverage: 34:298/442 of query aligns to 11:269/388 of 3k02A
- binding 4,6-dideoxy-4-{[(1S,2R,3R,4S,5S)-2,3,4-trihydroxy-5-(hydroxymethyl)cyclohexyl]amino}-alpha-D-allopyranosyl-(1->4)-alpha-D-glucopyranosyl-(1->4)-alpha-D-glucopyranosyl-(1->4)-alpha-D-glucopyranose: T11 (= T34), E16 (≠ H39), F43 (≠ E66), E67 (≠ G90), W70 (≠ K93), D117 (≠ E139), D164 (≠ R188), Y166 (≠ G190), W167 (= W191), W238 (≠ V267)
Sites not aligning to the query:
3jzjA Crystal structures of the gach receptor of streptomyces glaucescens gla.O in the unliganded form and in complex with acarbose and an acarbose homolog. Comparison with acarbose-loaded maltose binding protein of salmonella typhimurium. (see paper)
25% identity, 60% coverage: 34:298/442 of query aligns to 11:269/388 of 3jzjA
- binding 4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranose: E67 (≠ G90), W70 (≠ K93), Y166 (≠ G190)
- binding alpha-D-glucopyranose: T11 (= T34), E16 (≠ H39), F43 (≠ E66), R65 (≠ T88), E67 (≠ G90), D117 (≠ E139), D164 (≠ R188), W238 (≠ V267), W238 (≠ V267)
Sites not aligning to the query:
G7CES0 Trehalose-binding lipoprotein LpqY; Extracellular solute-binding protein; SugABC transporter substrate-binding protein LpqY; SugABC transporter SBP LpqY from Mycolicibacterium thermoresistibile (strain ATCC 19527 / DSM 44167 / CIP 105390 / JCM 6362 / NCTC 10409 / 316) (Mycobacterium thermoresistibile) (see paper)
26% identity, 65% coverage: 1:286/442 of query aligns to 7:297/471 of G7CES0
- N45 (≠ H39) binding alpha,alpha-trehalose; mutation to A: About 3-fold increase in constant dissociation (Kd) value of trehalose compared to wild-type.; mutation to T: Increased trehalose-binding; when associated with D-46.
- E46 (≠ R42) binding alpha,alpha-trehalose; mutation to A: About 3-fold increase in constant dissociation (Kd) value of trehalose compared to wild-type.; mutation to D: Increased trehalose-binding; when associated with T-45.
- C57 (≠ A53) modified: Disulfide link with 375
- Q79 (≠ D76) binding alpha,alpha-trehalose; mutation to A: About 10-fold increase in constant dissociation (Kd) value of trehalose compared to wild-type.
- D100 (≠ G90) binding alpha,alpha-trehalose; mutation to A: Structurally unstable.
- N154 (≠ E139) binding alpha,alpha-trehalose; mutation to A: About 100-fold increase in constant dissociation (Kd) value of trehalose compared to wild-type.
- Y198 (vs. gap) binding alpha,alpha-trehalose
- E261 (= E249) mutation to A: Loss of trehalose-binding.
- W279 (vs. gap) binding alpha,alpha-trehalose; mutation to A: Loss of trehalose-binding.
- Y281 (≠ T266) binding alpha,alpha-trehalose
Sites not aligning to the query:
- 354 binding alpha,alpha-trehalose
- 355 L→A: About 13-fold increase in constant dissociation (Kd) value of trehalose compared to wild-type.
- 375 modified: Disulfide link with 57
- 424 binding alpha,alpha-trehalose; R→A: Loss of trehalose-binding.
8s5bA Sulfoquinovosyl glycerol-binding protein SmoF (see paper)
21% identity, 88% coverage: 49:436/442 of query aligns to 17:377/377 of 8s5bA
- binding [(2~{S},3~{S},4~{S},5~{R},6~{S})-6-octoxy-3,4,5-tris(oxidanyl)oxan-2-yl]methanesulfonic acid: T35 (vs. gap), S36 (= S67), D60 (≠ G90), F104 (≠ Y137), D106 (≠ E139), E158 (vs. gap), G159 (vs. gap), T210 (≠ Y247), W228 (≠ P265), Y230 (≠ V267), G264 (≠ W302), G265 (≠ A303), W266 (= W304), R335 (≠ P384)
8artB Abc transporter binding protein male from streptomyces scabiei in complex with maltose
24% identity, 67% coverage: 44:340/442 of query aligns to 22:313/393 of 8artB
Sites not aligning to the query:
6lceA Crystal structure of beta-l-arabinobiose binding protein - selenomethionine derivative (see paper)
25% identity, 72% coverage: 41:360/442 of query aligns to 27:349/407 of 6lceA
Sites not aligning to the query:
4aq4A Substrate bound sn-glycerol-3-phosphate binding periplasmic protein ugpb from escherichia coli (see paper)
25% identity, 83% coverage: 41:405/442 of query aligns to 20:383/418 of 4aq4A
- binding sn-glycerol-3-phosphate: Y46 (≠ L69), E70 (≠ T88), S125 (≠ E139), W173 (≠ R188), W176 (= W191), S251 (≠ A268), G287 (≠ W302), G288 (≠ A303), Y327 (≠ W342), R378 (≠ I400)
- binding glycerol: Y46 (≠ L69), G107 (≠ K123), W173 (≠ R188), D234 (≠ G248), K367 (≠ P389)
Sites not aligning to the query:
P0AG80 sn-glycerol-3-phosphate-binding periplasmic protein UgpB; Bile-responsive chaperone from Escherichia coli (strain K12) (see 2 papers)
25% identity, 83% coverage: 41:405/442 of query aligns to 39:402/438 of P0AG80
- Y65 (≠ L69) binding sn-glycerol 3-phosphate
- E89 (≠ T88) binding sn-glycerol 3-phosphate; mutation to A: Constitutively active as a chaperone. Not affected by G3P.
- S144 (≠ E139) binding sn-glycerol 3-phosphate
- W192 (≠ R188) mutation to H: Cannot bind G3P. Fails to stimulate ATPase activity of the complex.; mutation to S: Cannot bind G3P. Fails to stimulate ATPase activity of the complex. Constitutively active as a chaperone, independently of the presence or absence of G3P. Exhibit lower anti-aggregation activity.
- W195 (= W191) mutation to H: Slight increase in the dissociation constant of G3P.; mutation to S: Strong increase in the dissociation constant of G3P. Fails to stimulate ATPase activity of the complex.
- S270 (≠ A268) binding sn-glycerol 3-phosphate
- G307 (≠ A303) binding sn-glycerol 3-phosphate
- Y346 (≠ W342) binding sn-glycerol 3-phosphate
- R397 (≠ I400) binding sn-glycerol 3-phosphate; mutation to V: Constitutively active as a chaperone. Not affected by G3P.
Query Sequence
>WP_004302132.1 NCBI__GCF_000310185.1:WP_004302132.1
MKSRSSCLALCFVLAALTLFVALPVRAGALVIATVDSAHMRRLQTLSSEFEKANPEIRIR
WVVLEESELRRVASADVETRDGLFDVITIGIFKAPIWAASGWIKPLRSPDDFDVDDLLPT
VRKALSYQQELYAAPIYGESSMLMYRKDLLKKAGLTMPDRPTWTEVAAFAAKLHDPANGV
HGICLRGRPGWIENMALVSTMVNSFGGQWFDAGWRPQLDSLPWKKAVGLYAELLNRYGPP
DAASLGYGENLSLFASGRCAQWVGPTVAAEVLTNPESSAVAGEVGFAAAPYEVTAKGAQW
LWAWALAIPSSIDPVREADARKFIHWVASRDYVELVAARQGWRAVPTGTRRSTYARPEFQ
RKAPWAVHELEAMLNADPENATLPPSPYPGIQFAAIPEFILIGDEVGNLIAEALAGRLSV
EEALARGQDAAQRRMVRGGYPR
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory