SitesBLAST
Comparing WP_004303778.1 NCBI__GCF_000310185.1:WP_004303778.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
8i01A Crystal structure of escherichia coli glyoxylate carboligase (see paper)
79% identity, 100% coverage: 1:590/591 of query aligns to 2:591/594 of 8i01A
- binding flavin-adenine dinucleotide: R155 (= R154), G212 (= G211), G213 (= G212), G214 (= G213), N217 (= N216), T238 (= T237), L239 (= L238), M240 (= M239), V256 (≠ A255), G257 (= G256), Q259 (= Q258), T260 (= T259), G279 (= G278), N280 (= N279), R281 (= R280), A283 (= A282), R285 (= R284), H286 (= H285), D303 (= D302), I304 (= I303), Q308 (= Q307), D322 (= D321), A323 (= A322), G417 (= G416)
- binding magnesium ion: D447 (= D446), F452 (= F451), E455 (= E454), N474 (= N473), Y476 (= Y475)
- binding thiamine diphosphate: G395 (= G394), L396 (= L395), S397 (= S396), L422 (= L421), G446 (= G445), D447 (= D446), F448 (≠ Y447), D449 (= D448), N474 (= N473), Y476 (= Y475), L477 (= L476), G478 (= G477), L479 (= L478), I480 (= I479)
- binding 2,3-dimethoxy-5-methyl-1,4-benzoquinone: Q354 (= Q353), C492 (= C491), Q494 (= Q493), C589 (≠ S588)
8i07D Crystal structure of escherichia coli glyoxylate carboligase double mutant in complex with glycolaldehyde (see paper)
79% identity, 100% coverage: 1:590/591 of query aligns to 2:591/594 of 8i07D
- binding 2-oxidanylethanal: R285 (= R284), I480 (= I479)
- binding flavin-adenine dinucleotide: R155 (= R154), P156 (= P155), G212 (= G211), G213 (= G212), G214 (= G213), N217 (= N216), T238 (= T237), L239 (= L238), M240 (= M239), V256 (≠ A255), G257 (= G256), Q259 (= Q258), T260 (= T259), G279 (= G278), N280 (= N279), R281 (= R280), R285 (= R284), H286 (= H285), D303 (= D302), I304 (= I303), Q308 (= Q307), D322 (= D321), A323 (= A322), I399 (= I398), G417 (= G416)
- binding magnesium ion: D447 (= D446), F452 (= F451), L453 (≠ M452), E455 (= E454), N474 (= N473), Y476 (= Y475)
- binding thiamine diphosphate: V52 (= V51), T76 (= T75), G395 (= G394), L396 (= L395), S397 (= S396), L422 (= L421), G446 (= G445), D447 (= D446), F448 (≠ Y447), D449 (= D448), N474 (= N473), Y476 (= Y475), L477 (= L476), G478 (= G477), L479 (= L478), I480 (= I479)
- binding ubiquinone-1: Q354 (= Q353), R358 (= R357), C492 (= C491), Q494 (= Q493), C589 (≠ S588)
8i07A Crystal structure of escherichia coli glyoxylate carboligase double mutant in complex with glycolaldehyde (see paper)
79% identity, 100% coverage: 1:590/591 of query aligns to 2:591/594 of 8i07A
- binding flavin-adenine dinucleotide: R155 (= R154), P156 (= P155), G212 (= G211), G213 (= G212), G214 (= G213), N217 (= N216), T238 (= T237), L239 (= L238), M240 (= M239), V256 (≠ A255), G257 (= G256), Q259 (= Q258), T260 (= T259), G279 (= G278), N280 (= N279), R281 (= R280), R285 (= R284), H286 (= H285), D303 (= D302), I304 (= I303), Q308 (= Q307), D322 (= D321), A323 (= A322), I394 (= I393), I399 (= I398), G417 (= G416)
- binding magnesium ion: D447 (= D446), F452 (= F451), L453 (≠ M452), E455 (= E454), N474 (= N473), Y476 (= Y475)
- binding thiamine diphosphate: I394 (= I393), G395 (= G394), L396 (= L395), S397 (= S396), L422 (= L421), G446 (= G445), D447 (= D446), F448 (≠ Y447), D449 (= D448), N474 (= N473), Y476 (= Y475), L477 (= L476), G478 (= G477), L479 (= L478), I480 (= I479)
- binding ubiquinone-1: Q354 (= Q353), C492 (= C491), Q494 (= Q493), C589 (≠ S588)
8beoB Crystal structure of e. Coli glyoxylate carboligase mutant i393a with map
79% identity, 100% coverage: 2:590/591 of query aligns to 1:589/592 of 8beoB
- binding methyl hydrogen (s)-acetylphosphonate: C490 (= C491), Q492 (= Q493)
- binding flavin-adenine dinucleotide: R153 (= R154), P154 (= P155), G210 (= G211), G211 (= G212), G212 (= G213), N215 (= N216), T236 (= T237), L237 (= L238), M238 (= M239), V254 (≠ A255), G255 (= G256), Q257 (= Q258), T258 (= T259), G277 (= G278), N278 (= N279), R279 (= R280), A281 (= A282), R283 (= R284), H284 (= H285), D301 (= D302), I302 (= I303), Q306 (= Q307), D320 (= D321), A321 (= A322), G415 (= G416)
- binding magnesium ion: D445 (= D446), F450 (= F451), L451 (≠ M452), E453 (= E454), N472 (= N473), Y474 (= Y475)
- binding 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-{(1s)-1-hydroxy-1-[(r)-hydroxy(methoxy)phosphoryl]ethyl}-5-(2-{[(s)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium: R283 (= R284), G393 (= G394), L394 (= L395), S395 (= S396), L420 (= L421), G444 (= G445), D445 (= D446), F446 (≠ Y447), D447 (= D448), N472 (= N473), Y474 (= Y475), L475 (= L476), G476 (= G477), L477 (= L478), I478 (= I479)
- binding 2,3-dimethoxy-5-methyl-1,4-benzoquinone: Q352 (= Q353), R356 (= R357), C587 (≠ S588)
8beoA Crystal structure of e. Coli glyoxylate carboligase mutant i393a with map
79% identity, 100% coverage: 2:590/591 of query aligns to 1:589/592 of 8beoA
- binding flavin-adenine dinucleotide: R153 (= R154), P154 (= P155), G210 (= G211), G211 (= G212), G212 (= G213), N215 (= N216), T236 (= T237), L237 (= L238), M238 (= M239), V254 (≠ A255), G255 (= G256), Q257 (= Q258), T258 (= T259), G277 (= G278), N278 (= N279), R279 (= R280), A281 (= A282), R283 (= R284), H284 (= H285), D301 (= D302), I302 (= I303), Q306 (= Q307), D320 (= D321), A321 (= A322), I397 (= I398), G415 (= G416)
- binding magnesium ion: R384 (≠ K385), V405 (= V406), F406 (≠ Y407), H410 (= H411), D445 (= D446), F450 (= F451), L451 (≠ M452), E453 (= E454), N472 (= N473), Y474 (= Y475)
- binding 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-{(1s)-1-hydroxy-1-[(r)-hydroxy(methoxy)phosphoryl]ethyl}-5-(2-{[(s)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium: R283 (= R284), G393 (= G394), L394 (= L395), S395 (= S396), L420 (= L421), G444 (= G445), D445 (= D446), F446 (≠ Y447), D447 (= D448), N472 (= N473), Y474 (= Y475), L475 (= L476), G476 (= G477), L477 (= L478), I478 (= I479)
- binding 2,3-dimethoxy-5-methyl-1,4-benzoquinone: E248 (≠ P249), Q352 (= Q353), C587 (≠ S588)
6lpiB Crystal structure of ahas holo-enzyme (see paper)
35% identity, 80% coverage: 14:486/591 of query aligns to 16:468/539 of 6lpiB
- active site: I27 (≠ V25), G29 (= G27), G30 (≠ A28), S31 (≠ A29), I32 (= I30), E53 (≠ V51), C76 (≠ T75), F115 (= F114), Q116 (= Q115), E117 (≠ A116), K165 (≠ F164), M256 (≠ L257), A283 (≠ H285), V375 (≠ I393), G401 (= G419), M403 (≠ L421), D428 (= D446), N455 (= N473), A457 (≠ Y475), L458 (= L476), L460 (= L478), V461 (≠ I479), Q464 (≠ S482)
- binding flavin-adenine dinucleotide: R155 (= R154), G212 (= G211), G213 (= G212), G214 (= G213), T236 (= T237), L237 (= L238), M238 (= M239), L254 (≠ A255), M256 (≠ L257), H257 (≠ Q258), G276 (= G278), A277 (≠ N279), R278 (= R280), D280 (≠ A282), R282 (= R284), A283 (≠ H285), D300 (= D302), I301 (= I303), D319 (= D321), V320 (≠ A322), M380 (≠ I398), G398 (= G416)
- binding magnesium ion: D428 (= D446), N455 (= N473)
- binding thiamine diphosphate: E53 (≠ V51), C76 (≠ T75), P79 (= P78), G376 (= G394), Q377 (≠ L395), H378 (≠ S396), G401 (= G419), M403 (≠ L421), G427 (= G445), D428 (= D446), G429 (≠ Y447), S430 (≠ D448), M433 (≠ F451), N455 (= N473), A457 (≠ Y475), L458 (= L476), G459 (= G477), L460 (= L478), V461 (≠ I479)
P09342 Acetolactate synthase 1, chloroplastic; ALS I; Acetohydroxy-acid synthase I; Acetolactate synthase I; EC 2.2.1.6 from Nicotiana tabacum (Common tobacco) (see 2 papers)
33% identity, 93% coverage: 5:555/591 of query aligns to 95:638/667 of P09342
- C161 (= C72) modified: Disulfide link with 307
- P194 (= P105) mutation to Q: In C3; highly resistant to sulfonylurea herbicides.
- C307 (≠ V214) modified: Disulfide link with 161
P09114 Acetolactate synthase 2, chloroplastic; ALS II; Acetohydroxy-acid synthase II; Acetolactate synthase II; EC 2.2.1.6 from Nicotiana tabacum (Common tobacco) (see paper)
33% identity, 93% coverage: 5:555/591 of query aligns to 92:635/664 of P09114
- P191 (= P105) mutation to A: In S4-Hra; highly resistant to sulfonylurea herbicides; when associated with L-568.
- W568 (≠ S482) mutation to L: In S4-Hra; highly resistant to sulfonylurea herbicides; when associated with A-191.
5k3sA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a pyrimidinyl-benzoate herbicide, bispyribac-sodium (see paper)
34% identity, 82% coverage: 5:486/591 of query aligns to 13:493/583 of 5k3sA
- active site: Y33 (≠ V25), G35 (= G27), G36 (≠ A28), A37 (= A29), S38 (≠ I30), E59 (≠ V51), T82 (= T75), F121 (= F114), Q122 (= Q115), E123 (≠ A116), K171 (≠ F164), M266 (≠ L257), V293 (≠ H285), V400 (≠ I393), G426 (= G419), M428 (≠ L421), D453 (= D446), N480 (= N473), H482 (≠ Y475), L483 (= L476), M485 (≠ L478), V486 (≠ I479), W489 (≠ S482)
- binding 2,6-bis[(4,6-dimethoxypyrimidin-2-yl)oxy]benzoic acid: R292 (= R284), M485 (≠ L478), W489 (≠ S482)
- binding flavin-adenine dinucleotide: R161 (= R154), G222 (= G211), G223 (= G212), G224 (= G213), T246 (= T237), L247 (= L238), M248 (= M239), L264 (≠ A255), M266 (≠ L257), G286 (= G278), R288 (= R280), D290 (≠ A282), V293 (≠ H285), D310 (= D302), I311 (= I303), D329 (= D321), V330 (≠ A322), M405 (≠ I398), G423 (= G416)
- binding magnesium ion: D453 (= D446), N480 (= N473), H482 (≠ Y475)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (≠ I393), G401 (= G394), Q402 (≠ L395), H403 (≠ S396), G426 (= G419), M428 (≠ L421), D453 (= D446), G454 (≠ Y447), S455 (≠ D448), N480 (= N473), H482 (≠ Y475), L483 (= L476), G484 (= G477), M485 (≠ L478), V486 (≠ I479)
Sites not aligning to the query:
8et4A Crystal structure of wild-type arabidopsis thaliana acetohydroxyacid synthase in complex with amidosulfuron (see paper)
34% identity, 82% coverage: 5:486/591 of query aligns to 13:493/582 of 8et4A
- binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V400 (≠ I393), G401 (= G394), Q402 (≠ L395), H403 (≠ S396), G426 (= G419), M428 (≠ L421), G452 (= G445), D453 (= D446), G454 (≠ Y447), S455 (≠ D448), M458 (≠ F451), N480 (= N473), H482 (≠ Y475), L483 (= L476), G484 (= G477), M485 (≠ L478), V486 (≠ I479)
- binding flavin-adenine dinucleotide: R161 (= R154), G222 (= G211), G223 (= G212), G224 (= G213), T246 (= T237), L247 (= L238), M248 (= M239), L264 (≠ A255), M266 (≠ L257), H267 (≠ Q258), G286 (= G278), V287 (≠ N279), R288 (= R280), D290 (≠ A282), R292 (= R284), V293 (≠ H285), D310 (= D302), I311 (= I303), D329 (= D321), V330 (≠ A322), M405 (≠ I398), G423 (= G416)
- binding magnesium ion: F370 (≠ R361), D453 (= D446), M458 (≠ F451), Q461 (≠ E454), N480 (= N473), H482 (≠ Y475)
- binding N-{[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]sulfamoyl}-N-methylmethanesulfonamide: M266 (≠ L257), R292 (= R284), M485 (≠ L478), W489 (≠ S482)
Sites not aligning to the query:
5wj1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a triazolopyrimidine herbicide, penoxsulam (see paper)
34% identity, 82% coverage: 5:486/591 of query aligns to 13:493/582 of 5wj1A
- active site: Y33 (≠ V25), G35 (= G27), G36 (≠ A28), A37 (= A29), S38 (≠ I30), E59 (≠ V51), T82 (= T75), F121 (= F114), Q122 (= Q115), E123 (≠ A116), K171 (≠ F164), M266 (≠ L257), V293 (≠ H285), V400 (≠ I393), G426 (= G419), M428 (≠ L421), D453 (= D446), N480 (= N473), H482 (≠ Y475), L483 (= L476), M485 (≠ L478), V486 (≠ I479), W489 (≠ S482)
- binding flavin-adenine dinucleotide: R161 (= R154), G222 (= G211), G223 (= G212), G224 (= G213), T246 (= T237), L247 (= L238), M248 (= M239), M263 (= M254), L264 (≠ A255), G286 (= G278), R288 (= R280), V293 (≠ H285), D310 (= D302), I311 (= I303), D329 (= D321), V330 (≠ A322), M405 (≠ I398), G423 (= G416), G424 (≠ Q417)
- binding magnesium ion: D453 (= D446), N480 (= N473), H482 (≠ Y475)
- binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: M266 (≠ L257), D291 (≠ N283), R292 (= R284), M485 (≠ L478), W489 (≠ S482)
- binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (≠ I393), G401 (= G394), Q402 (≠ L395), H403 (≠ S396), M428 (≠ L421), D453 (= D446), G454 (≠ Y447), S455 (≠ D448), M458 (≠ F451), N480 (= N473), H482 (≠ Y475), L483 (= L476), G484 (= G477), M485 (≠ L478), V486 (≠ I479)
Sites not aligning to the query:
5k6tA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, propoxycarbazone-sodium (see paper)
34% identity, 82% coverage: 5:486/591 of query aligns to 13:493/582 of 5k6tA
- active site: Y33 (≠ V25), G35 (= G27), G36 (≠ A28), A37 (= A29), S38 (≠ I30), E59 (≠ V51), T82 (= T75), F121 (= F114), Q122 (= Q115), E123 (≠ A116), K171 (≠ F164), M266 (≠ L257), V293 (≠ H285), V400 (≠ I393), G426 (= G419), M428 (≠ L421), D453 (= D446), N480 (= N473), H482 (≠ Y475), L483 (= L476), M485 (≠ L478), V486 (≠ I479), W489 (≠ S482)
- binding methyl 2-[(4-methyl-5-oxidanylidene-3-propoxy-1,2,4-triazol-1-yl)carbonylsulfamoyl]benzoate: H267 (≠ Q258), R292 (= R284), M485 (≠ L478), W489 (≠ S482)
- binding flavin-adenine dinucleotide: R161 (= R154), G222 (= G211), G223 (= G212), G224 (= G213), T246 (= T237), L247 (= L238), M248 (= M239), L264 (≠ A255), G286 (= G278), R288 (= R280), D290 (≠ A282), R292 (= R284), V293 (≠ H285), D310 (= D302), I311 (= I303), D329 (= D321), V330 (≠ A322), Q404 (= Q397), M405 (≠ I398), G423 (= G416)
- binding magnesium ion: D453 (= D446), N480 (= N473), H482 (≠ Y475)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V400 (≠ I393), G401 (= G394), Q402 (≠ L395), H403 (≠ S396), G426 (= G419), M428 (≠ L421), G452 (= G445), G454 (≠ Y447), S455 (≠ D448), N480 (= N473), H482 (≠ Y475), L483 (= L476), G484 (= G477)
Sites not aligning to the query:
5k6rA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, thiencarbazone-methyl (see paper)
34% identity, 82% coverage: 5:486/591 of query aligns to 13:493/582 of 5k6rA
- active site: Y33 (≠ V25), G35 (= G27), G36 (≠ A28), A37 (= A29), S38 (≠ I30), E59 (≠ V51), T82 (= T75), F121 (= F114), Q122 (= Q115), E123 (≠ A116), K171 (≠ F164), M266 (≠ L257), V293 (≠ H285), V400 (≠ I393), G426 (= G419), M428 (≠ L421), D453 (= D446), N480 (= N473), H482 (≠ Y475), L483 (= L476), M485 (≠ L478), V486 (≠ I479), W489 (≠ S482)
- binding methyl 4-[(3-methoxy-4-methyl-5-oxidanylidene-1,2,4-triazol-1-yl)carbonylsulfamoyl]-5-methyl-thiophene-3-carboxylate: R292 (= R284), W489 (≠ S482)
- binding flavin-adenine dinucleotide: R161 (= R154), G222 (= G211), G223 (= G212), G224 (= G213), T246 (= T237), L247 (= L238), M248 (= M239), L264 (≠ A255), M266 (≠ L257), G286 (= G278), R288 (= R280), R292 (= R284), V293 (≠ H285), D310 (= D302), I311 (= I303), G328 (≠ S320), D329 (= D321), V330 (≠ A322), M405 (≠ I398), G423 (= G416)
- binding magnesium ion: D453 (= D446), N480 (= N473), H482 (≠ Y475)
- binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V400 (≠ I393), G401 (= G394), Q402 (≠ L395), H403 (≠ S396), G426 (= G419), M428 (≠ L421), D453 (= D446), G454 (≠ Y447), S455 (≠ D448), M458 (≠ F451), N480 (= N473), H482 (≠ Y475), L483 (= L476), G484 (= G477), M485 (≠ L478), V486 (≠ I479)
Sites not aligning to the query:
1z8nA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with an imidazolinone herbicide, imazaquin (see paper)
34% identity, 82% coverage: 5:486/591 of query aligns to 13:493/582 of 1z8nA
- active site: Y33 (≠ V25), G35 (= G27), G36 (≠ A28), A37 (= A29), S38 (≠ I30), E59 (≠ V51), T82 (= T75), F121 (= F114), Q122 (= Q115), E123 (≠ A116), K171 (≠ F164), M266 (≠ L257), V293 (≠ H285), V400 (≠ I393), G426 (= G419), M428 (≠ L421), D453 (= D446), N480 (= N473), H482 (≠ Y475), L483 (= L476), M485 (≠ L478), V486 (≠ I479), W489 (≠ S482)
- binding 2-(4-isopropyl-4-methyl-5-oxo-4,5-dihydro-1h-imidazol-2-yl)quinoline-3-carboxylic acid: K135 (= K128), R161 (= R154), Y191 (= Y184), R194 (vs. gap), D291 (≠ N283), R292 (= R284), D312 (≠ E304), W489 (≠ S482)
- binding flavin-adenine dinucleotide: R161 (= R154), G222 (= G211), G224 (= G213), T246 (= T237), L247 (= L238), M248 (= M239), L264 (≠ A255), G265 (= G256), M266 (≠ L257), H267 (≠ Q258), G286 (= G278), V287 (≠ N279), R288 (= R280), D290 (≠ A282), R292 (= R284), V293 (≠ H285), D310 (= D302), I311 (= I303), D329 (= D321), V330 (≠ A322), M405 (≠ I398), G423 (= G416), G424 (≠ Q417)
- binding magnesium ion: D453 (= D446), N480 (= N473)
- binding thiamine diphosphate: V400 (≠ I393), G401 (= G394), Q402 (≠ L395), H403 (≠ S396), G426 (= G419), M428 (≠ L421), G452 (= G445), G454 (≠ Y447), S455 (≠ D448), N480 (= N473), H482 (≠ Y475), L483 (= L476), G484 (= G477), M485 (≠ L478), V486 (≠ I479)
Sites not aligning to the query:
1yi1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl (see paper)
34% identity, 82% coverage: 5:486/591 of query aligns to 13:493/582 of 1yi1A
- active site: Y33 (≠ V25), G35 (= G27), G36 (≠ A28), A37 (= A29), S38 (≠ I30), E59 (≠ V51), T82 (= T75), F121 (= F114), Q122 (= Q115), E123 (≠ A116), K171 (≠ F164), M266 (≠ L257), V293 (≠ H285), V400 (≠ I393), G426 (= G419), M428 (≠ L421), D453 (= D446), N480 (= N473), H482 (≠ Y475), L483 (= L476), M485 (≠ L478), V486 (≠ I479), W489 (≠ S482)
- binding methyl 2-[4-methoxy-6-methyl-1,3,5-trazin-2-yl(methyl)carbamoylsulfamoyl]benzoate: D291 (≠ N283), R292 (= R284), W489 (≠ S482)
- binding flavin-adenine dinucleotide: R161 (= R154), G223 (= G212), G224 (= G213), T246 (= T237), L247 (= L238), M248 (= M239), M263 (= M254), L264 (≠ A255), G265 (= G256), M266 (≠ L257), H267 (≠ Q258), G286 (= G278), V287 (≠ N279), R288 (= R280), D290 (≠ A282), V293 (≠ H285), D310 (= D302), I311 (= I303), D329 (= D321), V330 (≠ A322), M405 (≠ I398), G423 (= G416), G424 (≠ Q417)
- binding magnesium ion: D453 (= D446), N480 (= N473), H482 (≠ Y475)
Sites not aligning to the query:
1yi0A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl (see paper)
34% identity, 82% coverage: 5:486/591 of query aligns to 13:493/582 of 1yi0A
- active site: Y33 (≠ V25), G35 (= G27), G36 (≠ A28), A37 (= A29), S38 (≠ I30), E59 (≠ V51), T82 (= T75), F121 (= F114), Q122 (= Q115), E123 (≠ A116), K171 (≠ F164), M266 (≠ L257), V293 (≠ H285), V400 (≠ I393), G426 (= G419), M428 (≠ L421), D453 (= D446), N480 (= N473), H482 (≠ Y475), L483 (= L476), M485 (≠ L478), V486 (≠ I479), W489 (≠ S482)
- binding methyl 2-[({[(4,6-dimethylpyrimidin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D291 (≠ N283), R292 (= R284), W489 (≠ S482)
- binding flavin-adenine dinucleotide: R161 (= R154), G222 (= G211), G223 (= G212), G224 (= G213), T246 (= T237), L247 (= L238), M248 (= M239), L264 (≠ A255), G265 (= G256), M266 (≠ L257), H267 (≠ Q258), G286 (= G278), V287 (≠ N279), R288 (= R280), D290 (≠ A282), R292 (= R284), V293 (≠ H285), D310 (= D302), I311 (= I303), G328 (≠ S320), D329 (= D321), V330 (≠ A322), M405 (≠ I398), G423 (= G416), G424 (≠ Q417)
- binding magnesium ion: D453 (= D446), N480 (= N473), H482 (≠ Y475)
Sites not aligning to the query:
1yhzA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron (see paper)
34% identity, 82% coverage: 5:486/591 of query aligns to 13:493/582 of 1yhzA
- active site: Y33 (≠ V25), G35 (= G27), G36 (≠ A28), A37 (= A29), S38 (≠ I30), E59 (≠ V51), T82 (= T75), F121 (= F114), Q122 (= Q115), E123 (≠ A116), K171 (≠ F164), M266 (≠ L257), V293 (≠ H285), V400 (≠ I393), G426 (= G419), M428 (≠ L421), D453 (= D446), N480 (= N473), H482 (≠ Y475), L483 (= L476), M485 (≠ L478), V486 (≠ I479), W489 (≠ S482)
- binding 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-l,3,5-triazin-2-yl)urea: D291 (≠ N283), R292 (= R284), M485 (≠ L478), W489 (≠ S482)
- binding flavin-adenine dinucleotide: R161 (= R154), G223 (= G212), G224 (= G213), T246 (= T237), L247 (= L238), M248 (= M239), L264 (≠ A255), M266 (≠ L257), H267 (≠ Q258), G286 (= G278), V287 (≠ N279), R288 (= R280), D290 (≠ A282), V293 (≠ H285), D310 (= D302), I311 (= I303), D329 (= D321), V330 (≠ A322), Q404 (= Q397), M405 (≠ I398), G423 (= G416), G424 (≠ Q417)
- binding magnesium ion: D453 (= D446), N480 (= N473), H482 (≠ Y475)
Sites not aligning to the query:
1yhyA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl (see paper)
34% identity, 82% coverage: 5:486/591 of query aligns to 13:493/582 of 1yhyA
- active site: Y33 (≠ V25), G35 (= G27), G36 (≠ A28), A37 (= A29), S38 (≠ I30), E59 (≠ V51), T82 (= T75), F121 (= F114), Q122 (= Q115), E123 (≠ A116), K171 (≠ F164), M266 (≠ L257), V293 (≠ H285), V400 (≠ I393), G426 (= G419), M428 (≠ L421), D453 (= D446), N480 (= N473), H482 (≠ Y475), L483 (= L476), M485 (≠ L478), V486 (≠ I479), W489 (≠ S482)
- binding methyl 2-[({[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl}amino)sulfonyl]benzoate: D291 (≠ N283), R292 (= R284), V486 (≠ I479), W489 (≠ S482)
- binding flavin-adenine dinucleotide: R161 (= R154), G222 (= G211), G223 (= G212), G224 (= G213), T246 (= T237), L247 (= L238), M248 (= M239), L264 (≠ A255), G265 (= G256), M266 (≠ L257), H267 (≠ Q258), G286 (= G278), V287 (≠ N279), R288 (= R280), D290 (≠ A282), V293 (≠ H285), D310 (= D302), I311 (= I303), D329 (= D321), V330 (≠ A322), Q404 (= Q397), M405 (≠ I398), G423 (= G416), G424 (≠ Q417)
- binding magnesium ion: D453 (= D446), N480 (= N473), H482 (≠ Y475)
Sites not aligning to the query:
1ybhA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylurea herbicide chlorimuron ethyl (see paper)
34% identity, 82% coverage: 5:486/591 of query aligns to 13:493/582 of 1ybhA
- active site: Y33 (≠ V25), G35 (= G27), G36 (≠ A28), A37 (= A29), S38 (≠ I30), E59 (≠ V51), T82 (= T75), F121 (= F114), Q122 (= Q115), E123 (≠ A116), K171 (≠ F164), M266 (≠ L257), V293 (≠ H285), V400 (≠ I393), G426 (= G419), M428 (≠ L421), D453 (= D446), N480 (= N473), H482 (≠ Y475), L483 (= L476), M485 (≠ L478), V486 (≠ I479), W489 (≠ S482)
- binding 2-[[[[(4-chloro-6-methoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]benzoic acid ethyl ester: M266 (≠ L257), D291 (≠ N283), R292 (= R284), M485 (≠ L478), W489 (≠ S482)
- binding flavin-adenine dinucleotide: R161 (= R154), G223 (= G212), G224 (= G213), T246 (= T237), L247 (= L238), M248 (= M239), L264 (≠ A255), M266 (≠ L257), H267 (≠ Q258), G286 (= G278), V287 (≠ N279), R288 (= R280), D290 (≠ A282), V293 (≠ H285), D310 (= D302), I311 (= I303), D329 (= D321), V330 (≠ A322), Q404 (= Q397), M405 (≠ I398), G423 (= G416), G424 (≠ Q417)
- binding magnesium ion: D453 (= D446), N480 (= N473), H482 (≠ Y475)
Sites not aligning to the query:
3ea4A Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron-ester (see paper)
34% identity, 82% coverage: 5:486/591 of query aligns to 12:492/582 of 3ea4A
- active site: Y32 (≠ V25), G34 (= G27), G35 (≠ A28), A36 (= A29), S37 (≠ I30), E58 (≠ V51), T81 (= T75), F120 (= F114), Q121 (= Q115), E122 (≠ A116), K170 (≠ F164), M265 (≠ L257), V292 (≠ H285), V399 (≠ I393), G425 (= G419), M427 (≠ L421), D452 (= D446), N479 (= N473), H481 (≠ Y475), L482 (= L476), M484 (≠ L478), V485 (≠ I479), W488 (≠ S482)
- binding methyl 2-{[(4-methylpyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: D290 (≠ N283), R291 (= R284), W488 (≠ S482)
- binding flavin-adenine dinucleotide-n5-isobutyl ketone: R160 (= R154), G221 (= G211), G222 (= G212), G223 (= G213), T245 (= T237), L246 (= L238), M247 (= M239), L263 (≠ A255), G264 (= G256), M265 (≠ L257), H266 (≠ Q258), G285 (= G278), R287 (= R280), D289 (≠ A282), R291 (= R284), D309 (= D302), I310 (= I303), G327 (≠ S320), D328 (= D321), V329 (≠ A322), M404 (≠ I398), G422 (= G416)
- binding magnesium ion: D452 (= D446), N479 (= N473), H481 (≠ Y475)
- binding 2-[(2e)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-hydroxyethylidene)-4-methyl-2,3-dihydro-1,3-thiazol-5-yl]ethyltrihydrogen diphosphate: V399 (≠ I393), G400 (= G394), Q401 (≠ L395), H402 (≠ S396), M427 (≠ L421), G451 (= G445), D452 (= D446), G453 (≠ Y447), S454 (≠ D448), N479 (= N473), H481 (≠ Y475), L482 (= L476), G483 (= G477), M484 (≠ L478), V485 (≠ I479)
Sites not aligning to the query:
Query Sequence
>WP_004303778.1 NCBI__GCF_000310185.1:WP_004303778.1
MARMRAVDAAAAVMRKEGVSTVFGVPGAAINPLYSAMKKDGGFRHILGRHVEGASHMAEG
YTRANPGNIGVCIGTSGPAGTDMITGLYSASADSVPILCITGQAPRARLHKEDFQAVDIE
SIAKPVTKWAVTVREPALVPRVFQQAFHLMRSGRPGPVLIDLPFDVQMAEIEFDIDTYES
LGAYKPAATRAQAEKAMAMLNAAERPLIVAGGGVINADAADRLQEFAELVGVPVIPTLMG
WGAIPDDHPLMAGMAGLQTSHRYGNATMLASDFVFGIGNRWANRHTGSVEVYTRGRKFVH
VDIEPTQIGRVFGPDYGIVSDAGAALDRLLEVAHGMKAAGTLPDRGAWVAECQQRKRTLQ
RKTHFDQVPMKPQRVYEEMNLAFGKDACYVSTIGLSQIAAAQFLHVYKPRHWINCGQAGP
LGWTIPAALGVCAADPGRKVVAISGDYDFQFMIEELAVGAQFKLPYLHVLVNNAYLGLIR
QSQRGFDMDFCVQLAFENINAPETEGYGVDHVGVVEGLGCKAIRVRTPEEIQPAFAQAKQ
WMEEFRVPVVVEIILERVTNIAMGTEIDAINEFEELAERGEDAPTAISMLD
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory