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Comparing WP_004511464.1 NCBI__GCF_000012925.1:WP_004511464.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
3osuA Crystal structure of the 3-oxoacyl-acyl carrier protein reductase, fabg, from staphylococcus aureus
59% identity, 98% coverage: 6:246/246 of query aligns to 5:246/246 of 3osuA
3sj7A Structure of beta-ketoacetyl-coa reductase (fabg) from staphylococcus aureus complex with NADPH (see paper)
58% identity, 98% coverage: 6:246/246 of query aligns to 2:239/239 of 3sj7A
- active site: G12 (= G16), S138 (= S141), Q148 (= Q151), Y151 (= Y154), K155 (= K158)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G8 (= G12), S10 (= S14), R11 (= R15), I13 (= I17), N31 (≠ T35), Y32 (vs. gap), A33 (= A36), G34 (≠ T37), S35 (≠ T38), A58 (≠ V61), N59 (≠ D62), V60 (= V63), N86 (= N89), A87 (= A90), T109 (≠ V112), S138 (= S141), Y151 (= Y154), K155 (= K158), P181 (= P184), G182 (= G185)
4jroC Crystal structure of 3-oxoacyl-[acyl-carrier protein]reductase (fabg) from listeria monocytogenes in complex with NADP+
55% identity, 100% coverage: 1:246/246 of query aligns to 1:247/247 of 4jroC
- active site: G16 (= G16), S142 (= S141), Q152 (= Q151), Y155 (= Y154), K159 (= K158)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G12 (= G12), S14 (= S14), R15 (= R15), G16 (= G16), I17 (= I17), N35 (≠ T35), Y36 (≠ A36), N37 (≠ T37), G38 (vs. gap), S39 (≠ T38), N63 (≠ D62), V64 (= V63), N90 (= N89), A91 (= A90), I93 (= I92), I113 (≠ V112), S142 (= S141), Y155 (= Y154), K159 (= K158), P185 (= P184), I188 (= I187), T190 (= T189)
P0AEK2 3-oxoacyl-[acyl-carrier-protein] reductase FabG; 3-ketoacyl-acyl carrier protein reductase; Beta-Ketoacyl-acyl carrier protein reductase; Beta-ketoacyl-ACP reductase; EC 1.1.1.100 from Escherichia coli (strain K12) (see 2 papers)
54% identity, 100% coverage: 1:246/246 of query aligns to 1:243/244 of P0AEK2
- GASR 12:15 (= GASR 12:15) binding NADP(+)
- T37 (= T37) binding NADP(+)
- NV 59:60 (≠ DV 62:63) binding NADP(+)
- N86 (= N89) binding NADP(+)
- Y151 (= Y154) mutation to F: Defect in the affinity for NADPH.
- YAAAK 151:155 (≠ YCASK 154:158) binding NADP(+)
- A154 (≠ S157) mutation to T: Decreases in the thermolability of the reductase; when associated with K-233.
- K155 (= K158) mutation to A: Defect in the affinity for NADPH.
- I184 (= I187) binding NADP(+)
- E233 (≠ H236) mutation to K: Decreases in the thermolability of the reductase; when associated with T-154.
P0A2C9 3-oxoacyl-[acyl-carrier-protein] reductase FabG; 3-ketoacyl-acyl carrier protein reductase; Beta-Ketoacyl-acyl carrier protein reductase; Beta-ketoacyl-ACP reductase; EC 1.1.1.100 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
54% identity, 100% coverage: 1:246/246 of query aligns to 1:243/244 of P0A2C9
- M125 (= M128) mutation to I: Loss of the temperature-sensitive phenotype; when associated with T-223.
- A223 (≠ V226) mutation to T: Loss of the temperature-sensitive phenotype; when associated with I-125.
- S224 (= S227) mutation to F: Distorts the local conformation and prevent stacking around Phe-221. The S224F mutation would additionally disrupt the hydrogen bond formed between Ser-224 and Glu-226.
6t77A Crystal structure of klebsiella pneumoniae fabg(NADPH-dependent) NADP- complex at 1.75 a resolution (see paper)
54% identity, 100% coverage: 1:246/246 of query aligns to 1:243/244 of 6t77A
- active site: G16 (= G16), S138 (= S141), Y151 (= Y154)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G12 (= G12), S14 (= S14), R15 (= R15), T37 (= T37), L58 (≠ V61), N59 (≠ D62), V60 (= V63), A87 (= A90), G88 (= G91), I89 (= I92)
1q7bA The structure of betaketoacyl-[acp] reductase from e. Coli in complex with NADP+ (see paper)
54% identity, 100% coverage: 2:246/246 of query aligns to 1:242/243 of 1q7bA
- active site: G15 (= G16), E101 (≠ D105), S137 (= S141), Q147 (= Q151), Y150 (= Y154), K154 (= K158)
- binding calcium ion: E232 (≠ H236), T233 (≠ V237)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G11 (= G12), S13 (= S14), R14 (= R15), T36 (= T37), N58 (≠ D62), V59 (= V63), N85 (= N89), A86 (= A90), G87 (= G91), I88 (= I92), S137 (= S141), Y150 (= Y154), K154 (= K158), P180 (= P184), G181 (= G185), I183 (= I187)
1q7cA The structure of betaketoacyl-[acp] reductase y151f mutant in complex with NADPH fragment (see paper)
53% identity, 100% coverage: 2:246/246 of query aligns to 1:242/243 of 1q7cA
- active site: G15 (= G16), S137 (= S141), Q147 (= Q151), F150 (≠ Y154), K154 (= K158)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G11 (= G12), S13 (= S14), R14 (= R15), A35 (= A36), T36 (= T37), L57 (≠ V61), N58 (≠ D62), V59 (= V63), G87 (= G91), I88 (= I92)
3op4A Crystal structure of putative 3-ketoacyl-(acyl-carrier-protein) reductase from vibrio cholerae o1 biovar eltor str. N16961 in complex with NADP+ (see paper)
53% identity, 100% coverage: 1:246/246 of query aligns to 4:246/247 of 3op4A
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G15 (= G12), S17 (= S14), R18 (= R15), I20 (= I17), T40 (= T37), N62 (≠ D62), V63 (= V63), N89 (= N89), A90 (= A90), I92 (= I92), V139 (≠ I139), S141 (= S141), Y154 (= Y154), K158 (= K158), P184 (= P184), G185 (= G185), I187 (= I187), T189 (= T189), M191 (= M191)
4i08A Crystal structure of beta-ketoacyl-acyl carrier protein reductase (fabg) from vibrio cholerae in complex with NADPH (see paper)
52% identity, 100% coverage: 1:246/246 of query aligns to 4:242/243 of 4i08A
- active site: G19 (= G16), N113 (= N113), S141 (= S141), Q151 (= Q151), Y154 (= Y154), K158 (= K158)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G15 (= G12), S17 (= S14), R18 (= R15), I20 (= I17), T40 (= T37), N62 (≠ D62), V63 (= V63), N89 (= N89), A90 (= A90), G140 (≠ S140), S141 (= S141), Y154 (= Y154), K158 (= K158), P184 (= P184), G185 (= G185), T189 (= T189)
4ag3A Crystal structure of 3-ketoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with NADPH at 1.8a resolution (see paper)
52% identity, 100% coverage: 1:246/246 of query aligns to 8:253/254 of 4ag3A
- active site: G23 (= G16), S148 (= S141), Y161 (= Y154), K165 (= K158)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G19 (= G12), S21 (= S14), R22 (= R15), G23 (= G16), I24 (= I17), T44 (= T37), L68 (≠ V61), D69 (= D62), V70 (= V63), N96 (= N89), A97 (= A90), I146 (= I139), S148 (= S141), Y161 (= Y154), K165 (= K158), P191 (= P184), G192 (= G185), F193 (= F186), I194 (= I187), T196 (= T189), M198 (= M191), T199 (= T192)
7emgB Carbonyl reductase variant 4 (r123c/l209p/f183y/v61k) from serratia marcescens complexed with NADP+ (see paper)
51% identity, 100% coverage: 2:246/246 of query aligns to 1:242/243 of 7emgB
4dmmB 3-oxoacyl-[acyl-carrier-protein] reductase from synechococcus elongatus pcc 7942 in complex with NADP
55% identity, 100% coverage: 1:246/246 of query aligns to 1:239/240 of 4dmmB
- active site: G16 (= G16), S142 (= S141), Q152 (= Q151), Y155 (= Y154), K159 (= K158)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G12 (= G12), S14 (= S14), R15 (= R15), G16 (= G16), I17 (= I17), A37 (= A36), S38 (≠ T37), S39 (≠ T38), A62 (≠ V61), D63 (= D62), V64 (= V63), N90 (= N89), A91 (= A90), L113 (≠ V112), I140 (= I139), S142 (= S141), Y155 (= Y154), K159 (= K158), P185 (= P184), G186 (= G185), I188 (= I187), T190 (= T189), M192 (= M191)
1edoA The x-ray structure of beta-keto acyl carrier protein reductase from brassica napus complexed with NADP+ (see paper)
50% identity, 97% coverage: 7:244/246 of query aligns to 3:242/244 of 1edoA
- active site: G12 (= G16), S138 (= S141), Y151 (= Y154), K155 (= K158)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G8 (= G12), S10 (= S14), R11 (= R15), I13 (= I17), N31 (≠ T35), Y32 (vs. gap), A33 (= A36), R34 (≠ T37), S35 (≠ T38), D59 (= D62), V60 (= V63), N86 (= N89), A87 (= A90), S138 (= S141), Y151 (= Y154), K155 (= K158), P181 (= P184), G182 (= G185), I184 (= I187), S186 (≠ T189), M188 (= M191)
6wprA Crystal structure of a putative 3-oxoacyl-acp reductase (fabg) with NADP(h) from acinetobacter baumannii (see paper)
50% identity, 100% coverage: 1:246/246 of query aligns to 1:243/244 of 6wprA
- active site: G16 (= G16), S138 (= S141), Y151 (= Y154)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G12 (= G12), S14 (= S14), R15 (= R15), T37 (= T37), L58 (≠ V61), D59 (= D62), V60 (= V63), N86 (= N89), A87 (= A90), G88 (= G91), I89 (= I92), I136 (= I139), Y151 (= Y154), K155 (= K158), P181 (= P184)
6t62A Crystal structure of acinetobacter baumannii fabg in complex with NADPH at 1.8 a resolution (see paper)
50% identity, 100% coverage: 1:246/246 of query aligns to 1:243/244 of 6t62A
- active site: G16 (= G16), S138 (= S141), Y151 (= Y154)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G12 (= G12), S14 (= S14), R15 (= R15), A36 (= A36), T37 (= T37), L58 (≠ V61), D59 (= D62), V60 (= V63), N86 (= N89), A87 (= A90), G88 (= G91), I89 (= I92), I136 (= I139), S137 (= S140), S138 (= S141), Y151 (= Y154), K155 (= K158), P181 (= P184), G182 (= G185), I184 (= I187), M188 (= M191)
4bo4C Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with n-(2-methoxyphenyl)-3,4- dihydro-2h-quinoline-1-carboxamide at 2.7a resolution (see paper)
52% identity, 100% coverage: 1:246/246 of query aligns to 14:254/255 of 4bo4C
P73574 3-oxoacyl-[acyl-carrier-protein] reductase; 3-ketoacyl-acyl carrier protein reductase; EC 1.1.1.100 from Synechocystis sp. (strain PCC 6803 / Kazusa) (see paper)
52% identity, 100% coverage: 2:246/246 of query aligns to 3:246/247 of P73574
- A14 (= A13) mutation to G: 4.2-fold increase in activity on acetoacetyl-CoA.
- P151 (≠ A149) mutation to F: 2.7-fold increase in activity on acetoacetyl-CoA.; mutation to V: 5.7-fold increase in activity on acetoacetyl-CoA.
- K160 (= K158) mutation to A: Almost no activity on acetoacetyl-CoA.
- F188 (= F186) mutation to Y: 3.3-fold increase in activity on acetoacetyl-CoA.
- N198 (≠ S196) mutation to R: 3.5-fold increase in activity on acetoacetyl-CoA.
7tzpG Crystal structure of putataive short-chain dehydrogenase/reductase (fabg) from klebsiella pneumoniae subsp. Pneumoniae ntuh-k2044 in complex with nadh (see paper)
50% identity, 100% coverage: 1:246/246 of query aligns to 4:247/247 of 7tzpG
- binding 1,4-dihydronicotinamide adenine dinucleotide: G15 (= G12), R18 (= R15), G19 (= G16), I20 (= I17), D39 (≠ T37), R40 (≠ T38), C63 (≠ V61), I65 (≠ V63), N91 (= N89), G93 (= G91), I94 (= I92), V114 (= V112), Y155 (= Y154), K159 (= K158), I188 (= I187), T190 (= T189), T193 (= T192)
4bnzA Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with 1-methyl-n-phenylindole- 3-carboxamide at 2.5a resolution (see paper)
50% identity, 100% coverage: 1:246/246 of query aligns to 3:240/241 of 4bnzA
Query Sequence
>WP_004511464.1 NCBI__GCF_000012925.1:WP_004511464.1
MSLEGKVAIVTGASRGIGRAIALKLAREGASVVVTATTLESARKTAAEIEALGHKALSLA
VDVADSSAVEAMFVSAVGAFGKVDILVNNAGITKDGLLLRMKDADWDAVIDVNLKGAFNC
IREAAKLMVKARSGRIVNISSVVGEMGNAGQINYCASKAGMIGLTKSAARELAKRGITVN
AVTPGFIETNMTSVLSDKVREGLLQQIPLERLGTSDDVANAVFFLVSSMGDYITGHVLSV
NGGMYM
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory