SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_004512691.1 NCBI__GCF_000012925.1:WP_004512691.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 14 hits to proteins with known functional sites (download)

3oa4A Crystal structure of hypothetical protein bh1468 from bacillus halodurans c-125
53% identity, 96% coverage: 3:131/134 of query aligns to 3:131/138 of 3oa4A

query
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active site: H7 (= H7), I43 (≠ V43), E54 (= E54), H78 (= H78), E128 (= E128)
binding zinc ion: H7 (= H7), E54 (= E54), H78 (= H78), E128 (= E128)

6wf6A Streptomyces coelicolor methylmalonyl-coa epimerase (see paper)
46% identity, 96% coverage: 2:129/134 of query aligns to 2:135/141 of 6wf6A

query
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active site: H7 (= H7), E43 (≠ V43), Q60 (≠ E54), H84 (= H78), E134 (= E128)
binding cobalt (ii) ion: H7 (= H7), Q60 (≠ E54), H84 (= H78), E134 (= E128)

6wfhA Streptomyces coelicolor methylmalonyl-coa epimerase substrate complex (see paper)
46% identity, 96% coverage: 2:129/134 of query aligns to 2:135/139 of 6wfhA

query
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active site: H7 (= H7), E43 (≠ V43), Q60 (≠ E54), H84 (= H78), E134 (= E128)
binding cobalt (ii) ion: H7 (= H7), Q60 (≠ E54), H84 (= H78), E134 (= E128)
binding (3S,5R,9R,19E)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9,19-tetrahydroxy-8,8,20-trimethyl-10,14-dioxo-2,4,6-trioxa-18-thia-11,15-diaza-3,5-diphosphahenicos-19-en-21-oic acid 3,5-dioxide (non-preferred name): H7 (= H7), Q39 (= Q39), Q60 (≠ E54), A70 (≠ P64), K73 (= K67), W74 (≠ F68), H83 (= H77), H84 (= H78), L107 (≠ I101), G114 (= G108), S115 (≠ A109), F122 (= F116), P125 (= P119), K126 (= K120), L132 (= L126), E134 (= E128)

6xbqA Streptomyces coelicolor methylmalonyl-coa epimerase in complex with carboxy-carba(dethia)-coa
46% identity, 96% coverage: 2:129/134 of query aligns to 2:135/144 of 6xbqA

query
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active site: H7 (= H7), E43 (≠ V43), Q60 (≠ E54), H84 (= H78), E134 (= E128)
binding carboxymethyldethia coenzyme *a: Q39 (= Q39), Q60 (≠ E54), A70 (≠ P64), K73 (= K67), W74 (≠ F68), H83 (= H77), H84 (= H78), L107 (≠ I101), F122 (= F116), P125 (= P119), K126 (= K120), L132 (= L126)
binding cobalt (ii) ion: H7 (= H7), Q60 (≠ E54), H84 (= H78), E134 (= E128)

6wfiA Methylmalonyl-coa epimerase in complex with 2-nitronate-propionyl-coa (see paper)
46% identity, 96% coverage: 2:129/134 of query aligns to 2:135/144 of 6wfiA

query
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active site: H7 (= H7), E43 (≠ V43), Q60 (≠ E54), H84 (= H78), E134 (= E128)
binding cobalt (ii) ion: H7 (= H7), Q60 (≠ E54), H84 (= H78), E134 (= E128)
binding [1-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethylsulfanyl]-1-oxidanylidene-propan-2-ylidene]-bis(oxidanidyl)azanium: H7 (= H7), Q39 (= Q39), Q60 (≠ E54), A70 (≠ P64), K73 (= K67), W74 (≠ F68), H83 (= H77), H84 (= H78), L107 (≠ I101), G114 (= G108), S115 (≠ A109), I120 (= I114), F122 (= F116), P125 (= P119), L132 (= L126), E134 (= E128)

6wf7A Methylmalonyl-coa epimerase in complex with methylmalonyl-coa and nh4+ (see paper)
46% identity, 96% coverage: 2:129/134 of query aligns to 2:135/144 of 6wf7A

query
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active site: H7 (= H7), E43 (≠ V43), Q60 (≠ E54), H84 (= H78), E134 (= E128)
binding (S)-Methylmalonyl-Coenzyme A: Q39 (= Q39), E43 (≠ V43), Q60 (≠ E54), A70 (≠ P64), W74 (≠ F68), H83 (= H77), H84 (= H78), L107 (≠ I101), G114 (= G108), S115 (≠ A109), F122 (= F116), P125 (= P119), K126 (= K120), L132 (= L126), E134 (= E128)
binding methylmalonyl-coenzyme a: Q39 (= Q39), Q60 (≠ E54), A70 (≠ P64), W74 (≠ F68), H83 (= H77), H84 (= H78), L107 (≠ I101), G114 (= G108), S115 (≠ A109), I120 (= I114), F122 (= F116), P125 (= P119), K126 (= K120), L132 (= L126), E134 (= E128)

Q96PE7 Methylmalonyl-CoA epimerase, mitochondrial; DL-methylmalonyl-CoA racemase; EC 5.1.99.1 from Homo sapiens (Human) (see paper)
43% identity, 97% coverage: 2:131/134 of query aligns to 45:175/176 of Q96PE7

query
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H50 (= H7) binding Co(2+)
R104 (≠ D61) to L: in dbSNP:rs6748672
H122 (= H78) binding Co(2+)
E172 (= E128) binding Co(2+)

6xbtA Streptomyces coelicolor methylmalonyl-coa epimerase (q60a) in complex with 2-nitronate-propionyl-coa
46% identity, 96% coverage: 2:129/134 of query aligns to 2:135/140 of 6xbtA

query
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x
A

L

L

L

L

E

E

P

P

T

T

S

R

D

E

D

D

S

S

P
x
A

V

V

A

G

K
|
K

F
x
W

I

L

E

A

K
|
K

N

N

G

G

A

E

G

G

I

V

H
|
H

H
|
H

I

I

A

A

Y

F

E

G

V

T

E

A

D

D

I

V

E

D

A

A

A

D

I

A

A

A

R

D

L

I

V

R

A

D

D

K

G

G

A

V

R

R

M

V

I
x
L

D

Y

S

D

V

E

P

P

R

R

N

R

G
|
G

A
x
S

H

M

G

G

A

S

R

R

I

I

A

T

F
|
F

I

L

H

H

P
|
P

K
|
K

T

D

S

C

R

H

G

G

V

V

L
|
L

T

T

E
|
E

L

L

active site: H7 (= H7), E43 (≠ V43), A60 (≠ E54), H84 (= H78), E134 (= E128)
binding cobalt (ii) ion: H7 (= H7), H84 (= H78), E134 (= E128)
binding coenzyme a: Q39 (= Q39), A70 (≠ P64), K73 (= K67), W74 (≠ F68), K77 (= K71), H83 (= H77), L107 (≠ I101), F122 (= F116), P125 (= P119), K126 (= K120), L132 (= L126)
binding [1-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethylsulfanyl]-1-oxidanylidene-propan-2-ylidene]-bis(oxidanidyl)azanium: H7 (= H7), Q39 (= Q39), A70 (≠ P64), K73 (= K67), W74 (≠ F68), H83 (= H77), H84 (= H78), L107 (≠ I101), G114 (= G108), S115 (≠ A109), P125 (= P119), K126 (= K120), L132 (= L126), E134 (= E128)

6qh4C Crystal structure of human methylmalonyl-coa epimerase (mcee) p.Arg143cys variant
42% identity, 98% coverage: 1:131/134 of query aligns to 8:137/138 of 6qh4C

query
sites
6qh4C

M

M

L

L

T

G

K

R

I

L

N

N

H
|
H

I

V

G

A

I

I

A

A

V

V

Q

P

S

D

L

L

A

E

D

K

A

A

V

A

P

A

F

F

Y

Y

R

K

D

N

N

I

L

L

G

G

M

A

A

Q

F

V

M

S

G

E

T

A

E

V

E

P

V

L

P

P

E

E

Q

H

K

G

V

V

T

S

V
|
V

A

V

F

F

F

V

Q

N

I

L

G

G

E

N

S

T

K

K

I

M

E
|
E

L

L

L

L

E

H

P

P

T

L

S

G

D

L

D

D

S

S

P

P

V

I

A

A

K

G

F

F

I

L

E

Q

K

K

N

N

G

K

A

A

-

G

G

G

I

M

H

H

H
|
H

I

I

A

C

Y

I

E

E

V

V

E

D

D

N

I

I

E

N

A

A

A

A

I

V

A

M

R

D

L

L

V

-

A

-

D

K

G

K

A

K

R

K

M

I

I

C

D

S

S

L

V

S

P

V

R

K

N

I

G

G

A

A

H

H

G

G

A

K

R

P

I

V

A

I

F

F

I

L

H

H

P

P

K

K

T

D

S

C

R

G

G

G

V

V

L

L

T

V

E
|
E

L

L

C

E

Q

Q

active site: H14 (= H7), V50 (= V43), E61 (= E54), H86 (= H78), E134 (= E128)
binding cobalt (ii) ion: H14 (= H7), H86 (= H78), E134 (= E128)

2qh0A Crystal structure of a glyoxalase from clostridium acetobutylicum
33% identity, 72% coverage: 4:100/134 of query aligns to 3:98/129 of 2qh0A

query
sites
2qh0A

K

K

I

V

N

H

H
|
H

I

I

G

G

I

Y

A

A

V

V

Q

K

S

N

L

I

A

D

D

S

A

A

V

L

P

K

F

K

Y

F

R

K

D

R

N

-

L

-

G

-

M

L

A

G

F

Y

M

V

G

E

T

E

E

S

E

E

V

V

P

V

E

R

-

D

-

E

-

V

Q

R

K

K

V

V

T

Y

V

I

A

Q

F

F

F

V

Q

I

I

N

G

G

E

G

S

Y

K

R

I

V

E
|
E

L

L

L

V

E

A

P

P

T

D

S

G

D

E

D

D

S

S

P

P

V

I

A

N

K

K

F

T

I

I

E

K

K

K

N

-

G

G

A

S

G

T

I

P

H

Y

H
|
H

I

I

A

C

Y

Y

E

E

V

V

E

E

D

D

I

I

E

Q

A

K

A

S

I

I

A

E

R

E

L

M

V

S

A

Q

D

I

G

G

A

Y

R

T

M

L

binding zinc ion: H6 (= H7), E53 (= E54), H76 (= H78)

Sites not aligning to the query:

binding zinc ion: 125

3l7tB Crystal structure of smu.1112c
24% identity, 87% coverage: 2:117/134 of query aligns to 2:121/133 of 3l7tB

query
sites
3l7tB

L

L

T

K

K

A

I

V

N

H

H
|
H

I

V

G

A

I

L

A

I

V

V

Q

S

S

D

L

Y

A

D

D

K

A

S

V

Y

P

E

F

F

Y

Y

R

V

D

N

N

Q

L

L

G

G

M

F

A

E

F

V

M

I

G

R

T

E

E

N

E

H

V

R

P

P

E

K

Q

R

K

H

V

D

T

Y

V

K

A

L

F

D

F

L

Q

K

I

C

G

G

E

D

S

I

K

E

I

L

E
|
E

L

I

L

F

E

G

P

N

T

K

S

L

D

T

D

D

S

S

-

N

-

Y

-

C

-

A

-

P

P

P

V

E

A

R

K

I

F

S

I

W

E

P

K

R

N

E

G

A

A

C

G

G

I

L

H

R

H

H

I

L

A

A

Y

F

E

Y

V

V

E

E

D

D

I

V

E

E

A

A

A

S

I

R

A

Q

R

E

L

L

V

I

A

A

D

L

G

G

A

I

R

R

M

-

I

V

D

E

S

E

V

V

P

R

R

Y

N

D

G

D

A

Y

H

T

G

G

A

K

R

K

I

M

A

A

F

F

I

F

binding zinc ion: H7 (= H7), E54 (= E54)

7yvvA Acmp1, r-4-hydroxymandelate synthase
33% identity, 78% coverage: 4:108/134 of query aligns to 7:106/335 of 7yvvA

query
sites
7yvvA

K

E

I

L

N

D

H

Y

I

V

G

R

I

F

A

Y

V

V

Q

G

S

S

L

L

A

D

D

T

A

A

V

-

P

-

F

-

Y

-

R

R

D

D

N

W

L

L

G

V

M

R

A

G

F

Y

M

-

G

G

T

L

E

G

E

E

V

R

P

P

E

-

Q

-

K

W

V

A

T

T

V

V

A

R

F

S

F

T

Q

E

I

I

G

G

E

A

S

N

K

D

I

I

E

R

L

F

L

V

-

F

-

S

E

E

P

P

T

L

S

V

D

D

D

D

S

H

P

P

V

G

A

T

K

A

F

Y

I

V

E

D

K

R

N

H

G

G

A

D

G

G

I

V

H

S

H

D

I

I

A

A

Y

L

E

R

V

V

E

T

D

D

I

A

E

K

A

A

A

A

I

F

A

E

R

E

L

A

V

V

A

A

D

R

G

G

A

A

R

R

M

P

I

V

D

A

S

G

V

P

P

S

R

R

N

A

G

G

Sites not aligning to the query:

binding fe (iii) ion: 149, 229, 308

2r5vA Hydroxymandelate synthase crystal structure (see paper)
30% identity, 83% coverage: 4:114/134 of query aligns to 4:109/346 of 2r5vA

query
sites
2r5vA

K

E

I

I

N

D

H

Y

I

V

G

E

I

M

A

Y

V

V

Q

E

S

N

L

L

A

E

D

V

A

A

V

A

P

F

F

S

Y

W

R

V

D

D

N

K

L

Y

G

A

M

F

A

A

F

V

M

A

G

G

T

T

E

S

E

R

V

S

P

A

E

D

Q

H

K

R

V

-

T

S

V

I

A

A

F

L

F

R

Q

Q

I

-

G

G

E

Q

S

V

K

T

I

L

E

V

L

L

L

T

E

E

P

P

T

T

S

S

D

D

D

R

S

H

P

P

V

A

A

A

K

A

F

Y

I

L

E

Q

K

T

N

H

G

G

A

D

G

G

I

V

H

A

H

D

I

I

A

A

Y

M

E

A

V

T

E

S

D

D

I

V

E

A

A

A

A

A

I

Y

A

E

R

A

L

A

V

V

A

R

D

A

G

G

A

A

R

-

M

-

I

-

D

E

S

A

V

V

P

R

R

A

N

P

G

G

A

Q

H

H

G

S

A

A

R

A

I

V

Sites not aligning to the query:

binding cobalt (ii) ion: 159, 239, 318
binding (2S)-hydroxy(4-hydroxyphenyl)ethanoic acid: 159, 186, 199, 201, 212, 239, 303, 318, 328, 333

O52791 4-hydroxymandelate synthase; HMS; HmaS; 4-hydroxyphenylpyruvate dioxygenase II; EC 1.13.11.46 from Amycolatopsis orientalis (Nocardia orientalis) (see paper)
30% identity, 73% coverage: 4:101/134 of query aligns to 5:100/357 of O52791

query
sites
O52791

K

E

I

I

N

D

H

Y

I

V

G

E

I

M

A

Y

V

V

Q

E

S

N

L

L

A

E

D

V

A

A

V

A

P

F

F

S

Y

W

R

V

D

D

N

K

L

Y

G

A

M

F

A

A

F

V

M

A

G

G

T

T

E

S

E

R

V

S

P

A

E

D

Q

H

K

R

V

-

T

S

V

I

A

A

F

L

F

R

Q

Q

I

-

G

G

E

Q

S

V

K

T

I

L

E

V

L

L

L

T

E

E

P

P

T

T

S

S

D

D

D

R

S

H

P

P

V

A

A

A

K

A

F

Y

I

L

E

Q

K

T

N

H

G

G

A

D

G

G

I

V

H

A

H

D

I

I

A

A

Y

M

E

A

V

T

E

S

D

D

I

V

E

A

A

A

A

A

I

Y

A

E

R

A

L

A

V

V

A

R

D

A

G

G

A

A

R

E

M

A

I

V

Sites not aligning to the query:

201 binding substrate
214 binding substrate
241 binding substrate
305 binding substrate

Query Sequence

>WP_004512691.1 NCBI__GCF_000012925.1:WP_004512691.1
MLTKINHIGIAVQSLADAVPFYRDNLGMAFMGTEEVPEQKVTVAFFQIGESKIELLEPTS
DDSPVAKFIEKNGAGIHHIAYEVEDIEAAIARLVADGARMIDSVPRNGAHGARIAFIHPK
TSRGVLTELCQMGH

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory