SitesBLAST
Comparing WP_004514590.1 NCBI__GCF_000012925.1:WP_004514590.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
3sf6A Crystal structure of glutaryl-coa dehydrogenase from mycobacterium smegmatis (see paper)
57% identity, 98% coverage: 9:392/392 of query aligns to 6:387/387 of 3sf6A
- active site: L134 (= L137), T135 (= T138), A245 (= A250), E366 (= E371), Q378 (≠ E383)
- binding dihydroflavine-adenine dinucleotide: F132 (= F135), L134 (= L137), T135 (= T138), G140 (= G143), S141 (= S144), W165 (= W169), I166 (= I170), T167 (= T171), S361 (≠ A366), T364 (= T369), Y365 (= Y370), T368 (= T373), E370 (≠ D375), M371 (= M376)
3swoA Crystal structure of a glutaryl-coa dehydrogenase from mycobacterium smegmatis in complex with fadh2 (see paper)
56% identity, 96% coverage: 16:392/392 of query aligns to 15:388/388 of 3swoA
- active site: L135 (= L137), T136 (= T138), A246 (= A250), E367 (= E371), K379 (≠ E383)
- binding dihydroflavine-adenine dinucleotide: F133 (= F135), L135 (= L137), T136 (= T138), G141 (= G143), S142 (= S144), W166 (= W169), I167 (= I170), T168 (= T171), R272 (= R276), V274 (≠ Q278), F275 (= F279), L279 (≠ I283), Y282 (= Y286), T340 (= T344), L341 (≠ I345), G344 (≠ A348), I347 (= I351), T365 (= T369), Y366 (= Y370), T369 (= T373), E371 (≠ D375), M372 (= M376)
2ebaA Crystal structure of the putative glutaryl-coa dehydrogenase from thermus thermophilus
58% identity, 98% coverage: 7:391/392 of query aligns to 1:380/380 of 2ebaA
- active site: L131 (= L137), T132 (= T138), A239 (= A250), E360 (= E371), R372 (≠ E383)
- binding flavin-adenine dinucleotide: L131 (= L137), T132 (= T138), G136 (≠ F142), G137 (= G143), S138 (= S144), W161 (= W169), T163 (= T171), R265 (= R276), L272 (≠ I283), K275 (≠ Y286), D333 (≠ T344), I334 (= I345), G337 (≠ A348), T355 (≠ A366), T358 (= T369), Y359 (= Y370), T362 (= T373)
2r0nA The effect of a glu370asp mutation in glutaryl-coa dehydrogenase on proton transfer to the dienolate intermediate (see paper)
55% identity, 96% coverage: 17:391/392 of query aligns to 14:388/390 of 2r0nA
- active site: L133 (= L137), T134 (= T138), A247 (= A250), E368 (= E371), R380 (≠ E383)
- binding flavin-adenine dinucleotide: F131 (= F135), L133 (= L137), T134 (= T138), G139 (= G143), S140 (= S144), W166 (= W169), I167 (= I170), T168 (= T171), Y367 (= Y370), T370 (= T373), D372 (= D375)
- binding 3-thiaglutaryl-CoA: R92 (= R96), S93 (= S97), V97 (= V101), P142 (= P146), G238 (≠ K241), F241 (≠ L244), L244 (= L247), N245 (≠ T248), P318 (= P321), Y367 (= Y370), E368 (= E371), I377 (= I380)
1sirA The crystal structure and mechanism of human glutaryl-coa dehydrogenase (see paper)
55% identity, 96% coverage: 17:391/392 of query aligns to 14:388/390 of 1sirA
- active site: L133 (= L137), T134 (= T138), A247 (= A250), E368 (= E371), R380 (≠ E383)
- binding flavin-adenine dinucleotide: F131 (= F135), L133 (= L137), T134 (= T138), G139 (= G143), S140 (= S144), W166 (= W169), I167 (= I170), T168 (= T171), Y367 (= Y370), T370 (= T373)
- binding s-4-nitrobutyryl-coa: S93 (= S97), S140 (= S144), F241 (≠ L244), G242 (= G245), L244 (= L247), N245 (≠ T248), R248 (= R251), P318 (= P321), Y367 (= Y370), E368 (= E371), R380 (≠ E383)
2r0mA The effect of a glu370asp mutation in glutaryl-coa dehydrogenase on proton transfer to the dienolate intermediate (see paper)
55% identity, 96% coverage: 17:391/392 of query aligns to 14:388/390 of 2r0mA
- active site: L133 (= L137), T134 (= T138), A247 (= A250), D368 (≠ E371), R380 (≠ E383)
- binding 4-nitrobutanoic acid: L101 (= L105), Y367 (= Y370), D368 (≠ E371)
- binding flavin-adenine dinucleotide: F131 (= F135), L133 (= L137), T134 (= T138), G139 (= G143), S140 (= S144), W166 (= W169), I167 (= I170), T168 (= T171), L210 (= L212), Y367 (= Y370), T370 (= T373)
3gqtC Crystal structure of glutaryl-coa dehydrogenase from burkholderia pseudomallei with fragment (1,4-dimethyl-1,2,3,4- tetrahydroquinoxalin-6-yl)methylamine (see paper)
52% identity, 96% coverage: 17:391/392 of query aligns to 15:385/385 of 3gqtC
- active site: L135 (= L137), T136 (= T138), A250 (= A250), E365 (= E371), R377 (≠ E383)
- binding 1-(1,4-dimethyl-1,2,3,4-tetrahydroquinoxalin-6-yl)methanamine: W166 (= W169), K210 (= K209), L213 (= L212), T218 (= T217), Y364 (= Y370)
3eonC 2.55a crystal structure of native glutaryl-coa dehydrogenase from burkholderia pseudomallei in complex with a small molecule (see paper)
51% identity, 95% coverage: 17:390/392 of query aligns to 15:382/382 of 3eonC
3gncA Crystal structure of glutaryl-coa dehydrogenase from burkholderia pseudomallei with fragment 6421 (see paper)
52% identity, 95% coverage: 17:390/392 of query aligns to 16:380/380 of 3gncA
3d6bC 2.2 a crystal structure of glutaryl-coa dehydrogenase from burkholderia pseudomallei (see paper)
51% identity, 95% coverage: 17:390/392 of query aligns to 15:377/377 of 3d6bC
2ix6A Short chain specific acyl-coa oxidase from arabidopsis thaliana, acx4 (see paper)
36% identity, 98% coverage: 8:392/392 of query aligns to 30:413/416 of 2ix6A
- active site: L158 (= L137), T159 (= T138), S271 (≠ A250), E392 (= E371), R404 (≠ E383)
- binding flavin-adenine dinucleotide: T159 (= T138), G164 (= G143), S165 (= S144), W189 (= W169), N239 (≠ T217), R297 (= R276), F300 (= F279), L304 (≠ I283), F307 (≠ Y286), N310 (≠ Q289), E365 (≠ T344), L366 (≠ I345), G369 (≠ A348), I372 (= I351), Y391 (= Y370), T394 (= T373), D396 (= D375)
2ix5A Short chain specific acyl-coa oxidase from arabidopsis thaliana, acx4 in complex with acetoacetyl-coa (see paper)
36% identity, 98% coverage: 8:392/392 of query aligns to 30:413/415 of 2ix5A
- active site: L158 (= L137), T159 (= T138), S271 (≠ A250), E392 (= E371), R404 (≠ E383)
- binding acetoacetyl-coenzyme a: S165 (= S144), A167 (≠ P146), S168 (≠ A147), F261 (≠ L240), L268 (= L247), R272 (= R251), E392 (= E371), G393 (= G372), R404 (≠ E383)
- binding flavin-adenine dinucleotide: L158 (= L137), T159 (= T138), G164 (= G143), S165 (= S144), W189 (= W169), N239 (≠ T217), R297 (= R276), F300 (= F279), L304 (≠ I283), F307 (≠ Y286), L309 (= L288), N310 (≠ Q289), E365 (≠ T344), L366 (≠ I345), G368 (= G347), G369 (≠ A348), Y391 (= Y370), T394 (= T373), D396 (= D375), I397 (≠ M376)
Q96329 Acyl-coenzyme A oxidase 4, peroxisomal; AOX 4; G6p; Short-chain acyl-CoA oxidase; AtCX4; AtG6; SAOX; EC 1.3.3.6 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
36% identity, 98% coverage: 8:392/392 of query aligns to 46:429/436 of Q96329
4n5fA Crystal structure of a putative acyl-coa dehydrogenase with bound fadh2 from burkholderia cenocepacia j2315
36% identity, 94% coverage: 16:385/392 of query aligns to 5:378/378 of 4n5fA
- active site: L126 (= L137), T127 (= T138), G243 (≠ A250), E364 (= E371), R376 (≠ E383)
- binding dihydroflavine-adenine dinucleotide: L126 (= L137), T127 (= T138), G132 (= G143), S133 (= S144), F157 (≠ W169), T159 (= T171), T210 (= T217), Y363 (= Y370), T366 (= T373), E368 (≠ D375), M372 (≠ L379)
4l1fA Electron transferring flavoprotein of acidaminococcus fermentans: towards a mechanism of flavin-based electron bifurcation (see paper)
36% identity, 93% coverage: 17:380/392 of query aligns to 5:372/380 of 4l1fA
- active site: L125 (= L137), T126 (= T138), G242 (≠ A250), E363 (= E371)
- binding coenzyme a persulfide: T132 (≠ S144), H179 (vs. gap), F232 (≠ L240), M236 (≠ L244), E237 (≠ G245), L239 (= L247), D240 (≠ T248), R243 (= R251), Y362 (= Y370), E363 (= E371), G364 (= G372)
- binding flavin-adenine dinucleotide: F123 (= F135), L125 (= L137), T126 (= T138), G131 (= G143), T132 (≠ S144), F156 (≠ W169), I157 (= I170), T158 (= T171), R268 (= R276), Q270 (= Q278), F271 (= F279), I275 (= I283), F278 (≠ Y286), L281 (≠ Q289), Q336 (≠ T344), I337 (= I345), G340 (≠ A348), I358 (≠ A366), Y362 (= Y370), T365 (= T373), Q367 (≠ D375)
- binding 1,3-propandiol: L5 (= L17), Q10 (≠ K22)
Sites not aligning to the query:
5lnxD Crystal structure of mmgc, an acyl-coa dehydrogenase from bacillus subtilis.
37% identity, 94% coverage: 20:387/392 of query aligns to 5:374/374 of 5lnxD
- active site: L122 (= L137), T123 (= T138), G239 (≠ A250), E358 (= E371), K370 (≠ E383)
- binding flavin-adenine dinucleotide: L122 (= L137), T123 (= T138), G128 (= G143), S129 (= S144), F153 (≠ W169), T155 (= T171), R265 (= R276), Q267 (= Q278), F268 (= F279), I272 (= I283), N275 (≠ Y286), I278 (≠ Q289), Q331 (≠ T344), I332 (= I345), G335 (≠ A348), Y357 (= Y370), T360 (= T373), E362 (≠ D375)
1jqiA Crystal structure of rat short chain acyl-coa dehydrogenase complexed with acetoacetyl-coa (see paper)
36% identity, 93% coverage: 17:382/392 of query aligns to 7:376/384 of 1jqiA
- binding acetoacetyl-coenzyme a: L95 (= L105), F125 (= F135), S134 (= S144), F234 (≠ L240), M238 (≠ L244), Q239 (≠ G245), L241 (= L247), D242 (≠ T248), R245 (= R251), Y364 (= Y370), E365 (= E371), G366 (= G372)
- binding flavin-adenine dinucleotide: F125 (= F135), L127 (= L137), S128 (≠ T138), G133 (= G143), S134 (= S144), W158 (= W169), T160 (= T171), R270 (= R276), F273 (= F279), L280 (≠ Y286), Q338 (≠ T344), I339 (= I345), G342 (≠ A348), I360 (≠ A366), T367 (= T373), E369 (≠ D375), I370 (≠ M376)
Sites not aligning to the query:
P15651 Short-chain specific acyl-CoA dehydrogenase, mitochondrial; SCAD; Butyryl-CoA dehydrogenase; EC 1.3.8.1 from Rattus norvegicus (Rat) (see 2 papers)
36% identity, 93% coverage: 17:382/392 of query aligns to 34:403/412 of P15651
- 152:161 (vs. 135:144, 60% identical) binding FAD
- S161 (= S144) binding substrate
- WIT 185:187 (= WIT 169:171) binding FAD
- DMGR 269:272 (≠ TQAR 248:251) binding substrate
- R297 (= R276) binding FAD
- QILGG 365:369 (≠ TILGA 344:348) binding FAD
- E392 (= E371) active site, Proton acceptor
- TSE 394:396 (≠ THD 373:375) binding FAD
Sites not aligning to the query:
- 1:24 modified: transit peptide, Mitochondrion
7y0aC Crystal structure of human short-chain acyl-coa dehydrogenase
35% identity, 93% coverage: 17:381/392 of query aligns to 10:378/387 of 7y0aC
- binding flavin-adenine dinucleotide: F128 (= F135), L130 (= L137), S131 (≠ T138), G136 (= G143), S137 (= S144), W161 (= W169), T163 (= T171), T214 (= T217), R273 (= R276), F276 (= F279), L280 (≠ I283), L283 (≠ Y286), V285 (≠ L288), Q341 (≠ T344), I342 (= I345), G345 (≠ A348), I363 (≠ A366), Y367 (= Y370), T370 (= T373), E372 (≠ D375), L376 (= L379)
8sgsA Human liver mitochondrial short-chain specific acyl-coa dehydrogenase (see paper)
35% identity, 93% coverage: 17:381/392 of query aligns to 4:372/381 of 8sgsA
- binding coenzyme a: S131 (= S144), A133 (= A147), N177 (vs. gap), F231 (≠ L240), M235 (≠ L244), L238 (= L247), I312 (≠ P321), E362 (= E371), G363 (= G372)
- binding flavin-adenine dinucleotide: F122 (= F135), L124 (= L137), S125 (≠ T138), G130 (= G143), S131 (= S144), W155 (= W169), T157 (= T171), R267 (= R276), F270 (= F279), L274 (≠ I283), L277 (≠ Y286), Q335 (≠ T344), I336 (= I345), G338 (= G347), G339 (≠ A348), I357 (≠ A366), I360 (≠ T369), Y361 (= Y370), T364 (= T373), E366 (≠ D375)
Query Sequence
>WP_004514590.1 NCBI__GCF_000012925.1:WP_004514590.1
MSVTTELTDYMGFQGLLTDEEKLVRETARKFVNDEVLPIIEEHALNETFPSHLIPKMGEL
GFYGPNLPEKYGCAGLSNVAYGLLMYELERGDSGLRSFASVQGSLVMYPIYAYGSEAQKE
YWLPKLAAGEKIGCFGLTEPDFGSNPAGMRTNAVREANGKWRINGSKMWITNGSVADVAV
VWARTDDGVRGFLVEKGTPGFSAPKMHGKWSLRASVTSELVFEDVIVDEEKSLLPNVKGL
KGPLGCLTQARYGIAWGALGAADACYQAALEYALSRIQFDKPIASYQLQQRKLAEMVTEI
TKGQLLVMQLGRLKDQGNYSPAQVSMAKMNNVHVAINICRTARTILGANGIMSEYPIMRH
ANNLEAVYTYEGTHDMHLLIIGEKVTGISAFR
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory