SitesBLAST

P07464 Galactoside O-acetyltransferase; GAT; Acetyl-CoA:galactoside 6-O-acetyltransferase; Thiogalactoside acetyltransferase; Thiogalactoside transacetylase; EC 2.3.1.18 from Escherichia coli (strain K12) (see 3 papers)
37% identity, 82% coverage: 28:188/196 of query aligns to 24:186/203 of P07464

query
sites
P07464

E

E

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N

N

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N

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N

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x
D

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D

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N

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L

L

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N

N

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H

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N

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N

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S

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N

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K

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N

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N

S71 (≠ D75) binding substrate
N85 (= N89) binding in other chain; binding in other chain
D93 (≠ Q97) binding substrate
H115 (= H119) mutation to A: Results in an 1800-fold decrease in catalytic activity.
S142 (≠ A144) binding in other chain
A160 (= A162) binding in other chain
TK 165:166 (= TK 167:168) binding acetyl-CoA
R180 (≠ K182) binding acetyl-CoA
R183 (= R185) binding in other chain

Sites not aligning to the query:

1 modified: Initiator methionine, Removed; Partial
17 binding substrate

1krvA Galactoside acetyltransferase in complex with coa and pnp-beta-gal (see paper)
37% identity, 82% coverage: 28:188/196 of query aligns to 23:185/201 of 1krvA

query
sites
1krvA

E

E

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N

N

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A

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N

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A

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N

binding 4-nitrophenyl beta-D-galactopyranoside: R25 (≠ S30), S70 (≠ D75), Y82 (≠ F87), N84 (= N89), V90 (≠ Q95), D92 (≠ Q97), M126 (= M129)
binding coenzyme a: A104 (≠ G109), S110 (≠ A115), T112 (≠ I117), W138 (= W141), G140 (= G143), S141 (≠ A144), N146 (≠ L149), A159 (= A162), P177 (= P180), R179 (≠ K182), R182 (= R185)

Sites not aligning to the query:

binding 4-nitrophenyl beta-D-galactopyranoside: 16

1kruA Galactoside acetyltransferase in complex with iptg and coenzyme a (see paper)
37% identity, 82% coverage: 28:188/196 of query aligns to 23:185/201 of 1kruA

query
sites
1kruA

E

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binding coenzyme a: H114 (= H119), W138 (= W141), G140 (= G143), S141 (≠ A144), G158 (≠ A161), A159 (= A162), P177 (= P180), R182 (= R185)
binding 1-methylethyl 1-thio-beta-D-galactopyranoside: R25 (≠ S30), W62 (≠ G67), S70 (≠ D75), Y82 (≠ F87), Y82 (≠ F87), N84 (= N89), V90 (≠ Q95), D92 (≠ Q97), L102 (= L107), H114 (= H119), M126 (= M129)

Sites not aligning to the query:

binding 1-methylethyl 1-thio-beta-D-galactopyranoside: 16, 22

1krrA Galactoside acetyltransferase in complex with acetyl-coenzyme a (see paper)
37% identity, 82% coverage: 28:188/196 of query aligns to 23:185/200 of 1krrA

query
sites
1krrA

E

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binding acetyl coenzyme *a: N84 (= N89), I103 (= I108), A104 (≠ G109), P105 (≠ H110), T112 (≠ I117), H114 (= H119), G140 (= G143), S141 (≠ A144), N146 (≠ L149), G158 (≠ A161), A159 (= A162), A174 (= A177), P177 (= P180), R182 (= R185)

3nz2C Crystal structure of hexapeptide-repeat containing-acetyltransferase vca0836 complexed with acetyl co enzyme a from vibrio cholerae o1 biovar eltor
37% identity, 93% coverage: 7:188/196 of query aligns to 4:182/183 of 3nz2C

query
sites
3nz2C

L

L

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L

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N

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N

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A

G

N

N

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I

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x
N

A

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D

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x
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K

binding acetyl coenzyme *a: Y107 (≠ A115), H111 (= H119), G137 (= G143), A155 (= A161), A156 (= A162), N161 (≠ T167), G171 (≠ A177), T173 (≠ V179), P174 (= P180), L178 (≠ I184), R179 (= R185)
binding magnesium ion: N157 (≠ G163), T173 (≠ V179)

3nz2J Crystal structure of hexapeptide-repeat containing-acetyltransferase vca0836 complexed with acetyl co enzyme a from vibrio cholerae o1 biovar eltor
37% identity, 93% coverage: 7:188/196 of query aligns to 7:185/185 of 3nz2J

query
sites
3nz2J

L

L

S

E

N

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M

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Y

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D

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G

G

A

S

S

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A

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L

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M

I

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E

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A

L

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A

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M

L

E

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L

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N

N

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N

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Y

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W

L

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G

A

G

N

N

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I

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A
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A

G

N

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N

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D

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R

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L

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K

binding acetyl coenzyme *a: G104 (= G109), Y110 (≠ A115), H114 (= H119), W138 (= W141), G140 (= G143), A158 (= A161), A159 (= A162), N164 (≠ T167), G174 (≠ A177), T176 (≠ V179), P177 (= P180), R182 (= R185)

3igjC Crystal structure of maltose o-acetyltransferase complexed with acetyl coenzyme a from bacillus anthracis
36% identity, 90% coverage: 14:189/196 of query aligns to 15:188/188 of 3igjC

query
sites
3igjC

Y

Y

I

I

V

A

D

D

G

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S

-

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D

E

E

H

E

L

L

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Q

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R

E

A

A

L

K

K

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T

M

R

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L

L

Y

N

N

N

E

K

A

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V

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E

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T

K

G

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R

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L

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G

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F

N

P

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P

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F

F

Y

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D

C

Y

G

G

R

Y

N

N

I

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H

I

V

G

G

K

K

N

S

V

F

F
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F

I

A

N

N

A

F

G

N

C

C

K

V

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L

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D

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V

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C

G

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Y

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V

C

L

M

I

F

G
x
A

H

P

N

G

A

V

V

H

L

I

A
x
Y

T

T

I
x
A

N

T

H
|
H

M

P

E

L

D

H

P

P

-

V

E

E

K

R

R

N

A

S

G

G

M

K

I

E

F

Y

-

G

Q

K

P

P

I

V

H

K

I

I

E

G

K

N

V

V

W

W

L

V

G
|
G

A

G

N

G

V

A

T

I

V

I

L
x
N

P

P

G

G

V

V

T

S

I

I

G

G

E

D

G

N

S

A

V

V

I

I

A
|
A

A
x
S

G

G

A

A

V

V

T
|
T

K

K

D

D

V

V

P

P

A

N

N

N

I

V

A

V

A

G

G

G

V
x
N

P

P

A

A

K

K

V

V

I

I

R

K

K

T

V

I

K

E

binding acetyl coenzyme *a: F84 (= F87), A106 (≠ G109), Y112 (≠ A115), A114 (≠ I117), H116 (= H119), G142 (= G143), N148 (≠ L149), A160 (= A161), S161 (≠ A162), T166 (= T167), N178 (≠ V179)

4isxA The crystal structure of maltose o-acetyltransferase from clostridium difficile 630 in complex with acetyl-coa
35% identity, 87% coverage: 20:189/196 of query aligns to 16:186/186 of 4isxA

query
sites
4isxA

S

A

E

N

E

D

H

E

L

L

V

L

M

V

H

K

E

E

L

-

S

R

Q

E

R

Y

A

C

L

K

K

K

I

L

T

T

M

R

E

L

L

F

N

N

-

T

-

L

-

E

-

D

K

E

Y

Y

H

E

T

K

K

R

E

E

E

D

I

I

I

L

Q

R

L

Q

M

L

S

F

E

G

L

S

T

V

G

G

Q

K

K

Q

I

I

D

N

E

V

S

E

F

Q

G

N

M

I

F

-

P

-

F

-

Y

R

T

C

D

D

C

Y

G

G

R

Y

N

N

I

I

H

H

I

V

G

G

K

E

N

N

V

F

F

F

I

A

N
|
N

A

Y

G

D

C

C

K

I

F

F

Q

L

D

D

Q

V

G

C

G

K

I

I

Y

E

I

I

E

G

D

D

G

N

V

V

L

M

I

L

G
x
A

H

P

N

N

A

V

V

Q

L

I

A

Y

T

T

I

A

N

Y

H

H

M

P

E

I

D

D

P

A

E

Q

K

L

R

R

-

N

A

S

G

G

M

I

I

E

F

Y

-

G

Q

S

P

P

I

V

H

K

I

I

E

G

K

D

K

N

V

V

W
|
W

L

I

G
|
G

A
x
G

N

G

V

V

T

I

V

I

L

T

P

P

G

G

V

I

T

T

I

I

G

G

E

D

G

N

S

V

V

V

I

I

A

G

A
|
A

G

G

A

S

V

V

T

T

K

K

D

D

V

I

P

P

A

P

N

N

I

T

I

V

A

A

A
x
V

G

G

V

N

P

P

A

C

K

R

V

V

I

I

R
x
K

K

K

V

I

K

E

binding acetyl coenzyme *a: N84 (= N89), A104 (≠ G109), W138 (= W141), G140 (= G143), G141 (≠ A144), A159 (= A162), V174 (≠ A177), K182 (≠ R185)

3ectA Crystal structure of the hexapeptide-repeat containing- acetyltransferase vca0836 from vibrio cholerae
38% identity, 82% coverage: 29:188/196 of query aligns to 16:175/176 of 3ectA

query
sites
3ectA

L

L

S

R

Q

S

R

Q

A

A

L

G

K

R

I

L

T

K

M

L

E

E

L

I

N

N

N

Q

K

S

Y

L

H

D

T

E

K

A

E

E

E

R

I

Y

I

-

Q

A

L

L

M

Q

S

R

E

E

L

L

T

F

G

G

Q

H

K

L

I

G

D

H

E

K

S

S

F

C

G

-

M

V

F

Q

P

P

F

F

Y

H

T

C

D

E

C

F

G

G

R

K

N

T

I

I

H

R

I

I

G

G

K

D

N

H

V

T

F

F

I

I

N

N

A

M

G

N

C

V

K

V

F

M

Q

L

D

D

Q

G

G

A

G

P

I

I

Y

T

I

I

E

G

D

D

G

H

V

V

L

L

I

I

G

G

H

P

N

S

A

T

V

Q

L

F

A

Y

T

T

I

A

N

S

H

H

M

S

E

L

D

D

P

Y

E

R

K

R

R

R

A

Q

G

A

M

W

-

E

-

T

I

I

F

C

Q

K

P

P

I

I

H

V

I

I

E

E

K

D

V

V

W

W

L

I

G

G

A

G

N

N

V

V

T

V

V

I

L

N

P

Q

G
|
G

V

V

T

T

I

I

G

G

E

A

G

R

S

S

V

V

I

V

A

A

G

N

A

S

V

V

T

N

K

Q

D
|
D

V

V

P

P

A

P

N

D

I

T

I

L

A

V

A

G

G

G

V

T

P

P

A

A

K

R

V

I

I

L

R

R

K

S

V

L

K

K

binding calcium ion: G138 (= G151), D156 (= D169)

4mzuF Crystal structure of fdtd, a bifunctional ketoisomerase/n- acetyltransferase from shewanella denitrificans (see paper)
40% identity, 52% coverage: 82:183/196 of query aligns to 49:140/294 of 4mzuF

query
sites
4mzuF

I

I

G

G

K

D

N

N

V

V

F

T

I

I

N

K

A

S

G

G

C

V

K

Q

F

I

Q

W

D

D

Q

-

G

-

G

G

I

I

Y

H

I

I

E

Q

D

D

G

D

V

V

L

F

I

I

G

G

H

P

N

N

A

V

V

-

L

-

A

-

T

T

I

F

N

T

H
x
N

M
x
D

E
x
K

D

Q

P

P

E

R

K

S

R

K

A

I

G

K

M

T

I

I

F

-

Q

-

P

-

I

-

H

-

I

V

E

K

K

K

K

G

V

A

W

S

L

I

G
|
G

A
|
A

N

N

V

S

T

T

V

I

L
|
L

P

P

G

G

V

I

T

L

I

I

G

G

E

E

G

N

S

A

V

M

I

V

A
x
G

A
|
A

G

G

A

A

V

V

V

I

T
|
T

K
|
K

D

N

V

V

P

P

A

D

N

N

I

A

I

I

A

V

A
x
I

G

G

V
x
N

P

P

A

G

K
x
R

V

I

binding coenzyme a: N81 (≠ H119), D82 (≠ M120), K83 (≠ E121), G100 (= G143), A101 (= A144), L106 (= L149), G118 (≠ A161), A119 (= A162), T124 (= T167), K125 (= K168), I134 (≠ A177), N136 (≠ V179), R139 (≠ K182)

Sites not aligning to the query:

binding thymine: 20, 21, 38
binding thymidine-5'-diphosphate: 189, 203, 205, 270

4mzuB Crystal structure of fdtd, a bifunctional ketoisomerase/n- acetyltransferase from shewanella denitrificans (see paper)
38% identity, 58% coverage: 79:192/196 of query aligns to 46:148/290 of 4mzuB

query
sites
4mzuB

N

D

I

V

H

V

I

I

G

G

K

D

N

N

V

V

F

T

I

I

N

K

A

S

G
|
G

C

V

K

Q

F

I

Q

W

D

D

Q

-

G

-

G

G

I

I

Y

H

I

I

E

Q

D

D

G

D

V

V

L
x
F

I

I

G

G

H

P

N
|
N

A

V

V

T

L

F

A
x
T

T
x
N

I

-

N

-

H

-

M

-

E

-

D
|
D

P
x
K

E

Q

K
x
P

R

R

A

S

G

-

M

-

I

-

F

L

Q

K

P

T

I

I

H

-

I

V

E

K

K

K

K

G

V

A

W

S

L

I

G
|
G

A
|
A

N

N

V

S

T

T

V

I

L

L

P

P

G

G

V

I

T

L

I

I

G

G

E

E

G

N

S

A

V

M

I

V

A
x
G

A
|
A

G

G

A

A

V

V

V

I

T
|
T

K
|
K

D

N

V

V

P

P

A

D

N

N

I

A

I

I

A

V

A
x
I

G

G

V

N

P

P

A

G

K
x
R

V

I

I

T

R

G

K

Y

V

V

K

E

K

A

D

N

T

F

E

E

binding coenzyme a: F72 (≠ L107), T80 (≠ A115), N81 (≠ T116), D82 (= D122), K83 (≠ P123), P85 (≠ K125), G99 (= G143), A100 (= A144), G117 (≠ A161), A118 (= A162), T123 (= T167), K124 (= K168), I133 (≠ A177), R138 (≠ K182)
binding magnesium ion: G58 (= G91), N76 (= N111)

Sites not aligning to the query:

binding coenzyme a: 199
binding thymine: 20, 21, 38, 39
binding thymidine-5'-diphosphate: 171, 176, 189, 191, 202, 203, 270

G3XD01 UDP-2-acetamido-3-amino-2,3-dideoxy-D-glucuronate N-acetyltransferase; UDP-D-GlcNAc3NA N-acetyltransferase; UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronic acid 3-N-acetyltransferase; EC 2.3.1.201 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
34% identity, 61% coverage: 77:195/196 of query aligns to 42:160/191 of G3XD01

query
sites
G3XD01

G

G

R

Q

N

N

I

V

H

F

I

V

G

G

K

N

N

K

V

V

F

V

I

I

N

G

A

D

G

R

C

C

K

K

F

I

Q

Q

D

N

Q

N

G

V

G

S

I

V

Y

Y

-

D

-

N

-

V

-

T

I

L

E

E

D

E

G

G

V

V

L

F

I

C

G

G

H

P

N

S

A

M

V

V

L

F

A

T

T

N

I

V

N

Y

H

N

M

P

E

R

D

S

P

L

E

I

K

E

R

R

A

K

G

D

M

Q

I

-

F

Y

Q

R

P

N

I

T

H

L

I

V

E

K

K

K

K

G

V

A

W

T

L

L

G

G

A

A

N

N

V

C

T

T

V

I

L

V

P

C

G

G

V

V

T

T

I

I

G

G

E

E

G

Y

S

A

V

F

I

V

A

G

A

A

G

G

A

A

V

V

V

I

T

N

K
|
K

D

N

V

V

P

P

A

S

N

Y

I

A

I

L

A

M

A

V

G

G

V

V

P

P

A

A

K

-

V

-

I

-

R

R

K

Q

V

I

K

G

K

W

D

M

T

S

E

E

K

F

G

G

E

E

K136 (= K168) mutation to A: Reduction in catalytic activity.; mutation to R: No effect on catalytic activity.

A1ADJ6 Polysialic acid O-acetyltransferase; Capsule O-acetyl transferase; EC 2.3.1.136 from Escherichia coli O1:K1 / APEC (see paper)
35% identity, 61% coverage: 77:196/196 of query aligns to 166:291/307 of A1ADJ6

query
sites
A1ADJ6

G

G

R

S

N

K

I

V

H

I

I

I

G

G

K

R

N

R

V

T

F

T

I

I

N

G

A

A

G

G

C

F

K

E

F

V

-

V

Q

T

D

D

Q

K

G

C

G

N

I

V

Y

T

I

I

E

G

D

H

G

D

V

C

L

M

I

I

G

A

H

R

N

D

A

V

V

I

L

L

-

R

A

A

T

S

I

D

N

G

H
|
H

-

P

-

I

M

F

E

D

D

I

P

H

E

S

K

K

R

K

A

R

G

I

M

N

I

W

F

A

Q

K

P

D

I

I

H

I

I

I

E

S

K

S

K

Y

V

V

W
|
W

L

V

G

G

A

R

N

N

V

V

T

S

V

I

L

M

P

K

G

G

V

V

T

S

I

V

G

G

E

S

G

G

S

S

V

V

I

I

A

G

A

Y

G

G

A

S

V

I

V

V

T

T

K

K

D

D

V

V

P

P

A

S

N

M

I

C

I

A

A

A

G

G

V

N

P

P

A

A

K

K

V

I

I

I

R

K

K

R

-

N

-

I

V

I

K

W

K

A

D

R

T

T

E

D

K

K

G

A

E

E

I

L

H210 (= H119) mutation to A: Loss of activity.
W234 (= W141) mutation to A: Loss of activity.

7s42A Crystal structure of an n-acetyltransferase from helicobacter pullorum in the presence of coenzyme a and dtdp-3-acetamido-3,6-dideoxy-d- galactose (see paper)
44% identity, 47% coverage: 78:170/196 of query aligns to 47:135/145 of 7s42A

query
sites
7s42A

R

N

N

D

I

V

H

K

I

I

G

G

K

N

N

N

V

V

F

T

I

I

N

K

A

C

G

G

C

V

K

Q

F

I

Q
x
W

D

D

Q

-

G

-

G

G

I

I

Y

E

I

I

E

E

D

D

G

D

V

V

L

F

I

I

G

G

H

P

N

N

A

V

V

T

L

F

A
x
C

T

-

I

-

N
|
N

H
x
D

M
x
K

E
x
Y

D
x
P

P

R

E

S

K

K

R

Q

A
x
Y

G

P

M

K

I

E

F

F

Q

S

P

K

I

T

H

I

I

I

E

K

K

K

K

G

V

A

W

S

L

I

G

G

A

A

N

N

V

A

T

T

V

I

L
|
L

P

P

G

G

V

I

T

T

I

I

G

G

E

E

G

N

S

A

V

M

I

I

A

G

A

A

G

G

A

A

V

I

V

V

T
|
T

K
|
K

D

D

V

V

binding [(2~{R},3~{R},4~{S},5~{R},6~{R})-4-acetamido-6-methyl-3,5-bis(oxidanyl)oxan-2-yl] [[(2~{R},3~{S},5~{R})-5-[5-methyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] hydrogen phosphate: W64 (≠ Q95), N83 (= N118), D84 (≠ H119), Y92 (≠ A127)
binding coenzyme a: C82 (≠ A115), D84 (≠ H119), K85 (≠ M120), Y86 (≠ E121), P87 (≠ D122), L114 (= L149), T132 (= T167), K133 (= K168)

Sites not aligning to the query:

binding [(2~{R},3~{R},4~{S},5~{R},6~{R})-4-acetamido-6-methyl-3,5-bis(oxidanyl)oxan-2-yl] [[(2~{R},3~{S},5~{R})-5-[5-methyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] hydrogen phosphate: 44, 46

7s41A Crystal structure of an n-acetyltransferase from helicobacter pullorum in the presence of coenzyme a and dtdp-3-acetamido-3,6-dideoxy-d- glucose (see paper)
44% identity, 47% coverage: 78:170/196 of query aligns to 47:135/145 of 7s41A

query
sites
7s41A

R

N

N

D

I

V

H

K

I

I

G

G

K

N

N

N

V

V

F

T

I

I

N

K

A

C

G

G

C

V

K

Q

F

I

Q
x
W

D

D

Q

-

G

-

G

G

I

I

Y

E

I

I

E

E

D

D

G

D

V

V

L

F

I

I

G

G

H

P

N

N

A

V

V

T

L

F

A
x
C

T

-

I

-

N
|
N

H
x
D

M
x
K

E
x
Y

D
x
P

P

R

E

S

K

K

R

Q

A
x
Y

G

P

M

K

I

E

F

F

Q

S

P

K

I

T

H

I

I

I

E

K

K

K

K

G

V

A

W

S

L

I

G

G

A

A

N

N

V

A

T

T

V

I

L
|
L

P

P

G

G

V

I

T

T

I

I

G

G

E

E

G

N

S

A

V

M

I

I

A

G

A

A

G

G

A

A

V

I

V

V

T
|
T

K
|
K

D

D

V

V

binding [(2~{R},3~{R},4~{S},5~{S},6~{R})-4-acetamido-6-methyl-3,5-bis(oxidanyl)oxan-2-yl] [[(2~{R},3~{S},5~{R})-5-[5-methyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] hydrogen phosphate : W64 (≠ Q95), N83 (= N118), D84 (≠ H119), Y92 (≠ A127)
binding coenzyme a: C82 (≠ A115), D84 (≠ H119), K85 (≠ M120), Y86 (≠ E121), P87 (≠ D122), L114 (= L149), T132 (= T167), K133 (= K168)

Sites not aligning to the query:

binding [(2~{R},3~{R},4~{S},5~{S},6~{R})-4-acetamido-6-methyl-3,5-bis(oxidanyl)oxan-2-yl] [[(2~{R},3~{S},5~{R})-5-[5-methyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] hydrogen phosphate : 44, 46

7s3wA Crystal structure of an n-acetyltransferase from helicobacter pullorum in the presence of coenzyme a and dtdp-3-amino-3,6-dideoxy-d- galactose (see paper)
44% identity, 47% coverage: 78:170/196 of query aligns to 47:135/145 of 7s3wA

query
sites
7s3wA

R

N

N

D

I

V

H

K

I

I

G

G

K

N

N

N

V

V

F

T

I

I

N

K

A

C

G

G

C

V

K

Q

F

I

Q

W

D

D

Q

-

G

-

G

G

I

I

Y

E

I

I

E

E

D

D

G

D

V

V

L

F

I

I

G

G

H

P

N

N

A

V

V

T

L

F

A
x
C

T

-

I

-

N

N

H
x
D

M
x
K

E
x
Y

D
x
P

P

R

E

S

K

K

R

Q

A
x
Y

G

P

M

K

I

E

F

F

Q

S

P

K

I

T

H

I

I

I

E

K

K

K

K

G

V

A

W

S

L

I

G

G

A

A

N

N

V

A

T

T

V

I

L
|
L

P

P

G

G

V

I

T

T

I

I

G

G

E

E

G

N

S

A

V

M

I

I

A

G

A

A

G

G

A

A

V

I

V

V

T
|
T

K
|
K

D

D

V

V

binding oxidized coenzyme a: C82 (≠ A115), D84 (≠ H119), K85 (≠ M120), Y86 (≠ E121), P87 (≠ D122), L114 (= L149), T132 (= T167), K133 (= K168)
binding (3R,4S,5R,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl][hydroxy-[[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy]phosphoryl] hydrogen phosphate: D84 (≠ H119), Y92 (≠ A127)

Sites not aligning to the query:

binding (3R,4S,5R,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl][hydroxy-[[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy]phosphoryl] hydrogen phosphate: 44, 46

7s3uA Crystal structure of an n-acetyltransferase from helicobacter pullorum in the presence of coenzyme a and dtdp-3-amino-3,6-dideoxy-d-glucose (see paper)
44% identity, 47% coverage: 78:170/196 of query aligns to 47:135/145 of 7s3uA

query
sites
7s3uA

R

N

N

D

I

V

H

K

I

I

G

G

K

N

N

N

V

V

F

T

I

I

N

K

A

C

G

G

C

V

K

Q

F

I

Q

W

D

D

Q

-

G

-

G

G

I

I

Y

E

I

I

E

E

D

D

G

D

V

V

L

F

I

I

G

G

H

P

N

N

A

V

V

T

L

F

A
x
C

T

-

I

-

N
|
N

H
x
D

M
x
K

E
x
Y

D
x
P

P

R

E

S

K

K

R

Q

A
x
Y

G

P

M

K

I

E

F

F

Q

S

P

K

I

T

H

I

I

I

E

K

K

K

K

G

V

A

W

S

L

I

G

G

A

A

N

N

V

A

T

T

V

I

L
|
L

P

P

G

G

V

I

T

T

I

I

G

G

E

E

G

N

S

A

V

M

I

I

A

G

A

A

G

G

A

A

V

I

V

V

T
|
T

K
|
K

D

D

V

V

binding coenzyme a: C82 (≠ A115), N83 (= N118), D84 (≠ H119), K85 (≠ M120), Y86 (≠ E121), P87 (≠ D122), L114 (= L149), T132 (= T167), K133 (= K168)
binding [(3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl][hydroxy-[[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy]phosphoryl] hydrogen phosphate: D84 (≠ H119), Y92 (≠ A127)

Sites not aligning to the query:

binding [(3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl][hydroxy-[[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy]phosphoryl] hydrogen phosphate: 44, 46

7s45A Crystal structure of an n-acetyltransferase, c80t mutant, from helicobacter pullorum in the presence of acetyl coenzyme a and dtdp (see paper)
44% identity, 47% coverage: 78:170/196 of query aligns to 47:131/141 of 7s45A

query
sites
7s45A

R

N

N

D

I

V

H

K

I

I

G

G

K

N

N

N

V

V

F

T

I

I

N

K

A

C

G

G

C

V

K

Q

F

I

Q
x
W

D

D

Q

-

G

-

G

G

I

I

Y

E

I

I

E

E

D

D

G

D

V

V

L

F

I

I

G

G

H

P

N

N

A

V

V

-

L

-

A

-

T

T

I

F

N
x
T

H
x
N

M
x
D

E
x
K

D
x
Y

P
|
P

E

R

K

S

R

K

A

Q

G

-

M

-

I

-

F

F

Q

S

P

K

I

T

H

I

I

I

E

K

K

K

K

G

V

A

W

S

L

I

G

G

A

A

N

N

V

A

T

T

V

I

L
|
L

P

P

G

G

V

I

T

T

I

I

G

G

E

E

G

N

S

A

V

M

I

I

A

G

A

A

G

G

A

A

V

I

V

V

T
|
T

K
|
K

D

D

V

V

binding acetyl coenzyme *a: W64 (≠ Q95), T82 (≠ N118), N83 (≠ H119), D84 (≠ M120), K85 (≠ E121), Y86 (≠ D122), P87 (= P123), L110 (= L149), T128 (= T167), K129 (= K168)

Sites not aligning to the query:

binding thymidine-5'-diphosphate: 44, 46

4husA Crystal structure of streptogramin group a antibiotic acetyltransferase vata from staphylococcus aureus in complex with virginiamycin m1 (see paper)
53% identity, 29% coverage: 134:190/196 of query aligns to 113:169/212 of 4husA

query
sites
4husA

I

I

H

E

I

I

E

G

K

N

K

D

V

V

W

W

L

I

G

G

A

R

N

D

V

V

T

T

V

I

L

M

P

P

G

G

V

V

T

K

I

I

G

G

E

D

G

G

S

A

V

I

I

I

A

A

G

E

A

A

V

V

T

T

K

K

D

N

V

V

P

A

A

P

N

Y

I

S

I

I

A

V

A

G

G

G

V

N

P

P

A

L

K

K

V

F

I

I

R

R

K

K

V

R

K

F

K

S

D

D

Sites not aligning to the query:

binding virginiamycin m1: 17, 36, 38

Query Sequence

>WP_005347213.1 NCBI__GCF_000173975.1:WP_005347213.1
MTCEEYLSNMKPGYIVDGGSEEHLVMHELSQRALKITMELNNKYHTKEEIIQLMSELTGQ
KIDESFGMFPPFYTDCGRNIHIGKNVFINAGCKFQDQGGIYIEDGVLIGHNAVLATINHM
EDPEKRAGMIFQPIHIEKKVWLGANVTVLPGVTIGEGSVIAAGAVVTKDVPANIIAAGVP
AKVIRKVKKDTEKGEI

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory